{"id":"https://openalex.org/W4401728977","doi":"https://doi.org/10.1093/braincomms/fcae247","title":"Multi-peptide characterization of plasma neurofilament light chain in preclinical and mild Alzheimer\u2019s disease","display_name":"Multi-peptide characterization of plasma neurofilament light chain in preclinical and mild Alzheimer\u2019s disease","publication_year":2024,"publication_date":"2024-01-01","ids":{"openalex":"https://openalex.org/W4401728977","doi":"https://doi.org/10.1093/braincomms/fcae247","pmid":"https://pubmed.ncbi.nlm.nih.gov/39165480","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11334934"},"language":"en","primary_location":{"id":"doi:10.1093/braincomms/fcae247","doi":"https://doi.org/10.1093/braincomms/fcae247","is_oa":true,"landing_page_url":"https://doi.org/10.1093/braincomms/fcae247","pdf_url":null,"source":{"id":"https://openalex.org/S4210235363","display_name":"Brain Communications","issn_l":"2632-1297","issn":["2632-1297"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brain Communications","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1093/braincomms/fcae247","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5013012718","display_name":"John B. Coulton","orcid":"https://orcid.org/0000-0002-1353-1180","observed_orcids":["https://orcid.org/0000-0002-1353-1180"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John B Coulton","raw_affiliation_strings":["Department of Neurology, Washington University School of Medicine , St. Louis, MO 63110 , USA","Tracy Family SILQ Center, Washington University School of Medicine , St. Louis, MO 63110 , USA"],"raw_orcid":"https://orcid.org/0000-0002-1353-1180","affiliations":[{"raw_affiliation_string":"Department of Neurology, Washington University School of Medicine , St. Louis, MO 63110 , USA","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"Tracy Family SILQ Center, Washington University School of Medicine , St. Louis, MO 63110 , USA","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026669710","display_name":"Yingxin He","orcid":"https://orcid.org/0000-0003-2543-4553","observed_orcids":["https://orcid.org/0000-0003-2543-4553"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yingxin He","raw_affiliation_strings":["Department of Neurology, Washington University School of Medicine , St. Louis, MO 63110 , USA","Tracy Family SILQ Center, Washington University School of Medicine , St. Louis, MO 63110 , USA"],"raw_orcid":"https://orcid.org/0000-0003-2543-4553","affiliations":[{"raw_affiliation_string":"Department of Neurology, Washington University School of Medicine , St. Louis, MO 63110 , USA","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"Tracy Family SILQ Center, Washington University School of Medicine , St. Louis, MO 63110 , USA","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068417558","display_name":"Nicolas R. Barth\u00e9lemy","orcid":"https://orcid.org/0000-0003-4937-2860","observed_orcids":["https://orcid.org/0000-0003-4937-2860"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nicolas R Barth\u00e9lemy","raw_affiliation_strings":["Department of Neurology, Washington University School of Medicine , St. Louis, MO 63110 , USA","Tracy Family SILQ Center, Washington University School of Medicine , St. Louis, MO 63110 , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Washington University School of Medicine , St. Louis, MO 63110 , USA","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"Tracy Family SILQ Center, Washington University School of Medicine , St. Louis, MO 63110 , USA","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5106943752","display_name":"Hong Jiang","orcid":"https://orcid.org/0000-0001-6480-7469","observed_orcids":["https://orcid.org/0000-0001-6480-7469"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]},{"id":"https://openalex.org/I4210123851","display_name":"Hope Center for Neurological Disorders","ror":"https://ror.org/035nzyk88","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210123851"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hong Jiang","raw_affiliation_strings":["Department of Neurology, Washington University School of Medicine , St. Louis, MO 63110 , USA","Hope Center for Neurological Disorders, Washington University School of Medicine , St. Louis, MO 63110 , USA","Knight Alzheimer\u2019s Disease Research Center, Washington University School of Medicine , St. Louis, MO 63108 , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Washington University School of Medicine , St. Louis, MO 63110 , USA","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"Hope Center for Neurological Disorders, Washington University School of Medicine , St. Louis, MO 63110 , USA","institution_ids":["https://openalex.org/I204465549","https://openalex.org/I4210123851"]},{"raw_affiliation_string":"Knight Alzheimer\u2019s Disease Research Center, Washington University School of Medicine , St. Louis, MO 63108 , USA","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088998527","display_name":"David M. Holtzman","orcid":"https://orcid.org/0000-0002-3400-0856","observed_orcids":["https://orcid.org/0000-0002-3400-0856"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]},{"id":"https://openalex.org/I4210123851","display_name":"Hope Center for Neurological Disorders","ror":"https://ror.org/035nzyk88","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210123851"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David M Holtzman","raw_affiliation_strings":["Department of Neurology, Washington University School of Medicine , St. Louis, MO 63110 , USA","Hope Center for Neurological Disorders, Washington University School of Medicine , St. Louis, MO 63110 , USA","Knight Alzheimer\u2019s Disease Research Center, Washington University School of Medicine , St. Louis, MO 63108 , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Washington University School of Medicine , St. Louis, MO 63110 , USA","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"Hope Center for Neurological Disorders, Washington University School of Medicine , St. Louis, MO 63110 , USA","institution_ids":["https://openalex.org/I204465549","https://openalex.org/I4210123851"]},{"raw_affiliation_string":"Knight Alzheimer\u2019s Disease Research Center, Washington University School of Medicine , St. Louis, MO 63108 , USA","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5022462599","display_name":"Randall John Bateman","orcid":"https://orcid.org/0000-0002-7729-1702","observed_orcids":["https://orcid.org/0000-0002-7729-1702"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]},{"id":"https://openalex.org/I4210123851","display_name":"Hope Center for Neurological Disorders","ror":"https://ror.org/035nzyk88","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210123851"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Randall J Bateman","raw_affiliation_strings":["Department of Neurology, Washington University School of Medicine , St. Louis, MO 63110 , USA","Hope Center for Neurological Disorders, Washington University School of Medicine , St. Louis, MO 63110 , USA","Knight Alzheimer\u2019s Disease Research Center, Washington University School of Medicine , St. Louis, MO 63108 , USA","Tracy Family SILQ Center, Washington University School of Medicine , St. Louis, MO 63110 , USA"],"raw_orcid":"https://orcid.org/0000-0002-7729-1702","affiliations":[{"raw_affiliation_string":"Department of Neurology, Washington University School of Medicine , St. Louis, MO 63110 , USA","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"Hope Center for Neurological Disorders, Washington University School of Medicine , St. Louis, MO 63110 , USA","institution_ids":["https://openalex.org/I204465549","https://openalex.org/I4210123851"]},{"raw_affiliation_string":"Knight Alzheimer\u2019s Disease Research Center, Washington University School of Medicine , St. Louis, MO 63108 , USA","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"Tracy Family SILQ Center, Washington University School of Medicine , St. Louis, MO 63110 , USA","institution_ids":["https://openalex.org/I204465549"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5022462599"],"corresponding_institution_ids":["https://openalex.org/I204465549","https://openalex.org/I4210123851"],"apc_list":{"value":3204,"currency":"GBP","value_usd":4095},"apc_paid":{"value":3204,"currency":"GBP","value_usd":4095},"fwci":4.8497,"has_fulltext":true,"cited_by_count":17,"citation_normalized_percentile":{"value":0.95949092,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":99},"biblio":{"volume":"6","issue":"4","first_page":"fcae247","last_page":"fcae247"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.6894999742507935,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.6894999742507935,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.19179999828338623,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10519","display_name":"Advanced Proteomics Techniques and Applications","score":0.033399999141693115,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neurofilament-light-chain","display_name":"neurofilament light chain","score":0.9909999966621399},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.8989999890327454},{"id":"https://openalex.org/keywords/preclinical-alzheimer-s-disease","display_name":"preclinical Alzheimer's disease","score":0.9819999933242798},{"id":"https://openalex.org/keywords/plasma-biomarkers","display_name":"plasma biomarkers","score":0.8709999918937683},{"id":"https://openalex.org/keywords/cerebrospinal-fluid","display_name":"cerebrospinal fluid","score":0.8930000066757202},{"id":"https://openalex.org/keywords/proteoforms","display_name":"proteoforms","score":0.8510000109672546},{"id":"https://openalex.org/keywords/peptide-profiling","display_name":"peptide profiling","score":0.7870000004768372},{"id":"https://openalex.org/keywords/monoclonal-antibodies","display_name":"monoclonal antibodies","score":0.8539999723434448},{"id":"https://openalex.org/keywords/age-related-increase","display_name":"age-related increase","score":0.3720000088214874},{"id":"https://openalex.org/keywords/body-mass-index","display_name":"body mass index","score":0.8510000109672546},{"id":"https://openalex.org/keywords/neurodegeneration","display_name":"neurodegeneration","score":0.5529999732971191}],"concepts":[{"id":"https://openalex.org/C157207234","wikidata":"https://www.wikidata.org/wiki/Q962115","display_name":"Neurofilament","level":3,"score":0.9157453775405884},{"id":"https://openalex.org/C36394416","wikidata":"https://www.wikidata.org/wiki/Q949267","display_name":"Immunoglobulin light chain","level":3,"score":0.7381706237792969},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.5262369513511658},{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.48022228479385376},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.45268288254737854},{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.4171852171421051},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.41686922311782837},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3607601523399353},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.33656060695648193},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.3239445984363556},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.2666410207748413},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2239251434803009},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2145160734653473}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1093/braincomms/fcae247","doi":"https://doi.org/10.1093/braincomms/fcae247","is_oa":true,"landing_page_url":"https://doi.org/10.1093/braincomms/fcae247","pdf_url":null,"source":{"id":"https://openalex.org/S4210235363","display_name":"Brain Communications","issn_l":"2632-1297","issn":["2632-1297"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brain Communications","raw_type":"journal-article"},{"id":"pmid:39165480","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39165480","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brain communications","raw_type":"Journal Article"},{"id":"pmh:oai:digitalcommons.wustl.edu:oa_4-8674","doi":null,"is_oa":true,"landing_page_url":"https://digitalcommons.wustl.edu/oa_4/7683","pdf_url":"https://digitalcommons.wustl.edu/context/oa_4/article/8674/viewcontent/Multi_peptide_characterization_of_plasma.pdf","source":{"id":"https://openalex.org/S4306400764","display_name":"Digital Commons@Becker (Washington University School of Medicine)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I204465549","host_organization_name":"Washington University in St. Louis","host_organization_lineage":["https://openalex.org/I204465549"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"2020-Current year OA Pubs","raw_type":"text"},{"id":"pmh:oai:pubmedcentral.nih.gov:11334934","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11334934","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11334934/pdf/fcae247.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Brain Commun","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/braincomms/fcae247","doi":"https://doi.org/10.1093/braincomms/fcae247","is_oa":true,"landing_page_url":"https://doi.org/10.1093/braincomms/fcae247","pdf_url":null,"source":{"id":"https://openalex.org/S4210235363","display_name":"Brain Communications","issn_l":"2632-1297","issn":["2632-1297"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brain Communications","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.7200000286102295}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G1064706334","display_name":null,"funder_award_id":"P30NS048056","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G1602390028","display_name":null,"funder_award_id":"P01-AG026276","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G2732375600","display_name":"Characterization of Neurofilament Light Chain in Alzheimer's Disease and Other Neurodegenerative Disorders","funder_award_id":"R21AG067559","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G3629740292","display_name":null,"funder_award_id":"P01 AG03991, P30 AG066444, P01 AG026276 and P30 NS048056","funder_id":"https://openalex.org/F4320327529","funder_display_name":"Norges Idrettsh\u00f8gskole"},{"id":"https://openalex.org/G4366310076","display_name":null,"funder_award_id":"R01NS065667","funder_id":"https://openalex.org/F4320327529","funder_display_name":"Norges Idrettsh\u00f8gskole"},{"id":"https://openalex.org/G7163257988","display_name":"Healthy Aging and Senile Dementia","funder_award_id":"P01AG003991","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G745210168","display_name":null,"funder_award_id":"R01 NS065667","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G9000002478","display_name":null,"funder_award_id":"P30-NS048056","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000060740","display_name":null,"funder_award_id":"P01AG026276","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000094498","display_name":null,"funder_award_id":"R01NS065667","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000239624","display_name":null,"funder_award_id":"AG 03991","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000266300","display_name":null,"funder_award_id":"AG066444","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000883349","display_name":"Alzheimer's Disease Research Center","funder_award_id":"P30AG066444","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"}],"funders":[{"id":"https://openalex.org/F4320327529","display_name":"Norges Idrettsh\u00f8gskole","ror":"https://ror.org/045016w83"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":29,"referenced_works":["https://openalex.org/W2006617902","https://openalex.org/W2030794912","https://openalex.org/W2073692210","https://openalex.org/W2133541776","https://openalex.org/W2141091417","https://openalex.org/W2525428069","https://openalex.org/W2599076725","https://openalex.org/W2600914407","https://openalex.org/W2604210857","https://openalex.org/W2730255373","https://openalex.org/W2736518852","https://openalex.org/W2910313823","https://openalex.org/W2939789416","https://openalex.org/W2966365568","https://openalex.org/W2995630198","https://openalex.org/W3004767455","https://openalex.org/W3024239323","https://openalex.org/W3033267790","https://openalex.org/W3045987239","https://openalex.org/W3183805246","https://openalex.org/W4212792306","https://openalex.org/W4220662787","https://openalex.org/W4220934337","https://openalex.org/W4254687493","https://openalex.org/W4292229870","https://openalex.org/W4309933528","https://openalex.org/W4324032790","https://openalex.org/W4327722598","https://openalex.org/W4384206832"],"related_works":["https://openalex.org/W2883286350","https://openalex.org/W4280573175","https://openalex.org/W3207243221","https://openalex.org/W4388597408","https://openalex.org/W2606815270","https://openalex.org/W4389373926","https://openalex.org/W3206148149","https://openalex.org/W6902342390","https://openalex.org/W4212792306","https://openalex.org/W3182172462"],"abstract_inverted_index":{"Although":[0],"neurofilament":[1,29,62,90],"light":[2,30,63,91],"chain":[3,31,64,92],"is":[4,17],"a":[5,22,80],"well-known":[6],"marker":[7],"of":[8,77],"neuronal":[9],"damage,":[10],"its":[11],"characterization":[12],"at":[13,34],"the":[14,35],"proteoform":[15],"level":[16],"underdeveloped.":[18],"Here,":[19],"we":[20],"describe":[21],"new":[23],"method":[24],"to":[25,51,65],"profile":[26],"and":[27,47,59,102,104,115,126,132,135],"quantify":[28],"in":[32,67,93],"plasma":[33,61,97,120],"peptide":[36],"level,":[37],"using":[38],"three":[39],"in-house":[40],"monoclonal":[41],"antibodies":[42],"targeting":[43],"distinct":[44],"protein":[45],"domains":[46],"nano-liquid":[48],"chromatography":[49],"coupled":[50],"high-resolution":[52],"tandem":[53],"mass":[54,139],"spectrometry.":[55],"This":[56],"study":[57],"profiled":[58],"compared":[60],"CSF":[66,105],"102":[68],"older":[69],"individuals":[70],"(73.9":[71],"\u00b1":[72],"6.3":[73],"years":[74],"old),":[75],"37":[76],"which":[78],"had":[79],"clinical":[81],"dementia":[82],"rating":[83],"greater":[84],"than":[85],"0.":[86],"We":[87,117],"observed":[88],"elevated":[89],"preclinical":[94],"Alzheimer's":[95],"disease":[96],"for":[98,106],"two":[99,133],"measures":[100,108],"(NfL101":[101],"NfL324)":[103,136],"seven":[107],"(NfL92,":[109,122],"NfL101,":[110,123],"NfL117,":[111,124],"NfL137,":[112],"NfL148,":[113],"NfL165":[114],"NfL530).":[116],"found":[118],"five":[119],"peptides":[121],"NfL324":[125],"NfL530)":[127],"significantly":[128],"associated":[129],"with":[130,137],"age":[131],"(NfL148":[134],"body":[138],"index.":[140]},"counts_by_year":[{"year":2026,"cited_by_count":8},{"year":2025,"cited_by_count":9}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2024-08-22T00:00:00"}
