{"id":"https://openalex.org/W4401907475","doi":"https://doi.org/10.18203/2349-3933.ijam20242308","title":"Outcome of severe to critical COVID-19 patients with tocilizumab therapy","display_name":"Outcome of severe to critical COVID-19 patients with tocilizumab therapy","publication_year":2024,"publication_date":"2024-08-27","ids":{"openalex":"https://openalex.org/W4401907475","doi":"https://doi.org/10.18203/2349-3933.ijam20242308"},"language":"en","primary_location":{"id":"doi:10.18203/2349-3933.ijam20242308","doi":"https://doi.org/10.18203/2349-3933.ijam20242308","is_oa":true,"landing_page_url":"http://dx.doi.org/10.18203/2349-3933.ijam20242308","pdf_url":"https://www.ijmedicine.com/index.php/ijam/article/download/4089/2733","source":{"id":"https://openalex.org/S2764699550","display_name":"International Journal of Advances in Medicine","issn_l":"2349-3925","issn":["2349-3925","2349-3933"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4322697004","host_organization_name":"Medip Academy","host_organization_lineage":["https://openalex.org/P4322697004"],"host_organization_lineage_names":["Medip Academy"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Advances in Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://www.ijmedicine.com/index.php/ijam/article/download/4089/2733","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5098976928","display_name":"M. Tanimul Haque Rijvy","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M. Tanimul Haque Rijvy","raw_affiliation_strings":["Jashore Medical College Hospital, Jashore, Bangladesh"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jashore Medical College Hospital, Jashore, Bangladesh","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110882399","display_name":"M. Shariful Alam","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210151104","display_name":"Directorate General of Health Services","ror":"https://ror.org/05xkzd182","country_code":"BD","type":"government","lineage":["https://openalex.org/I4210151104","https://openalex.org/I5476602"]}],"countries":["BD"],"is_corresponding":false,"raw_author_name":"M. Shariful Alam","raw_affiliation_strings":["OSD, DGHS, Mohakhali, Dhaka, Bangladesh"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"OSD, DGHS, Mohakhali, Dhaka, Bangladesh","institution_ids":["https://openalex.org/I4210151104"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002338647","display_name":"Uma Dhar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210151104","display_name":"Directorate General of Health Services","ror":"https://ror.org/05xkzd182","country_code":"BD","type":"government","lineage":["https://openalex.org/I4210151104","https://openalex.org/I5476602"]}],"countries":["BD"],"is_corresponding":false,"raw_author_name":"Uma Dhar","raw_affiliation_strings":["OSD, DGHS, Mohakhali, Dhaka, Bangladesh"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"OSD, DGHS, Mohakhali, Dhaka, Bangladesh","institution_ids":["https://openalex.org/I4210151104"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060842297","display_name":"Abir Hasan Dip","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Abir Hasan Dip","raw_affiliation_strings":["Department of Cardiology, Shaheed Ziaur Rahman Medical College Hospital, Bogura, Bangladesh"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Shaheed Ziaur Rahman Medical College Hospital, Bogura, Bangladesh","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5098976929","display_name":"Shafiul Azam Quadry","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shaiful Azam Quadry","raw_affiliation_strings":["Upazila Health Complex, Asamganj, Brahamanbaria, Bangladesh"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Upazila Health Complex, Asamganj, Brahamanbaria, Bangladesh","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5099527878","display_name":"Hosneara Parvin","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hosneara Parvin","raw_affiliation_strings":["250 Bedded General Hospital, Jashore, Bangladesh"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"250 Bedded General Hospital, Jashore, Bangladesh","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113350639","display_name":"Shilpy Akter","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shilpy Akter","raw_affiliation_strings":["Deparmtnet of Dermatology, 250 Bedded Mohammad Ali Hospital, Bogura, Bangladesh"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Deparmtnet of Dermatology, 250 Bedded Mohammad Ali Hospital, Bogura, Bangladesh","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"M. Ashrafuzzaman","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M. Ashrafuzzaman","raw_affiliation_strings":["250 Bedded General Hospital, Jashore, Bangladesh"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"250 Bedded General Hospital, Jashore, Bangladesh","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103984955","display_name":"Samprity Islam","orcid":"https://orcid.org/0000-0001-7642-617X","observed_orcids":["https://orcid.org/0000-0001-7642-617X"]},"institutions":[{"id":"https://openalex.org/I201969901","display_name":"Bangladesh Medical University","ror":"https://ror.org/042mrsz23","country_code":"BD","type":"education","lineage":["https://openalex.org/I201969901"]}],"countries":["BD"],"is_corresponding":false,"raw_author_name":"Samprity Islam","raw_affiliation_strings":["Department of Respiratory Medicine, BSMMU, Dhaka, Bangladesh"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Respiratory Medicine, BSMMU, Dhaka, Bangladesh","institution_ids":["https://openalex.org/I201969901"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108575120","display_name":"Arif Hossain","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201969901","display_name":"Bangladesh Medical University","ror":"https://ror.org/042mrsz23","country_code":"BD","type":"education","lineage":["https://openalex.org/I201969901"]}],"countries":["BD"],"is_corresponding":false,"raw_author_name":"A. K. M. Mosharraf Hossain","raw_affiliation_strings":["Department of Respiratory Medicine, BSMMU, Dhaka, Bangladesh"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Respiratory Medicine, BSMMU, Dhaka, Bangladesh","institution_ids":["https://openalex.org/I201969901"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"11","issue":"5","first_page":"455","last_page":"463"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10041","display_name":"COVID-19 Clinical Research Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10041","display_name":"COVID-19 Clinical Research Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10322","display_name":"Respiratory Support and Mechanisms","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10118","display_name":"SARS-CoV-2 and COVID-19 Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tocilizumab","display_name":"tocilizumab","score":0.9480000138282776},{"id":"https://openalex.org/keywords/covid-19","display_name":"COVID-19 pandemic","score":0.9829999804496765},{"id":"https://openalex.org/keywords/severe-covid-19","display_name":"severe COVID-19","score":0.875},{"id":"https://openalex.org/keywords/critical-covid-19","display_name":"critical COVID-19","score":0.7960000038146973},{"id":"https://openalex.org/keywords/il-6-receptor-inhibition","display_name":"IL-6 receptor inhibition","score":0.7749999761581421},{"id":"https://openalex.org/keywords/cytokine-storm","display_name":"cytokine storm","score":0.9829999804496765},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.6549999713897705},{"id":"https://openalex.org/keywords/mortality","display_name":"mortality","score":0.8199999928474426},{"id":"https://openalex.org/keywords/length-of-hospital-stay","display_name":"length of hospital stay","score":0.8600000143051147},{"id":"https://openalex.org/keywords/c-reactive-protein","display_name":"C-reactive protein","score":0.8759999871253967},{"id":"https://openalex.org/keywords/white-blood-cell-count","display_name":"white blood cell count","score":0.9089999794960022},{"id":"https://openalex.org/keywords/oxygen-demand","display_name":"oxygen requirement","score":0.699999988079071},{"id":"https://openalex.org/keywords/standard-therapy-comparison","display_name":"standard therapy comparison","score":0.640999972820282}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9585905075073242},{"id":"https://openalex.org/C2777178219","wikidata":"https://www.wikidata.org/wiki/Q425154","display_name":"Tocilizumab","level":3,"score":0.9468392729759216},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6552287340164185},{"id":"https://openalex.org/C3008058167","wikidata":"https://www.wikidata.org/wiki/Q84263196","display_name":"Coronavirus disease 2019 (COVID-19)","level":4,"score":0.5802663564682007},{"id":"https://openalex.org/C23131810","wikidata":"https://www.wikidata.org/wiki/Q818574","display_name":"Observational study","level":2,"score":0.5285006165504456},{"id":"https://openalex.org/C68122502","wikidata":"https://www.wikidata.org/wiki/Q764527","display_name":"Informed consent","level":3,"score":0.4566534757614136},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.20571070909500122},{"id":"https://openalex.org/C524204448","wikidata":"https://www.wikidata.org/wiki/Q788926","display_name":"Infectious disease (medical specialty)","level":3,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.18203/2349-3933.ijam20242308","doi":"https://doi.org/10.18203/2349-3933.ijam20242308","is_oa":true,"landing_page_url":"http://dx.doi.org/10.18203/2349-3933.ijam20242308","pdf_url":"https://www.ijmedicine.com/index.php/ijam/article/download/4089/2733","source":{"id":"https://openalex.org/S2764699550","display_name":"International Journal of Advances in Medicine","issn_l":"2349-3925","issn":["2349-3925","2349-3933"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4322697004","host_organization_name":"Medip Academy","host_organization_lineage":["https://openalex.org/P4322697004"],"host_organization_lineage_names":["Medip Academy"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Advances in Medicine","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.18203/2349-3933.ijam20242308","doi":"https://doi.org/10.18203/2349-3933.ijam20242308","is_oa":true,"landing_page_url":"http://dx.doi.org/10.18203/2349-3933.ijam20242308","pdf_url":"https://www.ijmedicine.com/index.php/ijam/article/download/4089/2733","source":{"id":"https://openalex.org/S2764699550","display_name":"International Journal of Advances in Medicine","issn_l":"2349-3925","issn":["2349-3925","2349-3933"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4322697004","host_organization_name":"Medip Academy","host_organization_lineage":["https://openalex.org/P4322697004"],"host_organization_lineage_names":["Medip Academy"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Advances in Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4401907475.pdf","grobid_xml":"https://content.openalex.org/works/W4401907475.grobid-xml"},"referenced_works_count":17,"referenced_works":["https://openalex.org/W3002108456","https://openalex.org/W3004280078","https://openalex.org/W3017287557","https://openalex.org/W3021269002","https://openalex.org/W3021915688","https://openalex.org/W3022970339","https://openalex.org/W3028902173","https://openalex.org/W3036398841","https://openalex.org/W3036770059","https://openalex.org/W3043999082","https://openalex.org/W3044601236","https://openalex.org/W3093604087","https://openalex.org/W3097465023","https://openalex.org/W3121693389","https://openalex.org/W3129397954","https://openalex.org/W3137971666","https://openalex.org/W3203649612"],"related_works":["https://openalex.org/W4323796469","https://openalex.org/W3201839032","https://openalex.org/W7219568766","https://openalex.org/W3203649612","https://openalex.org/W4389179103","https://openalex.org/W3083668848","https://openalex.org/W3022970339","https://openalex.org/W7153320163","https://openalex.org/W3166941853","https://openalex.org/W3036430736"],"abstract_inverted_index":{"Background:":[0],"The":[1,152],"inflammatory":[2,12],"response":[3],"plays":[4],"a":[5,123,243],"critical":[6,54,91,239],"role":[7],"in":[8,48,96,178,236],"COVID":[9],"19":[10],"and":[11,99,110,126,167,183,223],"cytokine":[13],"storm":[14],"increases":[15],"the":[16,30,39,49,66,138,142,190],"severity":[17,185],"of":[18,32,41,51,69,82,87,140,164],"COVID-19.":[19,35],"Tocilizumab,":[20],"an":[21],"IL-6":[22],"receptor":[23],"monoclonal":[24],"antibody,":[25],"has":[26,233],"been":[27],"used":[28],"for":[29,76],"treatment":[31],"patients":[33,93,156],"with":[34,44,106,134,170],"This":[36,58],"study":[37,62,98,246],"compared":[38],"outcome":[40],"tocilizumab":[42,191],"therapy":[43,47,108,115,232],"other":[45],"standard":[46,107,114],"management":[50],"severe":[52,89,173,237],"to":[53,90,238],"COVID-19":[55,67,92,174,240],"patients.":[56,241],"Methods:":[57],"observational":[59],"prospective":[60],"comparative":[61],"was":[63,146],"conducted":[64],"at":[65],"unit":[68],"Bangabandhu":[70],"Sheikh":[71],"Mujib":[72],"medical":[73],"university":[74],"(BSMMU),":[75],"one":[77],"year":[78],"period":[79],"following":[80],"approval":[81],"this":[83,97],"protocol.":[84],"A":[85],"total":[86],"60":[88],"were":[94,130],"enrolled":[95],"categorized":[100],"into":[101],"two":[102],"groups:":[103],"Tocilizumab":[104,231],"along":[105,133],"(n=30)":[109],"another":[111],"group":[112,192],"receiving":[113],"only":[116],"(n=30).":[117],"After":[118,137,187],"taking":[119],"written":[120],"informed":[121],"consent,":[122],"detailed":[124],"history":[125],"thorough":[127],"clinical":[128],"examination":[129],"carried":[131],"out":[132],"relevant":[135],"investigations.":[136],"collection":[139],"all":[141],"required":[143],"data,":[144],"analysis":[145],"done":[147],"by":[148],"SPSS":[149],"24.0.":[150],"Results:":[151],"study's":[153],"predominantly":[154],"male":[155],"(mean":[157],"age":[158],"53.7\u00b111":[159],"years)":[160],"had":[161,193],"high":[162],"rates":[163],"hypertension":[165],"(63.3%)":[166],"diabetes":[168],"(48.3%),":[169],"most":[171],"experiencing":[172],"(76.6%).":[175],"Initial":[176],"similarities":[177],"both":[179],"groups":[180],"included":[181],"socio-demographics":[182],"disease":[184],"(p>0.05).":[186],"2":[188],"weeks,":[189],"lower":[194,200,224],"WBC":[195],"counts":[196],"(5.15\u00b12.39":[197],"vs":[198,204,212,220,227],"7.56\u00b11.47\u00d7109/l),":[199],"CRP":[201],"levels":[202],"(2.7\u00b10.93":[203],"7.5\u00b12.38":[205],"mg/l,":[206],"p<0.05),":[207],"shorter":[208],"hospital":[209],"stays":[210],"(18.25\u00b14.58":[211],"25.4\u00b12.70":[213],"days,":[214],"p=0.005),":[215,222],"reduced":[216],"oxygen":[217],"requirements":[218],"(7.25\u00b14.23":[219],"12\u00b17.29%,":[221],"mortality":[225],"(40%":[226],"66.66%,":[228],"p=0.027).":[229],"Conclusions:":[230],"better":[234],"outcomes":[235],"However,":[242],"further":[244],"larger":[245],"is":[247],"recommended.":[248]},"counts_by_year":[],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2024-08-28T00:00:00"}
