{"id":"https://openalex.org/W4401735271","doi":"https://doi.org/10.1016/j.tiv.2024.105921","title":"Silencing Nrf2 in cisplatin resistant non-small cell lung cancer cells augments sensitivity towards EGFR inhibitor","display_name":"Silencing Nrf2 in cisplatin resistant non-small cell lung cancer cells augments sensitivity towards EGFR inhibitor","publication_year":2024,"publication_date":"2024-08-22","ids":{"openalex":"https://openalex.org/W4401735271","doi":"https://doi.org/10.1016/j.tiv.2024.105921","pmid":"https://pubmed.ncbi.nlm.nih.gov/39179137"},"language":"en","primary_location":{"id":"doi:10.1016/j.tiv.2024.105921","doi":"https://doi.org/10.1016/j.tiv.2024.105921","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.tiv.2024.105921","pdf_url":null,"source":{"id":"https://openalex.org/S39580544","display_name":"Toxicology in Vitro","issn_l":"0887-2333","issn":["0887-2333","1879-3177"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicology in Vitro","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5053844408","display_name":"Chandrani Fouzder","orcid":"https://orcid.org/0000-0001-8666-047X","observed_orcids":["https://orcid.org/0000-0001-8666-047X"]},"institutions":[{"id":"https://openalex.org/I130291710","display_name":"Visva-Bharati University","ror":"https://ror.org/02y28sc20","country_code":"IN","type":"education","lineage":["https://openalex.org/I130291710"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Chandrani Fouzder","raw_affiliation_strings":["Cell Signaling Laboratory, Department of Zoology, Siksha-Bhavana, Visva-Bharati (A Central University), Santiniketan 731 235, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cell Signaling Laboratory, Department of Zoology, Siksha-Bhavana, Visva-Bharati (A Central University), Santiniketan 731 235, India","institution_ids":["https://openalex.org/I130291710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028636616","display_name":"Alpana Mukhuty","orcid":"https://orcid.org/0000-0002-3408-1617","observed_orcids":["https://orcid.org/0000-0002-3408-1617"]},"institutions":[{"id":"https://openalex.org/I130291710","display_name":"Visva-Bharati University","ror":"https://ror.org/02y28sc20","country_code":"IN","type":"education","lineage":["https://openalex.org/I130291710"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Alpana Mukhuty","raw_affiliation_strings":["Cell Signaling Laboratory, Department of Zoology, Siksha-Bhavana, Visva-Bharati (A Central University), Santiniketan 731 235, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cell Signaling Laboratory, Department of Zoology, Siksha-Bhavana, Visva-Bharati (A Central University), Santiniketan 731 235, India","institution_ids":["https://openalex.org/I130291710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111115574","display_name":"Dipanjan Chattopadhyay","orcid":"https://orcid.org/0000-0001-9182-0765","observed_orcids":["https://orcid.org/0000-0001-9182-0765"]},"institutions":[{"id":"https://openalex.org/I130291710","display_name":"Visva-Bharati University","ror":"https://ror.org/02y28sc20","country_code":"IN","type":"education","lineage":["https://openalex.org/I130291710"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Dipanjan Chattopadhyay","raw_affiliation_strings":["Cellular and Molecular Endocrinology Laboratory, Department of Zoology, Siksha-Bhavana, Visva-Bharati (A Central University), Santiniketan 731 235, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cellular and Molecular Endocrinology Laboratory, Department of Zoology, Siksha-Bhavana, Visva-Bharati (A Central University), Santiniketan 731 235, India","institution_ids":["https://openalex.org/I130291710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014925750","display_name":"Snehasis Das","orcid":"https://orcid.org/0000-0002-5269-9269","observed_orcids":["https://orcid.org/0000-0002-5269-9269"]},"institutions":[{"id":"https://openalex.org/I130291710","display_name":"Visva-Bharati University","ror":"https://ror.org/02y28sc20","country_code":"IN","type":"education","lineage":["https://openalex.org/I130291710"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Snehasis Das","raw_affiliation_strings":["Cellular and Molecular Endocrinology Laboratory, Department of Zoology, Siksha-Bhavana, Visva-Bharati (A Central University), Santiniketan 731 235, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cellular and Molecular Endocrinology Laboratory, Department of Zoology, Siksha-Bhavana, Visva-Bharati (A Central University), Santiniketan 731 235, India","institution_ids":["https://openalex.org/I130291710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066525132","display_name":"Sumit Kumar Hira","orcid":"https://orcid.org/0000-0001-6113-4721","observed_orcids":["https://orcid.org/0000-0001-6113-4721"]},"institutions":[{"id":"https://openalex.org/I132359460","display_name":"University of Burdwan","ror":"https://ror.org/05cyd8v32","country_code":"IN","type":"education","lineage":["https://openalex.org/I132359460"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Sumit Kumar Hira","raw_affiliation_strings":["Cellular Immunology Laboratory, Department of Zoology, The University of Burdwan, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cellular Immunology Laboratory, Department of Zoology, The University of Burdwan, India","institution_ids":["https://openalex.org/I132359460"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5063065993","display_name":"Rakesh Kundu","orcid":"https://orcid.org/0000-0001-8871-0565","observed_orcids":["https://orcid.org/0000-0001-8871-0565"]},"institutions":[{"id":"https://openalex.org/I130291710","display_name":"Visva-Bharati University","ror":"https://ror.org/02y28sc20","country_code":"IN","type":"education","lineage":["https://openalex.org/I130291710"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Rakesh Kundu","raw_affiliation_strings":["Cell Signaling Laboratory, Department of Zoology, Siksha-Bhavana, Visva-Bharati (A Central University), Santiniketan 731 235, India. Electronic address: rakesh.kundu@visva-bharati.ac.in"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cell Signaling Laboratory, Department of Zoology, Siksha-Bhavana, Visva-Bharati (A Central University), Santiniketan 731 235, India. Electronic address: rakesh.kundu@visva-bharati.ac.in","institution_ids":["https://openalex.org/I130291710"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5063065993"],"corresponding_institution_ids":["https://openalex.org/I130291710"],"apc_list":{"value":4070,"currency":"USD","value_usd":4070},"apc_paid":null,"fwci":0.1084,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.29080011,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":95},"biblio":{"volume":"101","issue":null,"first_page":"105921","last_page":"105921"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11332","display_name":"Genomics, phytochemicals, and oxidative stress","score":0.6464999914169312,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11332","display_name":"Genomics, phytochemicals, and oxidative stress","score":0.6464999914169312,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.33640000224113464,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.0019000000320374966,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nrf2","display_name":"Nrf2","score":0.9819999933242798},{"id":"https://openalex.org/keywords/cisplatin-resistance","display_name":"cisplatin resistance","score":0.9810000061988831},{"id":"https://openalex.org/keywords/non-small-cell-lung-cancer","display_name":"non-small cell lung cancer","score":0.9950000047683716},{"id":"https://openalex.org/keywords/egfr","display_name":"EGFR","score":0.8690000176429749},{"id":"https://openalex.org/keywords/egfr-tyrosine-kinase-inhibitors","display_name":"EGFR tyrosine kinase inhibitors","score":0.925000011920929},{"id":"https://openalex.org/keywords/ag1478","display_name":"AG1478","score":0.9800000190734863},{"id":"https://openalex.org/keywords/drug-resistance","display_name":"drug resistance","score":0.7580000162124634},{"id":"https://openalex.org/keywords/nrf2-inhibition","display_name":"Nrf2 inhibition","score":0.6340000033378601},{"id":"https://openalex.org/keywords/sirna","display_name":"siRNA","score":0.6389999985694885},{"id":"https://openalex.org/keywords/drug-efflux","display_name":"drug efflux","score":0.7200000286102295},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.6539999842643738},{"id":"https://openalex.org/keywords/transcriptional-regulation","display_name":"transcriptional regulation","score":0.6359999775886536}],"concepts":[{"id":"https://openalex.org/C2778239845","wikidata":"https://www.wikidata.org/wiki/Q412415","display_name":"Cisplatin","level":3,"score":0.7621302604675293},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6574286818504333},{"id":"https://openalex.org/C2779438470","wikidata":"https://www.wikidata.org/wiki/Q424401","display_name":"Epidermal growth factor receptor","level":3,"score":0.6110134720802307},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.569939374923706},{"id":"https://openalex.org/C117262875","wikidata":"https://www.wikidata.org/wiki/Q5135057","display_name":"Clonogenic assay","level":3,"score":0.5111909508705139},{"id":"https://openalex.org/C55427017","wikidata":"https://www.wikidata.org/wiki/Q1638475","display_name":"Cancer stem cell","level":3,"score":0.4469802975654602},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.411133736371994},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3955310881137848},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.37996578216552734},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.34062182903289795},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.29632049798965454},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.29528748989105225},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.24209603667259216},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.1831253468990326},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002945","descriptor_name":"Cisplatin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011799","descriptor_name":"Quinazolines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D019008","descriptor_name":"Drug Resistance, Neoplasm","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D020032","descriptor_name":"Tyrphostins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D020868","descriptor_name":"Gene Silencing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D051267","descriptor_name":"NF-E2-Related Factor 2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D051267","descriptor_name":"NF-E2-Related Factor 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D066246","descriptor_name":"ErbB Receptors","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D066246","descriptor_name":"ErbB Receptors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D066246","descriptor_name":"ErbB Receptors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.tiv.2024.105921","doi":"https://doi.org/10.1016/j.tiv.2024.105921","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.tiv.2024.105921","pdf_url":null,"source":{"id":"https://openalex.org/S39580544","display_name":"Toxicology in Vitro","issn_l":"0887-2333","issn":["0887-2333","1879-3177"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicology in Vitro","raw_type":"journal-article"},{"id":"pmid:39179137","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39179137","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicology in vitro : an international journal published in association with BIBRA","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9922999739646912,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1375971993","display_name":null,"funder_award_id":"ECR/2017/001028/LS","funder_id":"https://openalex.org/F4320320719","funder_display_name":"Department of Science and Technology, Ministry of Science and Technology, India"},{"id":"https://openalex.org/G2989697645","display_name":null,"funder_award_id":"ECR/2017/001028","funder_id":"https://openalex.org/F4320334771","funder_display_name":"Science and Engineering Research Board"}],"funders":[{"id":"https://openalex.org/F4320320719","display_name":"Department of Science and Technology, Ministry of Science and Technology, India","ror":"https://ror.org/0101xrq71"},{"id":"https://openalex.org/F4320320767","display_name":"University Grants Commission","ror":"https://ror.org/04p800546"},{"id":"https://openalex.org/F4320334771","display_name":"Science and Engineering Research Board","ror":"https://ror.org/03ffdsr55"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":43,"referenced_works":["https://openalex.org/W138455674","https://openalex.org/W1920914663","https://openalex.org/W1936571436","https://openalex.org/W1980739328","https://openalex.org/W1993382872","https://openalex.org/W2026324708","https://openalex.org/W2029947074","https://openalex.org/W2030864103","https://openalex.org/W2037673492","https://openalex.org/W2038228368","https://openalex.org/W2142853881","https://openalex.org/W2143899065","https://openalex.org/W2151614363","https://openalex.org/W2152175948","https://openalex.org/W2352491315","https://openalex.org/W2507289596","https://openalex.org/W2560601914","https://openalex.org/W2561420332","https://openalex.org/W2614289898","https://openalex.org/W2738581806","https://openalex.org/W2770922541","https://openalex.org/W2776878739","https://openalex.org/W2789471747","https://openalex.org/W2921277883","https://openalex.org/W2927225477","https://openalex.org/W2959857170","https://openalex.org/W2969669884","https://openalex.org/W2980869324","https://openalex.org/W2987326625","https://openalex.org/W2996460992","https://openalex.org/W2999417355","https://openalex.org/W3008642968","https://openalex.org/W3037221486","https://openalex.org/W3042980549","https://openalex.org/W3094524575","https://openalex.org/W3107561854","https://openalex.org/W3142445179","https://openalex.org/W4256122203","https://openalex.org/W4286814472","https://openalex.org/W4297221746","https://openalex.org/W6605668606","https://openalex.org/W6770042236","https://openalex.org/W6786544691"],"related_works":["https://openalex.org/W2613011576","https://openalex.org/W3094524575","https://openalex.org/W3018250288","https://openalex.org/W2796682729","https://openalex.org/W2968033674","https://openalex.org/W3044380747","https://openalex.org/W1994604625","https://openalex.org/W7139479351","https://openalex.org/W2050735125","https://openalex.org/W3112263591"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2024-08-23T00:00:00"}