{"id":"https://openalex.org/W4401979679","doi":"https://doi.org/10.14740/jem1001","title":"Intestinal Absorption and Transformation of the Increased Dose of Paracetamol in Streptozotocin-Induced Diabetic Rats","display_name":"Intestinal Absorption and Transformation of the Increased Dose of Paracetamol in Streptozotocin-Induced Diabetic Rats","publication_year":2024,"publication_date":"2024-08-01","ids":{"openalex":"https://openalex.org/W4401979679","doi":"https://doi.org/10.14740/jem1001"},"language":"en","primary_location":{"id":"doi:10.14740/jem1001","doi":"https://doi.org/10.14740/jem1001","is_oa":true,"landing_page_url":"https://doi.org/10.14740/jem1001","pdf_url":"https://www.jofem.org/index.php/jofem/article/download/1001/284284731","source":{"id":"https://openalex.org/S2764861430","display_name":"Journal of Endocrinology and Metabolism","issn_l":"1923-2861","issn":["1923-2861","1923-287X"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4328135221","host_organization_name":"Elmer Press Inc.","host_organization_lineage":["https://openalex.org/P4328135221"],"host_organization_lineage_names":["Elmer Press Inc."],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Endocrinology and Metabolism","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W4401979679"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://www.jofem.org/index.php/jofem/article/download/1001/284284731","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5071611223","display_name":"Petra M\u00e9s\u017aaros","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79741316","display_name":"University of Pecs","ror":"https://ror.org/037b5pv06","country_code":"HU","type":"education","lineage":["https://openalex.org/I79741316"]}],"countries":["HU"],"is_corresponding":false,"raw_author_name":"Petra Meszaros","raw_affiliation_strings":["Institute of Pharmaceutical Chemistry, Pharmaceutical Faculty, University of Pecs, H-7624 Pecs"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Pharmaceutical Chemistry, Pharmaceutical Faculty, University of Pecs, H-7624 Pecs","institution_ids":["https://openalex.org/I79741316"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Sara Kovacs","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79741316","display_name":"University of Pecs","ror":"https://ror.org/037b5pv06","country_code":"HU","type":"education","lineage":["https://openalex.org/I79741316"]}],"countries":["HU"],"is_corresponding":false,"raw_author_name":"Sara Kovacs","raw_affiliation_strings":["Institute of Pharmaceutical Chemistry, Pharmaceutical Faculty, University of Pecs, H-7624 Pecs"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Pharmaceutical Chemistry, Pharmaceutical Faculty, University of Pecs, H-7624 Pecs","institution_ids":["https://openalex.org/I79741316"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5008625845","display_name":"Attila Alm\u00e1si","orcid":"https://orcid.org/0009-0000-4931-6530","observed_orcids":["https://orcid.org/0009-0000-4931-6530"]},"institutions":[{"id":"https://openalex.org/I79741316","display_name":"University of Pecs","ror":"https://ror.org/037b5pv06","country_code":"HU","type":"education","lineage":["https://openalex.org/I79741316"]}],"countries":["HU"],"is_corresponding":false,"raw_author_name":"Attila Almasi","raw_affiliation_strings":["Institute of Pharmaceutical Chemistry, Pharmaceutical Faculty, University of Pecs, H-7624 Pecs"],"raw_orcid":"https://orcid.org/0009-0000-4931-6530","affiliations":[{"raw_affiliation_string":"Institute of Pharmaceutical Chemistry, Pharmaceutical Faculty, University of Pecs, H-7624 Pecs","institution_ids":["https://openalex.org/I79741316"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I79741316"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"14","issue":"4","first_page":"174","last_page":"183"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.9023000001907349,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.9023000001907349,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.010400000028312206,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10256","display_name":"Drug Solubulity and Delivery Systems","score":0.008299999870359898,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/paracetamol","display_name":"paracetamol","score":0.984000027179718},{"id":"https://openalex.org/keywords/intestinal-absorption","display_name":"intestinal absorption","score":0.8960000276565552},{"id":"https://openalex.org/keywords/streptozotocin-induced-diabetes","display_name":"streptozotocin-induced diabetes","score":0.8619999885559082},{"id":"https://openalex.org/keywords/paracetamol-metabolites","display_name":"paracetamol metabolites","score":0.8220000267028809},{"id":"https://openalex.org/keywords/glutathione","display_name":"glutathione","score":0.800000011920929},{"id":"https://openalex.org/keywords/glutathione-disulfide","display_name":"glutathione disulfide","score":0.9470000267028809},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.9900000095367432},{"id":"https://openalex.org/keywords/small-intestine","display_name":"small intestine","score":0.7559999823570251},{"id":"https://openalex.org/keywords/luminal-perfusion","display_name":"luminal perfusion","score":0.6930000185966492},{"id":"https://openalex.org/keywords/drug-metabolism","display_name":"drug metabolism","score":0.45500001311302185}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9715589284896851},{"id":"https://openalex.org/C2779280383","wikidata":"https://www.wikidata.org/wiki/Q257331","display_name":"Streptozotocin","level":3,"score":0.8098385334014893},{"id":"https://openalex.org/C125287762","wikidata":"https://www.wikidata.org/wiki/Q1758948","display_name":"Absorption (acoustics)","level":2,"score":0.5148776769638062},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.46925660967826843},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.4505954682826996},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3864409625530243},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.2916910648345947},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C24890656","wikidata":"https://www.wikidata.org/wiki/Q82811","display_name":"Acoustics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.14740/jem1001","doi":"https://doi.org/10.14740/jem1001","is_oa":true,"landing_page_url":"https://doi.org/10.14740/jem1001","pdf_url":"https://www.jofem.org/index.php/jofem/article/download/1001/284284731","source":{"id":"https://openalex.org/S2764861430","display_name":"Journal of Endocrinology and Metabolism","issn_l":"1923-2861","issn":["1923-2861","1923-287X"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4328135221","host_organization_name":"Elmer Press Inc.","host_organization_lineage":["https://openalex.org/P4328135221"],"host_organization_lineage_names":["Elmer Press Inc."],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Endocrinology and Metabolism","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.14740/jem1001","doi":"https://doi.org/10.14740/jem1001","is_oa":true,"landing_page_url":"https://doi.org/10.14740/jem1001","pdf_url":"https://www.jofem.org/index.php/jofem/article/download/1001/284284731","source":{"id":"https://openalex.org/S2764861430","display_name":"Journal of Endocrinology and Metabolism","issn_l":"1923-2861","issn":["1923-2861","1923-287X"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4328135221","host_organization_name":"Elmer Press Inc.","host_organization_lineage":["https://openalex.org/P4328135221"],"host_organization_lineage_names":["Elmer Press Inc."],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Endocrinology and Metabolism","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9940000176429749,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4401979679.pdf","grobid_xml":"https://content.openalex.org/works/W4401979679.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4303710123","https://openalex.org/W2421628228","https://openalex.org/W2285032515","https://openalex.org/W4321784776","https://openalex.org/W2023931037","https://openalex.org/W2060380683","https://openalex.org/W1970584851","https://openalex.org/W2157921192","https://openalex.org/W2029580713","https://openalex.org/W2067013968"],"abstract_inverted_index":{"Background:":[0],"Luminal":[1],"disappearance":[2],"of":[3,9,33,46,63,94,105,141,154,168,184,198],"the":[4,7,34,44,60,67,76,99,103,106,110,120,126,135,139,142,152,155,165,169,177,182,185,196,199],"paracetamol":[5,14,17,21,36,54,95,122,156,159,174],"and":[6,20,28,66,70,102,146,176],"appearance":[8,167],"its":[10,71,147],"metabolites":[11,72,96],"(paracetamol-\u03b2-D-glucuronide":[12],"(PG),":[13],"sulfate":[15],"(PS),":[16],"cysteine":[18],"(PC)":[19],"mercapturate":[22],"(PM))":[23],"were":[24,73],"investigated":[25],"in":[26,29,109],"control":[27],"experimental":[30,178],"diabetic":[31],"rats":[32],"perfused":[35,58,121],"substrate.":[37],"Methods:":[38],"Experimental":[39],"diabetes":[40,179],"was":[41,56,149,204],"induced":[42],"by":[43,134,151],"administration":[45,160],"streptozotocin":[47],"(STZ)":[48],"(65":[49],"mg/kg,":[50],"intravenous":[51],"(IV)).":[52],"The":[53,91,130,158,172,187],"solution":[55,78],"luminally":[57],"through":[59],"small":[61,111],"intestine":[62,112],"anesthetized":[64],"rats,":[65],"parent":[68],"compound":[69],"determined":[74],"from":[75],"perfusion":[77],"with":[79],"an":[80],"isocratic":[81],"reverse":[82],"phased":[83],"high":[84],"performance":[85],"liquid":[86],"chromatography":[87],"(RP-HPLC)":[88],"method.":[89],"Results:":[90],"excreted":[92],"amount":[93],"increased":[97],"after":[98],"STZ":[100,136],"pretreatment,":[101],"concentration":[104,175],"glutathione":[107,144],"(GSH)":[108],"tissue":[113],"homogenate":[114],"showed":[115,191],"a":[116,192],"decreasing":[117,193],"tendency,":[118,194],"although":[119],"does":[123],"not":[124,163],"accelerate":[125],"observed":[127],"changing":[128],"tendency.":[129],"oxidative":[131,200],"stress":[132,201],"caused":[133],"contributed":[137],"to":[138],"formation":[140],"oxidized":[143],"(GSSG),":[145],"level":[148,190,197],"elevated":[150,173],"effect":[153],"administration.":[157],"alone":[161],"did":[162],"provoke":[164],"detectable":[166],"GSSG.":[170],"Conclusions:":[171],"negatively":[180],"influenced":[181],"absorption":[183],"paracetamol.":[186],"protective":[188],"GSH":[189],"while":[195],"indicator":[202],"GSSG":[203],"higher.":[205],"J":[206],"Endocrinol":[207],"Metab.":[208],"2024;14(4):174-183":[209],"doi:":[210],"https://doi.org/10.14740/jem1001":[211]},"counts_by_year":[],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2024-08-29T00:00:00"}
