{"id":"https://openalex.org/W4401995339","doi":"https://doi.org/10.1039/d4nr01487a","title":"Lipid nanoparticles for enhancing oral bioavailability","display_name":"Lipid nanoparticles for enhancing oral bioavailability","publication_year":2024,"publication_date":"2024-01-01","ids":{"openalex":"https://openalex.org/W4401995339","doi":"https://doi.org/10.1039/d4nr01487a","pmid":"https://pubmed.ncbi.nlm.nih.gov/39291697"},"language":"en","primary_location":{"id":"doi:10.1039/d4nr01487a","doi":"https://doi.org/10.1039/d4nr01487a","is_oa":true,"landing_page_url":"https://doi.org/10.1039/d4nr01487a","pdf_url":"https://pubs.rsc.org/en/content/articlepdf/2024/nr/d4nr01487a","source":{"id":"https://openalex.org/S23181512","display_name":"Nanoscale","issn_l":"2040-3364","issn":["2040-3364","2040-3372"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nanoscale","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://pubs.rsc.org/en/content/articlepdf/2024/nr/d4nr01487a","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5106808964","display_name":"Anushareddy Gangavarapu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I368840534","display_name":"University of Mississippi","ror":"https://ror.org/02teq1165","country_code":"US","type":"education","lineage":["https://openalex.org/I368840534","https://openalex.org/I4210141039"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anushareddy Gangavarapu","raw_affiliation_strings":["Department of Pharmaceutics and Drug Delivery, School of Pharmacy, University of Mississippi, MS 38677, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutics and Drug Delivery, School of Pharmacy, University of Mississippi, MS 38677, USA","institution_ids":["https://openalex.org/I368840534"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028310451","display_name":"Lillian V. Tapia-Lopez","orcid":"https://orcid.org/0000-0003-1279-0858","observed_orcids":["https://orcid.org/0000-0003-1279-0858"]},"institutions":[{"id":"https://openalex.org/I164936912","display_name":"The University of Texas at El Paso","ror":"https://ror.org/04d5vba33","country_code":"US","type":"education","lineage":["https://openalex.org/I164936912"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lillian V. Tapia-Lopez","raw_affiliation_strings":["Department of Pharmaceutical Sciences, School of Pharmacy, University of Texas at El Paso, El Paso, TX 79902, USA"],"raw_orcid":"https://orcid.org/0000-0003-1279-0858","affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Sciences, School of Pharmacy, University of Texas at El Paso, El Paso, TX 79902, USA","institution_ids":["https://openalex.org/I164936912"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114216370","display_name":"Barnali Sarkar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I164936912","display_name":"The University of Texas at El Paso","ror":"https://ror.org/04d5vba33","country_code":"US","type":"education","lineage":["https://openalex.org/I164936912"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Barnali Sarkar","raw_affiliation_strings":["Department of Pharmaceutical Sciences, School of Pharmacy, University of Texas at El Paso, El Paso, TX 79902, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Sciences, School of Pharmacy, University of Texas at El Paso, El Paso, TX 79902, USA","institution_ids":["https://openalex.org/I164936912"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022634556","display_name":"Jaqueline Pena\u2010Zacarias","orcid":"https://orcid.org/0000-0001-6851-7231","observed_orcids":["https://orcid.org/0000-0001-6851-7231"]},"institutions":[{"id":"https://openalex.org/I164936912","display_name":"The University of Texas at El Paso","ror":"https://ror.org/04d5vba33","country_code":"US","type":"education","lineage":["https://openalex.org/I164936912"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jaqueline Pena-Zacarias","raw_affiliation_strings":["Biological Sciences Program, College of Science, University of Texas at El Paso, El Paso, TX 79965, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biological Sciences Program, College of Science, University of Texas at El Paso, El Paso, TX 79965, USA","institution_ids":["https://openalex.org/I164936912"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108567338","display_name":"Abu Zayed Md Badruddoza","orcid":"https://orcid.org/0000-0002-7914-540X","observed_orcids":["https://orcid.org/0000-0002-7914-540X"]},"institutions":[{"id":"https://openalex.org/I180857899","display_name":"Pfizer (United States)","ror":"https://ror.org/01xdqrp08","country_code":"US","type":"company","lineage":["https://openalex.org/I180857899"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Abu Zayed Md Badruddoza","raw_affiliation_strings":["Pharmaceutical Sciences Small Molecule, Pfizer Worldwide Research and Development, Groton, CT 06340, USA"],"raw_orcid":"https://orcid.org/0000-0002-7914-540X","affiliations":[{"raw_affiliation_string":"Pharmaceutical Sciences Small Molecule, Pfizer Worldwide Research and Development, Groton, CT 06340, USA","institution_ids":["https://openalex.org/I180857899"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5023401002","display_name":"Md Nurunnabi","orcid":"https://orcid.org/0000-0003-4457-3401","observed_orcids":["https://orcid.org/0000-0003-4457-3401"]},"institutions":[{"id":"https://openalex.org/I368840534","display_name":"University of Mississippi","ror":"https://ror.org/02teq1165","country_code":"US","type":"education","lineage":["https://openalex.org/I368840534","https://openalex.org/I4210141039"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Md Nurunnabi","raw_affiliation_strings":["Department of Pharmaceutics and Drug Delivery, School of Pharmacy, University of Mississippi, MS 38677, USA"],"raw_orcid":"https://orcid.org/0000-0003-4457-3401","affiliations":[{"raw_affiliation_string":"Department of Pharmaceutics and Drug Delivery, School of Pharmacy, University of Mississippi, MS 38677, USA","institution_ids":["https://openalex.org/I368840534"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5023401002","https://openalex.org/A5108567338"],"corresponding_institution_ids":["https://openalex.org/I180857899","https://openalex.org/I368840534"],"apc_list":null,"apc_paid":null,"fwci":2.6303,"has_fulltext":true,"cited_by_count":81,"citation_normalized_percentile":{"value":0.93951613,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":100},"biblio":{"volume":"16","issue":"39","first_page":"18319","last_page":"18338"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10256","display_name":"Drug Solubulity and Delivery Systems","score":0.8544999957084656,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10256","display_name":"Drug Solubulity and Delivery Systems","score":0.8544999957084656,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.11159999668598175,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.01640000008046627,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lipid-nanoparticles","display_name":"lipid nanoparticles","score":1.0},{"id":"https://openalex.org/keywords/oral-bioavailability","display_name":"oral bioavailability","score":0.9639999866485596},{"id":"https://openalex.org/keywords/oral-drug-delivery","display_name":"oral drug delivery","score":0.9860000014305115},{"id":"https://openalex.org/keywords/gastrointestinal-absorption","display_name":"gastrointestinal absorption","score":0.5490000247955322},{"id":"https://openalex.org/keywords/drug-permeability","display_name":"drug permeability","score":0.6759999990463257},{"id":"https://openalex.org/keywords/drug-transport-kinetics","display_name":"drug transport kinetics","score":0.7919999957084656},{"id":"https://openalex.org/keywords/lymphatic-drainage-pathways","display_name":"lymphatic drainage pathways","score":0.6259999871253967}],"concepts":[{"id":"https://openalex.org/C181389837","wikidata":"https://www.wikidata.org/wiki/Q461809","display_name":"Bioavailability","level":2,"score":0.9385408163070679},{"id":"https://openalex.org/C155672457","wikidata":"https://www.wikidata.org/wiki/Q61231","display_name":"Nanoparticle","level":2,"score":0.6535383462905884},{"id":"https://openalex.org/C199529486","wikidata":"https://www.wikidata.org/wiki/Q7557912","display_name":"Solid lipid nanoparticle","level":3,"score":0.5078864693641663},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.4870143532752991},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.44349944591522217},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.32305675745010376},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.14719274640083313},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.09097751975059509}],"mesh":[{"descriptor_ui":"D000284","descriptor_name":"Administration, Oral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001682","descriptor_name":"Biological Availability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004337","descriptor_name":"Drug Carriers","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008055","descriptor_name":"Lipids","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D008081","descriptor_name":"Liposomes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016503","descriptor_name":"Drug Delivery Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053758","descriptor_name":"Nanoparticles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1039/d4nr01487a","doi":"https://doi.org/10.1039/d4nr01487a","is_oa":true,"landing_page_url":"https://doi.org/10.1039/d4nr01487a","pdf_url":"https://pubs.rsc.org/en/content/articlepdf/2024/nr/d4nr01487a","source":{"id":"https://openalex.org/S23181512","display_name":"Nanoscale","issn_l":"2040-3364","issn":["2040-3364","2040-3372"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nanoscale","raw_type":"journal-article"},{"id":"pmid:39291697","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39291697","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nanoscale","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1039/d4nr01487a","doi":"https://doi.org/10.1039/d4nr01487a","is_oa":true,"landing_page_url":"https://doi.org/10.1039/d4nr01487a","pdf_url":"https://pubs.rsc.org/en/content/articlepdf/2024/nr/d4nr01487a","source":{"id":"https://openalex.org/S23181512","display_name":"Nanoscale","issn_l":"2040-3364","issn":["2040-3364","2040-3372"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nanoscale","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4401995339.pdf","grobid_xml":"https://content.openalex.org/works/W4401995339.grobid-xml"},"referenced_works_count":117,"referenced_works":["https://openalex.org/W181415430","https://openalex.org/W190838317","https://openalex.org/W1451167366","https://openalex.org/W1498354276","https://openalex.org/W1503492363","https://openalex.org/W1536793745","https://openalex.org/W1555170461","https://openalex.org/W1602491094","https://openalex.org/W1911274345","https://openalex.org/W1964896591","https://openalex.org/W1966515457","https://openalex.org/W1970176633","https://openalex.org/W1973488401","https://openalex.org/W1973968477","https://openalex.org/W1974050571","https://openalex.org/W1974148324","https://openalex.org/W1974166640","https://openalex.org/W1980766303","https://openalex.org/W1984885382","https://openalex.org/W1988383608","https://openalex.org/W1992521891","https://openalex.org/W1994294415","https://openalex.org/W1997059713","https://openalex.org/W2003026126","https://openalex.org/W2003275588","https://openalex.org/W2011920500","https://openalex.org/W2013567835","https://openalex.org/W2013630484","https://openalex.org/W2013735026","https://openalex.org/W2016195561","https://openalex.org/W2017138846","https://openalex.org/W2019210911","https://openalex.org/W2022905205","https://openalex.org/W2027414332","https://openalex.org/W2044903986","https://openalex.org/W2045948644","https://openalex.org/W2052338782","https://openalex.org/W2052804020","https://openalex.org/W2056764794","https://openalex.org/W2060208262","https://openalex.org/W2060992818","https://openalex.org/W2065254628","https://openalex.org/W2078481291","https://openalex.org/W2083095583","https://openalex.org/W2092607934","https://openalex.org/W2094323693","https://openalex.org/W2102253230","https://openalex.org/W2117630026","https://openalex.org/W2118762743","https://openalex.org/W2126020016","https://openalex.org/W2133265422","https://openalex.org/W2150471474","https://openalex.org/W2153192347","https://openalex.org/W2162980328","https://openalex.org/W2181724120","https://openalex.org/W2278370115","https://openalex.org/W2285881370","https://openalex.org/W2369103875","https://openalex.org/W2477103182","https://openalex.org/W2495316794","https://openalex.org/W2522590257","https://openalex.org/W2539051639","https://openalex.org/W2564239734","https://openalex.org/W2574256996","https://openalex.org/W2593053298","https://openalex.org/W2597190528","https://openalex.org/W2600400434","https://openalex.org/W2732877934","https://openalex.org/W2800488651","https://openalex.org/W2801767769","https://openalex.org/W2803001759","https://openalex.org/W2804846127","https://openalex.org/W2805833715","https://openalex.org/W2810248278","https://openalex.org/W2892686211","https://openalex.org/W2895891965","https://openalex.org/W2909579525","https://openalex.org/W2913094782","https://openalex.org/W2916175089","https://openalex.org/W2946091336","https://openalex.org/W2946284859","https://openalex.org/W2981958957","https://openalex.org/W3008004285","https://openalex.org/W3022452929","https://openalex.org/W3044962842","https://openalex.org/W3047510030","https://openalex.org/W3082499795","https://openalex.org/W3084354451","https://openalex.org/W3117390716","https://openalex.org/W3127911256","https://openalex.org/W3128860426","https://openalex.org/W3156272201","https://openalex.org/W3158110844","https://openalex.org/W3165063405","https://openalex.org/W3166661471","https://openalex.org/W3176841467","https://openalex.org/W3184644021","https://openalex.org/W3204577118","https://openalex.org/W3216282807","https://openalex.org/W4200599268","https://openalex.org/W4213090198","https://openalex.org/W4225120435","https://openalex.org/W4253670085","https://openalex.org/W4283803576","https://openalex.org/W4289203947","https://openalex.org/W4289639546","https://openalex.org/W4289930104","https://openalex.org/W4293029499","https://openalex.org/W4296806810","https://openalex.org/W4321482556","https://openalex.org/W4322504431","https://openalex.org/W4323660325","https://openalex.org/W4386030674","https://openalex.org/W4386134570","https://openalex.org/W4387230036","https://openalex.org/W4387491319","https://openalex.org/W4391322999"],"related_works":["https://openalex.org/W7153591440","https://openalex.org/W2916175089","https://openalex.org/W2913651519","https://openalex.org/W4225649893","https://openalex.org/W3206353028","https://openalex.org/W2884347405","https://openalex.org/W3047510030","https://openalex.org/W2540269711","https://openalex.org/W7020949837","https://openalex.org/W2532936887"],"abstract_inverted_index":{"a":[0,10],"selective":[1],"lymphatic":[2],"pathway.":[3],"This":[4],"review":[5],"mainly":[6],"focuses":[7],"on":[8,13],"providing":[9],"brief":[11],"update":[12],"lipid":[14],"nanoparticles":[15],"(LNPs)":[16],"that":[17],"synergistically":[18],"increase":[19],"the":[20,28,34,45],"bioavailability":[21],"of":[22,31,51],"limited":[23],"permeable":[24],"drugs":[25],"and":[26,41,48],"highlight":[27],"transversal":[29],"mechanisms":[30],"LNPs":[32,52],"across":[33],"gastrointestinal":[35],"hurdles,":[36],"transmembrane":[37],"absorption,":[38],"transport":[39],"kinetics,":[40],"computational":[42],"tools.":[43],"Finally,":[44],"present":[46],"hurdles":[47],"future":[49],"perspectives":[50],"for":[53],"oral":[54],"drug":[55],"delivery":[56],"systems":[57],"are":[58],"discussed.":[59]},"counts_by_year":[{"year":2026,"cited_by_count":46},{"year":2025,"cited_by_count":32},{"year":2024,"cited_by_count":3}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2024-08-30T00:00:00"}