{"id":"https://openalex.org/W4401974680","doi":"https://doi.org/10.1093/jleuko/qiae179","title":"Unraveling spontaneous humoral immune responses against human cancer: a road to novel immunotherapies","display_name":"Unraveling spontaneous humoral immune responses against human cancer: a road to novel immunotherapies","publication_year":2024,"publication_date":"2024-08-27","ids":{"openalex":"https://openalex.org/W4401974680","doi":"https://doi.org/10.1093/jleuko/qiae179","pmid":"https://pubmed.ncbi.nlm.nih.gov/39190797"},"language":"en","primary_location":{"id":"doi:10.1093/jleuko/qiae179","doi":"https://doi.org/10.1093/jleuko/qiae179","is_oa":false,"landing_page_url":"https://doi.org/10.1093/jleuko/qiae179","pdf_url":null,"source":{"id":"https://openalex.org/S199011235","display_name":"Journal of Leukocyte Biology","issn_l":"0741-5400","issn":["0741-5400","1938-3673"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Leukocyte Biology","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5060460614","display_name":"Jose Ramon Conejo-Garcia","orcid":"https://orcid.org/0000-0001-6431-4074","observed_orcids":["https://orcid.org/0000-0001-6431-4074"]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]},{"id":"https://openalex.org/I4390039326","display_name":"Duke Cancer Institute","ror":"https://ror.org/04vt65461","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876","https://openalex.org/I4390039326"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jose R Conejo-Garcia","raw_affiliation_strings":["Department of Integrative Immunobiology, Duke School of Medicine , Durham, NC 27710 ,","Duke Cancer Institute, Duke School of Medicine , Durham, NC 27710 ,","Department of Integrative Immunobiology, Duke School of Medicine, Durham, NC 27710, USA","Duke Cancer Institute, Duke School of Medicine, Durham, NC 27710, USA"],"raw_orcid":"https://orcid.org/0000-0001-6431-4074","affiliations":[{"raw_affiliation_string":"Department of Integrative Immunobiology, Duke School of Medicine , Durham, NC 27710 ,","institution_ids":["https://openalex.org/I170897317"]},{"raw_affiliation_string":"Duke Cancer Institute, Duke School of Medicine , Durham, NC 27710 ,","institution_ids":["https://openalex.org/I170897317","https://openalex.org/I4390039326"]},{"raw_affiliation_string":"Department of Integrative Immunobiology, Duke School of Medicine, Durham, NC 27710, USA","institution_ids":["https://openalex.org/I170897317"]},{"raw_affiliation_string":"Duke Cancer Institute, Duke School of Medicine, Durham, NC 27710, USA","institution_ids":["https://openalex.org/I170897317","https://openalex.org/I4390039326"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088183141","display_name":"Luis Uriel Lopez-Bailon","orcid":"https://orcid.org/0009-0004-4279-4977","observed_orcids":["https://orcid.org/0009-0004-4279-4977"]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]},{"id":"https://openalex.org/I4390039326","display_name":"Duke Cancer Institute","ror":"https://ror.org/04vt65461","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876","https://openalex.org/I4390039326"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Luis U Lopez-Bailon","raw_affiliation_strings":["Department of Integrative Immunobiology, Duke School of Medicine , Durham, NC 27710 ,","Duke Cancer Institute, Duke School of Medicine , Durham, NC 27710 ,","Department of Integrative Immunobiology, Duke School of Medicine, Durham, NC 27710, USA","Duke Cancer Institute, Duke School of Medicine, Durham, NC 27710, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Integrative Immunobiology, Duke School of Medicine , Durham, NC 27710 ,","institution_ids":["https://openalex.org/I170897317"]},{"raw_affiliation_string":"Duke Cancer Institute, Duke School of Medicine , Durham, NC 27710 ,","institution_ids":["https://openalex.org/I170897317","https://openalex.org/I4390039326"]},{"raw_affiliation_string":"Department of Integrative Immunobiology, Duke School of Medicine, Durham, NC 27710, USA","institution_ids":["https://openalex.org/I170897317"]},{"raw_affiliation_string":"Duke Cancer Institute, Duke School of Medicine, Durham, NC 27710, USA","institution_ids":["https://openalex.org/I170897317","https://openalex.org/I4390039326"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5071750923","display_name":"Carmen M. Anadon","orcid":"https://orcid.org/0000-0002-8851-4545","observed_orcids":["https://orcid.org/0000-0002-8851-4545"]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]},{"id":"https://openalex.org/I4390039326","display_name":"Duke Cancer Institute","ror":"https://ror.org/04vt65461","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876","https://openalex.org/I4390039326"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Carmen M Anadon","raw_affiliation_strings":["Department of Integrative Immunobiology, Duke School of Medicine , Durham, NC 27710 ,","Duke Cancer Institute, Duke School of Medicine , Durham, NC 27710 ,","Department of Integrative Immunobiology, Duke School of Medicine, Durham, NC 27710, USA","Duke Cancer Institute, Duke School of Medicine, Durham, NC 27710, USA"],"raw_orcid":"https://orcid.org/0000-0002-8851-4545","affiliations":[{"raw_affiliation_string":"Department of Integrative Immunobiology, Duke School of Medicine , Durham, NC 27710 ,","institution_ids":["https://openalex.org/I170897317"]},{"raw_affiliation_string":"Duke Cancer Institute, Duke School of Medicine , Durham, NC 27710 ,","institution_ids":["https://openalex.org/I170897317","https://openalex.org/I4390039326"]},{"raw_affiliation_string":"Department of Integrative Immunobiology, Duke School of Medicine, Durham, NC 27710, USA","institution_ids":["https://openalex.org/I170897317"]},{"raw_affiliation_string":"Duke Cancer Institute, Duke School of Medicine, Durham, NC 27710, USA","institution_ids":["https://openalex.org/I170897317","https://openalex.org/I4390039326"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5071750923"],"corresponding_institution_ids":["https://openalex.org/I170897317","https://openalex.org/I4390039326"],"apc_list":{"value":3990,"currency":"USD","value_usd":3990},"apc_paid":null,"fwci":0.1069,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.17776439,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":96},"biblio":{"volume":"116","issue":"5","first_page":"919","last_page":"926"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.46799999475479126,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.46799999475479126,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.30079999566078186,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.13660000264644623,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/humoral-immune-response","display_name":"humoral immune response","score":0.8600000143051147},{"id":"https://openalex.org/keywords/b-cells","display_name":"B cells","score":0.7910000085830688},{"id":"https://openalex.org/keywords/engineered-antibodies","display_name":"engineered antibodies","score":0.7020000219345093},{"id":"https://openalex.org/keywords/antitumor-immunity","display_name":"antitumor immunity","score":0.7910000085830688},{"id":"https://openalex.org/keywords/cancer-immunotherapy","display_name":"cancer immunotherapy","score":0.7979999780654907},{"id":"https://openalex.org/keywords/tumor-cell-penetration","display_name":"tumor cell penetration","score":0.36000001430511475}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8115044832229614},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.7613351345062256},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5782570242881775},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5330378413200378},{"id":"https://openalex.org/C2780674031","wikidata":"https://www.wikidata.org/wiki/Q2012719","display_name":"Cancer immunotherapy","level":4,"score":0.4856671094894409},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.46588578820228577},{"id":"https://openalex.org/C2778235839","wikidata":"https://www.wikidata.org/wiki/Q4891747","display_name":"Cancer immunology","level":4,"score":0.44218432903289795},{"id":"https://openalex.org/C3017712846","wikidata":"https://www.wikidata.org/wiki/Q4891747","display_name":"Tumor immunology","level":4,"score":0.4414479732513428},{"id":"https://openalex.org/C2776548049","wikidata":"https://www.wikidata.org/wiki/Q1142875","display_name":"Humoral immunity","level":3,"score":0.4245806634426117},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3761720657348633},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.082293301820755}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007167","descriptor_name":"Immunotherapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D056724","descriptor_name":"Immunity, Humoral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1093/jleuko/qiae179","doi":"https://doi.org/10.1093/jleuko/qiae179","is_oa":false,"landing_page_url":"https://doi.org/10.1093/jleuko/qiae179","pdf_url":null,"source":{"id":"https://openalex.org/S199011235","display_name":"Journal of Leukocyte Biology","issn_l":"0741-5400","issn":["0741-5400","1938-3673"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Leukocyte Biology","raw_type":"journal-article"},{"id":"pmid:39190797","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39190797","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of leukocyte biology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320306155","display_name":"Cancer Research Institute","ror":"https://ror.org/02f3xk561"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":83,"referenced_works":["https://openalex.org/W1479890493","https://openalex.org/W1542041702","https://openalex.org/W1548282964","https://openalex.org/W1554400778","https://openalex.org/W1599843559","https://openalex.org/W1970658892","https://openalex.org/W1982910732","https://openalex.org/W1989025673","https://openalex.org/W2009900556","https://openalex.org/W2014805409","https://openalex.org/W2020627452","https://openalex.org/W2025012298","https://openalex.org/W2025309264","https://openalex.org/W2027516399","https://openalex.org/W2035523654","https://openalex.org/W2038640078","https://openalex.org/W2040835861","https://openalex.org/W2045812733","https://openalex.org/W2055891785","https://openalex.org/W2062957127","https://openalex.org/W2069578730","https://openalex.org/W2074572506","https://openalex.org/W2084707952","https://openalex.org/W2088328410","https://openalex.org/W2094999215","https://openalex.org/W2096322385","https://openalex.org/W2107455390","https://openalex.org/W2109467642","https://openalex.org/W2124385473","https://openalex.org/W2129509656","https://openalex.org/W2134307294","https://openalex.org/W2143772132","https://openalex.org/W2160834915","https://openalex.org/W2170423927","https://openalex.org/W2248004572","https://openalex.org/W2339442385","https://openalex.org/W2411733041","https://openalex.org/W2468424480","https://openalex.org/W2510426677","https://openalex.org/W2528849844","https://openalex.org/W2576425501","https://openalex.org/W2583500487","https://openalex.org/W2588951305","https://openalex.org/W2772891258","https://openalex.org/W2808892459","https://openalex.org/W2895165331","https://openalex.org/W2904803926","https://openalex.org/W2914377725","https://openalex.org/W2924317925","https://openalex.org/W2945057866","https://openalex.org/W2947361459","https://openalex.org/W2982897711","https://openalex.org/W2994452502","https://openalex.org/W2998795792","https://openalex.org/W3000282923","https://openalex.org/W3000311037","https://openalex.org/W3046688476","https://openalex.org/W3111324986","https://openalex.org/W3116357308","https://openalex.org/W3128459342","https://openalex.org/W3130132448","https://openalex.org/W3137343275","https://openalex.org/W3170835308","https://openalex.org/W3211769556","https://openalex.org/W3217307638","https://openalex.org/W4200368692","https://openalex.org/W4205954020","https://openalex.org/W4206799282","https://openalex.org/W4214620261","https://openalex.org/W4221041063","https://openalex.org/W4226068368","https://openalex.org/W4289936629","https://openalex.org/W4296111817","https://openalex.org/W4324046120","https://openalex.org/W4367300965","https://openalex.org/W4376133743","https://openalex.org/W4383340992","https://openalex.org/W4388099072","https://openalex.org/W4388673747","https://openalex.org/W4389685476","https://openalex.org/W4391449441","https://openalex.org/W4394063358","https://openalex.org/W4396574532"],"related_works":["https://openalex.org/W4393131745","https://openalex.org/W4311751487","https://openalex.org/W3101698580","https://openalex.org/W3160580145","https://openalex.org/W7007556459","https://openalex.org/W2415219063","https://openalex.org/W2084374909","https://openalex.org/W4399589443","https://openalex.org/W7203681105","https://openalex.org/W2902244724"],"abstract_inverted_index":{"In":[0],"immuno-oncology,":[1],"the":[2,26,36,43,77,104,117,121,131,155,163,175],"focus":[3],"has":[4,58],"traditionally":[5],"been":[6],"on":[7,109],"\u03b1\u03b2":[8],"T":[9],"cells,":[10,67],"and":[11,42,73,102,141],"immune":[12,136],"checkpoint":[13],"inhibitors":[14],"that":[15,60,83],"primarily":[16],"target":[17],"PD-1":[18],"or":[19],"CTLA4":[20],"in":[21,47,71,138],"these":[22,160],"lymphocytes":[23],"have":[24,162],"revolutionized":[25],"management":[27],"of":[28,39,106,123,133,150,157,170,177],"multiple":[29],"human":[30,139],"malignancies.":[31],"However,":[32],"recent":[33],"research":[34],"highlights":[35],"crucial":[37],"role":[38],"B":[40],"cells":[41],"antibodies":[44,85],"they":[45,144],"produce":[46],"antagonizing":[48],"malignant":[49,110],"progression,":[50],"offering":[51],"new":[52,114,148],"avenues":[53],"for":[54,116],"immunotherapy.":[55],"Our":[56],"group":[57],"demonstrated":[59],"dimeric":[61],"Immunoglobulin":[62],"A":[63],"can":[64],"penetrate":[65],"tumor":[66,178],"neutralize":[68],"oncogenic":[69],"drivers":[70],"endosomes,":[72],"expel":[74],"them":[75],"from":[76],"cytosol.":[78],"This":[79,126],"mechanistic":[80],"insight":[81],"suggests":[82],"engineered":[84],"targeting":[86],"this":[87],"pathway":[88],"may":[89],"effectively":[90],"reach":[91],"previously":[92],"inaccessible":[93],"targets.":[94],"Investigating":[95],"antibody":[96],"production":[97],"within":[98],"intratumoral":[99],"germinal":[100],"centers":[101],"understanding":[103],"impact":[105],"different":[107],"immunoglobulins":[108],"progression":[111],"could":[112,145],"furnish":[113],"tools":[115],"therapeutic":[118],"arsenal,":[119],"including":[120],"development":[122],"tumor-penetrating":[124],"antibodies.":[125,180],"review":[127],"aims":[128],"to":[129,165],"elucidate":[130],"nature":[132],"humoral":[134],"adaptive":[135],"responses":[137],"cancer":[140,171],"explore":[142],"how":[143],"herald":[146],"a":[147,167],"era":[149],"immunotherapeutic":[151],"modalities.":[152],"By":[153],"expanding":[154],"scope":[156],"antitumor":[158],"immunotherapies,":[159],"approaches":[161],"potential":[164],"benefit":[166],"broader":[168],"range":[169],"patients,":[172],"particularly":[173],"through":[174],"utilization":[176],"cell-penetrating":[179]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2024-08-29T00:00:00"}
