{"id":"https://openalex.org/W4401728949","doi":"https://doi.org/10.1177/1358863x241265335","title":"Efficacy and safety of aspirin plus clopidogrel versus aspirin alone in ischemic stroke or high-risk transient ischemic attack: A meta-analysis of randomized controlled trials","display_name":"Efficacy and safety of aspirin plus clopidogrel versus aspirin alone in ischemic stroke or high-risk transient ischemic attack: A meta-analysis of randomized controlled trials","publication_year":2024,"publication_date":"2024-08-20","ids":{"openalex":"https://openalex.org/W4401728949","doi":"https://doi.org/10.1177/1358863x241265335","pmid":"https://pubmed.ncbi.nlm.nih.gov/39164077"},"language":"en","primary_location":{"id":"doi:10.1177/1358863x241265335","doi":"https://doi.org/10.1177/1358863x241265335","is_oa":false,"landing_page_url":"https://doi.org/10.1177/1358863x241265335","pdf_url":null,"source":{"id":"https://openalex.org/S139675103","display_name":"Vascular Medicine","issn_l":"1358-863X","issn":["1358-863X","1477-0377"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Vascular Medicine","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5004058768","display_name":"Mushood Ahmed","orcid":"https://orcid.org/0000-0001-9872-8224","observed_orcids":["https://orcid.org/0000-0001-9872-8224"]},"institutions":[{"id":"https://openalex.org/I171003132","display_name":"Rawalpindi Medical University","ror":"https://ror.org/02maedm12","country_code":"PK","type":"healthcare","lineage":["https://openalex.org/I171003132"]}],"countries":["PK"],"is_corresponding":true,"raw_author_name":"Mushood Ahmed","raw_affiliation_strings":["Department of Medicine, Rawalpindi Medical University, Rawalpindi, Pakistan"],"raw_orcid":"https://orcid.org/0000-0001-9872-8224","affiliations":[{"raw_affiliation_string":"Department of Medicine, Rawalpindi Medical University, Rawalpindi, Pakistan","institution_ids":["https://openalex.org/I171003132"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074770477","display_name":"Areeba Ahsan","orcid":"https://orcid.org/0000-0003-2390-7775","observed_orcids":["https://orcid.org/0000-0003-2390-7775","https://orcid.org/0009-0005-8209-3283"]},"institutions":[{"id":"https://openalex.org/I152236710","display_name":"Foundation University Islamabad","ror":"https://ror.org/0130a6s10","country_code":"PK","type":"education","lineage":["https://openalex.org/I152236710"]},{"id":"https://openalex.org/I2801712768","display_name":"Foundation University Medical College","ror":"https://ror.org/020jkns84","country_code":"PK","type":"education","lineage":["https://openalex.org/I2801712768"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Areeba Ahsan","raw_affiliation_strings":["Department of Medicine, Foundation University Medical College, Islamabad, Pakistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Foundation University Medical College, Islamabad, Pakistan","institution_ids":["https://openalex.org/I152236710","https://openalex.org/I2801712768"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058227461","display_name":"Laveeza Fatima","orcid":"https://orcid.org/0000-0002-4152-8202","observed_orcids":["https://orcid.org/0000-0002-4152-8202"]},"institutions":[{"id":"https://openalex.org/I205173300","display_name":"Allama Iqbal Medical College","ror":"https://ror.org/04vhsg885","country_code":"PK","type":"education","lineage":["https://openalex.org/I205173300"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Laveeza Fatima","raw_affiliation_strings":["Department of Medicine, Allama Iqbal Medical College, Lahore, Pakistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Allama Iqbal Medical College, Lahore, Pakistan","institution_ids":["https://openalex.org/I205173300"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003560282","display_name":"Jawad Basit","orcid":"https://orcid.org/0000-0002-5298-019X","observed_orcids":["https://orcid.org/0000-0002-5298-019X"]},"institutions":[{"id":"https://openalex.org/I171003132","display_name":"Rawalpindi Medical University","ror":"https://ror.org/02maedm12","country_code":"PK","type":"healthcare","lineage":["https://openalex.org/I171003132"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Jawad Basit","raw_affiliation_strings":["Cardiovascular Analytics Group, Canterbury, UK","Department of Medicine, Rawalpindi Medical University, Rawalpindi, Pakistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Analytics Group, Canterbury, UK","institution_ids":[]},{"raw_affiliation_string":"Department of Medicine, Rawalpindi Medical University, Rawalpindi, Pakistan","institution_ids":["https://openalex.org/I171003132"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072402135","display_name":"Abdulqadir J. Nashwan","orcid":"https://orcid.org/0000-0003-4845-4119","observed_orcids":["https://orcid.org/0000-0003-4845-4119"]},"institutions":[{"id":"https://openalex.org/I49828101","display_name":"Hamad Medical Corporation","ror":"https://ror.org/02zwb6n98","country_code":"QA","type":"nonprofit","lineage":["https://openalex.org/I49828101"]}],"countries":["QA"],"is_corresponding":false,"raw_author_name":"Abdulqadir J Nashwan","raw_affiliation_strings":["Hamad Medical Corporation, Doha, Qatar"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hamad Medical Corporation, Doha, Qatar","institution_ids":["https://openalex.org/I49828101"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086539587","display_name":"Shafaqat Ali","orcid":"https://orcid.org/0000-0002-3773-5196","observed_orcids":["https://orcid.org/0000-0002-3773-5196"]},"institutions":[{"id":"https://openalex.org/I26489229","display_name":"Louisiana State University in Shreveport","ror":"https://ror.org/02c4cbt39","country_code":"US","type":"education","lineage":["https://openalex.org/I26489229"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shafaqat Ali","raw_affiliation_strings":["Louisiana State University, Shreveport, LA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Louisiana State University, Shreveport, LA, USA","institution_ids":["https://openalex.org/I26489229"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113399281","display_name":"Mohammad Hamza","orcid":"https://orcid.org/0000-0002-6237-0221","observed_orcids":["https://orcid.org/0000-0002-6237-0221"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mohammad Hamza","raw_affiliation_strings":["Guthrie Medical Group, Cortland, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Guthrie Medical Group, Cortland, NY, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010676818","display_name":"Iosif Karalis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210096640","display_name":"Royal Brompton Hospital","ror":"https://ror.org/00cv4n034","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2800036501","https://openalex.org/I4210096640"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Iosif Karalis","raw_affiliation_strings":["Royal Brompton Hospital, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Royal Brompton Hospital, London, UK","institution_ids":["https://openalex.org/I4210096640"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080908050","display_name":"Raheel Ahmed","orcid":"https://orcid.org/0000-0003-2814-7314","observed_orcids":["https://orcid.org/0000-0003-2814-7314"]},"institutions":[{"id":"https://openalex.org/I4210096640","display_name":"Royal Brompton Hospital","ror":"https://ror.org/00cv4n034","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2800036501","https://openalex.org/I4210096640"]},{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Raheel Ahmed","raw_affiliation_strings":["National Heart and Lung Institute, Imperial College London, London, UK","Royal Brompton Hospital, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Heart and Lung Institute, Imperial College London, London, UK","institution_ids":["https://openalex.org/I47508984"]},{"raw_affiliation_string":"Royal Brompton Hospital, London, UK","institution_ids":["https://openalex.org/I4210096640"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053214014","display_name":"Ahmad Alareed","orcid":"https://orcid.org/0009-0008-5478-4871","observed_orcids":["https://orcid.org/0009-0008-5478-4871"]},"institutions":[{"id":"https://openalex.org/I2802965805","display_name":"University Hospital Southampton NHS Foundation Trust","ror":"https://ror.org/0485axj58","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802965805"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Ahmad Alareed","raw_affiliation_strings":["Division of Neurophysiology, University Hospital Southampton (UHS), Southampton, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Neurophysiology, University Hospital Southampton (UHS), Southampton, UK","institution_ids":["https://openalex.org/I2802965805"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056260101","display_name":"Nkechinyere Ijioma","orcid":"https://orcid.org/0000-0002-6982-3158","observed_orcids":["https://orcid.org/0000-0002-6982-3158"]},"institutions":[{"id":"https://openalex.org/I2802841970","display_name":"The Ohio State University Wexner Medical Center","ror":"https://ror.org/00c01js51","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2802841970"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nkechinyere N Ijioma","raw_affiliation_strings":["Ohio State University Wexner Medical Center, Columbus, OH, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ohio State University Wexner Medical Center, Columbus, OH, USA","institution_ids":["https://openalex.org/I2802841970"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5087694600","display_name":"M. Chadi Alraies","orcid":"https://orcid.org/0000-0002-7874-4566","observed_orcids":["https://orcid.org/0000-0002-7874-4566"]},"institutions":[{"id":"https://openalex.org/I185443292","display_name":"Wayne State University","ror":"https://ror.org/01070mq45","country_code":"US","type":"education","lineage":["https://openalex.org/I185443292"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M Chadi Alraies","raw_affiliation_strings":["Wayne State University, Detroit, MI, USA"],"raw_orcid":"https://orcid.org/0000-0002-7874-4566","affiliations":[{"raw_affiliation_string":"Wayne State University, Detroit, MI, USA","institution_ids":["https://openalex.org/I185443292"]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":11,"corresponding_author_ids":["https://openalex.org/A5004058768"],"corresponding_institution_ids":["https://openalex.org/I171003132"],"apc_list":{"value":4200,"currency":"USD","value_usd":4200},"apc_paid":null,"fwci":2.3726,"has_fulltext":false,"cited_by_count":18,"citation_normalized_percentile":{"value":0.89774859,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"29","issue":"5","first_page":"517","last_page":"525"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11064","display_name":"Antiplatelet Therapy and Cardiovascular Diseases","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11064","display_name":"Antiplatelet Therapy and Cardiovascular Diseases","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10227","display_name":"Acute Ischemic Stroke Management","score":0.002899999963119626,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10816","display_name":"Cerebrovascular and Carotid Artery Diseases","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dual-antiplatelet-therapy","display_name":"dual antiplatelet therapy","score":0.9179999828338623},{"id":"https://openalex.org/keywords/aspirin","display_name":"aspirin","score":0.9470000267028809},{"id":"https://openalex.org/keywords/clopidogrel","display_name":"clopidogrel","score":1.0},{"id":"https://openalex.org/keywords/ischemic-stroke","display_name":"ischemic stroke","score":0.8690000176429749},{"id":"https://openalex.org/keywords/transient-ischemic-attack","display_name":"transient ischemic attack","score":0.9169999957084656},{"id":"https://openalex.org/keywords/stroke-recurrence","display_name":"stroke recurrence","score":0.6299999952316284},{"id":"https://openalex.org/keywords/major-adverse-cardiovascular-events","display_name":"major adverse cardiovascular events","score":0.8700000047683716},{"id":"https://openalex.org/keywords/bleeding-risk","display_name":"bleeding risk","score":0.8650000095367432},{"id":"https://openalex.org/keywords/hemorrhagic-stroke","display_name":"hemorrhagic stroke","score":0.9549999833106995},{"id":"https://openalex.org/keywords/all-cause-mortality","display_name":"all-cause mortality","score":0.8360000252723694},{"id":"https://openalex.org/keywords/cardiovascular-mortality","display_name":"cardiovascular mortality","score":0.8220000267028809},{"id":"https://openalex.org/keywords/myocardial-infarction","display_name":"myocardial infarction","score":0.9409999847412109},{"id":"https://openalex.org/keywords/antiplatelet-therapy","display_name":"antiplatelet therapy","score":0.6830000281333923},{"id":"https://openalex.org/keywords/secondary-stroke-prevention","display_name":"secondary stroke prevention","score":0.5580000281333923},{"id":"https://openalex.org/keywords/treatment-efficacy-and-safety","display_name":"treatment efficacy and safety","score":0.44999998807907104},{"id":"https://openalex.org/keywords/bleeding-risk-stratification","display_name":"bleeding risk stratification","score":0.3490000069141388}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.977144718170166},{"id":"https://openalex.org/C2777628954","wikidata":"https://www.wikidata.org/wiki/Q18216","display_name":"Aspirin","level":2,"score":0.9405121803283691},{"id":"https://openalex.org/C2777849778","wikidata":"https://www.wikidata.org/wiki/Q410237","display_name":"Clopidogrel","level":3,"score":0.8716473579406738},{"id":"https://openalex.org/C2780645631","wikidata":"https://www.wikidata.org/wiki/Q671554","display_name":"Stroke (engine)","level":2,"score":0.6669945120811462},{"id":"https://openalex.org/C3020199598","wikidata":"https://www.wikidata.org/wiki/Q12202","display_name":"Ischemic stroke","level":3,"score":0.6257660388946533},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.5411086082458496},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.5363174080848694},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5256444215774536},{"id":"https://openalex.org/C2909112448","wikidata":"https://www.wikidata.org/wiki/Q721432","display_name":"Platelet aggregation inhibitor","level":3,"score":0.4317641258239746},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.3342534303665161},{"id":"https://openalex.org/C541997718","wikidata":"https://www.wikidata.org/wiki/Q188151","display_name":"Ischemia","level":2,"score":0.19747665524482727},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C78519656","wikidata":"https://www.wikidata.org/wiki/Q101333","display_name":"Mechanical engineering","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000077144","descriptor_name":"Clopidogrel","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D000077144","descriptor_name":"Clopidogrel","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D000077144","descriptor_name":"Clopidogrel","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D000077144","descriptor_name":"Clopidogrel","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D000077144","descriptor_name":"Clopidogrel","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D000077144","descriptor_name":"Clopidogrel","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D000077144","descriptor_name":"Clopidogrel","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D000077144","descriptor_name":"Clopidogrel","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D000077144","descriptor_name":"Clopidogrel","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D000077144","descriptor_name":"Clopidogrel","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D000077144","descriptor_name":"Clopidogrel","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D000077144","descriptor_name":"Clopidogrel","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D000080903","descriptor_name":"Dual Anti-Platelet Therapy","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D000080903","descriptor_name":"Dual Anti-Platelet Therapy","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D000080903","descriptor_name":"Dual Anti-Platelet Therapy","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D000080903","descriptor_name":"Dual Anti-Platelet Therapy","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D000080903","descriptor_name":"Dual Anti-Platelet Therapy","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D000080903","descriptor_name":"Dual Anti-Platelet Therapy","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D000083242","descriptor_name":"Ischemic Stroke","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D000083242","descriptor_name":"Ischemic Stroke","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D000083242","descriptor_name":"Ischemic Stroke","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D000083242","descriptor_name":"Ischemic Stroke","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D000083242","descriptor_name":"Ischemic Stroke","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D000083242","descriptor_name":"Ischemic Stroke","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D000083242","descriptor_name":"Ischemic Stroke","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":true},{"descriptor_ui":"D000083242","descriptor_name":"Ischemic Stroke","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":true},{"descriptor_ui":"D000083242","descriptor_name":"Ischemic Stroke","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":true},{"descriptor_ui":"D000083242","descriptor_name":"Ischemic Stroke","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":true},{"descriptor_ui":"D000083242","descriptor_name":"Ischemic Stroke","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":true},{"descriptor_ui":"D000083242","descriptor_name":"Ischemic Stroke","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":true},{"descriptor_ui":"D000083242","descriptor_name":"Ischemic Stroke","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D000083242","descriptor_name":"Ischemic Stroke","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D000083242","descriptor_name":"Ischemic Stroke","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D000083242","descriptor_name":"Ischemic Stroke","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D000083242","descriptor_name":"Ischemic Stroke","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D000083242","descriptor_name":"Ischemic Stroke","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001241","descriptor_name":"Aspirin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D001241","descriptor_name":"Aspirin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D001241","descriptor_name":"Aspirin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D001241","descriptor_name":"Aspirin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D001241","descriptor_name":"Aspirin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D001241","descriptor_name":"Aspirin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D001241","descriptor_name":"Aspirin","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D001241","descriptor_name":"Aspirin","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D001241","descriptor_name":"Aspirin","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D001241","descriptor_name":"Aspirin","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D001241","descriptor_name":"Aspirin","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D001241","descriptor_name":"Aspirin","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D002546","descriptor_name":"Ischemic Attack, Transient","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":true},{"descriptor_ui":"D002546","descriptor_name":"Ischemic Attack, Transient","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":true},{"descriptor_ui":"D002546","descriptor_name":"Ischemic Attack, Transient","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":true},{"descriptor_ui":"D002546","descriptor_name":"Ischemic Attack, Transient","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":true},{"descriptor_ui":"D002546","descriptor_name":"Ischemic Attack, Transient","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":true},{"descriptor_ui":"D002546","descriptor_name":"Ischemic Attack, Transient","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":true},{"descriptor_ui":"D002546","descriptor_name":"Ischemic Attack, Transient","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D002546","descriptor_name":"Ischemic Attack, Transient","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D002546","descriptor_name":"Ischemic Attack, Transient","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D002546","descriptor_name":"Ischemic Attack, Transient","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D002546","descriptor_name":"Ischemic Attack, Transient","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D002546","descriptor_name":"Ischemic Attack, Transient","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D004359","descriptor_name":"Drug Therapy, Combination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004359","descriptor_name":"Drug Therapy, Combination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004359","descriptor_name":"Drug Therapy, Combination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004359","descriptor_name":"Drug Therapy, Combination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004359","descriptor_name":"Drug Therapy, Combination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004359","descriptor_name":"Drug Therapy, Combination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006470","descriptor_name":"Hemorrhage","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D006470","descriptor_name":"Hemorrhage","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D006470","descriptor_name":"Hemorrhage","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D006470","descriptor_name":"Hemorrhage","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D006470","descriptor_name":"Hemorrhage","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D006470","descriptor_name":"Hemorrhage","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010975","descriptor_name":"Platelet Aggregation Inhibitors","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D010975","descriptor_name":"Platelet Aggregation Inhibitors","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D010975","descriptor_name":"Platelet Aggregation Inhibitors","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D010975","descriptor_name":"Platelet Aggregation Inhibitors","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D010975","descriptor_name":"Platelet Aggregation Inhibitors","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D010975","descriptor_name":"Platelet Aggregation Inhibitors","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D010975","descriptor_name":"Platelet Aggregation Inhibitors","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D010975","descriptor_name":"Platelet Aggregation Inhibitors","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D010975","descriptor_name":"Platelet Aggregation Inhibitors","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D010975","descriptor_name":"Platelet Aggregation Inhibitors","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D010975","descriptor_name":"Platelet Aggregation Inhibitors","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D010975","descriptor_name":"Platelet Aggregation Inhibitors","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D012008","descriptor_name":"Recurrence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012008","descriptor_name":"Recurrence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012008","descriptor_name":"Recurrence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012008","descriptor_name":"Recurrence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012008","descriptor_name":"Recurrence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012008","descriptor_name":"Recurrence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016017","descriptor_name":"Odds Ratio","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016017","descriptor_name":"Odds Ratio","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016017","descriptor_name":"Odds Ratio","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016017","descriptor_name":"Odds Ratio","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016017","descriptor_name":"Odds Ratio","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016017","descriptor_name":"Odds Ratio","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016032","descriptor_name":"Randomized Controlled Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016032","descriptor_name":"Randomized Controlled Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016032","descriptor_name":"Randomized Controlled Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016032","descriptor_name":"Randomized Controlled Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016032","descriptor_name":"Randomized Controlled Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016032","descriptor_name":"Randomized Controlled Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018570","descriptor_name":"Risk Assessment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018570","descriptor_name":"Risk Assessment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018570","descriptor_name":"Risk Assessment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018570","descriptor_name":"Risk Assessment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018570","descriptor_name":"Risk Assessment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018570","descriptor_name":"Risk Assessment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055502","descriptor_name":"Secondary Prevention","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055502","descriptor_name":"Secondary Prevention","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055502","descriptor_name":"Secondary Prevention","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055502","descriptor_name":"Secondary Prevention","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055502","descriptor_name":"Secondary Prevention","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055502","descriptor_name":"Secondary Prevention","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1177/1358863x241265335","doi":"https://doi.org/10.1177/1358863x241265335","is_oa":false,"landing_page_url":"https://doi.org/10.1177/1358863x241265335","pdf_url":null,"source":{"id":"https://openalex.org/S139675103","display_name":"Vascular Medicine","issn_l":"1358-863X","issn":["1358-863X","1477-0377"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Vascular Medicine","raw_type":"journal-article"},{"id":"pmid:39164077","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39164077","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Vascular medicine (London, England)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8399999737739563}],"study_designs":[{"id":"https://openalex.org/study-designs/systematic-review","display_name":"Systematic Review"},{"id":"https://openalex.org/study-designs/meta-analysis","display_name":"Meta-Analysis"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":23,"referenced_works":["https://openalex.org/W1968961210","https://openalex.org/W2000244911","https://openalex.org/W2081615170","https://openalex.org/W2092001267","https://openalex.org/W2107328434","https://openalex.org/W2111089169","https://openalex.org/W2125435699","https://openalex.org/W2132247347","https://openalex.org/W2139156225","https://openalex.org/W2150912899","https://openalex.org/W2165920141","https://openalex.org/W2316997036","https://openalex.org/W2339795684","https://openalex.org/W2804570339","https://openalex.org/W2911196419","https://openalex.org/W2969448124","https://openalex.org/W2970684805","https://openalex.org/W2979817571","https://openalex.org/W2991016007","https://openalex.org/W3043492355","https://openalex.org/W3118615836","https://openalex.org/W4385809604","https://openalex.org/W4390262423"],"related_works":["https://openalex.org/W2336413601","https://openalex.org/W2883947381","https://openalex.org/W2394368222","https://openalex.org/W2263774463","https://openalex.org/W188894582","https://openalex.org/W2099734408","https://openalex.org/W1977409210","https://openalex.org/W1970178609","https://openalex.org/W2098421595","https://openalex.org/W2391224852"],"abstract_inverted_index":{"Background:":[0],"Antiplatelet":[1],"therapy":[2,41],"plays":[3],"an":[4,251],"important":[5],"role":[6],"in":[7,14,38,47,77,110],"reducing":[8],"the":[9,29,116],"risk":[10,92,117,171,253],"of":[11,33,118,172,254],"stroke":[12,19,50,80,120,132,196,243],"recurrence":[13,244],"patients":[15,107],"with":[16,96,105,167],"mild":[17,48,78],"ischemic":[18,23,49,79,131],"or":[20,81,174,256],"high-risk":[21,82],"transient":[22],"attack":[24],"(TIA).":[25],"However,":[26,163],"data":[27],"regarding":[28],"effectiveness":[30],"and":[31,58,143,225,245],"safety":[32],"using":[34],"aspirin":[35,45,71,161,187,239,261],"plus":[36,240],"clopidogrel":[37,241],"dual":[39],"antiplatelet":[40],"(DAPT)":[42],"compared":[43,68,159,185,259],"to":[44,70,90,160,186,250,260],"alone":[46,72],"is":[51],"limited.":[52],"Methods:":[53],"PubMed/MEDLINE,":[54],"Embase,":[55],"Cochrane":[56],"Library,":[57],"ClinicalTrials.gov":[59],"were":[60,108,192],"searched":[61],"for":[62,99,194],"randomized":[63],"controlled":[64],"trials":[65],"(RCTs)":[66],"that":[67],"DAPT":[69,113,164,237],"started":[73],"within":[74],"72":[75],"hours":[76],"TIA.":[83],"We":[84],"used":[85],"a":[86,168],"random":[87],"effects":[88],"model":[89],"pool":[91],"ratios":[93],"(RRs)":[94],"along":[95],"95%":[97,125,137,153,179,199,209,219,230],"CIs":[98],"clinical":[100],"outcomes.":[101],"Results:":[102],"Four":[103],"RCTs":[104],"16,547":[106],"included":[109],"this":[111],"study.":[112],"significantly":[114,169],"reduced":[115],"recurrent":[119],"by":[121,133,149],"26%":[122],"(RR:":[123,135,151,177,197,207,217,228],"0.74;":[124],"CI:":[126,138,154,180,200,210,220,231],"0.67\u20130.83;":[127],"p":[128,140,156,182,202,212,222,233],"<":[129,141,157],"0.00001),":[130,142],"28%":[134],"0.72;":[136],"0.65\u20130.80;":[139],"major":[144],"adverse":[145],"cardiovascular":[146,215],"events":[147],"(MACE)":[148],"24%":[150],"0.76;":[152],"0.68\u20130.84;":[155],"0.00001)":[158],"monotherapy.":[162,262],"was":[165],"associated":[166],"increased":[170,252],"moderate":[173,255],"severe":[175,257],"bleeding":[176,258],"1.88;":[178],"1.10\u20133.23;":[181],"=":[183,203,213,223,234],"0.02)":[184],"alone.":[188],"No":[189],"significant":[190],"differences":[191],"observed":[193],"hemorrhagic":[195],"1.77;":[198],"0.96\u20133.29;":[201],"0.07),":[204],"all-cause":[205],"mortality":[206,216],"1.25;":[208],"0.87\u20131.80;":[211],"0.23),":[214,224],"1.38;":[218],"0.81\u20132.33;":[221],"myocardial":[226],"infarction":[227],"1.63;":[229],"0.77\u20133.46;":[232],"0.20).":[235],"Conclusion:":[236],"involving":[238],"reduces":[242],"MACE":[246],"but":[247],"can":[248],"lead":[249],"(PROSPERO":[263],"ID:":[264],"CRD42024499310)":[265]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":15}],"updated_date":"2026-10-10T09:11:00.788812","created_date":"2025-10-10T00:00:00"}