{"id":"https://openalex.org/W4401946907","doi":"https://doi.org/10.1016/j.jad.2024.08.182","title":"Multi-omics combined to investigate potential druggable therapeutic targets for stroke: A systematic Mendelian randomization study and transcriptome verification","display_name":"Multi-omics combined to investigate potential druggable therapeutic targets for stroke: A systematic Mendelian randomization study and transcriptome verification","publication_year":2024,"publication_date":"2024-08-28","ids":{"openalex":"https://openalex.org/W4401946907","doi":"https://doi.org/10.1016/j.jad.2024.08.182","pmid":"https://pubmed.ncbi.nlm.nih.gov/39214372"},"language":"en","primary_location":{"id":"doi:10.1016/j.jad.2024.08.182","doi":"https://doi.org/10.1016/j.jad.2024.08.182","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jad.2024.08.182","pdf_url":null,"source":{"id":"https://openalex.org/S113871862","display_name":"Journal of Affective Disorders","issn_l":"0165-0327","issn":["0165-0327","1573-2517"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Affective Disorders","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5016524417","display_name":"Yi\u2010Ming Shi","orcid":"https://orcid.org/0000-0001-6933-4971","observed_orcids":["https://orcid.org/0000-0001-6933-4971"]},"institutions":[{"id":"https://openalex.org/I14992734","display_name":"Hunan University of Traditional Chinese Medicine","ror":"https://ror.org/05qfq0x09","country_code":"CN","type":"education","lineage":["https://openalex.org/I14992734"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yiming Shi","raw_affiliation_strings":["Hunan University of Chinese Medicine, Key Laboratory of Hunan Province for Integrated Traditional Chinese and Western Medicine on Prevention and Treatment of Cardio-Cerebral Diseases, Changsha, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hunan University of Chinese Medicine, Key Laboratory of Hunan Province for Integrated Traditional Chinese and Western Medicine on Prevention and Treatment of Cardio-Cerebral Diseases, Changsha, China","institution_ids":["https://openalex.org/I14992734"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Le Bao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I14992734","display_name":"Hunan University of Traditional Chinese Medicine","ror":"https://ror.org/05qfq0x09","country_code":"CN","type":"education","lineage":["https://openalex.org/I14992734"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Le Bao","raw_affiliation_strings":["Hunan University of Chinese Medicine, Key Laboratory of Hunan Province for Integrated Traditional Chinese and Western Medicine on Prevention and Treatment of Cardio-Cerebral Diseases, Changsha, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hunan University of Chinese Medicine, Key Laboratory of Hunan Province for Integrated Traditional Chinese and Western Medicine on Prevention and Treatment of Cardio-Cerebral Diseases, Changsha, China","institution_ids":["https://openalex.org/I14992734"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107859649","display_name":"Yanling Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I14992734","display_name":"Hunan University of Traditional Chinese Medicine","ror":"https://ror.org/05qfq0x09","country_code":"CN","type":"education","lineage":["https://openalex.org/I14992734"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yanling Li","raw_affiliation_strings":["Hunan University of Chinese Medicine, Key Laboratory of Hunan Province for Integrated Traditional Chinese and Western Medicine on Prevention and Treatment of Cardio-Cerebral Diseases, Changsha, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hunan University of Chinese Medicine, Key Laboratory of Hunan Province for Integrated Traditional Chinese and Western Medicine on Prevention and Treatment of Cardio-Cerebral Diseases, Changsha, China","institution_ids":["https://openalex.org/I14992734"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102636293","display_name":"Dian Ou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I14992734","display_name":"Hunan University of Traditional Chinese Medicine","ror":"https://ror.org/05qfq0x09","country_code":"CN","type":"education","lineage":["https://openalex.org/I14992734"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Dian Ou","raw_affiliation_strings":["Hunan University of Chinese Medicine, Key Laboratory of Hunan Province for Integrated Traditional Chinese and Western Medicine on Prevention and Treatment of Cardio-Cerebral Diseases, Changsha, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hunan University of Chinese Medicine, Key Laboratory of Hunan Province for Integrated Traditional Chinese and Western Medicine on Prevention and Treatment of Cardio-Cerebral Diseases, Changsha, China","institution_ids":["https://openalex.org/I14992734"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109428177","display_name":"Jiating Li","orcid":"https://orcid.org/0009-0007-4222-1900","observed_orcids":["https://orcid.org/0009-0007-4222-1900"]},"institutions":[{"id":"https://openalex.org/I14992734","display_name":"Hunan University of Traditional Chinese Medicine","ror":"https://ror.org/05qfq0x09","country_code":"CN","type":"education","lineage":["https://openalex.org/I14992734"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiating Li","raw_affiliation_strings":["Hunan University of Chinese Medicine, Key Laboratory of Hunan Province for Integrated Traditional Chinese and Western Medicine on Prevention and Treatment of Cardio-Cerebral Diseases, Changsha, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hunan University of Chinese Medicine, Key Laboratory of Hunan Province for Integrated Traditional Chinese and Western Medicine on Prevention and Treatment of Cardio-Cerebral Diseases, Changsha, China","institution_ids":["https://openalex.org/I14992734"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100628843","display_name":"Xiaodan Liu","orcid":"https://orcid.org/0000-0002-9796-8215","observed_orcids":["https://orcid.org/0000-0002-9796-8215"]},"institutions":[{"id":"https://openalex.org/I14992734","display_name":"Hunan University of Traditional Chinese Medicine","ror":"https://ror.org/05qfq0x09","country_code":"CN","type":"education","lineage":["https://openalex.org/I14992734"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaodan Liu","raw_affiliation_strings":["Hunan University of Chinese Medicine, Key Laboratory of Hunan Province for Integrated Traditional Chinese and Western Medicine on Prevention and Treatment of Cardio-Cerebral Diseases, Changsha, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hunan University of Chinese Medicine, Key Laboratory of Hunan Province for Integrated Traditional Chinese and Western Medicine on Prevention and Treatment of Cardio-Cerebral Diseases, Changsha, China","institution_ids":["https://openalex.org/I14992734"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110944883","display_name":"Nujiao Deng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I14992734","display_name":"Hunan University of Traditional Chinese Medicine","ror":"https://ror.org/05qfq0x09","country_code":"CN","type":"education","lineage":["https://openalex.org/I14992734"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Nujiao Deng","raw_affiliation_strings":["Hunan University of Chinese Medicine, Key Laboratory of Hunan Province for Integrated Traditional Chinese and Western Medicine on Prevention and Treatment of Cardio-Cerebral Diseases, Changsha, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hunan University of Chinese Medicine, Key Laboratory of Hunan Province for Integrated Traditional Chinese and Western Medicine on Prevention and Treatment of Cardio-Cerebral Diseases, Changsha, China","institution_ids":["https://openalex.org/I14992734"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017803442","display_name":"Chang-Qing Deng","orcid":"https://orcid.org/0000-0002-9058-3304","observed_orcids":["https://orcid.org/0000-0002-9058-3304"]},"institutions":[{"id":"https://openalex.org/I14992734","display_name":"Hunan University of Traditional Chinese Medicine","ror":"https://ror.org/05qfq0x09","country_code":"CN","type":"education","lineage":["https://openalex.org/I14992734"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Changqing Deng","raw_affiliation_strings":["Hunan University of Chinese Medicine, Key Laboratory of Hunan Province for Integrated Traditional Chinese and Western Medicine on Prevention and Treatment of Cardio-Cerebral Diseases, Changsha, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hunan University of Chinese Medicine, Key Laboratory of Hunan Province for Integrated Traditional Chinese and Western Medicine on Prevention and Treatment of Cardio-Cerebral Diseases, Changsha, China","institution_ids":["https://openalex.org/I14992734"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101757619","display_name":"Xiaoping Huang","orcid":"https://orcid.org/0009-0005-3731-6695","observed_orcids":["https://orcid.org/0009-0005-3731-6695"]},"institutions":[{"id":"https://openalex.org/I14992734","display_name":"Hunan University of Traditional Chinese Medicine","ror":"https://ror.org/05qfq0x09","country_code":"CN","type":"education","lineage":["https://openalex.org/I14992734"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xiaoping Huang","raw_affiliation_strings":["Hunan University of Chinese Medicine, Key Laboratory of Hunan Province for Integrated Traditional Chinese and Western Medicine on Prevention and Treatment of Cardio-Cerebral Diseases, Changsha, China. Electronic address: xiaopinghuang@hnucm.edu.cn"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hunan University of Chinese Medicine, Key Laboratory of Hunan Province for Integrated Traditional Chinese and Western Medicine on Prevention and Treatment of Cardio-Cerebral Diseases, Changsha, China. Electronic address: xiaopinghuang@hnucm.edu.cn","institution_ids":["https://openalex.org/I14992734"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077601572","display_name":"Wei Zhang","orcid":"https://orcid.org/0000-0001-9459-680X","observed_orcids":["https://orcid.org/0000-0001-9459-680X","https://orcid.org/0000-0002-9407-9551"]},"institutions":[{"id":"https://openalex.org/I14992734","display_name":"Hunan University of Traditional Chinese Medicine","ror":"https://ror.org/05qfq0x09","country_code":"CN","type":"education","lineage":["https://openalex.org/I14992734"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Wei Zhang","raw_affiliation_strings":["Hunan University of Chinese Medicine, Key Laboratory of Hunan Province for Integrated Traditional Chinese and Western Medicine on Prevention and Treatment of Cardio-Cerebral Diseases, Changsha, China. Electronic address: Zhangwei1979@hnucm.edu.cn"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hunan University of Chinese Medicine, Key Laboratory of Hunan Province for Integrated Traditional Chinese and Western Medicine on Prevention and Treatment of Cardio-Cerebral Diseases, Changsha, China. Electronic address: Zhangwei1979@hnucm.edu.cn","institution_ids":["https://openalex.org/I14992734"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103021144","display_name":"Huang Ding","orcid":"https://orcid.org/0000-0001-8628-884X","observed_orcids":["https://orcid.org/0000-0001-8628-884X"]},"institutions":[{"id":"https://openalex.org/I14992734","display_name":"Hunan University of Traditional Chinese Medicine","ror":"https://ror.org/05qfq0x09","country_code":"CN","type":"education","lineage":["https://openalex.org/I14992734"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Huang Ding","raw_affiliation_strings":["Hunan University of Chinese Medicine, Key Laboratory of Hunan Province for Integrated Traditional Chinese and Western Medicine on Prevention and Treatment of Cardio-Cerebral Diseases, Changsha, China. Electronic address: 004594@hnucm.edu.cn"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hunan University of Chinese Medicine, Key Laboratory of Hunan Province for Integrated Traditional Chinese and Western Medicine on Prevention and Treatment of Cardio-Cerebral Diseases, Changsha, China. Electronic address: 004594@hnucm.edu.cn","institution_ids":["https://openalex.org/I14992734"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5077601572","https://openalex.org/A5101757619","https://openalex.org/A5103021144"],"corresponding_institution_ids":["https://openalex.org/I14992734"],"apc_list":{"value":3340,"currency":"USD","value_usd":3340},"apc_paid":null,"fwci":2.1145,"has_fulltext":false,"cited_by_count":8,"citation_normalized_percentile":{"value":0.87464252,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":99},"biblio":{"volume":"366","issue":null,"first_page":"196","last_page":"209"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.9740999937057495,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.9740999937057495,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10227","display_name":"Acute Ischemic Stroke Management","score":0.006399999838322401,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13648","display_name":"Cerebrovascular and genetic disorders","score":0.0034000000450760126,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/stroke","display_name":"stroke","score":0.9900000095367432},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.7329999804496765},{"id":"https://openalex.org/keywords/druggable-proteins","display_name":"druggable proteins","score":0.7269999980926514},{"id":"https://openalex.org/keywords/ginsenoside-rg1","display_name":"ginsenoside Rg1","score":0.8569999933242798},{"id":"https://openalex.org/keywords/adenine-phosphoribosyltransferase","display_name":"adenine phosphoribosyltransferase","score":0.8059999942779541},{"id":"https://openalex.org/keywords/il15ra","display_name":"IL15RA","score":0.9959999918937683},{"id":"https://openalex.org/keywords/plasma-proteins","display_name":"plasma proteins","score":0.4959999918937683},{"id":"https://openalex.org/keywords/inflammatory-proteins","display_name":"inflammatory proteins","score":0.718999981880188},{"id":"https://openalex.org/keywords/causal-inference","display_name":"causal inference","score":0.4880000054836273},{"id":"https://openalex.org/keywords/multi-omics-integration","display_name":"multi-omics integration","score":0.6060000061988831},{"id":"https://openalex.org/keywords/transcriptome","display_name":"transcriptome","score":0.4970000088214874},{"id":"https://openalex.org/keywords/stroke-subtypes","display_name":"stroke subtypes","score":0.640999972820282},{"id":"https://openalex.org/keywords/drug-development","display_name":"drug development","score":0.41499999165534973}],"concepts":[{"id":"https://openalex.org/C2779901538","wikidata":"https://www.wikidata.org/wiki/Q6816584","display_name":"Mendelian randomization","level":5,"score":0.885562002658844},{"id":"https://openalex.org/C10679952","wikidata":"https://www.wikidata.org/wiki/Q5308937","display_name":"Druggability","level":3,"score":0.789050817489624},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.6801829934120178},{"id":"https://openalex.org/C157585117","wikidata":"https://www.wikidata.org/wiki/Q158666","display_name":"Omics","level":2,"score":0.5997937321662903},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5645580291748047},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.5163687467575073},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.4789443612098694},{"id":"https://openalex.org/C2780645631","wikidata":"https://www.wikidata.org/wiki/Q671554","display_name":"Stroke (engine)","level":2,"score":0.44327160716056824},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.39682212471961975},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3914513885974884},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.23656943440437317},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.19719868898391724},{"id":"https://openalex.org/C2993967602","wikidata":"https://www.wikidata.org/wiki/Q5532932","display_name":"Genetic variants","level":4,"score":0.17655926942825317},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.08690273761749268},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.0752505362033844},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.0},{"id":"https://openalex.org/C78519656","wikidata":"https://www.wikidata.org/wiki/Q101333","display_name":"Mechanical engineering","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000095028","descriptor_name":"Multiomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020521","descriptor_name":"Stroke","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D057182","descriptor_name":"Mendelian Randomization Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.jad.2024.08.182","doi":"https://doi.org/10.1016/j.jad.2024.08.182","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jad.2024.08.182","pdf_url":null,"source":{"id":"https://openalex.org/S113871862","display_name":"Journal of Affective Disorders","issn_l":"0165-0327","issn":["0165-0327","1573-2517"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Affective Disorders","raw_type":"journal-article"},{"id":"pmid:39214372","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39214372","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of affective disorders","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G3202280924","display_name":null,"funder_award_id":"82174218","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G3475214786","display_name":null,"funder_award_id":"U22A20377","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G6798987794","display_name":null,"funder_award_id":"B202303077469","funder_id":"https://openalex.org/F4320318564","funder_display_name":"Health Commission of Henan Province"},{"id":"https://openalex.org/G8839460308","display_name":null,"funder_award_id":"82305031","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320318564","display_name":"Health Commission of Henan Province","ror":"https://ror.org/04nne1357"},{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320333642","display_name":"Scientific Research Foundation of Hunan Provincial Education Department","ror":null}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":73,"referenced_works":["https://openalex.org/W180853016","https://openalex.org/W862623470","https://openalex.org/W1801720123","https://openalex.org/W1905058580","https://openalex.org/W1942897646","https://openalex.org/W2009800174","https://openalex.org/W2023776791","https://openalex.org/W2034530918","https://openalex.org/W2057542725","https://openalex.org/W2076710326","https://openalex.org/W2089290215","https://openalex.org/W2113699335","https://openalex.org/W2118743532","https://openalex.org/W2151096860","https://openalex.org/W2155143852","https://openalex.org/W2191395588","https://openalex.org/W2324862792","https://openalex.org/W2328393125","https://openalex.org/W2613603864","https://openalex.org/W2765167973","https://openalex.org/W2788609121","https://openalex.org/W2803072880","https://openalex.org/W2805712258","https://openalex.org/W2885738092","https://openalex.org/W2886245587","https://openalex.org/W2896754653","https://openalex.org/W2903296270","https://openalex.org/W2911941199","https://openalex.org/W2914349469","https://openalex.org/W2924371616","https://openalex.org/W2943722240","https://openalex.org/W2949195531","https://openalex.org/W2950099124","https://openalex.org/W2965771651","https://openalex.org/W2972471285","https://openalex.org/W2984870382","https://openalex.org/W3037339341","https://openalex.org/W3083496521","https://openalex.org/W3093285665","https://openalex.org/W3119476193","https://openalex.org/W3131103390","https://openalex.org/W3131620884","https://openalex.org/W3165025616","https://openalex.org/W3167089249","https://openalex.org/W3181676409","https://openalex.org/W3183086812","https://openalex.org/W3195291379","https://openalex.org/W4200521334","https://openalex.org/W4210384295","https://openalex.org/W4210440929","https://openalex.org/W4212785708","https://openalex.org/W4221095311","https://openalex.org/W4281748283","https://openalex.org/W4294992189","https://openalex.org/W4297129346","https://openalex.org/W4308603268","https://openalex.org/W4308739215","https://openalex.org/W4317390883","https://openalex.org/W4321351181","https://openalex.org/W4321452579","https://openalex.org/W4366082854","https://openalex.org/W4384499482","https://openalex.org/W4385631321","https://openalex.org/W4385740978","https://openalex.org/W4385945377","https://openalex.org/W4386703670","https://openalex.org/W4387344358","https://openalex.org/W4387408372","https://openalex.org/W4387445706","https://openalex.org/W4388141554","https://openalex.org/W4389160629","https://openalex.org/W4390696487","https://openalex.org/W4391276387"],"related_works":["https://openalex.org/W4306412215","https://openalex.org/W4411900203","https://openalex.org/W7160913978","https://openalex.org/W7139939475","https://openalex.org/W4233041834","https://openalex.org/W4409968310","https://openalex.org/W2950591584","https://openalex.org/W4412884265","https://openalex.org/W4389074536","https://openalex.org/W7167253982"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":6}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2024-08-29T00:00:00"}