{"id":"https://openalex.org/W4401894635","doi":"https://doi.org/10.3390/cells13171418","title":"Unlocking the Secrets of Adipose Tissue: How an Obesity-Associated Secretome Promotes Osteoblast Dedifferentiation via TGF-\u03b21 Signaling, Paving the Path to an Adipogenic Phenotype","display_name":"Unlocking the Secrets of Adipose Tissue: How an Obesity-Associated Secretome Promotes Osteoblast Dedifferentiation via TGF-\u03b21 Signaling, Paving the Path to an Adipogenic Phenotype","publication_year":2024,"publication_date":"2024-08-25","ids":{"openalex":"https://openalex.org/W4401894635","doi":"https://doi.org/10.3390/cells13171418","pmid":"https://pubmed.ncbi.nlm.nih.gov/39272990"},"language":"en","primary_location":{"id":"doi:10.3390/cells13171418","doi":"https://doi.org/10.3390/cells13171418","is_oa":true,"landing_page_url":"http://dx.doi.org/10.3390/cells13171418","pdf_url":"https://www.mdpi.com/2073-4409/13/17/1418/pdf?version=1724772341","source":{"id":"https://openalex.org/S2736626452","display_name":"Cells","issn_l":"2073-4409","issn":["2073-4409"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cells","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/2073-4409/13/17/1418/pdf?version=1724772341","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5031256101","display_name":"Yasmin Silva Forte","orcid":"https://orcid.org/0000-0002-9238-8086","observed_orcids":["https://orcid.org/0000-0002-9238-8086"]},"institutions":[{"id":"https://openalex.org/I40034438","display_name":"Universidade do Estado do Rio de Janeiro","ror":"https://ror.org/0198v2949","country_code":"BR","type":"education","lineage":["https://openalex.org/I40034438"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Yasmin Silva Forte","raw_affiliation_strings":["Laboratory of Cellular & Molecular Pharmacology, Department of Cell Biology, Instituto de Biologia Roberto Alcantara Gomes (IBRAG), Universidade do Estado do Rio de Janeiro, Rio de Janeiro 20551-030, Brazil"],"raw_orcid":"https://orcid.org/0000-0002-9238-8086","affiliations":[{"raw_affiliation_string":"Laboratory of Cellular & Molecular Pharmacology, Department of Cell Biology, Instituto de Biologia Roberto Alcantara Gomes (IBRAG), Universidade do Estado do Rio de Janeiro, Rio de Janeiro 20551-030, Brazil","institution_ids":["https://openalex.org/I40034438"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046992036","display_name":"Vany Nascimento-Silva","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I40034438","display_name":"Universidade do Estado do Rio de Janeiro","ror":"https://ror.org/0198v2949","country_code":"BR","type":"education","lineage":["https://openalex.org/I40034438"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Vany Nascimento-Silva","raw_affiliation_strings":["Laboratory of Cellular & Molecular Pharmacology, Department of Cell Biology, Instituto de Biologia Roberto Alcantara Gomes (IBRAG), Universidade do Estado do Rio de Janeiro, Rio de Janeiro 20551-030, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Cellular & Molecular Pharmacology, Department of Cell Biology, Instituto de Biologia Roberto Alcantara Gomes (IBRAG), Universidade do Estado do Rio de Janeiro, Rio de Janeiro 20551-030, Brazil","institution_ids":["https://openalex.org/I40034438"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5106740721","display_name":"Caio Andrade-Santos","orcid":"https://orcid.org/0009-0003-8655-3158","observed_orcids":["https://orcid.org/0009-0003-8655-3158"]},"institutions":[{"id":"https://openalex.org/I40034438","display_name":"Universidade do Estado do Rio de Janeiro","ror":"https://ror.org/0198v2949","country_code":"BR","type":"education","lineage":["https://openalex.org/I40034438"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Caio Andrade-Santos","raw_affiliation_strings":["Laboratory of Cellular & Molecular Pharmacology, Department of Cell Biology, Instituto de Biologia Roberto Alcantara Gomes (IBRAG), Universidade do Estado do Rio de Janeiro, Rio de Janeiro 20551-030, Brazil"],"raw_orcid":"https://orcid.org/0009-0003-8655-3158","affiliations":[{"raw_affiliation_string":"Laboratory of Cellular & Molecular Pharmacology, Department of Cell Biology, Instituto de Biologia Roberto Alcantara Gomes (IBRAG), Universidade do Estado do Rio de Janeiro, Rio de Janeiro 20551-030, Brazil","institution_ids":["https://openalex.org/I40034438"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034829281","display_name":"Isadora Ramos-Andrade","orcid":"https://orcid.org/0000-0002-6894-0379","observed_orcids":["https://orcid.org/0000-0002-6894-0379"]},"institutions":[{"id":"https://openalex.org/I40034438","display_name":"Universidade do Estado do Rio de Janeiro","ror":"https://ror.org/0198v2949","country_code":"BR","type":"education","lineage":["https://openalex.org/I40034438"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Isadora Ramos-Andrade","raw_affiliation_strings":["Laboratory of Cellular & Molecular Pharmacology, Department of Cell Biology, Instituto de Biologia Roberto Alcantara Gomes (IBRAG), Universidade do Estado do Rio de Janeiro, Rio de Janeiro 20551-030, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Cellular & Molecular Pharmacology, Department of Cell Biology, Instituto de Biologia Roberto Alcantara Gomes (IBRAG), Universidade do Estado do Rio de Janeiro, Rio de Janeiro 20551-030, Brazil","institution_ids":["https://openalex.org/I40034438"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084559917","display_name":"Ge\u00f3rgia C. Atella","orcid":"https://orcid.org/0000-0003-0755-5538","observed_orcids":["https://orcid.org/0000-0003-0755-5538"]},"institutions":[{"id":"https://openalex.org/I122140584","display_name":"Universidade Federal do Rio de Janeiro","ror":"https://ror.org/03490as77","country_code":"BR","type":"education","lineage":["https://openalex.org/I122140584"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Georgia Correa Atella","raw_affiliation_strings":["Institute of Medical Biochemistry, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-902, Brazil"],"raw_orcid":"https://orcid.org/0000-0003-0755-5538","affiliations":[{"raw_affiliation_string":"Institute of Medical Biochemistry, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-902, Brazil","institution_ids":["https://openalex.org/I122140584"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074453697","display_name":"Luiz Guilherme Kraemer\u2010Aguiar","orcid":"https://orcid.org/0000-0002-3528-5881","observed_orcids":["https://orcid.org/0000-0002-3528-5881"]},"institutions":[{"id":"https://openalex.org/I40034438","display_name":"Universidade do Estado do Rio de Janeiro","ror":"https://ror.org/0198v2949","country_code":"BR","type":"education","lineage":["https://openalex.org/I40034438"]},{"id":"https://openalex.org/I4210099359","display_name":"Hospital Universit\u00e1rio Pedro Ernesto","ror":"https://ror.org/00hrmgq26","country_code":"BR","type":"healthcare","lineage":["https://openalex.org/I4210099359"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Luiz Guilherme Kraemer-Aguiar","raw_affiliation_strings":["Obesity Unit, Multiuser Clinical Research Center (CePEM), Hospital Universit\u00e1rio Pedro Ernesto, Universidade do Estado do Rio de Janeiro, Rio de Janeiro 20551-030, Brazil"],"raw_orcid":"https://orcid.org/0000-0002-3528-5881","affiliations":[{"raw_affiliation_string":"Obesity Unit, Multiuser Clinical Research Center (CePEM), Hospital Universit\u00e1rio Pedro Ernesto, Universidade do Estado do Rio de Janeiro, Rio de Janeiro 20551-030, Brazil","institution_ids":["https://openalex.org/I40034438","https://openalex.org/I4210099359"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028396132","display_name":"Paulo Roberto Falc\u00e3o Leal","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I40034438","display_name":"Universidade do Estado do Rio de Janeiro","ror":"https://ror.org/0198v2949","country_code":"BR","type":"education","lineage":["https://openalex.org/I40034438"]},{"id":"https://openalex.org/I4210099359","display_name":"Hospital Universit\u00e1rio Pedro Ernesto","ror":"https://ror.org/00hrmgq26","country_code":"BR","type":"healthcare","lineage":["https://openalex.org/I4210099359"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Paulo Roberto Falc\u00e3o Leal","raw_affiliation_strings":["Obesity Unit, Multiuser Clinical Research Center (CePEM), Hospital Universit\u00e1rio Pedro Ernesto, Universidade do Estado do Rio de Janeiro, Rio de Janeiro 20551-030, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Obesity Unit, Multiuser Clinical Research Center (CePEM), Hospital Universit\u00e1rio Pedro Ernesto, Universidade do Estado do Rio de Janeiro, Rio de Janeiro 20551-030, Brazil","institution_ids":["https://openalex.org/I40034438","https://openalex.org/I4210099359"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038545700","display_name":"Mariana Renovato\u2010Martins","orcid":"https://orcid.org/0000-0002-9860-5272","observed_orcids":["https://orcid.org/0000-0002-9860-5272"]},"institutions":[{"id":"https://openalex.org/I161127581","display_name":"Universidade Federal Fluminense","ror":"https://ror.org/02rjhbb08","country_code":"BR","type":"education","lineage":["https://openalex.org/I161127581"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Mariana Renovato-Martins","raw_affiliation_strings":["Department of Molecular & Cellular Biology, Universidade Federal Fluminense, Rio de Janeiro 24020-141, Brazil"],"raw_orcid":"https://orcid.org/0000-0002-9860-5272","affiliations":[{"raw_affiliation_string":"Department of Molecular & Cellular Biology, Universidade Federal Fluminense, Rio de Janeiro 24020-141, Brazil","institution_ids":["https://openalex.org/I161127581"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5000167265","display_name":"Christina Barja\u2010Fidalgo","orcid":"https://orcid.org/0000-0002-1917-4401","observed_orcids":["https://orcid.org/0000-0002-1917-4401"]},"institutions":[{"id":"https://openalex.org/I40034438","display_name":"Universidade do Estado do Rio de Janeiro","ror":"https://ror.org/0198v2949","country_code":"BR","type":"education","lineage":["https://openalex.org/I40034438"]}],"countries":["BR"],"is_corresponding":true,"raw_author_name":"Christina Barja-Fidalgo","raw_affiliation_strings":["Laboratory of Cellular & Molecular Pharmacology, Department of Cell Biology, Instituto de Biologia Roberto Alcantara Gomes (IBRAG), Universidade do Estado do Rio de Janeiro, Rio de Janeiro 20551-030, Brazil"],"raw_orcid":"https://orcid.org/0000-0002-1917-4401","affiliations":[{"raw_affiliation_string":"Laboratory of Cellular & Molecular Pharmacology, Department of Cell Biology, Instituto de Biologia Roberto Alcantara Gomes (IBRAG), Universidade do Estado do Rio de Janeiro, Rio de Janeiro 20551-030, Brazil","institution_ids":["https://openalex.org/I40034438"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5000167265"],"corresponding_institution_ids":["https://openalex.org/I40034438"],"apc_list":{"value":2700,"currency":"CHF","value_usd":3069},"apc_paid":{"value":2700,"currency":"CHF","value_usd":3069},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.09222108,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"13","issue":"17","first_page":"1418","last_page":"1418"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.9878000020980835,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.9878000020980835,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.00430000014603138,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.9359999895095825},{"id":"https://openalex.org/keywords/adipose-tissue-secretome","display_name":"adipose tissue secretome","score":0.9819999933242798},{"id":"https://openalex.org/keywords/tgf-beta1-signaling","display_name":"TGF-\u03b21 signaling","score":0.9800000190734863},{"id":"https://openalex.org/keywords/adipogenic-differentiation","display_name":"adipogenesis","score":0.7170000076293945},{"id":"https://openalex.org/keywords/subcutaneous-adipose-tissue","display_name":"subcutaneous adipose tissue","score":0.8519999980926514},{"id":"https://openalex.org/keywords/bone-loss","display_name":"bone loss","score":0.7850000262260437},{"id":"https://openalex.org/keywords/osteogenic-differentiation","display_name":"osteogenic differentiation","score":0.5820000171661377},{"id":"https://openalex.org/keywords/lipid-droplets","display_name":"lipid droplets","score":0.75},{"id":"https://openalex.org/keywords/mesenchymal-phenotype","display_name":"mesenchymal phenotype","score":0.8640000224113464},{"id":"https://openalex.org/keywords/saos-2-cells","display_name":"Saos-2 cells","score":0.7139999866485596},{"id":"https://openalex.org/keywords/adipose-tissue-microenvironment","display_name":"adipose tissue microenvironment","score":0.675000011920929}],"concepts":[{"id":"https://openalex.org/C122927707","wikidata":"https://www.wikidata.org/wiki/Q2824461","display_name":"Adipogenesis","level":3,"score":0.9102391004562378},{"id":"https://openalex.org/C171089720","wikidata":"https://www.wikidata.org/wiki/Q193583","display_name":"Adipose tissue","level":2,"score":0.7697625756263733},{"id":"https://openalex.org/C2778260815","wikidata":"https://www.wikidata.org/wiki/Q917177","display_name":"Osteoblast","level":3,"score":0.7451795339584351},{"id":"https://openalex.org/C198826908","wikidata":"https://www.wikidata.org/wiki/Q1922379","display_name":"Mesenchymal stem cell","level":2,"score":0.7213276028633118},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5855108499526978},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.5242981314659119},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5066126585006714},{"id":"https://openalex.org/C25095133","wikidata":"https://www.wikidata.org/wiki/Q573950","display_name":"Lipid droplet","level":2,"score":0.4713054597377777},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4599979817867279},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.38671639561653137},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.38359734416007996},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2294541299343109},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.10247296094894409},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.07963737845420837},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.05808556079864502}],"mesh":[{"descriptor_ui":"D000089282","descriptor_name":"Secretome","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000089282","descriptor_name":"Secretome","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000089282","descriptor_name":"Secretome","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000089282","descriptor_name":"Secretome","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000089282","descriptor_name":"Secretome","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000089282","descriptor_name":"Secretome","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000273","descriptor_name":"Adipose Tissue","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000273","descriptor_name":"Adipose Tissue","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000273","descriptor_name":"Adipose Tissue","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000273","descriptor_name":"Adipose Tissue","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000273","descriptor_name":"Adipose Tissue","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000273","descriptor_name":"Adipose Tissue","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000273","descriptor_name":"Adipose Tissue","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D000273","descriptor_name":"Adipose Tissue","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D000273","descriptor_name":"Adipose Tissue","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D000273","descriptor_name":"Adipose Tissue","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D000273","descriptor_name":"Adipose Tissue","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D000273","descriptor_name":"Adipose Tissue","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D010006","descriptor_name":"Osteoblasts","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010006","descriptor_name":"Osteoblasts","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010006","descriptor_name":"Osteoblasts","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010006","descriptor_name":"Osteoblasts","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010006","descriptor_name":"Osteoblasts","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010006","descriptor_name":"Osteoblasts","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010006","descriptor_name":"Osteoblasts","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D010006","descriptor_name":"Osteoblasts","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D010006","descriptor_name":"Osteoblasts","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D010006","descriptor_name":"Osteoblasts","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D010006","descriptor_name":"Osteoblasts","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D010006","descriptor_name":"Osteoblasts","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D010012","descriptor_name":"Osteogenesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010012","descriptor_name":"Osteogenesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010012","descriptor_name":"Osteogenesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010012","descriptor_name":"Osteogenesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010012","descriptor_name":"Osteogenesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010012","descriptor_name":"Osteogenesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050156","descriptor_name":"Adipogenesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D050156","descriptor_name":"Adipogenesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D050156","descriptor_name":"Adipogenesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D050156","descriptor_name":"Adipogenesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D050156","descriptor_name":"Adipogenesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D050156","descriptor_name":"Adipogenesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053773","descriptor_name":"Transforming Growth Factor beta1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D053773","descriptor_name":"Transforming Growth Factor beta1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D053773","descriptor_name":"Transforming Growth Factor beta1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D053773","descriptor_name":"Transforming Growth Factor beta1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D053773","descriptor_name":"Transforming Growth Factor beta1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D053773","descriptor_name":"Transforming Growth Factor beta1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D054337","descriptor_name":"Cell Dedifferentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D054337","descriptor_name":"Cell Dedifferentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D054337","descriptor_name":"Cell Dedifferentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D054337","descriptor_name":"Cell Dedifferentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D054337","descriptor_name":"Cell Dedifferentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D054337","descriptor_name":"Cell Dedifferentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.3390/cells13171418","doi":"https://doi.org/10.3390/cells13171418","is_oa":true,"landing_page_url":"http://dx.doi.org/10.3390/cells13171418","pdf_url":"https://www.mdpi.com/2073-4409/13/17/1418/pdf?version=1724772341","source":{"id":"https://openalex.org/S2736626452","display_name":"Cells","issn_l":"2073-4409","issn":["2073-4409"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cells","raw_type":"journal-article"},{"id":"pmid:39272990","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39272990","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cells","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11394205","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11394205","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11394205/pdf/cells-13-01418.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cells","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:31cd35b04cf84021b81254f0683e74bd","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/31cd35b04cf84021b81254f0683e74bd","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cells, Vol 13, Iss 17, p 1418 (2024)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/cells13171418","doi":"https://doi.org/10.3390/cells13171418","is_oa":true,"landing_page_url":"http://dx.doi.org/10.3390/cells13171418","pdf_url":"https://www.mdpi.com/2073-4409/13/17/1418/pdf?version=1724772341","source":{"id":"https://openalex.org/S2736626452","display_name":"Cells","issn_l":"2073-4409","issn":["2073-4409"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cells","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9476000070571899}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.5299999713897705}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1838733238","display_name":null,"funder_award_id":"E-26/210.065/2023","funder_id":"https://openalex.org/F4320322025","funder_display_name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico"},{"id":"https://openalex.org/G1840770272","display_name":null,"funder_award_id":"E-26/","funder_id":"https://openalex.org/F4320322749","funder_display_name":"Funda\u00e7\u00e3o Carlos Chagas Filho de Amparo \u00e0 Pesquisa do Estado do Rio de Janeiro"},{"id":"https://openalex.org/G2050603865","display_name":null,"funder_award_id":"E-26/200.898/2021","funder_id":"https://openalex.org/F4320322025","funder_display_name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico"},{"id":"https://openalex.org/G2311368543","display_name":null,"funder_award_id":"E-26/210","funder_id":"https://openalex.org/F4320322749","funder_display_name":"Funda\u00e7\u00e3o Carlos Chagas Filho de Amparo \u00e0 Pesquisa do Estado do Rio de Janeiro"},{"id":"https://openalex.org/G2584274330","display_name":null,"funder_award_id":"E-26/200","funder_id":"https://openalex.org/F4320322749","funder_display_name":"Funda\u00e7\u00e3o Carlos Chagas Filho de Amparo \u00e0 Pesquisa do Estado do Rio de Janeiro"},{"id":"https://openalex.org/G2738159553","display_name":null,"funder_award_id":"305737/2021-0","funder_id":"https://openalex.org/F4320322025","funder_display_name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico"},{"id":"https://openalex.org/G3456272654","display_name":null,"funder_award_id":"E-26/210.065/2023","funder_id":"https://openalex.org/F4320322749","funder_display_name":"Funda\u00e7\u00e3o Carlos Chagas Filho de Amparo \u00e0 Pesquisa do Estado do Rio de Janeiro"},{"id":"https://openalex.org/G4986829342","display_name":null,"funder_award_id":"E-26/200.898/2021","funder_id":"https://openalex.org/F4320322749","funder_display_name":"Funda\u00e7\u00e3o Carlos Chagas Filho de Amparo \u00e0 Pesquisa do Estado do Rio de Janeiro"},{"id":"https://openalex.org/G7276444342","display_name":null,"funder_award_id":"E-26/210.110/2020","funder_id":"https://openalex.org/F4320322025","funder_display_name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico"},{"id":"https://openalex.org/G8287289773","display_name":null,"funder_award_id":"E-26/210.110/2020","funder_id":"https://openalex.org/F4320322749","funder_display_name":"Funda\u00e7\u00e3o Carlos Chagas Filho de Amparo \u00e0 Pesquisa do Estado do Rio de Janeiro"}],"funders":[{"id":"https://openalex.org/F4320321091","display_name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","ror":"https://ror.org/00x0ma614"},{"id":"https://openalex.org/F4320322025","display_name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","ror":"https://ror.org/03swz6y49"},{"id":"https://openalex.org/F4320322749","display_name":"Funda\u00e7\u00e3o Carlos Chagas Filho de Amparo \u00e0 Pesquisa do Estado do Rio de Janeiro","ror":"https://ror.org/03kk0s825"},{"id":"https://openalex.org/F4320324048","display_name":"Universidade do Estado do Rio de Janeiro","ror":"https://ror.org/0198v2949"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4401894635.pdf","grobid_xml":"https://content.openalex.org/works/W4401894635.grobid-xml"},"referenced_works_count":47,"referenced_works":["https://openalex.org/W590926286","https://openalex.org/W1968835093","https://openalex.org/W1970089712","https://openalex.org/W1995572821","https://openalex.org/W2025371271","https://openalex.org/W2031590544","https://openalex.org/W2036385471","https://openalex.org/W2042409961","https://openalex.org/W2045333877","https://openalex.org/W2064720410","https://openalex.org/W2070640771","https://openalex.org/W2085703672","https://openalex.org/W2119071014","https://openalex.org/W2123573371","https://openalex.org/W2343938601","https://openalex.org/W2519109099","https://openalex.org/W2523178423","https://openalex.org/W2581189470","https://openalex.org/W2744661612","https://openalex.org/W2755950135","https://openalex.org/W2773506264","https://openalex.org/W2793805129","https://openalex.org/W2797980949","https://openalex.org/W2807951035","https://openalex.org/W2917520831","https://openalex.org/W2919303484","https://openalex.org/W2921584057","https://openalex.org/W2924743030","https://openalex.org/W2944549000","https://openalex.org/W2997370188","https://openalex.org/W3007630579","https://openalex.org/W3031351488","https://openalex.org/W3036591912","https://openalex.org/W3045616811","https://openalex.org/W3107034233","https://openalex.org/W3115561383","https://openalex.org/W3133725907","https://openalex.org/W3138933334","https://openalex.org/W3155511402","https://openalex.org/W3172993534","https://openalex.org/W3176706319","https://openalex.org/W3197278104","https://openalex.org/W3202218096","https://openalex.org/W4200324393","https://openalex.org/W4283360355","https://openalex.org/W4287532062","https://openalex.org/W4319316276"],"related_works":["https://openalex.org/W4308142614","https://openalex.org/W3217615580","https://openalex.org/W2006248782","https://openalex.org/W3177859811","https://openalex.org/W3169375705","https://openalex.org/W1889378448","https://openalex.org/W2496342221","https://openalex.org/W2084245009","https://openalex.org/W3017238456","https://openalex.org/W4214727915"],"abstract_inverted_index":{"BACKGROUND:":[0],"Obesity":[1],"poses":[2],"a":[3,134,138,182],"significant":[4],"global":[5],"health":[6],"challenge,":[7],"given":[8],"its":[9],"association":[10],"with":[11,30,104,141,193],"the":[12,24,34,57,73,76,94,119,122,148,152,155,163,189,206,212],"excessive":[13],"accumulation":[14],"of":[15,36,60,75,121,157,165,185,208],"adipose":[16,25],"tissue":[17],"(AT)":[18],"and":[19,28,39,80,86,110,147,159,210],"various":[20],"systemic":[21],"disruptions.":[22],"Within":[23],"microenvironment,":[26],"expansion":[27],"enrichment":[29],"immune":[31],"cells":[32,90,171],"trigger":[33],"release":[35],"inflammatory":[37],"mediators":[38],"growth":[40,195],"factors,":[41],"which":[42],"can":[43],"disrupt":[44],"tissues,":[45],"including":[46],"bones.":[47],"While":[48],"obesity's":[49],"contribution":[50],"to":[51,71,93,173],"bone":[52],"loss":[53],"is":[54],"well":[55],"established,":[56],"direct":[58],"impact":[59],"obese":[61,79,202],"AT":[62,82,101,204],"on":[63,83,113,144],"osteoblast":[64,84],"maturation":[65],"remains":[66],"uncertain.":[67],"This":[68],"study":[69],"aimed":[70],"explore":[72],"influence":[74],"secretomes":[77,95],"from":[78,102],"lean":[81,108],"differentiation":[85,176],"activity.":[87],"METHODS:":[88],"SAOS-2":[89,170],"were":[91,115],"exposed":[92,172],"obtained":[96],"by":[97,133],"culturing":[98],"human":[99],"subcutaneous":[100,203],"individuals":[103],"obesity":[105],"(OATS)":[106],"or":[107],"patients,":[109],"their":[111],"effects":[112,143],"osteoblasts":[114,125,209],"evaluated.":[116],"RESULTS:":[117],"In":[118],"presence":[120],"OATS,":[123],"mature":[124],"underwent":[126],"dedifferentiation,":[127],"showing":[128],"an":[129,174],"increased":[130],"proliferation":[131],"accompanied":[132],"morphological":[135],"shift":[136],"towards":[137],"mesenchymal":[139,158],"phenotype,":[140],"detrimental":[142],"osteogenic":[145],"markers":[146],"calcification":[149],"capacity.":[150],"Concurrently,":[151],"OATS":[153,190],"promoted":[154],"expression":[156],"adipogenic":[160,175,213],"markers,":[161],"inducing":[162],"formation":[164],"cytoplasmic":[166],"lipid":[167],"droplets":[168],"in":[169,215],"medium.":[177],"Additionally,":[178],"TGF-\u03b21":[179],"emerged":[180],"as":[181,188],"key":[183],"mediator":[184],"these":[186,216],"effects,":[187],"was":[191],"enriched":[192],"this":[194],"factor.":[196],"CONCLUSIONS:":[197],"Our":[198],"findings":[199],"demonstrate":[200],"that":[201],"promotes":[205],"dedifferentiation":[207],"increases":[211],"profile":[214],"cells.":[217]},"counts_by_year":[],"updated_date":"2026-09-26T08:19:03.415552","created_date":"2025-10-10T00:00:00"}
