{"id":"https://openalex.org/W4401976016","doi":"https://doi.org/10.2174/0122103031304145240805092718","title":"Lipid Drug Conjugates in Pharmaceutical Formulations and Drug Delivery Systems","display_name":"Lipid Drug Conjugates in Pharmaceutical Formulations and Drug Delivery Systems","publication_year":2024,"publication_date":"2024-08-20","ids":{"openalex":"https://openalex.org/W4401976016","doi":"https://doi.org/10.2174/0122103031304145240805092718"},"language":"en","primary_location":{"id":"doi:10.2174/0122103031304145240805092718","doi":"https://doi.org/10.2174/0122103031304145240805092718","is_oa":false,"landing_page_url":"https://doi.org/10.2174/0122103031304145240805092718","pdf_url":null,"source":{"id":"https://openalex.org/S4210210790","display_name":"Drug Delivery Letters","issn_l":"2210-3031","issn":["2210-3031","2210-304X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-20","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug Delivery Letters","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5092268978","display_name":"Chitrali Talele","orcid":"https://orcid.org/0009-0009-4274-0764","observed_orcids":["https://orcid.org/0009-0009-4274-0764"]},"institutions":[{"id":"https://openalex.org/I4210119093","display_name":"Suamandeep Vidyapeeth University","ror":"https://ror.org/02mpq1w39","country_code":"IN","type":"education","lineage":["https://openalex.org/I4210119093"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Chitrali Talele","raw_affiliation_strings":["Department of Pharmacy, Sumandeep Vidyapeeth Deemed to be University, Piparia, Waghodia, Vadodara, 391760, Gujarat, India"],"raw_orcid":"https://orcid.org/0009-0009-4274-0764","affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Sumandeep Vidyapeeth Deemed to be University, Piparia, Waghodia, Vadodara, 391760, Gujarat, India","institution_ids":["https://openalex.org/I4210119093"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068765808","display_name":"Dipali R. Talele","orcid":"https://orcid.org/0000-0003-0493-7207","observed_orcids":["https://orcid.org/0000-0003-0493-7207"]},"institutions":[{"id":"https://openalex.org/I4387152961","display_name":"Vishwakarma University","ror":"https://ror.org/016zwj547","country_code":"IN","type":"education","lineage":["https://openalex.org/I4387152961"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Dipali Talele","raw_affiliation_strings":["Faculty of Pharmacy, Vishwakarma University, Survey No. 2,3,4 Laxmi Nagar, Kondhwa, Budruk, Pune, 41104, Maharashtra, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Pharmacy, Vishwakarma University, Survey No. 2,3,4 Laxmi Nagar, Kondhwa, Budruk, Pune, 41104, Maharashtra, India","institution_ids":["https://openalex.org/I4387152961"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008022512","display_name":"Niyati Shah","orcid":"https://orcid.org/0009-0003-2563-4157","observed_orcids":["https://orcid.org/0009-0003-2563-4157"]},"institutions":[{"id":"https://openalex.org/I4210119093","display_name":"Suamandeep Vidyapeeth University","ror":"https://ror.org/02mpq1w39","country_code":"IN","type":"education","lineage":["https://openalex.org/I4210119093"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Niyati Shah","raw_affiliation_strings":["Department of Pharmacy, Sumandeep Vidyapeeth Deemed to be University, Piparia, Waghodia, Vadodara, 391760, Gujarat, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Sumandeep Vidyapeeth Deemed to be University, Piparia, Waghodia, Vadodara, 391760, Gujarat, India","institution_ids":["https://openalex.org/I4210119093"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109500901","display_name":"Mamta Kumari","orcid":"https://orcid.org/0000-0002-9917-2077","observed_orcids":["https://orcid.org/0000-0002-9917-2077"]},"institutions":[{"id":"https://openalex.org/I4210119093","display_name":"Suamandeep Vidyapeeth University","ror":"https://ror.org/02mpq1w39","country_code":"IN","type":"education","lineage":["https://openalex.org/I4210119093"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Mamta Kumari","raw_affiliation_strings":["Department of Pharmacy, Sumandeep Vidyapeeth Deemed to be University, Piparia, Waghodia, Vadodara, 391760, Gujarat, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Sumandeep Vidyapeeth Deemed to be University, Piparia, Waghodia, Vadodara, 391760, Gujarat, India","institution_ids":["https://openalex.org/I4210119093"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079150677","display_name":"Piyushkumar Sadhu","orcid":"https://orcid.org/0000-0001-5725-1861","observed_orcids":["https://orcid.org/0000-0001-5725-1861"]},"institutions":[{"id":"https://openalex.org/I4210119093","display_name":"Suamandeep Vidyapeeth University","ror":"https://ror.org/02mpq1w39","country_code":"IN","type":"education","lineage":["https://openalex.org/I4210119093"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Piyushkumar Sadhu","raw_affiliation_strings":["Department of Pharmacy, Sumandeep Vidyapeeth Deemed to be University, Piparia, Waghodia, Vadodara, 391760, Gujarat, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Sumandeep Vidyapeeth Deemed to be University, Piparia, Waghodia, Vadodara, 391760, Gujarat, India","institution_ids":["https://openalex.org/I4210119093"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5027283189","display_name":"Chintan J. Aundhia","orcid":"https://orcid.org/0000-0002-2355-8897","observed_orcids":["https://orcid.org/0000-0002-2355-8897"]},"institutions":[{"id":"https://openalex.org/I4210119093","display_name":"Suamandeep Vidyapeeth University","ror":"https://ror.org/02mpq1w39","country_code":"IN","type":"education","lineage":["https://openalex.org/I4210119093"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Chintan Aundhia","raw_affiliation_strings":["Department of Pharmacy, Sumandeep Vidyapeeth Deemed to be University, Piparia, Waghodia, Vadodara, 391760, Gujarat, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Sumandeep Vidyapeeth Deemed to be University, Piparia, Waghodia, Vadodara, 391760, Gujarat, India","institution_ids":["https://openalex.org/I4210119093"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5068765808"],"corresponding_institution_ids":["https://openalex.org/I4387152961"],"apc_list":null,"apc_paid":null,"fwci":0.2462,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.2883058,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"15","issue":"1","first_page":"1","last_page":"14"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.4381999969482422,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.4381999969482422,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10256","display_name":"Drug Solubulity and Delivery Systems","score":0.3546999990940094,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.15839999914169312,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lipid-drug-conjugates","display_name":"lipid-drug conjugates","score":0.9950000047683716},{"id":"https://openalex.org/keywords/lipophilicity","display_name":"lipophilicity","score":0.6679999828338623},{"id":"https://openalex.org/keywords/oral-bioavailability","display_name":"oral bioavailability","score":0.8820000290870667},{"id":"https://openalex.org/keywords/lymph-node-targeting","display_name":"lymph node targeting","score":0.9819999933242798},{"id":"https://openalex.org/keywords/tumor-targeting","display_name":"tumor targeting","score":0.9980000257492065},{"id":"https://openalex.org/keywords/chemical-linkers","display_name":"chemical linkers","score":0.7089999914169312},{"id":"https://openalex.org/keywords/drug-delivery-systems","display_name":"drug delivery systems","score":0.7120000123977661},{"id":"https://openalex.org/keywords/pharmaceutical-formulations","display_name":"drug formulation","score":0.7990000247955322},{"id":"https://openalex.org/keywords/drug-loading","display_name":"drug loading","score":0.5690000057220459},{"id":"https://openalex.org/keywords/drug-stability","display_name":"drug stability","score":0.5979999899864197}],"concepts":[{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.773554801940918},{"id":"https://openalex.org/C2779820397","wikidata":"https://www.wikidata.org/wiki/Q1392806","display_name":"Drug delivery","level":2,"score":0.6862258911132812},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5539520978927612},{"id":"https://openalex.org/C197336794","wikidata":"https://www.wikidata.org/wiki/Q5161150","display_name":"Conjugate","level":2,"score":0.5033835768699646},{"id":"https://openalex.org/C178855305","wikidata":"https://www.wikidata.org/wiki/Q614304","display_name":"Pharmaceutical sciences","level":2,"score":0.4913467466831207},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.42236968874931335},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3349974751472473},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.07538631558418274},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.07470330595970154},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.2174/0122103031304145240805092718","doi":"https://doi.org/10.2174/0122103031304145240805092718","is_oa":false,"landing_page_url":"https://doi.org/10.2174/0122103031304145240805092718","pdf_url":null,"source":{"id":"https://openalex.org/S4210210790","display_name":"Drug Delivery Letters","issn_l":"2210-3031","issn":["2210-3031","2210-304X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-20","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug Delivery Letters","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8371999859809875}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":99,"referenced_works":["https://openalex.org/W146714217","https://openalex.org/W1963819006","https://openalex.org/W1967014383","https://openalex.org/W1969169139","https://openalex.org/W1969694232","https://openalex.org/W1970280907","https://openalex.org/W1974139131","https://openalex.org/W1974695334","https://openalex.org/W1978363645","https://openalex.org/W1979118079","https://openalex.org/W1979693908","https://openalex.org/W1980485904","https://openalex.org/W1984216302","https://openalex.org/W1985923741","https://openalex.org/W1988291642","https://openalex.org/W1988895992","https://openalex.org/W1989346639","https://openalex.org/W1993975221","https://openalex.org/W1996895516","https://openalex.org/W2000568918","https://openalex.org/W2000823236","https://openalex.org/W2001016996","https://openalex.org/W2002150064","https://openalex.org/W2007755698","https://openalex.org/W2008402078","https://openalex.org/W2011709000","https://openalex.org/W2014873714","https://openalex.org/W2015856484","https://openalex.org/W2017370892","https://openalex.org/W2018056059","https://openalex.org/W2023435253","https://openalex.org/W2025876035","https://openalex.org/W2026095095","https://openalex.org/W2026739140","https://openalex.org/W2030698414","https://openalex.org/W2030928269","https://openalex.org/W2031807045","https://openalex.org/W2035838854","https://openalex.org/W2037264159","https://openalex.org/W2040035594","https://openalex.org/W2045268646","https://openalex.org/W2047925052","https://openalex.org/W2048240425","https://openalex.org/W2053622985","https://openalex.org/W2055498907","https://openalex.org/W2057932988","https://openalex.org/W2062530126","https://openalex.org/W2067845253","https://openalex.org/W2068951857","https://openalex.org/W2069599167","https://openalex.org/W2070446670","https://openalex.org/W2071403550","https://openalex.org/W2072884229","https://openalex.org/W2085208277","https://openalex.org/W2088253659","https://openalex.org/W2089902817","https://openalex.org/W2094168523","https://openalex.org/W2102478723","https://openalex.org/W2106915652","https://openalex.org/W2116424844","https://openalex.org/W2117487911","https://openalex.org/W2122899977","https://openalex.org/W2122935177","https://openalex.org/W2126116274","https://openalex.org/W2127019408","https://openalex.org/W2139578776","https://openalex.org/W2140095109","https://openalex.org/W2140181820","https://openalex.org/W2145871683","https://openalex.org/W2151238839","https://openalex.org/W2152510700","https://openalex.org/W2156955518","https://openalex.org/W2163181535","https://openalex.org/W2204416339","https://openalex.org/W2223289940","https://openalex.org/W2274657786","https://openalex.org/W2292099554","https://openalex.org/W2309627571","https://openalex.org/W2315191920","https://openalex.org/W2320416886","https://openalex.org/W2325657690","https://openalex.org/W2326151615","https://openalex.org/W2329642880","https://openalex.org/W2330380201","https://openalex.org/W2466317733","https://openalex.org/W2468996757","https://openalex.org/W2507558963","https://openalex.org/W2574256996","https://openalex.org/W2754960822","https://openalex.org/W2807582167","https://openalex.org/W2885312426","https://openalex.org/W2913380421","https://openalex.org/W2982222521","https://openalex.org/W3044362950","https://openalex.org/W3133252082","https://openalex.org/W3217711864","https://openalex.org/W4210792895","https://openalex.org/W4214665197","https://openalex.org/W4237212024"],"related_works":["https://openalex.org/W2574256996","https://openalex.org/W4285655812","https://openalex.org/W3012163617","https://openalex.org/W4409088612","https://openalex.org/W4409050904","https://openalex.org/W7161243448","https://openalex.org/W2735481791","https://openalex.org/W4409050877","https://openalex.org/W4409050896","https://openalex.org/W2766546488"],"abstract_inverted_index":{"Drugs":[0],"that":[1],"have":[2],"been":[3],"covalently":[4],"altered":[5,16],"with":[6,152],"lipids":[7,23,96],"are":[8,15,24,83,89,107,125],"known":[9],"as":[10],"lipid-drug":[11,60,72,92,100],"conjugates.":[12,93],"Drug":[13,131],"characteristics":[14],"and":[17,46,52,69,102,156],"their":[18,77],"lipophilicity":[19],"is":[20],"increased":[21,37],"when":[22],"conjugated":[25],"to":[26,58,74,98,150],"drug":[27,154],"molecules.":[28],"The":[29,94],"conjugates":[30,61,73,101,114],"exhibit":[31],"a":[32,119],"number":[33],"of":[34,67,123,136],"benefits,":[35],"including":[36],"oral":[38],"bioavailability,":[39],"improved":[40,43,141],"lymphatic":[41],"targeting,":[42,45],"tumor":[44],"reduced":[47],"cytotoxicity.":[48],"Different":[49],"conjugation":[50,81,105],"techniques":[51,82,106],"chemical":[53,65],"bridges":[54],"can":[55,115,138],"be":[56,116,139],"utilized":[57,97],"create":[59],"depending":[62],"on":[63],"the":[64,103,143,147],"makeup":[66],"medicines":[68],"lipids.":[70],"For":[71],"function":[75],"at":[76],"best,":[78],"linkers":[79],"and/or":[80],"essential.":[84],"They":[85],"control":[86],"how":[87],"medications":[88],"released":[90],"from":[91],"numerous":[95],"make":[99],"various":[104],"outlined":[108],"in":[109,146],"this":[110],"article.":[111],"Although":[112],"these":[113],"delivered":[117],"without":[118],"delivery":[120,129],"vehicle,":[121],"many":[122],"them":[124],"put":[126],"into":[127,133],"suitable":[128],"techniques.":[130],"loading":[132],"lipophilic":[134],"parts":[135],"vehicles":[137],"considerably":[140],"by":[142],"lipid":[144],"component":[145],"conjugates,":[148],"leading":[149],"combinations":[151],"significant":[153],"content":[155],"superior":[157],"stability.":[158]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1}],"updated_date":"2026-10-27T15:51:10.671819","created_date":"2024-08-29T00:00:00"}