{"id":"https://openalex.org/W4401920156","doi":"https://doi.org/10.1192/j.eurpsy.2024.1070","title":"Hematological impact of COVID-19 mRNA vaccination in patients treated with Clozapine","display_name":"Hematological impact of COVID-19 mRNA vaccination in patients treated with Clozapine","publication_year":2024,"publication_date":"2024-04-01","ids":{"openalex":"https://openalex.org/W4401920156","doi":"https://doi.org/10.1192/j.eurpsy.2024.1070","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11860758"},"language":"en","primary_location":{"id":"doi:10.1192/j.eurpsy.2024.1070","doi":"https://doi.org/10.1192/j.eurpsy.2024.1070","is_oa":true,"landing_page_url":"https://doi.org/10.1192/j.eurpsy.2024.1070","pdf_url":"https://www.cambridge.org/core/services/aop-cambridge-core/content/view/8EAB30090BD45C564B75D26AFB3BD807/S0924933824010708a.pdf/div-class-title-hematological-impact-of-covid-19-mrna-vaccination-in-patients-treated-with-clozapine-div.pdf","source":{"id":"https://openalex.org/S87202501","display_name":"European Psychiatry","issn_l":"0924-9338","issn":["0924-9338","1778-3585"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311721","host_organization_name":"Cambridge University Press","host_organization_lineage":["https://openalex.org/P4310311721","https://openalex.org/P4310311702"],"host_organization_lineage_names":["Cambridge University Press","University of Cambridge"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Psychiatry","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.cambridge.org/core/services/aop-cambridge-core/content/view/8EAB30090BD45C564B75D26AFB3BD807/S0924933824010708a.pdf/div-class-title-hematological-impact-of-covid-19-mrna-vaccination-in-patients-treated-with-clozapine-div.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5106757390","display_name":"A. Touiti","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210166419","display_name":"H\u00f4pital Razi de La Manouba","ror":"https://ror.org/01j6t9363","country_code":"TN","type":"healthcare","lineage":["https://openalex.org/I4210166419"]},{"id":"https://openalex.org/I4403386600","display_name":"Facult\u00e9 de m\u00e9decine de Tunis","ror":"https://ror.org/03pyhhg10","country_code":"TN","type":"education","lineage":["https://openalex.org/I4403386600","https://openalex.org/I63596082"]},{"id":"https://openalex.org/I63596082","display_name":"Tunis El Manar University","ror":"https://ror.org/029cgt552","country_code":"TN","type":"education","lineage":["https://openalex.org/I63596082"]}],"countries":["TN"],"is_corresponding":true,"raw_author_name":"A. Touiti","raw_affiliation_strings":["1Forensic Psychiatry Departement, Razi Hospital, La Manouba","2Faculty of Medecine of Tunis, Tunis El Manar University, Tunis, Tunisia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Forensic Psychiatry Departement, Razi Hospital, La Manouba","institution_ids":["https://openalex.org/I4210166419"]},{"raw_affiliation_string":"2Faculty of Medecine of Tunis, Tunis El Manar University, Tunis, Tunisia","institution_ids":["https://openalex.org/I4403386600","https://openalex.org/I63596082"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5106757195","display_name":"I. Yaich","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210166419","display_name":"H\u00f4pital Razi de La Manouba","ror":"https://ror.org/01j6t9363","country_code":"TN","type":"healthcare","lineage":["https://openalex.org/I4210166419"]},{"id":"https://openalex.org/I4403386600","display_name":"Facult\u00e9 de m\u00e9decine de Tunis","ror":"https://ror.org/03pyhhg10","country_code":"TN","type":"education","lineage":["https://openalex.org/I4403386600","https://openalex.org/I63596082"]},{"id":"https://openalex.org/I63596082","display_name":"Tunis El Manar University","ror":"https://ror.org/029cgt552","country_code":"TN","type":"education","lineage":["https://openalex.org/I63596082"]}],"countries":["TN"],"is_corresponding":false,"raw_author_name":"I. Yaich","raw_affiliation_strings":["1Forensic Psychiatry Departement, Razi Hospital, La Manouba","2Faculty of Medecine of Tunis, Tunis El Manar University, Tunis, Tunisia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Forensic Psychiatry Departement, Razi Hospital, La Manouba","institution_ids":["https://openalex.org/I4210166419"]},{"raw_affiliation_string":"2Faculty of Medecine of Tunis, Tunis El Manar University, Tunis, Tunisia","institution_ids":["https://openalex.org/I4403386600","https://openalex.org/I63596082"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018862872","display_name":"C. Ben Said","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210166419","display_name":"H\u00f4pital Razi de La Manouba","ror":"https://ror.org/01j6t9363","country_code":"TN","type":"healthcare","lineage":["https://openalex.org/I4210166419"]},{"id":"https://openalex.org/I4403386600","display_name":"Facult\u00e9 de m\u00e9decine de Tunis","ror":"https://ror.org/03pyhhg10","country_code":"TN","type":"education","lineage":["https://openalex.org/I4403386600","https://openalex.org/I63596082"]},{"id":"https://openalex.org/I63596082","display_name":"Tunis El Manar University","ror":"https://ror.org/029cgt552","country_code":"TN","type":"education","lineage":["https://openalex.org/I63596082"]}],"countries":["TN"],"is_corresponding":false,"raw_author_name":"C. Ben Said","raw_affiliation_strings":["1Forensic Psychiatry Departement, Razi Hospital, La Manouba","2Faculty of Medecine of Tunis, Tunis El Manar University, Tunis, Tunisia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Forensic Psychiatry Departement, Razi Hospital, La Manouba","institution_ids":["https://openalex.org/I4210166419"]},{"raw_affiliation_string":"2Faculty of Medecine of Tunis, Tunis El Manar University, Tunis, Tunisia","institution_ids":["https://openalex.org/I4403386600","https://openalex.org/I63596082"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110404428","display_name":"N. Bram","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210166419","display_name":"H\u00f4pital Razi de La Manouba","ror":"https://ror.org/01j6t9363","country_code":"TN","type":"healthcare","lineage":["https://openalex.org/I4210166419"]},{"id":"https://openalex.org/I4403386600","display_name":"Facult\u00e9 de m\u00e9decine de Tunis","ror":"https://ror.org/03pyhhg10","country_code":"TN","type":"education","lineage":["https://openalex.org/I4403386600","https://openalex.org/I63596082"]},{"id":"https://openalex.org/I63596082","display_name":"Tunis El Manar University","ror":"https://ror.org/029cgt552","country_code":"TN","type":"education","lineage":["https://openalex.org/I63596082"]}],"countries":["TN"],"is_corresponding":false,"raw_author_name":"N. Bram","raw_affiliation_strings":["1Forensic Psychiatry Departement, Razi Hospital, La Manouba","2Faculty of Medecine of Tunis, Tunis El Manar University, Tunis, Tunisia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Forensic Psychiatry Departement, Razi Hospital, La Manouba","institution_ids":["https://openalex.org/I4210166419"]},{"raw_affiliation_string":"2Faculty of Medecine of Tunis, Tunis El Manar University, Tunis, Tunisia","institution_ids":["https://openalex.org/I4403386600","https://openalex.org/I63596082"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5106757390"],"corresponding_institution_ids":["https://openalex.org/I4210166419","https://openalex.org/I4403386600","https://openalex.org/I63596082"],"apc_list":{"value":3150,"currency":"USD","value_usd":3150},"apc_paid":{"value":3150,"currency":"USD","value_usd":3150},"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"67","issue":"S1","first_page":"S515","last_page":"S515"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10023","display_name":"Schizophrenia research and treatment","score":0.9340999722480774,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10023","display_name":"Schizophrenia research and treatment","score":0.9340999722480774,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10041","display_name":"COVID-19 Clinical Research Studies","score":0.014700000174343586,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10118","display_name":"SARS-CoV-2 and COVID-19 Research","score":0.01209999993443489,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/covid-19-mrna-vaccine","display_name":"COVID-19 mRNA vaccine","score":0.9789999723434448},{"id":"https://openalex.org/keywords/clozapine","display_name":"clozapine","score":0.9940000176429749},{"id":"https://openalex.org/keywords/treatment-resistant-schizophrenia","display_name":"treatment-resistant schizophrenia","score":0.8949999809265137},{"id":"https://openalex.org/keywords/agranulocytosis","display_name":"agranulocytosis","score":0.9660000205039978},{"id":"https://openalex.org/keywords/hematological-adverse-events","display_name":"hematologic adverse events","score":0.8230000138282776},{"id":"https://openalex.org/keywords/neutropenia","display_name":"neutropenia","score":0.8230000138282776},{"id":"https://openalex.org/keywords/vaccine-safety","display_name":"vaccine safety","score":0.6349999904632568},{"id":"https://openalex.org/keywords/antipsychotic-drugs","display_name":"antipsychotic drugs","score":0.8130000233650208},{"id":"https://openalex.org/keywords/complete-blood-count","display_name":"complete blood count","score":0.671999990940094}],"concepts":[{"id":"https://openalex.org/C2780864610","wikidata":"https://www.wikidata.org/wiki/Q221361","display_name":"Clozapine","level":3,"score":0.7299131155014038},{"id":"https://openalex.org/C3008058167","wikidata":"https://www.wikidata.org/wiki/Q84263196","display_name":"Coronavirus disease 2019 (COVID-19)","level":4,"score":0.7235775589942932},{"id":"https://openalex.org/C22070199","wikidata":"https://www.wikidata.org/wiki/Q192995","display_name":"Vaccination","level":2,"score":0.6691032648086548},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5315755605697632},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.45259734988212585},{"id":"https://openalex.org/C3006700255","wikidata":"https://www.wikidata.org/wiki/Q81068910","display_name":"2019-20 coronavirus outbreak","level":3,"score":0.4225539565086365},{"id":"https://openalex.org/C3007834351","wikidata":"https://www.wikidata.org/wiki/Q82069695","display_name":"Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)","level":5,"score":0.41919001936912537},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.36070919036865234},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.339688777923584},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3327549695968628},{"id":"https://openalex.org/C2776412080","wikidata":"https://www.wikidata.org/wiki/Q7431605","display_name":"Schizophrenia (object-oriented programming)","level":2,"score":0.20341390371322632},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.17771661281585693},{"id":"https://openalex.org/C116675565","wikidata":"https://www.wikidata.org/wiki/Q3241045","display_name":"Outbreak","level":2,"score":0.07141315937042236},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.05249887704849243},{"id":"https://openalex.org/C524204448","wikidata":"https://www.wikidata.org/wiki/Q788926","display_name":"Infectious disease (medical specialty)","level":3,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1192/j.eurpsy.2024.1070","doi":"https://doi.org/10.1192/j.eurpsy.2024.1070","is_oa":true,"landing_page_url":"https://doi.org/10.1192/j.eurpsy.2024.1070","pdf_url":"https://www.cambridge.org/core/services/aop-cambridge-core/content/view/8EAB30090BD45C564B75D26AFB3BD807/S0924933824010708a.pdf/div-class-title-hematological-impact-of-covid-19-mrna-vaccination-in-patients-treated-with-clozapine-div.pdf","source":{"id":"https://openalex.org/S87202501","display_name":"European Psychiatry","issn_l":"0924-9338","issn":["0924-9338","1778-3585"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311721","host_organization_name":"Cambridge University Press","host_organization_lineage":["https://openalex.org/P4310311721","https://openalex.org/P4310311702"],"host_organization_lineage_names":["Cambridge University Press","University of Cambridge"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Psychiatry","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11860758","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11860758","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11860758/pdf/S0924933824010708a.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Eur Psychiatry","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:d8779f60a3834ee4a997e1e7db1a0ec7","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/d8779f60a3834ee4a997e1e7db1a0ec7","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"European Psychiatry, Vol 67, Pp S515-S515 (2024)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1192/j.eurpsy.2024.1070","doi":"https://doi.org/10.1192/j.eurpsy.2024.1070","is_oa":true,"landing_page_url":"https://doi.org/10.1192/j.eurpsy.2024.1070","pdf_url":"https://www.cambridge.org/core/services/aop-cambridge-core/content/view/8EAB30090BD45C564B75D26AFB3BD807/S0924933824010708a.pdf/div-class-title-hematological-impact-of-covid-19-mrna-vaccination-in-patients-treated-with-clozapine-div.pdf","source":{"id":"https://openalex.org/S87202501","display_name":"European Psychiatry","issn_l":"0924-9338","issn":["0924-9338","1778-3585"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311721","host_organization_name":"Cambridge University Press","host_organization_lineage":["https://openalex.org/P4310311721","https://openalex.org/P4310311702"],"host_organization_lineage_names":["Cambridge University Press","University of Cambridge"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Psychiatry","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4401920156.pdf","grobid_xml":"https://content.openalex.org/works/W4401920156.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4366977324","https://openalex.org/W4367602007","https://openalex.org/W4213166037","https://openalex.org/W4410472881","https://openalex.org/W4401925757","https://openalex.org/W4210517073","https://openalex.org/W4294200186","https://openalex.org/W4312799309","https://openalex.org/W3195874124","https://openalex.org/W3196699886"],"abstract_inverted_index":{"Introduction":[0],"Clozapine":[1],"is":[2,7,21,36,60,259,289,295],"an":[3],"atypical":[4],"antipsychotic":[5],"that":[6],"primarily":[8],"prescribed":[9],"for":[10,42,107,276],"treatment-resistant":[11,98],"schizophrenia.":[12],"Despite":[13],"its":[14,25],"proven":[15],"efficacy,":[16],"the":[17,32,47,64,67,70,83,87,110,156,162,170,192,197,214,236,247,252,256,266,287],"prescription":[18,233],"of":[19,46,53,66,72,86,95,114,148,155,169,199,234,255,265,279,301],"clozapine":[20,179,208,285,299],"sometimes":[22],"limited":[23,61],"by":[24,178,246,284,286],"hematologic":[26,73,84,280],"side":[27,281],"effects,":[28],"including":[29],"agranulocytosis.":[30],"During":[31],"SARS-CoV-2":[33],"pandemic,":[34],"schizophrenia":[35,99,108],"recognized":[37],"as":[38,153,273],"a":[39,93],"risk":[40,71,254],"factor":[41],"developing":[43],"severe":[44,224,263],"forms":[45,264],"infection.":[48],"Early":[49],"and":[50,128,166,239],"complete":[51,149],"vaccination":[52,181],"patients":[54,76,96,105,123,130,138,205,215,274],"has":[55],"been":[56,243],"recommended.":[57],"However,":[58],"there":[59,221],"data":[62],"on":[63,69],"effect":[65,85],"vaccine":[68,89,288,294],"abnormalities":[74],"in":[75,92,117,196,204,269],"treated":[77,100,125,132,206,216,275],"with":[78,97,101,126,133,207,217,298],"clozapine.":[79,102],"Objectives":[80],"To":[81],"study":[82],"mRNA":[88,293],"against":[90,182],"COVID-19":[91,248,292],"population":[94],"Methods":[103],"Twenty-five":[104],"hospitalized":[106],"at":[109],"forensic":[111],"psychiatry":[112],"department":[113],"Razi":[115],"Hospital":[116],"Manouba,":[118],"Tunisia,":[119],"were":[120,124,131,159,190],"included.":[121],"Eighteen":[122],"clozapine,":[127,235],"seven":[129],"other":[134,218],"antipsychotics.":[135],"Consent":[136],"from":[137],"and/or":[139],"their":[140],"relatives":[141],"was":[142,202,222],"obtained":[143],"before":[144,165],"vaccination.":[145],"The":[146,232],"results":[147],"blood":[150,186],"counts":[151],"performed":[152],"part":[154],"therapeutic":[157],"protocol":[158],"compared":[160,212],"between":[161],"two":[163],"groups":[164],"after":[167,180],"administration":[168,241],"vaccine.":[171],"Results":[172],"No":[173],"patient":[174],"experienced":[175],"agranulocytosis":[176],"induced":[177,283],"COVID-19.Blood":[183],"cells":[184,187],"counts,red":[185],"counts,and":[188],"platelets":[189],"within":[191],"normal":[193],"ranges.However,a":[194],"decrease":[195],"number":[198],"WBCs,neutrophils,and":[200],"lymphocytes":[201],"observed":[203],"without":[209],"significant":[210],"difference":[211],"to":[213,228,251,261],"neuroleptics,":[219],"but":[220],"no":[223],"neutropenia":[225],"or":[226],"need":[227],"stop":[229],"treatment.":[230],"Conclusions":[231],"introduction":[237],"protocol,":[238],"treatment":[240],"have":[242],"greatly":[244],"influenced":[245],"pandemic":[249],"due":[250],"hepatotoxic":[253],"drug.":[257],"Vaccination":[258],"essential":[260],"prevent":[262],"infection,":[267],"especially":[268],"at-risk":[270],"populations":[271],"such":[272],"schizophrenia.The":[277],"potentiation":[278],"effects":[282],"not":[290],"documented.The":[291],"safe":[296],"even":[297],"Disclosure":[300],"Interest":[302],"None":[303],"Declared":[304]},"counts_by_year":[],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2024-08-28T00:00:00"}