{"id":"https://openalex.org/W4401884279","doi":"https://doi.org/10.1016/j.cmet.2024.07.021","title":"Serine and glycine physiology reversibly modulate retinal and peripheral nerve function","display_name":"Serine and glycine physiology reversibly modulate retinal and peripheral nerve function","publication_year":2024,"publication_date":"2024-08-26","ids":{"openalex":"https://openalex.org/W4401884279","doi":"https://doi.org/10.1016/j.cmet.2024.07.021","pmid":"https://pubmed.ncbi.nlm.nih.gov/39191258"},"language":"en","primary_location":{"id":"doi:10.1016/j.cmet.2024.07.021","doi":"https://doi.org/10.1016/j.cmet.2024.07.021","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.cmet.2024.07.021","pdf_url":null,"source":{"id":"https://openalex.org/S177533077","display_name":"Cell Metabolism","issn_l":"1550-4131","issn":["1550-4131","1932-7420"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Metabolism","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1016/j.cmet.2024.07.021","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5077573341","display_name":"Esther W. Lim","orcid":"https://orcid.org/0000-0002-6216-1120","observed_orcids":["https://orcid.org/0000-0002-6216-1120"]},"institutions":[{"id":"https://openalex.org/I1307098950","display_name":"Salk Institute for Biological Studies","ror":"https://ror.org/03xez1567","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1307098950"]},{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Esther W. Lim","raw_affiliation_strings":["Molecular and Cellular Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA; Department of Bioengineering, University of California, San Diego, La Jolla, CA 92093, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular and Cellular Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA; Department of Bioengineering, University of California, San Diego, La Jolla, CA 92093, USA","institution_ids":["https://openalex.org/I1307098950","https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044342710","display_name":"Regis J. Fallon","orcid":"https://orcid.org/0000-0002-2391-2534","observed_orcids":["https://orcid.org/0000-0002-2391-2534"]},"institutions":[{"id":"https://openalex.org/I4210108657","display_name":"The Lowy Medical Research Institute","ror":"https://ror.org/01jgzvw27","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210108657"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Regis J. Fallon","raw_affiliation_strings":["Lowy Medical Research Institute, La Jolla, CA 92037, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lowy Medical Research Institute, La Jolla, CA 92037, USA","institution_ids":["https://openalex.org/I4210108657"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108974529","display_name":"Caleb Bates","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210108657","display_name":"The Lowy Medical Research Institute","ror":"https://ror.org/01jgzvw27","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210108657"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Caleb Bates","raw_affiliation_strings":["Lowy Medical Research Institute, La Jolla, CA 92037, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lowy Medical Research Institute, La Jolla, CA 92037, USA","institution_ids":["https://openalex.org/I4210108657"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043925237","display_name":"Yoichiro Ideguchi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210108657","display_name":"The Lowy Medical Research Institute","ror":"https://ror.org/01jgzvw27","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210108657"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yoichiro Ideguchi","raw_affiliation_strings":["Lowy Medical Research Institute, La Jolla, CA 92037, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lowy Medical Research Institute, La Jolla, CA 92037, USA","institution_ids":["https://openalex.org/I4210108657"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065200542","display_name":"Takayuki Nagasaki","orcid":"https://orcid.org/0000-0002-7531-5176","observed_orcids":["https://orcid.org/0000-0002-7531-5176"]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Takayuki Nagasaki","raw_affiliation_strings":["Columbia University, New York, NY 10027, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Columbia University, New York, NY 10027, USA","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022380997","display_name":"Michal K. Handzlik","orcid":"https://orcid.org/0000-0002-4653-1902","observed_orcids":["https://orcid.org/0000-0002-4653-1902"]},"institutions":[{"id":"https://openalex.org/I1307098950","display_name":"Salk Institute for Biological Studies","ror":"https://ror.org/03xez1567","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1307098950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michal K. Handzlik","raw_affiliation_strings":["Molecular and Cellular Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular and Cellular Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA","institution_ids":["https://openalex.org/I1307098950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079133560","display_name":"Emeline Joulia","orcid":"https://orcid.org/0000-0003-3278-4412","observed_orcids":["https://orcid.org/0000-0003-3278-4412"]},"institutions":[{"id":"https://openalex.org/I1307098950","display_name":"Salk Institute for Biological Studies","ror":"https://ror.org/03xez1567","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1307098950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Emeline Joulia","raw_affiliation_strings":["Molecular and Cellular Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular and Cellular Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA","institution_ids":["https://openalex.org/I1307098950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015055038","display_name":"Roberto Bonelli","orcid":"https://orcid.org/0000-0003-2676-1230","observed_orcids":["https://orcid.org/0000-0003-2676-1230","https://orcid.org/0000-0001-8526-3309"]},"institutions":[{"id":"https://openalex.org/I196021976","display_name":"Walter and Eliza Hall Institute of Medical Research","ror":"https://ror.org/01b6kha49","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I196021976"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Roberto Bonelli","raw_affiliation_strings":["Lowy Medical Research Institute, La Jolla, CA 92037, USA; Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lowy Medical Research Institute, La Jolla, CA 92037, USA; Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia","institution_ids":["https://openalex.org/I196021976"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Courtney R. Green","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1307098950","display_name":"Salk Institute for Biological Studies","ror":"https://ror.org/03xez1567","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1307098950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Courtney R. Green","raw_affiliation_strings":["Molecular and Cellular Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular and Cellular Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA","institution_ids":["https://openalex.org/I1307098950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008609876","display_name":"Brendan R. E. Ansell","orcid":"https://orcid.org/0000-0003-0297-897X","observed_orcids":["https://orcid.org/0000-0003-0297-897X"]},"institutions":[{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]},{"id":"https://openalex.org/I196021976","display_name":"Walter and Eliza Hall Institute of Medical Research","ror":"https://ror.org/01b6kha49","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I196021976"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Brendan R.E. Ansell","raw_affiliation_strings":["Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia; Department of Medical Biology, University of Melbourne, Parkville, VIC 3052, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia; Department of Medical Biology, University of Melbourne, Parkville, VIC 3052, Australia","institution_ids":["https://openalex.org/I165779595","https://openalex.org/I196021976"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078439459","display_name":"Maki Kitano","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Maki Kitano","raw_affiliation_strings":["The Scripps Research Institute, La Jolla, CA 92037, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Scripps Research Institute, La Jolla, CA 92037, USA","institution_ids":["https://openalex.org/I123431417"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041180378","display_name":"Ilham Y. Polis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ilham Polis","raw_affiliation_strings":["The Scripps Research Institute, La Jolla, CA 92037, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Scripps Research Institute, La Jolla, CA 92037, USA","institution_ids":["https://openalex.org/I123431417"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101840977","display_name":"Amanda J. Roberts","orcid":"https://orcid.org/0000-0002-4044-8884","observed_orcids":["https://orcid.org/0000-0002-4044-8884"]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amanda J. Roberts","raw_affiliation_strings":["The Scripps Research Institute, La Jolla, CA 92037, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Scripps Research Institute, La Jolla, CA 92037, USA","institution_ids":["https://openalex.org/I123431417"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011286772","display_name":"Shigeki Furuya","orcid":"https://orcid.org/0000-0001-9020-3597","observed_orcids":["https://orcid.org/0000-0001-9020-3597"]},"institutions":[{"id":"https://openalex.org/I135598925","display_name":"Kyushu University","ror":"https://ror.org/00p4k0j84","country_code":"JP","type":"education","lineage":["https://openalex.org/I135598925"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shigeki Furuya","raw_affiliation_strings":["Department of Bioscience and Biotechnology, Kyushu University, Fukuoka 812-0053, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioscience and Biotechnology, Kyushu University, Fukuoka 812-0053, Japan","institution_ids":["https://openalex.org/I135598925"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021548595","display_name":"Rando L. Allikmets","orcid":"https://orcid.org/0000-0002-3344-4447","observed_orcids":["https://orcid.org/0000-0002-3344-4447"]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rando Allikmets","raw_affiliation_strings":["Columbia University, New York, NY 10027, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Columbia University, New York, NY 10027, USA","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015075333","display_name":"Martina Wallace","orcid":"https://orcid.org/0000-0001-8272-5678","observed_orcids":["https://orcid.org/0000-0001-8272-5678"]},"institutions":[{"id":"https://openalex.org/I100930933","display_name":"University College Dublin","ror":"https://ror.org/05m7pjf47","country_code":"IE","type":"education","lineage":["https://openalex.org/I100930933"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"Martina Wallace","raw_affiliation_strings":["School of Agriculture and Food Science, University College Dublin, Dublin 4, Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Agriculture and Food Science, University College Dublin, Dublin 4, Ireland","institution_ids":["https://openalex.org/I100930933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040174959","display_name":"Martin Friedlander","orcid":"https://orcid.org/0000-0003-4238-9651","observed_orcids":["https://orcid.org/0000-0003-4238-9651"]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Martin Friedlander","raw_affiliation_strings":["Lowy Medical Research Institute, La Jolla, CA 92037, USA; The Scripps Research Institute, La Jolla, CA 92037, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lowy Medical Research Institute, La Jolla, CA 92037, USA; The Scripps Research Institute, La Jolla, CA 92037, USA","institution_ids":["https://openalex.org/I123431417"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042375667","display_name":"Christian M. Metallo","orcid":"https://orcid.org/0000-0003-2404-3040","observed_orcids":["https://orcid.org/0000-0003-2404-3040"]},"institutions":[{"id":"https://openalex.org/I1307098950","display_name":"Salk Institute for Biological Studies","ror":"https://ror.org/03xez1567","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1307098950"]},{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Christian M. Metallo","raw_affiliation_strings":["Molecular and Cellular Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA; Department of Bioengineering, University of California, San Diego, La Jolla, CA 92093, USA. Electronic address: metallo@salk.edu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular and Cellular Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA; Department of Bioengineering, University of California, San Diego, La Jolla, CA 92093, USA. Electronic address: metallo@salk.edu","institution_ids":["https://openalex.org/I1307098950","https://openalex.org/I36258959"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5088873767","display_name":"Marin L. Gantner","orcid":"https://orcid.org/0000-0001-5385-2563","observed_orcids":["https://orcid.org/0000-0001-5385-2563"]},"institutions":[{"id":"https://openalex.org/I4210108657","display_name":"The Lowy Medical Research Institute","ror":"https://ror.org/01jgzvw27","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210108657"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Marin L. Gantner","raw_affiliation_strings":["Lowy Medical Research Institute, La Jolla, CA 92037, USA. Electronic address: mgantner@lmri.net"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lowy Medical Research Institute, La Jolla, CA 92037, USA. Electronic address: mgantner@lmri.net","institution_ids":["https://openalex.org/I4210108657"]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":9,"corresponding_author_ids":["https://openalex.org/A5042375667","https://openalex.org/A5088873767"],"corresponding_institution_ids":["https://openalex.org/I1307098950","https://openalex.org/I36258959","https://openalex.org/I4210108657"],"apc_list":{"value":9350,"currency":"USD","value_usd":9350},"apc_paid":{"value":9350,"currency":"USD","value_usd":9350},"fwci":10.4348,"has_fulltext":false,"cited_by_count":30,"citation_normalized_percentile":{"value":0.99199907,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":100},"biblio":{"volume":"36","issue":"10","first_page":"2315","last_page":"2328.e6"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10691","display_name":"Retinal Development and Disorders","score":0.6215999722480774,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10691","display_name":"Retinal Development and Disorders","score":0.6215999722480774,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10499","display_name":"Folate and B Vitamins Research","score":0.17810000479221344,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.11230000108480453,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/serine","display_name":"serine","score":0.8100000023841858},{"id":"https://openalex.org/keywords/glycine","display_name":"glycine","score":1.0},{"id":"https://openalex.org/keywords/one-carbon-metabolism","display_name":"one-carbon metabolism","score":0.9940000176429749},{"id":"https://openalex.org/keywords/retinal-function","display_name":"retinal function","score":0.6859999895095825},{"id":"https://openalex.org/keywords/peripheral-neuropathy","display_name":"peripheral neuropathy","score":0.8399999737739563},{"id":"https://openalex.org/keywords/macular-telangiectasia","display_name":"macular telangiectasia","score":0.9520000219345093},{"id":"https://openalex.org/keywords/serine-supplementation","display_name":"serine supplementation","score":0.7480000257492065},{"id":"https://openalex.org/keywords/retinopathy","display_name":"retinopathy","score":0.6940000057220459},{"id":"https://openalex.org/keywords/amino-acid-metabolism","display_name":"amino acid metabolism","score":0.6589999794960022},{"id":"https://openalex.org/keywords/metabolic-homeostasis","display_name":"metabolic homeostasis","score":0.6710000038146973},{"id":"https://openalex.org/keywords/dietary-restriction","display_name":"dietary restriction","score":0.3959999978542328}],"concepts":[{"id":"https://openalex.org/C2776414213","wikidata":"https://www.wikidata.org/wiki/Q183290","display_name":"Serine","level":3,"score":0.8243315815925598},{"id":"https://openalex.org/C2777756961","wikidata":"https://www.wikidata.org/wiki/Q620730","display_name":"Glycine","level":3,"score":0.7535688877105713},{"id":"https://openalex.org/C2780827179","wikidata":"https://www.wikidata.org/wiki/Q422001","display_name":"Retinal","level":2,"score":0.6375525593757629},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5108832716941833},{"id":"https://openalex.org/C63645605","wikidata":"https://www.wikidata.org/wiki/Q103191","display_name":"Homeostasis","level":2,"score":0.4990501403808594},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.49870967864990234},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.47780925035476685},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.44541600346565247},{"id":"https://openalex.org/C2779932687","wikidata":"https://www.wikidata.org/wiki/Q24770006","display_name":"Serine hydroxymethyltransferase","level":4,"score":0.4441969692707062},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3607267737388611},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.2897416949272156},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.244227796792984}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005998","descriptor_name":"Glycine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010525","descriptor_name":"Peripheral Nerves","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012160","descriptor_name":"Retina","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012164","descriptor_name":"Retinal Diseases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012694","descriptor_name":"Serine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.cmet.2024.07.021","doi":"https://doi.org/10.1016/j.cmet.2024.07.021","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.cmet.2024.07.021","pdf_url":null,"source":{"id":"https://openalex.org/S177533077","display_name":"Cell Metabolism","issn_l":"1550-4131","issn":["1550-4131","1932-7420"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Metabolism","raw_type":"journal-article"},{"id":"pmid:39191258","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39191258","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell metabolism","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/j.cmet.2024.07.021","doi":"https://doi.org/10.1016/j.cmet.2024.07.021","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.cmet.2024.07.021","pdf_url":null,"source":{"id":"https://openalex.org/S177533077","display_name":"Cell Metabolism","issn_l":"1550-4131","issn":["1550-4131","1932-7420"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Metabolism","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1410991136","display_name":"Non-essential amino acids and sphingolipid diversity in cancer progression","funder_award_id":"R01CA234245","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G8432426645","display_name":"Integrated clinical, genetic and functional analysis of the ABCA4 locus","funder_award_id":"R01EY029315","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"}],"funders":[{"id":"https://openalex.org/F4320318281","display_name":"Lowy Medical Research Institute","ror":"https://ror.org/01jgzvw27"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337350","display_name":"National Eye Institute","ror":"https://ror.org/03wkg3b53"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":76,"referenced_works":["https://openalex.org/W1512720139","https://openalex.org/W1533335653","https://openalex.org/W1546952499","https://openalex.org/W1604834760","https://openalex.org/W2012034410","https://openalex.org/W2026556168","https://openalex.org/W2028449239","https://openalex.org/W2076575215","https://openalex.org/W2078541819","https://openalex.org/W2083807792","https://openalex.org/W2097895708","https://openalex.org/W2102212449","https://openalex.org/W2109899629","https://openalex.org/W2114268291","https://openalex.org/W2126505667","https://openalex.org/W2127572467","https://openalex.org/W2144205118","https://openalex.org/W2147221915","https://openalex.org/W2149932734","https://openalex.org/W2155103183","https://openalex.org/W2160995259","https://openalex.org/W2167898988","https://openalex.org/W2264411128","https://openalex.org/W2306682746","https://openalex.org/W2400795251","https://openalex.org/W2405069786","https://openalex.org/W2508596879","https://openalex.org/W2519435458","https://openalex.org/W2521967673","https://openalex.org/W2535426958","https://openalex.org/W2549075372","https://openalex.org/W2591686881","https://openalex.org/W2673367329","https://openalex.org/W2751686252","https://openalex.org/W2760801784","https://openalex.org/W2763829738","https://openalex.org/W2788348358","https://openalex.org/W2789474544","https://openalex.org/W2790392407","https://openalex.org/W2802842185","https://openalex.org/W2889094742","https://openalex.org/W2889305184","https://openalex.org/W2943137980","https://openalex.org/W2944529335","https://openalex.org/W2949617913","https://openalex.org/W2963906096","https://openalex.org/W2971770812","https://openalex.org/W2972667145","https://openalex.org/W2980224303","https://openalex.org/W2984009413","https://openalex.org/W2999312477","https://openalex.org/W3005543542","https://openalex.org/W3010691813","https://openalex.org/W3010844199","https://openalex.org/W3034965483","https://openalex.org/W3048569636","https://openalex.org/W3080074298","https://openalex.org/W3120449903","https://openalex.org/W3123287010","https://openalex.org/W3125324301","https://openalex.org/W3135009658","https://openalex.org/W3137028944","https://openalex.org/W3139704615","https://openalex.org/W3155910100","https://openalex.org/W3174666956","https://openalex.org/W3216134080","https://openalex.org/W4283264522","https://openalex.org/W4285589733","https://openalex.org/W4294770898","https://openalex.org/W4295963273","https://openalex.org/W4317952789","https://openalex.org/W4361204913","https://openalex.org/W4380301670","https://openalex.org/W4383956733","https://openalex.org/W4387426430","https://openalex.org/W4390491750"],"related_works":["https://openalex.org/W3012463450","https://openalex.org/W4361204913","https://openalex.org/W4380301670","https://openalex.org/W3139704615","https://openalex.org/W3111154896","https://openalex.org/W4311135399","https://openalex.org/W2808852175","https://openalex.org/W3044204298","https://openalex.org/W7160291127","https://openalex.org/W3135009658"],"abstract_inverted_index":{"Metabolic":[0],"homeostasis":[1],"is":[2],"maintained":[3],"by":[4],"redundant":[5],"pathways":[6,18],"to":[7,148],"ensure":[8],"adequate":[9],"nutrient":[10],"supply":[11],"during":[12],"fasting":[13],"and":[14,24,30,38,47,54,69,116,138],"other":[15],"stresses.":[16],"These":[17,130],"are":[19,119,123],"regulated":[20],"locally":[21],"in":[22,74,82,125],"tissues":[23],"systemically":[25],"via":[26],"the":[27,44,136],"liver,":[28,46],"kidney,":[29],"circulation.":[31],"Here,":[32],"we":[33],"characterize":[34],"how":[35,103],"serine,":[36],"glycine,":[37,70],"one-carbon":[39],"(SGOC)":[40],"metabolism":[41],"fluxes":[42],"across":[43],"eye,":[45],"kidney":[48],"sustain":[49],"retinal":[50,63,96,109],"amino":[51],"acid":[52],"levels":[53],"function.":[55],"Individuals":[56],"with":[57,65],"macular":[58],"telangiectasia":[59],"(MacTel),":[60],"an":[61,79],"age-related":[62],"disease":[64],"reduced":[66],"circulating":[67,83],"serine":[68,128],"carrying":[71],"deleterious":[72],"alleles":[73],"SGOC":[75],"metabolic":[76,139],"enzymes":[77],"exhibit":[78],"exaggerated":[80],"reduction":[81],"serine.":[84],"A":[85],"Phgdh":[86],"+/":[87],"\u2212":[88],"mouse":[89],"model":[90],"of":[91,141],"this":[92,150],"haploinsufficiency":[93],"experiences":[94],"accelerated":[95],"defects":[97],"upon":[98,127],"dietary":[99],"serine/glycine":[100],"restriction,":[101],"highlighting":[102,145],"otherwise":[104],"silent":[105],"haploinsufficiencies":[106],"can":[107],"impact":[108],"health.":[110],"We":[111],"demonstrate":[112],"that":[113],"serine-associated":[114],"retinopathy":[115],"peripheral":[117],"neuropathy":[118],"reversible,":[120],"as":[121],"both":[122],"restored":[124],"mice":[126],"supplementation.":[129],"data":[131],"provide":[132],"molecular":[133],"insights":[134],"into":[135],"genetic":[137],"drivers":[140],"neuro-retinal":[142],"dysfunction":[143],"while":[144],"therapeutic":[146],"opportunities":[147],"ameliorate":[149],"pathogenesis.":[151]},"counts_by_year":[{"year":2026,"cited_by_count":19},{"year":2025,"cited_by_count":10},{"year":2024,"cited_by_count":1}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2024-08-27T00:00:00"}