{"id":"https://openalex.org/W4401936760","doi":"https://doi.org/10.22541/au.172488427.70822146/v1","title":"The human lysine oxidase-like 3 (LOXL3) high expression as a potential biomarker and association with poor prognosis in pleural mesothelioma","display_name":"The human lysine oxidase-like 3 (LOXL3) high expression as a potential biomarker and association with poor prognosis in pleural mesothelioma","publication_year":2024,"publication_date":"2024-08-28","ids":{"openalex":"https://openalex.org/W4401936760","doi":"https://doi.org/10.22541/au.172488427.70822146/v1"},"language":"en","primary_location":{"id":"doi:10.22541/au.172488427.70822146/v1","doi":"https://doi.org/10.22541/au.172488427.70822146/v1","is_oa":false,"landing_page_url":"https://doi.org/10.22541/au.172488427.70822146/v1","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},"volume":null,"type":"preprint","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Wen Mei","orcid":"https://orcid.org/0009-0009-5897-6560","observed_orcids":["https://orcid.org/0009-0009-5897-6560"]},"institutions":[{"id":"https://openalex.org/I4405282988","display_name":"The People's Hospital of Chuxiong Yi Autonomous Prefecture","ror":"https://ror.org/00syn8y15","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4405282988"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wen Mei","raw_affiliation_strings":["People's Hospital of Chuxiong Yi Autonomous Prefecture"],"raw_orcid":"https://orcid.org/0009-0009-5897-6560","affiliations":[{"raw_affiliation_string":"People's Hospital of Chuxiong Yi Autonomous Prefecture","institution_ids":["https://openalex.org/I4405282988"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102912028","display_name":"Shengjie Yang","orcid":"https://orcid.org/0000-0002-2403-7911","observed_orcids":["https://orcid.org/0000-0002-2403-7911"]},"institutions":[{"id":"https://openalex.org/I4405282988","display_name":"The People's Hospital of Chuxiong Yi Autonomous Prefecture","ror":"https://ror.org/00syn8y15","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4405282988"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shengjie Yang","raw_affiliation_strings":["People's Hospital of Chuxiong Yi Autonomous Prefecture"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"People's Hospital of Chuxiong Yi Autonomous Prefecture","institution_ids":["https://openalex.org/I4405282988"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113352339","display_name":"Qunshan Fu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405282988","display_name":"The People's Hospital of Chuxiong Yi Autonomous Prefecture","ror":"https://ror.org/00syn8y15","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4405282988"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qunshan Fu","raw_affiliation_strings":["People's Hospital of Chuxiong Yi Autonomous Prefecture"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"People's Hospital of Chuxiong Yi Autonomous Prefecture","institution_ids":["https://openalex.org/I4405282988"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039902970","display_name":"Bing He","orcid":"https://orcid.org/0000-0002-8564-0933","observed_orcids":["https://orcid.org/0000-0002-8564-0933"]},"institutions":[{"id":"https://openalex.org/I4405282988","display_name":"The People's Hospital of Chuxiong Yi Autonomous Prefecture","ror":"https://ror.org/00syn8y15","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4405282988"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Bing He1","raw_affiliation_strings":["People's Hospital of Chuxiong Yi Autonomous Prefecture"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"People's Hospital of Chuxiong Yi Autonomous Prefecture","institution_ids":["https://openalex.org/I4405282988"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101821429","display_name":"Xiaomei Sun","orcid":"https://orcid.org/0000-0002-8590-7466","observed_orcids":["https://orcid.org/0000-0002-8590-7466"]},"institutions":[{"id":"https://openalex.org/I4405282988","display_name":"The People's Hospital of Chuxiong Yi Autonomous Prefecture","ror":"https://ror.org/00syn8y15","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4405282988"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaomei Sun","raw_affiliation_strings":["People's Hospital of Chuxiong Yi Autonomous Prefecture"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"People's Hospital of Chuxiong Yi Autonomous Prefecture","institution_ids":["https://openalex.org/I4405282988"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Liqin Zhou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405282988","display_name":"The People's Hospital of Chuxiong Yi Autonomous Prefecture","ror":"https://ror.org/00syn8y15","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4405282988"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Liqin Zhou","raw_affiliation_strings":["People's Hospital of Chuxiong Yi Autonomous Prefecture"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"People's Hospital of Chuxiong Yi Autonomous Prefecture","institution_ids":["https://openalex.org/I4405282988"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101803926","display_name":"Wei Xiong","orcid":"https://orcid.org/0000-0001-7719-1712","observed_orcids":["https://orcid.org/0000-0001-7719-1712"]},"institutions":[{"id":"https://openalex.org/I4405282988","display_name":"The People's Hospital of Chuxiong Yi Autonomous Prefecture","ror":"https://ror.org/00syn8y15","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4405282988"]},{"id":"https://openalex.org/I6593398","display_name":"Dali University","ror":"https://ror.org/02y7rck89","country_code":"CN","type":"education","lineage":["https://openalex.org/I6593398"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wei Xiong","raw_affiliation_strings":["Dali University School of Basic Medicine","People's Hospital of Chuxiong Yi Autonomous Prefecture"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dali University School of Basic Medicine","institution_ids":["https://openalex.org/I6593398"]},{"raw_affiliation_string":"People's Hospital of Chuxiong Yi Autonomous Prefecture","institution_ids":["https://openalex.org/I4405282988"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5050965879","display_name":"Yepin Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405282988","display_name":"The People's Hospital of Chuxiong Yi Autonomous Prefecture","ror":"https://ror.org/00syn8y15","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4405282988"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yepin Zhang","raw_affiliation_strings":["People's Hospital of Chuxiong Yi Autonomous Prefecture"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"People's Hospital of Chuxiong Yi Autonomous Prefecture","institution_ids":["https://openalex.org/I4405282988"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5050965879"],"corresponding_institution_ids":["https://openalex.org/I4405282988"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11026","display_name":"Occupational and environmental lung diseases","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11026","display_name":"Occupational and environmental lung diseases","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12334","display_name":"Lung Cancer Research Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12064","display_name":"Intraperitoneal and Appendiceal Malignancies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/loxl3","display_name":"LOXL3","score":0.9570000171661377},{"id":"https://openalex.org/keywords/pleural-mesothelioma","display_name":"pleural mesothelioma","score":0.9179999828338623},{"id":"https://openalex.org/keywords/lysine-oxidase","display_name":"lysine oxidase","score":0.8309999704360962},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.9419999718666077},{"id":"https://openalex.org/keywords/poor-prognosis","display_name":"poor prognosis","score":0.699999988079071},{"id":"https://openalex.org/keywords/loxl4","display_name":"LOXL4","score":0.7099999785423279},{"id":"https://openalex.org/keywords/wt1","display_name":"WT1","score":0.7870000004768372},{"id":"https://openalex.org/keywords/gene-expression-profiling","display_name":"gene expression profiling","score":0.609000027179718},{"id":"https://openalex.org/keywords/oxidative-phosphorylation","display_name":"oxidative phosphorylation","score":0.8569999933242798},{"id":"https://openalex.org/keywords/mtorc1-signaling","display_name":"mTORC1 signaling","score":0.7540000081062317},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.7390000224113464},{"id":"https://openalex.org/keywords/tumor-progression","display_name":"tumor progression","score":0.7329999804496765},{"id":"https://openalex.org/keywords/gene-set-enrichment-analysis","display_name":"gene set enrichment analysis","score":0.5910000205039978},{"id":"https://openalex.org/keywords/tcga-data","display_name":"TCGA data","score":0.42899999022483826},{"id":"https://openalex.org/keywords/clinicopathological-features","display_name":"clinicopathological features","score":0.6430000066757202},{"id":"https://openalex.org/keywords/il-2-stat5-signaling","display_name":"IL-2/STAT5 signaling","score":0.6240000128746033}],"concepts":[{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.6650809645652771},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.5572952628135681},{"id":"https://openalex.org/C2777407522","wikidata":"https://www.wikidata.org/wiki/Q1077603","display_name":"Mesothelioma","level":2,"score":0.5359889268875122},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.5300580859184265},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5096549987792969},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.5083031058311462},{"id":"https://openalex.org/C2775999222","wikidata":"https://www.wikidata.org/wiki/Q756289","display_name":"Wilms' tumor","level":2,"score":0.47610270977020264},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.475263774394989},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4689564108848572},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.43312007188796997},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.40227997303009033},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.37496036291122437},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3401670455932617},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.33451640605926514},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.27096641063690186},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.13529977202415466},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.22541/au.172488427.70822146/v1","doi":"https://doi.org/10.22541/au.172488427.70822146/v1","is_oa":false,"landing_page_url":"https://doi.org/10.22541/au.172488427.70822146/v1","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4416987532","https://openalex.org/W2784681693","https://openalex.org/W2561159244","https://openalex.org/W2739651421","https://openalex.org/W3129830414","https://openalex.org/W3002838186","https://openalex.org/W3092817828","https://openalex.org/W4389429296","https://openalex.org/W4391056189","https://openalex.org/W2068267881"],"abstract_inverted_index":{"Background:":[0],"The":[1,37,87,216],"human":[2,193],"lysine":[3],"oxidase-like":[4],"3":[5],"(LOXL3)":[6],"is":[7,184,312],"important":[8],"in":[9,29,55,126,135,180,192,242,255,284,300,337,379],"maintaining":[10],"genome":[11],"stability":[12],"and":[13,27,32,53,64,109,118,147,150,189,204,291,306,317,360,377],"promoting":[14],"mitosis":[15],"completion.":[16],"Through":[17],"a":[18,131,239,268,366],"variety":[19],"of":[20,34,39,48,80,90,100,124,145,154,161,208,220,251,257,260,319,328,346,357,363],"mechanisms,":[21],"LOXL3":[22,49,62,81,101,107,125,146,155,162,183,209,221,252,264,311,329,348,369],"regulates":[23],"signal":[24],"transduction":[25],"pathways":[26],"participates":[28],"the":[30,40,46,78,91,98,121,139,142,151,159,187,202,258,315,325,343,347,355],"carcinogenesis":[31],"development":[33,318],"multiple":[35],"tumors.":[36],"purpose":[38],"present":[41],"study":[42],"was":[43,128,210,222,238,253,350],"to":[44,76,96,373],"determine":[45],"association":[47],"with":[50,74,84,104,164,196,213,225,262,271,314,339,354],"tumor":[51],"progression":[52],"prognosis":[54,259],"pleural":[56,198],"mesothelioma":[57],"(":[58],"PMe)":[59],"patients.":[60],"Methods:":[61],"mRNA-SeqV2":[63],"clinical":[65,88],"data":[66,89],"for":[67],"PMe":[68,127,194],"cases":[69],"were":[70,94,112,156,169,282,298],"obtained":[71],"from":[72],"TCGA":[73],"R3.6.3":[75],"analyze":[77],"associations":[79,99,160],"mRNA":[82,110,188,203],"amounts":[83,103,111],"clinicopathological":[85,105,148],"parameters.":[86,106],"Chuxiong":[92],"population":[93],"collected":[95],"assess":[97],"protein":[102,108,190,205,217],"assessed":[113],"by":[114,130,171],"immunohistochemistry,":[115],"Western":[116],"blotting":[117],"qRT-PCR.":[119],"Next,":[120,138],"prognostic":[122,152,240],"value":[123,153],"examined":[129],"Cox":[132],"regression":[133],"model":[134],"multivariable":[136],"analysis.":[137],"relationships":[140],"between":[141],"expression":[143,163,206,218,249,266,274,327,344,356],"level":[144,207,219,250,345],"characteristics":[149],"analyzed.":[157],"Finally,":[158],"other":[165,292,307],"LOXL":[166],"family":[167],"members":[168],"analyzed":[170],"GEPIA.":[172],"GSEA":[173],"identified":[174],"16":[175],"gene":[176,265,273,349],"sets":[177],"significantly":[178,211,223,351],"enriched":[179,283,299],"PMe.":[181,243,263,320,340,364,380],"Results:":[182],"upregulated":[185],"at":[186],"levels":[191],"compared":[195],"noncancerous":[197],"tissues.":[199],"In":[200],"addition,":[201],"correlated":[212,224,353],"cancer":[214,236],"type.":[215],"Wilms":[226],"Tumor":[227],"Protein(WT-1)":[228],"level(":[229],"P":[230,276],"<0.05).":[231,277],"Further":[232,244],"analysis":[233,245],"showed":[234,246],"that":[235,247,324],"type":[237,362],"factor":[241],"high":[248],"unfavorable":[254],"terms":[256],"patients":[261,338],"had":[267],"positive":[269],"correlation":[270],"LOXL4":[272],"(R=0.26,":[275],"High-LOXL3":[278],"expressing":[279,295],"tissue":[280,296],"samples":[281,297],"oxidative":[285],"phosphorylation,":[286],"adipogenesis,":[287],"interferon":[288],"alpha":[289],"response":[290],"genes.":[293,309],"Low-LOXL3":[294],"apoptosis,":[301],"IL2-STAT5":[302],"signaling,":[303],"mTORC1":[304],"signaling":[305],"related":[308],"Conclusion:":[310],"associated":[313],"occurrence":[316],"Our":[321],"findings":[322],"reveal":[323],"elevated":[326],"may":[330],"potentially":[331],"predict":[332],"poor":[333],"overall":[334],"survival":[335],"(OS)":[336],"More":[341],"importantly,":[342],"positively":[352],"WT-1":[358],"genes":[359],"ancer":[361],"As":[365],"new":[367],"oncogene,":[368],"deserves":[370],"further":[371],"investigation":[372],"validate":[374],"its":[375],"role":[376],"mechanism":[378]},"counts_by_year":[],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2024-08-29T00:00:00"}
