{"id":"https://openalex.org/W4401896252","doi":"https://doi.org/10.1016/s2152-2650(24)00647-5","title":"Overall Survival (OS), Clinical Benefit, and Durable Red Blood Cell (RBC) Transfusion Independence (TI) With Imetelstat in the IMerge Phase 3 Trial of RBC-Transfusion Dependent (TD) Lower-Risk Myelodysplastic Syndromes (LR-MDS)","display_name":"Overall Survival (OS), Clinical Benefit, and Durable Red Blood Cell (RBC) Transfusion Independence (TI) With Imetelstat in the IMerge Phase 3 Trial of RBC-Transfusion Dependent (TD) Lower-Risk Myelodysplastic Syndromes (LR-MDS)","publication_year":2024,"publication_date":"2024-08-26","ids":{"openalex":"https://openalex.org/W4401896252","doi":"https://doi.org/10.1016/s2152-2650(24)00647-5"},"language":"en","primary_location":{"id":"doi:10.1016/s2152-2650(24)00647-5","doi":"https://doi.org/10.1016/s2152-2650(24)00647-5","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s2152-2650(24)00647-5","pdf_url":null,"source":{"id":"https://openalex.org/S186546955","display_name":"Clinical Lymphoma Myeloma & Leukemia","issn_l":"2152-2650","issn":["2152-2650","2152-2669"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Lymphoma Myeloma and Leukemia","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5091318797","display_name":"Valeria Santini","orcid":"https://orcid.org/0000-0002-5439-2172","observed_orcids":["https://orcid.org/0000-0002-5439-2172"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Valeria Santini","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010075752","display_name":"Rami S. Komrokji","orcid":"https://orcid.org/0000-0002-1876-5269","observed_orcids":["https://orcid.org/0000-0002-1876-5269"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rami S. Komrokji","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055740968","display_name":"Mikkael Aaron Sekeres","orcid":"https://orcid.org/0000-0003-2009-6524","observed_orcids":["https://orcid.org/0000-0003-2009-6524"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mikkael A. Sekeres","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049400849","display_name":"Michael Robert Savona","orcid":"https://orcid.org/0000-0003-3763-5504","observed_orcids":["https://orcid.org/0000-0003-3763-5504"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michael Robert Savona","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014838075","display_name":"Pierre Fenaux","orcid":"https://orcid.org/0000-0002-0468-3553","observed_orcids":["https://orcid.org/0000-0002-0468-3553"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Pierre Fenaux","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090985347","display_name":"Yazan F. Madanat","orcid":"https://orcid.org/0000-0001-9573-2690","observed_orcids":["https://orcid.org/0000-0001-9573-2690"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yazan F. Madanat","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000522683","display_name":"Esther Natalie Ol\u00edva","orcid":"https://orcid.org/0000-0001-9238-5734","observed_orcids":["https://orcid.org/0000-0001-9238-5734"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Esther Oliva","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044632878","display_name":"Rena J. Buckstein","orcid":"https://orcid.org/0000-0001-9520-7386","observed_orcids":["https://orcid.org/0000-0001-9520-7386"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rena Buckstein","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044809473","display_name":"Anna T Jonasova","orcid":"https://orcid.org/0000-0003-0246-1524","observed_orcids":["https://orcid.org/0000-0003-0246-1524"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Anna Jon\u00e1\u0161ov\u00e1","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113559069","display_name":"Ulrich Germing","orcid":"https://orcid.org/0009-0005-6027-6388","observed_orcids":["https://orcid.org/0009-0005-6027-6388"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ulrich Germing","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048794053","display_name":"Moshe Mittelman","orcid":"https://orcid.org/0000-0001-7677-9119","observed_orcids":["https://orcid.org/0000-0001-7677-9119"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Moshe Mittelman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011803879","display_name":"Sylvain Th\u00e9pot","orcid":"https://orcid.org/0000-0003-3492-2778","observed_orcids":["https://orcid.org/0000-0003-3492-2778"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sylvain Thepot","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063073508","display_name":"Jennifer R. Riggs","orcid":"https://orcid.org/0000-0001-9012-1428","observed_orcids":["https://orcid.org/0000-0001-9012-1428"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jennifer Riggs","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078437962","display_name":"Souria Dougherty","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Souria Dougherty","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113350088","display_name":"Tymara Berry","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tymara Berry","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113348914","display_name":"Shyamala Chendeal Navada","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shyamala Navada","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109737956","display_name":"Qi Xia","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Qi Xia","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5106038534","display_name":"Libo Sun","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Libo Sun","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067521829","display_name":"Amer Methqal Zeidan","orcid":"https://orcid.org/0000-0001-7017-8160","observed_orcids":["https://orcid.org/0000-0001-7017-8160"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Amer M. Zeidan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5079124367","display_name":"Uwe Platzbecker","orcid":"https://orcid.org/0000-0003-1863-3239","observed_orcids":["https://orcid.org/0000-0003-1863-3239"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Uwe Platzbecker","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3780,"currency":"USD","value_usd":3780},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.18689806,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"24","issue":null,"first_page":"S192","last_page":"S192"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.9750999808311462,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.9750999808311462,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.005400000140070915,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10554","display_name":"Hemoglobinopathies and Related Disorders","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/imetelstat","display_name":"imetelstat","score":0.9990000128746033},{"id":"https://openalex.org/keywords/lower-risk-myelodysplastic-syndromes","display_name":"lower-risk myelodysplastic syndromes","score":0.925000011920929},{"id":"https://openalex.org/keywords/red-blood-cell-transfusion-dependence","display_name":"red blood cell transfusion dependence","score":0.8930000066757202},{"id":"https://openalex.org/keywords/transfusion-independence","display_name":"transfusion independence","score":0.9470000267028809},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.9440000057220459},{"id":"https://openalex.org/keywords/clinical-benefit","display_name":"clinical benefit","score":0.9290000200271606},{"id":"https://openalex.org/keywords/spleen-tyrosine-kinase-inhibitor","display_name":"spleen tyrosine kinase inhibitor","score":0.6359999775886536}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9568070769309998},{"id":"https://openalex.org/C2780817109","wikidata":"https://www.wikidata.org/wiki/Q954625","display_name":"Myelodysplastic syndromes","level":3,"score":0.7934281826019287},{"id":"https://openalex.org/C2780014101","wikidata":"https://www.wikidata.org/wiki/Q183605","display_name":"Blood transfusion","level":2,"score":0.473448246717453},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4544749855995178},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.45378538966178894},{"id":"https://openalex.org/C2776557347","wikidata":"https://www.wikidata.org/wiki/Q37187","display_name":"Red blood cell","level":2,"score":0.44028711318969727},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3600626587867737},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.1199682354927063}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/s2152-2650(24)00647-5","doi":"https://doi.org/10.1016/s2152-2650(24)00647-5","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s2152-2650(24)00647-5","pdf_url":null,"source":{"id":"https://openalex.org/S186546955","display_name":"Clinical Lymphoma Myeloma & Leukemia","issn_l":"2152-2650","issn":["2152-2650","2152-2669"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Lymphoma Myeloma and Leukemia","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4401897158","https://openalex.org/W4401875886","https://openalex.org/W7207605830","https://openalex.org/W4417013408","https://openalex.org/W4389232365","https://openalex.org/W4401877107","https://openalex.org/W4389233897","https://openalex.org/W3165895858","https://openalex.org/W4389229209","https://openalex.org/W2953120750"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-09-27T08:07:27.782135","created_date":"2024-08-27T00:00:00"}