{"id":"https://openalex.org/W4401912582","doi":"https://doi.org/10.1159/000497547","title":"Structure-function studies on enterostatin inhibition of insulin release","display_name":"Structure-function studies on enterostatin inhibition of insulin release","publication_year":2019,"publication_date":"2019-03-01","ids":{"openalex":"https://openalex.org/W4401912582","doi":"https://doi.org/10.1159/000497547"},"language":"en","primary_location":{"id":"doi:10.1159/000497547","doi":"https://doi.org/10.1159/000497547","is_oa":true,"landing_page_url":"https://doi.org/10.1159/000497547","pdf_url":null,"source":{"id":"https://openalex.org/S4210210150","display_name":"International Journal of Diabetes and Metabolism","issn_l":"1606-7754","issn":["1606-7754","2073-5944"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-20"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Diabetes and Metabolism","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://doi.org/10.1159/000497547","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111551766","display_name":"Mohammad Tadayyon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I103990859","display_name":"Pennington Biomedical Research Center","ror":"https://ror.org/040cnym54","country_code":"US","type":"facility","lineage":["https://openalex.org/I103990859","https://openalex.org/I121820613"]},{"id":"https://openalex.org/I121820613","display_name":"Louisiana State University","ror":"https://ror.org/05ect4e57","country_code":"US","type":"education","lineage":["https://openalex.org/I121820613"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M. Tadayyon","raw_affiliation_strings":["Departments of (a)  Vascular Biology, (c) Synthetic Isotope Chemistry and (d) Medicinal Chemistry,\nGlaxoSmithKline Pharmaceuticals, Harlow, CM19 5AD, UK. (b) Pennington Biomedical Research\nCenter, Louisiana State University, Louisiana, 70808-4124, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of (a)  Vascular Biology, (c) Synthetic Isotope Chemistry and (d) Medicinal Chemistry,\nGlaxoSmithKline Pharmaceuticals, Harlow, CM19 5AD, UK. (b) Pennington Biomedical Research\nCenter, Louisiana State University, Louisiana, 70808-4124, USA","institution_ids":["https://openalex.org/I103990859","https://openalex.org/I121820613"]}]},{"author_position":"middle","author":{"id":null,"display_name":"S. Liou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I103990859","display_name":"Pennington Biomedical Research Center","ror":"https://ror.org/040cnym54","country_code":"US","type":"facility","lineage":["https://openalex.org/I103990859","https://openalex.org/I121820613"]},{"id":"https://openalex.org/I121820613","display_name":"Louisiana State University","ror":"https://ror.org/05ect4e57","country_code":"US","type":"education","lineage":["https://openalex.org/I121820613"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S. Liou","raw_affiliation_strings":["Departments of (a)  Vascular Biology, (c) Synthetic Isotope Chemistry and (d) Medicinal Chemistry,\nGlaxoSmithKline Pharmaceuticals, Harlow, CM19 5AD, UK. (b) Pennington Biomedical Research\nCenter, Louisiana State University, Louisiana, 70808-4124, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of (a)  Vascular Biology, (c) Synthetic Isotope Chemistry and (d) Medicinal Chemistry,\nGlaxoSmithKline Pharmaceuticals, Harlow, CM19 5AD, UK. (b) Pennington Biomedical Research\nCenter, Louisiana State University, Louisiana, 70808-4124, USA","institution_ids":["https://openalex.org/I103990859","https://openalex.org/I121820613"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060092830","display_name":"Celia P. Briscoe","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C.P. Briscoe","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085640241","display_name":"G. Badman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I103990859","display_name":"Pennington Biomedical Research Center","ror":"https://ror.org/040cnym54","country_code":"US","type":"facility","lineage":["https://openalex.org/I103990859","https://openalex.org/I121820613"]},{"id":"https://openalex.org/I121820613","display_name":"Louisiana State University","ror":"https://ror.org/05ect4e57","country_code":"US","type":"education","lineage":["https://openalex.org/I121820613"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"G. Badman","raw_affiliation_strings":["Departments of (a)  Vascular Biology, (c) Synthetic Isotope Chemistry and (d) Medicinal Chemistry,\nGlaxoSmithKline Pharmaceuticals, Harlow, CM19 5AD, UK. (b) Pennington Biomedical Research\nCenter, Louisiana State University, Louisiana, 70808-4124, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of (a)  Vascular Biology, (c) Synthetic Isotope Chemistry and (d) Medicinal Chemistry,\nGlaxoSmithKline Pharmaceuticals, Harlow, CM19 5AD, UK. (b) Pennington Biomedical Research\nCenter, Louisiana State University, Louisiana, 70808-4124, USA","institution_ids":["https://openalex.org/I103990859","https://openalex.org/I121820613"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004887791","display_name":"Drake S. Eggleston","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I103990859","display_name":"Pennington Biomedical Research Center","ror":"https://ror.org/040cnym54","country_code":"US","type":"facility","lineage":["https://openalex.org/I103990859","https://openalex.org/I121820613"]},{"id":"https://openalex.org/I121820613","display_name":"Louisiana State University","ror":"https://ror.org/05ect4e57","country_code":"US","type":"education","lineage":["https://openalex.org/I121820613"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D.S. Eggleston","raw_affiliation_strings":["Departments of (a)  Vascular Biology, (c) Synthetic Isotope Chemistry and (d) Medicinal Chemistry,\nGlaxoSmithKline Pharmaceuticals, Harlow, CM19 5AD, UK. (b) Pennington Biomedical Research\nCenter, Louisiana State University, Louisiana, 70808-4124, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of (a)  Vascular Biology, (c) Synthetic Isotope Chemistry and (d) Medicinal Chemistry,\nGlaxoSmithKline Pharmaceuticals, Harlow, CM19 5AD, UK. (b) Pennington Biomedical Research\nCenter, Louisiana State University, Louisiana, 70808-4124, USA","institution_ids":["https://openalex.org/I103990859","https://openalex.org/I121820613"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113565684","display_name":"Jonathan R. S. Arch","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I103990859","display_name":"Pennington Biomedical Research Center","ror":"https://ror.org/040cnym54","country_code":"US","type":"facility","lineage":["https://openalex.org/I103990859","https://openalex.org/I121820613"]},{"id":"https://openalex.org/I121820613","display_name":"Louisiana State University","ror":"https://ror.org/05ect4e57","country_code":"US","type":"education","lineage":["https://openalex.org/I121820613"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J.R.S. Arch","raw_affiliation_strings":["Departments of (a)  Vascular Biology, (c) Synthetic Isotope Chemistry and (d) Medicinal Chemistry,\nGlaxoSmithKline Pharmaceuticals, Harlow, CM19 5AD, UK. (b) Pennington Biomedical Research\nCenter, Louisiana State University, Louisiana, 70808-4124, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of (a)  Vascular Biology, (c) Synthetic Isotope Chemistry and (d) Medicinal Chemistry,\nGlaxoSmithKline Pharmaceuticals, Harlow, CM19 5AD, UK. (b) Pennington Biomedical Research\nCenter, Louisiana State University, Louisiana, 70808-4124, USA","institution_ids":["https://openalex.org/I103990859","https://openalex.org/I121820613"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5055502216","display_name":"David A. York","orcid":"https://orcid.org/0000-0002-6534-8572","observed_orcids":["https://orcid.org/0000-0002-6534-8572"]},"institutions":[{"id":"https://openalex.org/I103990859","display_name":"Pennington Biomedical Research Center","ror":"https://ror.org/040cnym54","country_code":"US","type":"facility","lineage":["https://openalex.org/I103990859","https://openalex.org/I121820613"]},{"id":"https://openalex.org/I121820613","display_name":"Louisiana State University","ror":"https://ror.org/05ect4e57","country_code":"US","type":"education","lineage":["https://openalex.org/I121820613"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D.A. York","raw_affiliation_strings":["Departments of (a)  Vascular Biology, (c) Synthetic Isotope Chemistry and (d) Medicinal Chemistry,\nGlaxoSmithKline Pharmaceuticals, Harlow, CM19 5AD, UK. (b) Pennington Biomedical Research\nCenter, Louisiana State University, Louisiana, 70808-4124, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of (a)  Vascular Biology, (c) Synthetic Isotope Chemistry and (d) Medicinal Chemistry,\nGlaxoSmithKline Pharmaceuticals, Harlow, CM19 5AD, UK. (b) Pennington Biomedical Research\nCenter, Louisiana State University, Louisiana, 70808-4124, USA","institution_ids":["https://openalex.org/I103990859","https://openalex.org/I121820613"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.46357242,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"14","last_page":"21"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.9883000254631042,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.9883000254631042,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.007600000128149986,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":0.002199999988079071,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/enterostatin","display_name":"enterostatin","score":1.0},{"id":"https://openalex.org/keywords/insulin-secretion","display_name":"insulin secretion","score":0.7789999842643738},{"id":"https://openalex.org/keywords/insulinoma-cells","display_name":"insulinoma cells","score":0.6150000095367432},{"id":"https://openalex.org/keywords/pancreatic-islets","display_name":"pancreatic islets","score":0.9169999957084656},{"id":"https://openalex.org/keywords/structure-function-relationship","display_name":"structure-function relationship","score":0.6740000247955322},{"id":"https://openalex.org/keywords/n-terminal-sequence","display_name":"N-terminal sequence","score":0.7139999866485596}],"concepts":[{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.5455670952796936},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.5019261837005615},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.44554343819618225},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4204847812652588},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.37691694498062134},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2821216583251953},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.22606033086776733},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1675949990749359}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1159/000497547","doi":"https://doi.org/10.1159/000497547","is_oa":true,"landing_page_url":"https://doi.org/10.1159/000497547","pdf_url":null,"source":{"id":"https://openalex.org/S4210210150","display_name":"International Journal of Diabetes and Metabolism","issn_l":"1606-7754","issn":["1606-7754","2073-5944"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-20"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Diabetes and Metabolism","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1159/000497547","doi":"https://doi.org/10.1159/000497547","is_oa":true,"landing_page_url":"https://doi.org/10.1159/000497547","pdf_url":null,"source":{"id":"https://openalex.org/S4210210150","display_name":"International Journal of Diabetes and Metabolism","issn_l":"1606-7754","issn":["1606-7754","2073-5944"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-20"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Diabetes and Metabolism","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.6240000128746033,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2026041707","https://openalex.org/W2316281209","https://openalex.org/W2074262540","https://openalex.org/W2007413109","https://openalex.org/W16405769","https://openalex.org/W2095063841","https://openalex.org/W1991725342","https://openalex.org/W64302251","https://openalex.org/W2007346010","https://openalex.org/W2068369557"],"abstract_inverted_index":{"The":[0,85],"pentapeptide":[1],"enterostatin":[2,27,44,64,93,121,137,156],"(Val-Pro-Asp-Pro-Arg":[3],"or":[4],"VPDPR1)":[5],"has":[6],"been":[7],"shown":[8],"to":[9,62,120,146],"inhibit":[10],"insulin":[11,59,140],"secretion":[12,141],"both":[13],"in":[14,17,28,32,57,103,138,153],"vivo":[15],"and":[16,31,65],"isolated":[18,37],"rat":[19,29,38],"islets.":[20],"We":[21],"report":[22],"on":[23],"structure-function":[24],"studies":[25,127],"of":[26,43,74,82,109,132,136],"islets":[30],"RINm5F":[33,104],"insulinoma":[34],"cells.":[35],"In":[36],"islets,":[39],"the":[40,75,106,129,133],"tyrosinated":[41],"version":[42],"(YVPDPR)":[45],"had":[46],"~10":[47],"fold":[48],"reduced":[49],"potency":[50],"at":[51,70,94,99],"lower":[52],"concentrations":[53],"(10nM":[54],"versus":[55],"1nM)":[56],"inhibiting":[58],"release":[60],"compared":[61],"nascent":[63],"did":[66],"not":[67],"exhibit":[68],"activity":[69,98],"1\u03bcM":[71],"concentrations.":[72,101],"Replacement":[73],"L-valine":[76],"with":[77],"D-valine":[78],"caused":[79],"total":[80],"loss":[81],"biological":[83],"activity.":[84],"peptide":[86],"YPDPR":[87,110,114],"was":[88,111],"more":[89],"efficacious":[90],"than":[91],"native":[92],"0.1nM":[95],"but":[96,142],"lost":[97],"higher":[100],"However,":[102],"cells,":[105],"inhibitory":[107,118],"effect":[108],"preserved.":[112],"3-iodo-":[113],"exhibited":[115],"a":[116,123],"similar":[117],"profile":[119],"across":[122],"wide":[124],"concentration.":[125],"These":[126],"demonstrate":[128],"functional":[130],"importance":[131],"N-terminal":[134],"sequences":[135],"regulating":[139],"also":[143],"suggest":[144],"tolerance":[145],"some":[147],"modifications.":[148],"Radio-iodinated-YPDPR":[149],"may":[150],"be":[151],"useful":[152],"characterising":[154],"putative":[155],"receptors.":[157]},"counts_by_year":[],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2024-08-28T00:00:00"}