{"id":"https://openalex.org/W4401864366","doi":"https://doi.org/10.1016/j.ejpb.2024.114474","title":"Hyaluronidase overcomes the extracellular matrix barrier to enhance local drug delivery","display_name":"Hyaluronidase overcomes the extracellular matrix barrier to enhance local drug delivery","publication_year":2024,"publication_date":"2024-08-25","ids":{"openalex":"https://openalex.org/W4401864366","doi":"https://doi.org/10.1016/j.ejpb.2024.114474","pmid":"https://pubmed.ncbi.nlm.nih.gov/39191305"},"language":"en","primary_location":{"id":"doi:10.1016/j.ejpb.2024.114474","doi":"https://doi.org/10.1016/j.ejpb.2024.114474","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.ejpb.2024.114474","pdf_url":null,"source":{"id":"https://openalex.org/S122302516","display_name":"European Journal of Pharmaceutics and Biopharmaceutics","issn_l":"0939-6411","issn":["0939-6411","1873-3441"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Pharmaceutics and Biopharmaceutics","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5042966232","display_name":"Jingru Zhao","orcid":"https://orcid.org/0000-0003-4785-839X","observed_orcids":["https://orcid.org/0000-0003-4785-839X"]},"institutions":[{"id":"https://openalex.org/I154099455","display_name":"Shandong University","ror":"https://ror.org/0207yh398","country_code":"CN","type":"education","lineage":["https://openalex.org/I154099455"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jingru Zhao","raw_affiliation_strings":["Marine College, Shandong University, Weihai, Shandong 264209, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Marine College, Shandong University, Weihai, Shandong 264209, China","institution_ids":["https://openalex.org/I154099455"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100394810","display_name":"Jing Chen","orcid":"https://orcid.org/0000-0001-6695-3013","observed_orcids":["https://orcid.org/0000-0001-6695-3013","https://orcid.org/0009-0003-4618-5477"]},"institutions":[{"id":"https://openalex.org/I154099455","display_name":"Shandong University","ror":"https://ror.org/0207yh398","country_code":"CN","type":"education","lineage":["https://openalex.org/I154099455"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jing Chen","raw_affiliation_strings":["Marine College, Shandong University, Weihai, Shandong 264209, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Marine College, Shandong University, Weihai, Shandong 264209, China","institution_ids":["https://openalex.org/I154099455"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100624129","display_name":"Changqing Li","orcid":"https://orcid.org/0000-0003-4237-1494","observed_orcids":["https://orcid.org/0000-0003-4237-1494","https://orcid.org/0000-0002-9423-9105","https://orcid.org/0009-0006-0136-3710"]},"institutions":[{"id":"https://openalex.org/I154099455","display_name":"Shandong University","ror":"https://ror.org/0207yh398","country_code":"CN","type":"education","lineage":["https://openalex.org/I154099455"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Changqing Li","raw_affiliation_strings":["Marine College, Shandong University, Weihai, Shandong 264209, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Marine College, Shandong University, Weihai, Shandong 264209, China","institution_ids":["https://openalex.org/I154099455"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Hong Xiang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154099455","display_name":"Shandong University","ror":"https://ror.org/0207yh398","country_code":"CN","type":"education","lineage":["https://openalex.org/I154099455"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hong Xiang","raw_affiliation_strings":["Marine College, Shandong University, Weihai, Shandong 264209, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Marine College, Shandong University, Weihai, Shandong 264209, China","institution_ids":["https://openalex.org/I154099455"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5012928916","display_name":"Xiaoqing Miao","orcid":"https://orcid.org/0000-0002-0609-5376","observed_orcids":["https://orcid.org/0000-0002-0609-5376"]},"institutions":[{"id":"https://openalex.org/I154099455","display_name":"Shandong University","ror":"https://ror.org/0207yh398","country_code":"CN","type":"education","lineage":["https://openalex.org/I154099455"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xiaoqing Miao","raw_affiliation_strings":["Marine College, Shandong University, Weihai, Shandong 264209, China. Electronic address: xiaoqingmiao@sdu.edu.cn"],"raw_orcid":"https://orcid.org/0000-0002-0609-5376","affiliations":[{"raw_affiliation_string":"Marine College, Shandong University, Weihai, Shandong 264209, China. Electronic address: xiaoqingmiao@sdu.edu.cn","institution_ids":["https://openalex.org/I154099455"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5012928916"],"corresponding_institution_ids":["https://openalex.org/I154099455"],"apc_list":{"value":4270,"currency":"USD","value_usd":4270},"apc_paid":null,"fwci":1.0474,"has_fulltext":false,"cited_by_count":28,"citation_normalized_percentile":{"value":0.69100391,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"203","issue":null,"first_page":"114474","last_page":"114474"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10704","display_name":"Advancements in Transdermal Drug Delivery","score":0.9829000234603882,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10704","display_name":"Advancements in Transdermal Drug Delivery","score":0.9829000234603882,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11131","display_name":"Proteoglycans and glycosaminoglycans research","score":0.010499999858438969,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.003000000026077032,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hyaluronidase","display_name":"hyaluronidase","score":1.0},{"id":"https://openalex.org/keywords/extracellular-matrix-degradation","display_name":"extracellular matrix degradation","score":0.7889999747276306},{"id":"https://openalex.org/keywords/hyaluronic-acid","display_name":"hyaluronic acid","score":0.8759999871253967},{"id":"https://openalex.org/keywords/stratum-corneum-barrier","display_name":"stratum corneum barrier","score":0.7850000262260437},{"id":"https://openalex.org/keywords/transdermal-drug-delivery","display_name":"transdermal drug delivery","score":0.9459999799728394},{"id":"https://openalex.org/keywords/topical-drug-delivery","display_name":"topical drug delivery","score":0.6909999847412109},{"id":"https://openalex.org/keywords/nanoformulations","display_name":"nanoformulations","score":0.8759999871253967},{"id":"https://openalex.org/keywords/skin-penetration","display_name":"skin penetration","score":0.42399999499320984}],"concepts":[{"id":"https://openalex.org/C2779820397","wikidata":"https://www.wikidata.org/wiki/Q1392806","display_name":"Drug delivery","level":2,"score":0.6295406222343445},{"id":"https://openalex.org/C2780375986","wikidata":"https://www.wikidata.org/wiki/Q904015","display_name":"Hyaluronidase","level":3,"score":0.618046760559082},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.5579424500465393},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5547710657119751},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.5244272351264954},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4437510669231415},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2464456856250763},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.18101948499679565},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.13726559281349182},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000279","descriptor_name":"Administration, Cutaneous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000279","descriptor_name":"Administration, Cutaneous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000279","descriptor_name":"Administration, Cutaneous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005109","descriptor_name":"Extracellular Matrix","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005109","descriptor_name":"Extracellular Matrix","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005109","descriptor_name":"Extracellular Matrix","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006820","descriptor_name":"Hyaluronic Acid","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D006820","descriptor_name":"Hyaluronic Acid","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D006820","descriptor_name":"Hyaluronic Acid","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D006820","descriptor_name":"Hyaluronic Acid","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D006820","descriptor_name":"Hyaluronic Acid","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D006820","descriptor_name":"Hyaluronic Acid","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D006821","descriptor_name":"Hyaluronoglucosaminidase","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D006821","descriptor_name":"Hyaluronoglucosaminidase","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D006821","descriptor_name":"Hyaluronoglucosaminidase","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D006821","descriptor_name":"Hyaluronoglucosaminidase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006821","descriptor_name":"Hyaluronoglucosaminidase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006821","descriptor_name":"Hyaluronoglucosaminidase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012867","descriptor_name":"Skin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012867","descriptor_name":"Skin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012867","descriptor_name":"Skin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012869","descriptor_name":"Skin Absorption","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D012869","descriptor_name":"Skin Absorption","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D012869","descriptor_name":"Skin Absorption","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D016503","descriptor_name":"Drug Delivery Systems","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D016503","descriptor_name":"Drug Delivery Systems","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D016503","descriptor_name":"Drug Delivery Systems","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D053758","descriptor_name":"Nanoparticles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D053758","descriptor_name":"Nanoparticles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D053758","descriptor_name":"Nanoparticles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.ejpb.2024.114474","doi":"https://doi.org/10.1016/j.ejpb.2024.114474","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.ejpb.2024.114474","pdf_url":null,"source":{"id":"https://openalex.org/S122302516","display_name":"European Journal of Pharmaceutics and Biopharmaceutics","issn_l":"0939-6411","issn":["0939-6411","1873-3441"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Pharmaceutics and Biopharmaceutics","raw_type":"journal-article"},{"id":"pmid:39191305","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39191305","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9476000070571899,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","score":0.4000000059604645,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":114,"referenced_works":["https://openalex.org/W1976683436","https://openalex.org/W1982699649","https://openalex.org/W1993606172","https://openalex.org/W2009426872","https://openalex.org/W2017454309","https://openalex.org/W2023026872","https://openalex.org/W2023231194","https://openalex.org/W2032058892","https://openalex.org/W2036537469","https://openalex.org/W2066418118","https://openalex.org/W2075629192","https://openalex.org/W2080000415","https://openalex.org/W2083726034","https://openalex.org/W2093429871","https://openalex.org/W2104891929","https://openalex.org/W2109219296","https://openalex.org/W2122029850","https://openalex.org/W2124675356","https://openalex.org/W2137788606","https://openalex.org/W2143218365","https://openalex.org/W2143674664","https://openalex.org/W2158303916","https://openalex.org/W2187985754","https://openalex.org/W2222803489","https://openalex.org/W2262018451","https://openalex.org/W2326188833","https://openalex.org/W2395873313","https://openalex.org/W2482681628","https://openalex.org/W2526144734","https://openalex.org/W2552447851","https://openalex.org/W2588466803","https://openalex.org/W2594354610","https://openalex.org/W2612448990","https://openalex.org/W2751209155","https://openalex.org/W2753160699","https://openalex.org/W2761840182","https://openalex.org/W2769114174","https://openalex.org/W2771893509","https://openalex.org/W2781877987","https://openalex.org/W2796698689","https://openalex.org/W2800451927","https://openalex.org/W2801488355","https://openalex.org/W2805079968","https://openalex.org/W2894591213","https://openalex.org/W2901509864","https://openalex.org/W2903909531","https://openalex.org/W2909362719","https://openalex.org/W2912407716","https://openalex.org/W2938679182","https://openalex.org/W2946943934","https://openalex.org/W2950182836","https://openalex.org/W2972065543","https://openalex.org/W2974204766","https://openalex.org/W2976114833","https://openalex.org/W2985713285","https://openalex.org/W2986126447","https://openalex.org/W2989412439","https://openalex.org/W3000511283","https://openalex.org/W3000668256","https://openalex.org/W3013119776","https://openalex.org/W3020058005","https://openalex.org/W3022179180","https://openalex.org/W3044895431","https://openalex.org/W3045310119","https://openalex.org/W3078996272","https://openalex.org/W3080077289","https://openalex.org/W3092641244","https://openalex.org/W3094221160","https://openalex.org/W3096653792","https://openalex.org/W3105288820","https://openalex.org/W3109746568","https://openalex.org/W3110981869","https://openalex.org/W3119486933","https://openalex.org/W3133999006","https://openalex.org/W3142072058","https://openalex.org/W3155477883","https://openalex.org/W3159312462","https://openalex.org/W3165369090","https://openalex.org/W3181153668","https://openalex.org/W3186524826","https://openalex.org/W3189485073","https://openalex.org/W3191840371","https://openalex.org/W3211486563","https://openalex.org/W3213047253","https://openalex.org/W3215080172","https://openalex.org/W3215123249","https://openalex.org/W4210706983","https://openalex.org/W4220915000","https://openalex.org/W4280518697","https://openalex.org/W4280611069","https://openalex.org/W4281255772","https://openalex.org/W4283077749","https://openalex.org/W4285680020","https://openalex.org/W4287877545","https://openalex.org/W4289135000","https://openalex.org/W4289943949","https://openalex.org/W4292256082","https://openalex.org/W4294405960","https://openalex.org/W4296952051","https://openalex.org/W4308681881","https://openalex.org/W4309245155","https://openalex.org/W4312018289","https://openalex.org/W4312083779","https://openalex.org/W4317425626","https://openalex.org/W4322619913","https://openalex.org/W4324020302","https://openalex.org/W4327894170","https://openalex.org/W4375856386","https://openalex.org/W4389560492","https://openalex.org/W4390442287","https://openalex.org/W4392571121","https://openalex.org/W6769829636","https://openalex.org/W6804111123","https://openalex.org/W6838428534"],"related_works":["https://openalex.org/W4312083779","https://openalex.org/W2020886530","https://openalex.org/W2130227220","https://openalex.org/W221430231","https://openalex.org/W3005350736","https://openalex.org/W7140081799","https://openalex.org/W2911800377","https://openalex.org/W4322619913","https://openalex.org/W2158548553","https://openalex.org/W2020134755"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":16},{"year":2025,"cited_by_count":12}],"updated_date":"2026-10-27T15:51:10.671819","created_date":"2024-08-26T00:00:00"}
