{"id":"https://openalex.org/W4401868702","doi":"https://doi.org/10.53555/ecb.v11:i12.17696","title":"Exosomal miR-24-2 in Mediating Mitral Valve Dysfunction by Elevation of TGF-\u0392 Levels during Rheumatic Heart Disease Pathogenesis","display_name":"Exosomal miR-24-2 in Mediating Mitral Valve Dysfunction by Elevation of TGF-\u0392 Levels during Rheumatic Heart Disease Pathogenesis","publication_year":2022,"publication_date":"2022-12-23","ids":{"openalex":"https://openalex.org/W4401868702","doi":"https://doi.org/10.53555/ecb.v11:i12.17696"},"language":"en","primary_location":{"id":"doi:10.53555/ecb.v11:i12.17696","doi":"https://doi.org/10.53555/ecb.v11:i12.17696","is_oa":true,"landing_page_url":"https://doi.org/10.53555/ecb.v11:i12.17696","pdf_url":"https://lwqh0y3rla.execute-api.ap-south-1.amazonaws.com/dev/download?articleId=17696","source":{"id":"https://openalex.org/S2737572108","display_name":"European Chemical Bulletin","issn_l":"2063-5346","issn":["2063-5346"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["norway-1","poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4310315421","host_organization_name":"Deuton-X","host_organization_lineage":["https://openalex.org/P4310315421"],"host_organization_lineage_names":["Deuton-X"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Chemical Bulletin","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://lwqh0y3rla.execute-api.ap-south-1.amazonaws.com/dev/download?articleId=17696","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5049498138","display_name":"Shruti Sharma","orcid":"https://orcid.org/0000-0001-8200-108X","observed_orcids":["https://orcid.org/0000-0001-8200-108X"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Shruti Sharma","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5049498138"],"corresponding_institution_ids":[],"apc_list":{"value":100,"currency":"EUR","value_usd":107},"apc_paid":{"value":100,"currency":"EUR","value_usd":107},"fwci":0.0816,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.32859319,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":94},"biblio":{"volume":null,"issue":null,"first_page":"4853","last_page":"4878"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10773","display_name":"Extracellular vesicles in disease","score":0.8842999935150146,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10773","display_name":"Extracellular vesicles in disease","score":0.8842999935150146,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11153","display_name":"Streptococcal Infections and Treatments","score":0.03310000151395798,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.016699999570846558,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/exosomal-mirna","display_name":"exosomal microRNAs","score":0.7879999876022339},{"id":"https://openalex.org/keywords/mir-24-2","display_name":"miR-24-2","score":0.996999979019165},{"id":"https://openalex.org/keywords/mitral-valve-dysfunction","display_name":"mitral valve dysfunction","score":0.9890000224113464},{"id":"https://openalex.org/keywords/transforming-growth-factor-beta","display_name":"TGF-beta","score":0.8629999756813049},{"id":"https://openalex.org/keywords/rheumatic-heart-disease","display_name":"rheumatic heart disease","score":0.9940000176429749},{"id":"https://openalex.org/keywords/pathogenesis","display_name":"pathogenesis","score":0.5170000195503235},{"id":"https://openalex.org/keywords/microvesicles","display_name":"microvesicles","score":0.5759999752044678}],"concepts":[{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.8711082935333252},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7125520706176758},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6466861963272095},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.6344488859176636},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5655295848846436},{"id":"https://openalex.org/C118131993","wikidata":"https://www.wikidata.org/wiki/Q423671","display_name":"Transforming growth factor","level":2,"score":0.4871823191642761},{"id":"https://openalex.org/C2777543888","wikidata":"https://www.wikidata.org/wiki/Q369939","display_name":"Mitral valve","level":2,"score":0.4273201823234558}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.53555/ecb.v11:i12.17696","doi":"https://doi.org/10.53555/ecb.v11:i12.17696","is_oa":true,"landing_page_url":"https://doi.org/10.53555/ecb.v11:i12.17696","pdf_url":"https://lwqh0y3rla.execute-api.ap-south-1.amazonaws.com/dev/download?articleId=17696","source":{"id":"https://openalex.org/S2737572108","display_name":"European Chemical Bulletin","issn_l":"2063-5346","issn":["2063-5346"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["norway-1","poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4310315421","host_organization_name":"Deuton-X","host_organization_lineage":["https://openalex.org/P4310315421"],"host_organization_lineage_names":["Deuton-X"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Chemical Bulletin","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.53555/ecb.v11:i12.17696","doi":"https://doi.org/10.53555/ecb.v11:i12.17696","is_oa":true,"landing_page_url":"https://doi.org/10.53555/ecb.v11:i12.17696","pdf_url":"https://lwqh0y3rla.execute-api.ap-south-1.amazonaws.com/dev/download?articleId=17696","source":{"id":"https://openalex.org/S2737572108","display_name":"European Chemical Bulletin","issn_l":"2063-5346","issn":["2063-5346"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["norway-1","poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4310315421","host_organization_name":"Deuton-X","host_organization_lineage":["https://openalex.org/P4310315421"],"host_organization_lineage_names":["Deuton-X"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Chemical Bulletin","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320720","display_name":"Indian Council of Medical Research","ror":"https://ror.org/0492wrx28"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4401868702.pdf","grobid_xml":"https://content.openalex.org/works/W4401868702.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7160704694","https://openalex.org/W7214109385","https://openalex.org/W4411555648","https://openalex.org/W4210642427","https://openalex.org/W4307844013","https://openalex.org/W4367059463","https://openalex.org/W4413355214","https://openalex.org/W2990812499","https://openalex.org/W2789325855","https://openalex.org/W2994597894"],"abstract_inverted_index":{"Rheumatic":[0,294],"heart":[1],"disease":[2],"(RHD)":[3],"is":[4,90],"an":[5,52,69],"autoimmune":[6],"sequel":[7],"of":[8,21,26,43,59,78,113,135,170,196,201,212,224,249,256,290],"rheumatic":[9],"fever":[10],"(RF)":[11],"that":[12,176],"results":[13],"in":[14,33,55,82,100,159,163,181,188,206,233,236,252,283],"permanent":[15],"damage":[16,85],"to":[17,50,74,148,191,238,268],"the":[18,22,27,34,40,44,76,102,119,171,189,197,253],"mitral":[19,28,83,254,273],"valves":[20,84,255,274],"heart.Endothelial":[23],"cells":[24],"(ECs)":[25],"valves,":[29],"take":[30],"up":[31,95],"exosomes":[32,103,133,154,207],"biological":[35,164],"fluids":[36],"which":[37,101,242],"may":[38,266],"change":[39,162],"cellular":[41],"characteristics":[42],"cells.Exosomal":[45],"miRNAs,":[46,61],"have":[47],"been":[48,72],"known":[49],"play":[51],"imminent":[53],"role":[54,77],"various":[56],"diseases.The":[57],"composition":[58],"exosomal":[60,79,173,202,263],"varies,":[62],"under":[63],"different":[64],"physiological":[65],"and":[66,96,110,116,142,161,168,194,221,227,272,277],"pathological":[67],"conditions.Herein,":[68],"attempt":[70],"has":[71],"made":[73],"unfurl":[75],"miRNA,":[80],"miR-24-2":[81,177,203,213,264,282],"during":[86,279,293],"RHD.The":[87],"present":[88],"study":[89],"focused":[91],"on":[92],"in-vitro":[93],"set":[94],"patient":[97,107],"samples":[98,108,184],"analysis":[99],"were":[104],"isolated":[105,172],"from":[106,118,137],"(serum":[109],"pericardial":[111],"fluid)":[112],"RHD":[114,122,138,182,257],"patients":[115],"simultaneously":[117],"media":[120],"extracted":[121],"patients'":[123,183],"serum":[124,140,145],"stimulated":[125],"HUVECs":[126,129,151,160,235],"(RHDin-vitro":[127],"model).Next,":[128],"were,":[130],"treated":[131,152,208,240],"with":[132,153,245],"(component":[134],"serum)":[136],"patient's":[139],"(R-exo)":[141],"normal":[143],"individuals'":[144],"(N-exo)":[146],"in-order":[147],"evaluate":[149],"whether":[150],"brings":[155],"about":[156],"morphological":[157],"changes":[158],"properties.Further,":[165],"miRNA":[166],"profiling":[167],"RT-PCR":[169],"RNA":[174],"revealed":[175],"level":[178],"was":[179,204,231,243],"attenuated":[180],"as":[185,187,214,216],"well":[186,215],"media.Finally,":[190],"check":[192],"cause":[193],"effect":[195],"study,":[198],"functional":[199],"inhibition":[200],"performed,":[205],"HUVECs.Decreased":[209],"expression":[210],"levels":[211,223,248,265],"endothelial":[217],"marker":[218,229],"(VE":[219],"cadherin)":[220],"increased":[222],"mesenchymal":[225],"(SMA-\u03b1)":[226],"fibrosis":[228],"(TGF-\u03b2)":[230],"observed":[232],"R-exo-treated":[234],"comparison":[237],"N-exo":[239],"HUVECs,":[241],"correlated":[244],"altered":[246],"proteins":[247],"these":[250,259],"markers":[251],"patients.Thus,":[258],"findings":[260],"suggests,":[261],"decreased":[262],"lead":[267],"enhanced":[269],"TGF-\u03b2":[270],"production":[271],"dysfunction":[275],"(stenosis":[276],"regurgitation)":[278],"RHD.":[280],"Exosomal":[281],"Mediating":[284],"Mitral":[285],"Valve":[286],"Dysfunction":[287],"by":[288],"Elevation":[289],"TGF-\u0392":[291],"Levels":[292],"Heart":[295],"Disease":[296],"Pathogenesis":[297]},"counts_by_year":[{"year":2025,"cited_by_count":1}],"updated_date":"2026-10-27T15:51:10.671819","created_date":"2024-08-26T00:00:00"}
