{"id":"https://openalex.org/W4401910232","doi":"https://doi.org/10.3390/ijms25179268","title":"In-Depth Analysis of the Peripheral Immune Profile of HER2+ Breast Cancer Patients on Neoadjuvant Treatment with Chemotherapy Plus Trastuzumab Plus Pertuzumab","display_name":"In-Depth Analysis of the Peripheral Immune Profile of HER2+ Breast Cancer Patients on Neoadjuvant Treatment with Chemotherapy Plus Trastuzumab Plus Pertuzumab","publication_year":2024,"publication_date":"2024-08-27","ids":{"openalex":"https://openalex.org/W4401910232","doi":"https://doi.org/10.3390/ijms25179268","pmid":"https://pubmed.ncbi.nlm.nih.gov/39273217","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11395157"},"language":"en","primary_location":{"id":"doi:10.3390/ijms25179268","doi":"https://doi.org/10.3390/ijms25179268","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms25179268","pdf_url":"https://www.mdpi.com/1422-0067/25/17/9268/pdf?version=1724812024","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/1422-0067/25/17/9268/pdf?version=1724812024","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5034294379","display_name":"Ayel\u00e9n Ivana Pesce Viglietti","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210131024","display_name":"Fundaci\u00f3n para la Investigaci\u00f3n, Docencia y Prevenci\u00f3n del C\u00e1ncer","ror":"https://ror.org/02z3t5745","country_code":"AR","type":"nonprofit","lineage":["https://openalex.org/I4210131024"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"Ayel\u00e9n Ivana Pesce Viglietti","raw_affiliation_strings":["Centro de Investigaciones Oncol\u00f3gicas (FUCA), Fundaci\u00f3n C\u00e1ncer, Ciudad Aut\u00f3noma de Buenos Aires C1426AOE, Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro de Investigaciones Oncol\u00f3gicas (FUCA), Fundaci\u00f3n C\u00e1ncer, Ciudad Aut\u00f3noma de Buenos Aires C1426AOE, Argentina","institution_ids":["https://openalex.org/I4210131024"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023537036","display_name":"Mar\u00eda Bel\u00e9n Bordignon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210131024","display_name":"Fundaci\u00f3n para la Investigaci\u00f3n, Docencia y Prevenci\u00f3n del C\u00e1ncer","ror":"https://ror.org/02z3t5745","country_code":"AR","type":"nonprofit","lineage":["https://openalex.org/I4210131024"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"Mar\u00eda Bel\u00e9n Bordignon","raw_affiliation_strings":["Centro de Investigaciones Oncol\u00f3gicas (FUCA), Fundaci\u00f3n C\u00e1ncer, Ciudad Aut\u00f3noma de Buenos Aires C1426AOE, Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro de Investigaciones Oncol\u00f3gicas (FUCA), Fundaci\u00f3n C\u00e1ncer, Ciudad Aut\u00f3noma de Buenos Aires C1426AOE, Argentina","institution_ids":["https://openalex.org/I4210131024"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029902791","display_name":"Alexis Ostinelli","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210125926","display_name":"Instituto Alexander Fleming","ror":"https://ror.org/02b0zvv74","country_code":"AR","type":"healthcare","lineage":["https://openalex.org/I4210125926"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"Alexis Ostinelli","raw_affiliation_strings":["Instituto Alexander Fleming, Ciudad Aut\u00f3noma de Buenos Aires C1426AOE, Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto Alexander Fleming, Ciudad Aut\u00f3noma de Buenos Aires C1426AOE, Argentina","institution_ids":["https://openalex.org/I4210125926"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033156236","display_name":"Manglio Rizzo","orcid":"https://orcid.org/0000-0003-2829-4701","observed_orcids":["https://orcid.org/0000-0003-2829-4701"]},"institutions":[{"id":"https://openalex.org/I4210099959","display_name":"Hospital Universitario Austral","ror":"https://ror.org/014nx0w70","country_code":"AR","type":"healthcare","lineage":["https://openalex.org/I4210099959"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"Manglio Miguel Rizzo","raw_affiliation_strings":["Clinical Oncology Unit, Hospital Universitario Austral, Derqui-Pilar, Buenos Aires B1629ODT, Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Oncology Unit, Hospital Universitario Austral, Derqui-Pilar, Buenos Aires B1629ODT, Argentina","institution_ids":["https://openalex.org/I4210099959"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Gerardo Cueto","orcid":"https://orcid.org/0000-0001-8230-8874","observed_orcids":["https://orcid.org/0000-0001-8230-8874"]},"institutions":[{"id":"https://openalex.org/I151201029","display_name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","ror":"https://ror.org/03cqe8w59","country_code":"AR","type":"government","lineage":["https://openalex.org/I151201029","https://openalex.org/I4210123736","https://openalex.org/I4387155568"]},{"id":"https://openalex.org/I24354313","display_name":"Universidad de Buenos Aires","ror":"https://ror.org/0081fs513","country_code":"AR","type":"education","lineage":["https://openalex.org/I24354313"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"Gerardo Cueto","raw_affiliation_strings":["Grupo de Bioestad\u00edstica Aplicada, Departamento de Ecolog\u00eda, Gen\u00e9tica y Evoluci\u00f3n, Instituto de Ecolog\u00eda, Gen\u00e9tica y Evoluci\u00f3n de Buenos Aires (IEGEBA-UBA/CONICET), Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Aut\u00f3noma de Buenos Aires C1428AOE, Argentina"],"raw_orcid":"https://orcid.org/0000-0001-8230-8874","affiliations":[{"raw_affiliation_string":"Grupo de Bioestad\u00edstica Aplicada, Departamento de Ecolog\u00eda, Gen\u00e9tica y Evoluci\u00f3n, Instituto de Ecolog\u00eda, Gen\u00e9tica y Evoluci\u00f3n de Buenos Aires (IEGEBA-UBA/CONICET), Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Aut\u00f3noma de Buenos Aires C1428AOE, Argentina","institution_ids":["https://openalex.org/I151201029","https://openalex.org/I24354313"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103901900","display_name":"Mar\u00eda Bel\u00e9n S\u00e1nchez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210131024","display_name":"Fundaci\u00f3n para la Investigaci\u00f3n, Docencia y Prevenci\u00f3n del C\u00e1ncer","ror":"https://ror.org/02z3t5745","country_code":"AR","type":"nonprofit","lineage":["https://openalex.org/I4210131024"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"Mar\u00eda Bel\u00e9n Sanchez","raw_affiliation_strings":["Centro de Investigaciones Oncol\u00f3gicas (FUCA), Fundaci\u00f3n C\u00e1ncer, Ciudad Aut\u00f3noma de Buenos Aires C1426AOE, Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro de Investigaciones Oncol\u00f3gicas (FUCA), Fundaci\u00f3n C\u00e1ncer, Ciudad Aut\u00f3noma de Buenos Aires C1426AOE, Argentina","institution_ids":["https://openalex.org/I4210131024"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034576651","display_name":"Florencia Perazzo","orcid":"https://orcid.org/0000-0002-4512-7684","observed_orcids":["https://orcid.org/0000-0002-4512-7684"]},"institutions":[{"id":"https://openalex.org/I4210139031","display_name":"Centro de Educaci\u00f3n M\u00e9dica e Investigaciones Cl\u00ednicas Norberto Quirno","ror":"https://ror.org/04czhsq43","country_code":"AR","type":"nonprofit","lineage":["https://openalex.org/I4210139031"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"Florencia Perazzo","raw_affiliation_strings":["Centro de Educaci\u00f3n M\u00e9dica e Investigaciones Cl\u00ednicas (CEMIC), Ciudad Aut\u00f3noma de Buenos Aires C1431AOE, Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro de Educaci\u00f3n M\u00e9dica e Investigaciones Cl\u00ednicas (CEMIC), Ciudad Aut\u00f3noma de Buenos Aires C1431AOE, Argentina","institution_ids":["https://openalex.org/I4210139031"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050250184","display_name":"Mora Amat","orcid":"https://orcid.org/0000-0001-8257-0004","observed_orcids":["https://orcid.org/0000-0001-8257-0004"]},"institutions":[{"id":"https://openalex.org/I4210125926","display_name":"Instituto Alexander Fleming","ror":"https://ror.org/02b0zvv74","country_code":"AR","type":"healthcare","lineage":["https://openalex.org/I4210125926"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"Mora Amat","raw_affiliation_strings":["Instituto Alexander Fleming, Ciudad Aut\u00f3noma de Buenos Aires C1426AOE, Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto Alexander Fleming, Ciudad Aut\u00f3noma de Buenos Aires C1426AOE, Argentina","institution_ids":["https://openalex.org/I4210125926"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080171215","display_name":"Federico Andr\u00e9s Col\u00f3","orcid":"https://orcid.org/0000-0002-4757-2992","observed_orcids":["https://orcid.org/0000-0002-4757-2992"]},"institutions":[{"id":"https://openalex.org/I4210125926","display_name":"Instituto Alexander Fleming","ror":"https://ror.org/02b0zvv74","country_code":"AR","type":"healthcare","lineage":["https://openalex.org/I4210125926"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"Federico Col\u00f3","raw_affiliation_strings":["Instituto Alexander Fleming, Ciudad Aut\u00f3noma de Buenos Aires C1426AOE, Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto Alexander Fleming, Ciudad Aut\u00f3noma de Buenos Aires C1426AOE, Argentina","institution_ids":["https://openalex.org/I4210125926"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066660883","display_name":"Mar\u00eda Victoria Costanzo","orcid":"https://orcid.org/0000-0003-0619-7329","observed_orcids":["https://orcid.org/0000-0003-0619-7329"]},"institutions":[{"id":"https://openalex.org/I4210125926","display_name":"Instituto Alexander Fleming","ror":"https://ror.org/02b0zvv74","country_code":"AR","type":"healthcare","lineage":["https://openalex.org/I4210125926"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"Mar\u00eda Victoria Costanzo","raw_affiliation_strings":["Instituto Alexander Fleming, Ciudad Aut\u00f3noma de Buenos Aires C1426AOE, Argentina"],"raw_orcid":"https://orcid.org/0000-0003-0619-7329","affiliations":[{"raw_affiliation_string":"Instituto Alexander Fleming, Ciudad Aut\u00f3noma de Buenos Aires C1426AOE, Argentina","institution_ids":["https://openalex.org/I4210125926"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030003312","display_name":"Adri\u00e1n Nervo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210125926","display_name":"Instituto Alexander Fleming","ror":"https://ror.org/02b0zvv74","country_code":"AR","type":"healthcare","lineage":["https://openalex.org/I4210125926"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"Adri\u00e1n Nervo","raw_affiliation_strings":["Instituto Alexander Fleming, Ciudad Aut\u00f3noma de Buenos Aires C1426AOE, Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto Alexander Fleming, Ciudad Aut\u00f3noma de Buenos Aires C1426AOE, Argentina","institution_ids":["https://openalex.org/I4210125926"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043208921","display_name":"Jorge Carlos Nadal","orcid":"https://orcid.org/0000-0001-6266-4070","observed_orcids":["https://orcid.org/0000-0001-6266-4070"]},"institutions":[{"id":"https://openalex.org/I4210125926","display_name":"Instituto Alexander Fleming","ror":"https://ror.org/02b0zvv74","country_code":"AR","type":"healthcare","lineage":["https://openalex.org/I4210125926"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"Jorge Nadal","raw_affiliation_strings":["Instituto Alexander Fleming, Ciudad Aut\u00f3noma de Buenos Aires C1426AOE, Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto Alexander Fleming, Ciudad Aut\u00f3noma de Buenos Aires C1426AOE, Argentina","institution_ids":["https://openalex.org/I4210125926"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001364892","display_name":"Gabriel Crimi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210139031","display_name":"Centro de Educaci\u00f3n M\u00e9dica e Investigaciones Cl\u00ednicas Norberto Quirno","ror":"https://ror.org/04czhsq43","country_code":"AR","type":"nonprofit","lineage":["https://openalex.org/I4210139031"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"Gabriel Crimi","raw_affiliation_strings":["Centro de Educaci\u00f3n M\u00e9dica e Investigaciones Cl\u00ednicas (CEMIC), Ciudad Aut\u00f3noma de Buenos Aires C1431AOE, Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro de Educaci\u00f3n M\u00e9dica e Investigaciones Cl\u00ednicas (CEMIC), Ciudad Aut\u00f3noma de Buenos Aires C1431AOE, Argentina","institution_ids":["https://openalex.org/I4210139031"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048800582","display_name":"Ignacio Mc Lean","orcid":"https://orcid.org/0000-0002-4278-4638","observed_orcids":["https://orcid.org/0000-0002-4278-4638"]},"institutions":[{"id":"https://openalex.org/I4210099959","display_name":"Hospital Universitario Austral","ror":"https://ror.org/014nx0w70","country_code":"AR","type":"healthcare","lineage":["https://openalex.org/I4210099959"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"Ignacio Mc Lean","raw_affiliation_strings":["Clinical Oncology Unit, Hospital Universitario Austral, Derqui-Pilar, Buenos Aires B1629ODT, Argentina"],"raw_orcid":"https://orcid.org/0000-0002-4278-4638","affiliations":[{"raw_affiliation_string":"Clinical Oncology Unit, Hospital Universitario Austral, Derqui-Pilar, Buenos Aires B1629ODT, Argentina","institution_ids":["https://openalex.org/I4210099959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009081778","display_name":"Eunice Spengler","orcid":"https://orcid.org/0000-0002-7819-2714","observed_orcids":["https://orcid.org/0000-0002-7819-2714"]},"institutions":[{"id":"https://openalex.org/I4210099959","display_name":"Hospital Universitario Austral","ror":"https://ror.org/014nx0w70","country_code":"AR","type":"healthcare","lineage":["https://openalex.org/I4210099959"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"Eunice Amancay Spengler","raw_affiliation_strings":["Clinical Oncology Unit, Hospital Universitario Austral, Derqui-Pilar, Buenos Aires B1629ODT, Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Oncology Unit, Hospital Universitario Austral, Derqui-Pilar, Buenos Aires B1629ODT, Argentina","institution_ids":["https://openalex.org/I4210099959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004184657","display_name":"Jos\u00e9 Mordoh","orcid":"https://orcid.org/0000-0002-8301-9617","observed_orcids":["https://orcid.org/0000-0002-8301-9617"]},"institutions":[{"id":"https://openalex.org/I4210131024","display_name":"Fundaci\u00f3n para la Investigaci\u00f3n, Docencia y Prevenci\u00f3n del C\u00e1ncer","ror":"https://ror.org/02z3t5745","country_code":"AR","type":"nonprofit","lineage":["https://openalex.org/I4210131024"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"Jos\u00e9 Mordoh","raw_affiliation_strings":["Centro de Investigaciones Oncol\u00f3gicas (FUCA), Fundaci\u00f3n C\u00e1ncer, Ciudad Aut\u00f3noma de Buenos Aires C1426AOE, Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro de Investigaciones Oncol\u00f3gicas (FUCA), Fundaci\u00f3n C\u00e1ncer, Ciudad Aut\u00f3noma de Buenos Aires C1426AOE, Argentina","institution_ids":["https://openalex.org/I4210131024"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088670404","display_name":"Pablo Mand\u00f3","orcid":"https://orcid.org/0000-0001-8387-9011","observed_orcids":["https://orcid.org/0000-0001-8387-9011"]},"institutions":[{"id":"https://openalex.org/I4210139031","display_name":"Centro de Educaci\u00f3n M\u00e9dica e Investigaciones Cl\u00ednicas Norberto Quirno","ror":"https://ror.org/04czhsq43","country_code":"AR","type":"nonprofit","lineage":["https://openalex.org/I4210139031"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"Pablo Mand\u00f3","raw_affiliation_strings":["Centro de Educaci\u00f3n M\u00e9dica e Investigaciones Cl\u00ednicas (CEMIC), Ciudad Aut\u00f3noma de Buenos Aires C1431AOE, Argentina"],"raw_orcid":"https://orcid.org/0000-0001-8387-9011","affiliations":[{"raw_affiliation_string":"Centro de Educaci\u00f3n M\u00e9dica e Investigaciones Cl\u00ednicas (CEMIC), Ciudad Aut\u00f3noma de Buenos Aires C1431AOE, Argentina","institution_ids":["https://openalex.org/I4210139031"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5045931580","display_name":"Estrella Mariel Levy","orcid":"https://orcid.org/0000-0003-2954-6667","observed_orcids":["https://orcid.org/0000-0003-2954-6667"]},"institutions":[{"id":"https://openalex.org/I4210131024","display_name":"Fundaci\u00f3n para la Investigaci\u00f3n, Docencia y Prevenci\u00f3n del C\u00e1ncer","ror":"https://ror.org/02z3t5745","country_code":"AR","type":"nonprofit","lineage":["https://openalex.org/I4210131024"]}],"countries":["AR"],"is_corresponding":true,"raw_author_name":"Estrella Mariel Levy","raw_affiliation_strings":["Centro de Investigaciones Oncol\u00f3gicas (FUCA), Fundaci\u00f3n C\u00e1ncer, Ciudad Aut\u00f3noma de Buenos Aires C1426AOE, Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro de Investigaciones Oncol\u00f3gicas (FUCA), Fundaci\u00f3n C\u00e1ncer, Ciudad Aut\u00f3noma de Buenos Aires C1426AOE, Argentina","institution_ids":["https://openalex.org/I4210131024"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5045931580"],"corresponding_institution_ids":["https://openalex.org/I4210131024"],"apc_list":{"value":2900,"currency":"CHF","value_usd":3296},"apc_paid":{"value":2900,"currency":"CHF","value_usd":3296},"fwci":0.1772,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.50366463,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":95},"biblio":{"volume":"25","issue":"17","first_page":"9268","last_page":"9268"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research","score":0.6654999852180481,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research","score":0.6654999852180481,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11020","display_name":"Immune Cell Function and Interaction","score":0.11969999969005585,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.11050000041723251,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/her2-positive-breast-cancer","display_name":"HER2-positive breast cancer","score":0.9990000128746033},{"id":"https://openalex.org/keywords/neoadjuvant-therapy","display_name":"neoadjuvant therapy","score":0.9010000228881836},{"id":"https://openalex.org/keywords/trastuzumab","display_name":"trastuzumab","score":0.996999979019165},{"id":"https://openalex.org/keywords/pertuzumab","display_name":"pertuzumab","score":1.0},{"id":"https://openalex.org/keywords/chemotherapy","display_name":"chemotherapy","score":0.8799999952316284},{"id":"https://openalex.org/keywords/natural-killer-cells","display_name":"natural killer cells","score":0.7440000176429749},{"id":"https://openalex.org/keywords/nkp30","display_name":"NKp30","score":0.9110000133514404},{"id":"https://openalex.org/keywords/pd-1","display_name":"PD-1","score":1.0},{"id":"https://openalex.org/keywords/tim-3","display_name":"TIM-3","score":1.0},{"id":"https://openalex.org/keywords/pathological-complete-response","display_name":"pathological complete response","score":0.8429999947547913},{"id":"https://openalex.org/keywords/interferon-gamma-production","display_name":"IFN-gamma production","score":0.699999988079071},{"id":"https://openalex.org/keywords/t-cell-subsets","display_name":"T cell subsets","score":0.609000027179718},{"id":"https://openalex.org/keywords/predictive-biomarkers","display_name":"predictive biomarkers","score":0.5910000205039978}],"concepts":[{"id":"https://openalex.org/C2779786085","wikidata":"https://www.wikidata.org/wiki/Q412616","display_name":"Trastuzumab","level":4,"score":0.8376150131225586},{"id":"https://openalex.org/C2781164504","wikidata":"https://www.wikidata.org/wiki/Q1998021","display_name":"Pertuzumab","level":5,"score":0.7818151712417603},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6152490377426147},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.6136280298233032},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5836752653121948},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.5417703986167908},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5288475751876831},{"id":"https://openalex.org/C553184892","wikidata":"https://www.wikidata.org/wiki/Q1141429","display_name":"Flow cytometry","level":2,"score":0.516061007976532},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5034129023551941},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4921666979789734},{"id":"https://openalex.org/C2781413609","wikidata":"https://www.wikidata.org/wiki/Q7308373","display_name":"Regimen","level":2,"score":0.48540815711021423},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4828272759914398},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3719164729118347},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000068878","descriptor_name":"Trastuzumab","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D000068878","descriptor_name":"Trastuzumab","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007694","descriptor_name":"Killer Cells, Natural","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D007694","descriptor_name":"Killer Cells, Natural","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018719","descriptor_name":"Erb-b2 Receptor Tyrosine Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D020360","descriptor_name":"Neoadjuvant Therapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D061067","descriptor_name":"Antibodies, Monoclonal, Humanized","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D061067","descriptor_name":"Antibodies, Monoclonal, Humanized","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.3390/ijms25179268","doi":"https://doi.org/10.3390/ijms25179268","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms25179268","pdf_url":"https://www.mdpi.com/1422-0067/25/17/9268/pdf?version=1724812024","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11395157","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11395157","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11395157/pdf/ijms-25-09268.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Mol Sci","raw_type":"Text"},{"id":"pmid:39273217","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39273217","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of molecular sciences","raw_type":"Journal Article"},{"id":"pmh:oai:ri.conicet.gov.ar:11336/259155","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/11336/259155","pdf_url":null,"source":{"id":"https://openalex.org/S4306401400","display_name":"Conicet","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210104196","host_organization_name":"Centro Cient\u00edfico Tecnol\u00f3gico - Nordeste","host_organization_lineage":["https://openalex.org/I4210104196"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.3390/ijms25179268","doi":"https://doi.org/10.3390/ijms25179268","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms25179268","pdf_url":"https://www.mdpi.com/1422-0067/25/17/9268/pdf?version=1724812024","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1547223240","display_name":null,"funder_award_id":"PICT 1866\u20132018","funder_id":"https://openalex.org/F4320334832","funder_display_name":"Agencia Nacional de Promoci\u00f3n Cient\u00edfica y Tecnol\u00f3gica"},{"id":"https://openalex.org/G4274825142","display_name":null,"funder_award_id":"PICT 1866-2018 and PICT 3347-2020","funder_id":"https://openalex.org/F4320331467","funder_display_name":"Agencia Nacional de Promoci\u00f3n de la Investigaci\u00f3n, el Desarrollo Tecnol\u00f3gico y la Innovaci\u00f3n"},{"id":"https://openalex.org/G6009560955","display_name":null,"funder_award_id":"PICT 3347-2020","funder_id":"https://openalex.org/F4320334832","funder_display_name":"Agencia Nacional de Promoci\u00f3n Cient\u00edfica y Tecnol\u00f3gica"}],"funders":[{"id":"https://openalex.org/F4320317550","display_name":"Fundaci\u00f3n Sales","ror":"https://ror.org/05eb5ne27"},{"id":"https://openalex.org/F4320331467","display_name":"Agencia Nacional de Promoci\u00f3n de la Investigaci\u00f3n, el Desarrollo Tecnol\u00f3gico y la Innovaci\u00f3n","ror":null},{"id":"https://openalex.org/F4320334832","display_name":"Agencia Nacional de Promoci\u00f3n Cient\u00edfica y Tecnol\u00f3gica","ror":"https://ror.org/03stxzb56"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4401910232.pdf","grobid_xml":"https://content.openalex.org/works/W4401910232.grobid-xml"},"referenced_works_count":43,"referenced_works":["https://openalex.org/W1525138842","https://openalex.org/W1548581509","https://openalex.org/W1912738970","https://openalex.org/W1967186439","https://openalex.org/W1969814796","https://openalex.org/W1987326983","https://openalex.org/W1996032846","https://openalex.org/W2001968322","https://openalex.org/W2006070721","https://openalex.org/W2014564738","https://openalex.org/W2016789384","https://openalex.org/W2066377591","https://openalex.org/W2095861620","https://openalex.org/W2104239861","https://openalex.org/W2107426197","https://openalex.org/W2109439031","https://openalex.org/W2114445859","https://openalex.org/W2123591186","https://openalex.org/W2138523530","https://openalex.org/W2142287133","https://openalex.org/W2162982444","https://openalex.org/W2503169485","https://openalex.org/W2506902454","https://openalex.org/W2524552969","https://openalex.org/W2525265150","https://openalex.org/W2560406314","https://openalex.org/W2599335551","https://openalex.org/W2796088951","https://openalex.org/W2808302887","https://openalex.org/W2883208697","https://openalex.org/W2890056446","https://openalex.org/W2952830835","https://openalex.org/W2969231750","https://openalex.org/W2969950347","https://openalex.org/W3093646952","https://openalex.org/W3157910622","https://openalex.org/W4233227576","https://openalex.org/W4283729313","https://openalex.org/W4353095442","https://openalex.org/W4366602895","https://openalex.org/W4379600909","https://openalex.org/W4382451260","https://openalex.org/W4385350281"],"related_works":["https://openalex.org/W2400260724","https://openalex.org/W1525138842","https://openalex.org/W2334427929","https://openalex.org/W3031001285","https://openalex.org/W2957739823","https://openalex.org/W2793525366","https://openalex.org/W2010941192","https://openalex.org/W4399491057","https://openalex.org/W3184953931","https://openalex.org/W2685815725"],"abstract_inverted_index":{"Currently,":[0],"therapy":[1,68,159],"for":[2,172],"early-stage":[3],"human":[4],"epidermal":[5],"growth":[6],"factor":[7],"receptor":[8],"2-positive":[9],"(HER2+)":[10],"breast":[11],"cancer":[12],"(BC)":[13],"is":[14],"based":[15],"on":[16],"the":[17,57,90,99,127,169,189,203],"combination":[18],"of":[19,59,89,104,129,191,205],"trastuzumab":[20,154],"and":[21,40,69,72,93,133,185,193,195],"pertuzumab":[22],"plus":[23,160],"chemotherapy":[24,161],"in":[25,37,98,117,121,139,165,188,202,210],"a":[26],"neoadjuvant":[27],"regimen.":[28],"The":[29,78,87],"INMUNOHER":[30],"study":[31],"aimed":[32],"to":[33],"detect":[34],"immunological":[35,174],"markers":[36],"peripheral":[38],"blood":[39],"their":[41],"association":[42],"with":[43,151,182],"treatment":[44],"response.":[45],"Sixty-two":[46],"HER2+":[47],"BC":[48],"patients":[49,105,212],"were":[50,54,64,73,115,137,208],"recruited.":[51],"Pre-treatment":[52],"samples":[53,63],"obtained":[55,65],"before":[56,70],"start":[58],"treatment,":[60,143,214],"while":[61],"post-treatment":[62],"after":[66,213],"completing":[67],"surgery":[71],"analyzed":[74],"by":[75,146],"flow":[76],"cytometry.":[77],"pathologic":[79],"complete":[80],"response":[81,183],"(pCR)":[82],"rate":[83],"achieved":[84],"was":[85,96,155],"82.3%.":[86],"expression":[88],"NKp30,":[91],"PD-1,":[92],"TIM-3":[94],"receptors":[95],"reduced":[97],"Natural":[100],"Killer":[101],"(NK)-CD56dim":[102],"subset":[103,178],"who":[106],"did":[107],"not":[108],"achieve":[109],"pCR.":[110],"Following":[111],"therapy,":[112],"many":[113],"changes":[114,136,187,201],"found":[116],"leukocytes,":[118],"including":[119],"alterations":[120],"T":[122,194],"cell":[123],"lymphocyte":[124],"proportions.":[125],"Also,":[126],"percentage":[128,190],"NK":[130,147,177,196,206],"cells":[131,148],"decreased,":[132],"several":[134],"phenotypic":[135],"observed":[138,209],"this":[140],"population.":[141],"After":[142],"IFN-\u03b3":[144],"production":[145],"against":[149],"HER2+-cells":[150],"or":[152],"without":[153],"significantly":[156],"reduced.":[157],"HER2-targeted":[158],"demonstrated":[162],"high":[163],"efficacy":[164],"most":[166,211],"patients,":[167],"reducing":[168],"statistical":[170],"power":[171],"finding":[173],"markers.":[175],"However,":[176],"phenotypes":[179],"correlated":[180],"better":[181],"groups,":[184],"numerous":[186],"leukocytes":[192],"cells,":[197,207],"as":[198,200],"well":[199],"functionality":[204],"encouraging":[215],"further":[216],"research":[217],"into":[218],"these":[219],"immune":[220],"populations.":[221]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2024-08-28T00:00:00"}
