{"id":"https://openalex.org/W4401715744","doi":"https://doi.org/10.1158/1535-7163.mct-23-0833","title":"Trametinib Potentiates Anti-PD-1 Efficacy in Tumors Established from Chemotherapy-Primed Pancreatic Cancer Cells","display_name":"Trametinib Potentiates Anti-PD-1 Efficacy in Tumors Established from Chemotherapy-Primed Pancreatic Cancer Cells","publication_year":2024,"publication_date":"2024-08-20","ids":{"openalex":"https://openalex.org/W4401715744","doi":"https://doi.org/10.1158/1535-7163.mct-23-0833","pmid":"https://pubmed.ncbi.nlm.nih.gov/39162011"},"language":"en","primary_location":{"id":"doi:10.1158/1535-7163.mct-23-0833","doi":"https://doi.org/10.1158/1535-7163.mct-23-0833","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1535-7163.mct-23-0833","pdf_url":null,"source":{"id":"https://openalex.org/S48437117","display_name":"Molecular Cancer Therapeutics","issn_l":"1535-7163","issn":["1535-7163","1538-8514"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Cancer Therapeutics","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11614707/pdf/nihms-2019210.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5039554820","display_name":"Thao D. Pham","orcid":"https://orcid.org/0000-0001-7547-0945","observed_orcids":["https://orcid.org/0000-0001-7547-0945"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]},{"id":"https://openalex.org/I4390039227","display_name":"Robert H. Lurie Comprehensive Cancer Center of Northwestern University","ror":"https://ror.org/02p4far57","country_code":null,"type":"healthcare","lineage":["https://openalex.org/I4210147348","https://openalex.org/I4390039227"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thao D. Pham","raw_affiliation_strings":["1Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois","2The Robert H. Lurie Comprehensive Cancer Center, Chicago, Illinois","Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois. 1","The Robert H. Lurie Comprehensive Cancer Center, Chicago, Illinois. 2"],"raw_orcid":"https://orcid.org/0000-0001-7547-0945","affiliations":[{"raw_affiliation_string":"1Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois","institution_ids":["https://openalex.org/I111979921"]},{"raw_affiliation_string":"2The Robert H. Lurie Comprehensive Cancer Center, Chicago, Illinois","institution_ids":["https://openalex.org/I4390039227"]},{"raw_affiliation_string":"Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois. 1","institution_ids":["https://openalex.org/I111979921"]},{"raw_affiliation_string":"The Robert H. Lurie Comprehensive Cancer Center, Chicago, Illinois. 2","institution_ids":["https://openalex.org/I4390039227"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009212491","display_name":"Anastasia E. Metropulos","orcid":"https://orcid.org/0000-0003-0504-6270","observed_orcids":["https://orcid.org/0000-0003-0504-6270"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]},{"id":"https://openalex.org/I4210135737","display_name":"Jesse Brown VA Medical Center","ror":"https://ror.org/049qtwc86","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210115976","https://openalex.org/I4210135737"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anastasia E. Metropulos","raw_affiliation_strings":["1Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois","3Jesse Brown VA Medical Center, Chicago, Illinois","Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois. 1","Jesse Brown VA Medical Center, Chicago, Illinois. 3"],"raw_orcid":"https://orcid.org/0000-0003-0504-6270","affiliations":[{"raw_affiliation_string":"1Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois","institution_ids":["https://openalex.org/I111979921"]},{"raw_affiliation_string":"3Jesse Brown VA Medical Center, Chicago, Illinois","institution_ids":["https://openalex.org/I4210135737"]},{"raw_affiliation_string":"Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois. 1","institution_ids":["https://openalex.org/I111979921"]},{"raw_affiliation_string":"Jesse Brown VA Medical Center, Chicago, Illinois. 3","institution_ids":["https://openalex.org/I4210135737"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084485764","display_name":"Nida Mubin","orcid":"https://orcid.org/0000-0001-9399-5008","observed_orcids":["https://orcid.org/0000-0001-9399-5008"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nida Mubin","raw_affiliation_strings":["1Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois","Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois. 1"],"raw_orcid":"https://orcid.org/0000-0001-9399-5008","affiliations":[{"raw_affiliation_string":"1Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois","institution_ids":["https://openalex.org/I111979921"]},{"raw_affiliation_string":"Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois. 1","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072157650","display_name":"Jeffrey H. Becker","orcid":"https://orcid.org/0000-0001-7645-2466","observed_orcids":["https://orcid.org/0000-0001-7645-2466"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]},{"id":"https://openalex.org/I4210135737","display_name":"Jesse Brown VA Medical Center","ror":"https://ror.org/049qtwc86","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210115976","https://openalex.org/I4210135737"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeffrey H. Becker","raw_affiliation_strings":["1Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois","3Jesse Brown VA Medical Center, Chicago, Illinois","Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois. 1","Jesse Brown VA Medical Center, Chicago, Illinois. 3"],"raw_orcid":"https://orcid.org/0000-0001-7645-2466","affiliations":[{"raw_affiliation_string":"1Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois","institution_ids":["https://openalex.org/I111979921"]},{"raw_affiliation_string":"3Jesse Brown VA Medical Center, Chicago, Illinois","institution_ids":["https://openalex.org/I4210135737"]},{"raw_affiliation_string":"Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois. 1","institution_ids":["https://openalex.org/I111979921"]},{"raw_affiliation_string":"Jesse Brown VA Medical Center, Chicago, Illinois. 3","institution_ids":["https://openalex.org/I4210135737"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053195132","display_name":"Dhavan N. Shah","orcid":"https://orcid.org/0000-0001-7519-1065","observed_orcids":["https://orcid.org/0000-0001-7519-1065"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dhavan Shah","raw_affiliation_strings":["4Department of Surgery, Feinberg School of Medicine, Northwestern University, Chicago, Illinois","Department of Surgery, Feinberg School of Medicine, Northwestern University, Chicago, Illinois. 4"],"raw_orcid":"https://orcid.org/0000-0001-7519-1065","affiliations":[{"raw_affiliation_string":"4Department of Surgery, Feinberg School of Medicine, Northwestern University, Chicago, Illinois","institution_ids":["https://openalex.org/I111979921"]},{"raw_affiliation_string":"Department of Surgery, Feinberg School of Medicine, Northwestern University, Chicago, Illinois. 4","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059353717","display_name":"Christina Spaulding","orcid":"https://orcid.org/0009-0004-3658-421X","observed_orcids":["https://orcid.org/0009-0004-3658-421X"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]},{"id":"https://openalex.org/I4210135737","display_name":"Jesse Brown VA Medical Center","ror":"https://ror.org/049qtwc86","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210115976","https://openalex.org/I4210135737"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christina Spaulding","raw_affiliation_strings":["1Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois","3Jesse Brown VA Medical Center, Chicago, Illinois","Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois. 1","Jesse Brown VA Medical Center, Chicago, Illinois. 3"],"raw_orcid":"https://orcid.org/0009-0004-3658-421X","affiliations":[{"raw_affiliation_string":"1Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois","institution_ids":["https://openalex.org/I111979921"]},{"raw_affiliation_string":"3Jesse Brown VA Medical Center, Chicago, Illinois","institution_ids":["https://openalex.org/I4210135737"]},{"raw_affiliation_string":"Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois. 1","institution_ids":["https://openalex.org/I111979921"]},{"raw_affiliation_string":"Jesse Brown VA Medical Center, Chicago, Illinois. 3","institution_ids":["https://openalex.org/I4210135737"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020129454","display_name":"Mario A. Shields","orcid":"https://orcid.org/0000-0002-3562-9875","observed_orcids":["https://orcid.org/0000-0002-3562-9875"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]},{"id":"https://openalex.org/I4390039227","display_name":"Robert H. Lurie Comprehensive Cancer Center of Northwestern University","ror":"https://ror.org/02p4far57","country_code":null,"type":"healthcare","lineage":["https://openalex.org/I4210147348","https://openalex.org/I4390039227"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mario A. Shields","raw_affiliation_strings":["1Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois","2The Robert H. Lurie Comprehensive Cancer Center, Chicago, Illinois","Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois. 1","The Robert H. Lurie Comprehensive Cancer Center, Chicago, Illinois. 2"],"raw_orcid":"https://orcid.org/0000-0002-3562-9875","affiliations":[{"raw_affiliation_string":"1Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois","institution_ids":["https://openalex.org/I111979921"]},{"raw_affiliation_string":"2The Robert H. Lurie Comprehensive Cancer Center, Chicago, Illinois","institution_ids":["https://openalex.org/I4390039227"]},{"raw_affiliation_string":"Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois. 1","institution_ids":["https://openalex.org/I111979921"]},{"raw_affiliation_string":"The Robert H. Lurie Comprehensive Cancer Center, Chicago, Illinois. 2","institution_ids":["https://openalex.org/I4390039227"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043187990","display_name":"David J. Bentrem","orcid":"https://orcid.org/0009-0007-2506-6187","observed_orcids":["https://orcid.org/0009-0007-2506-6187"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]},{"id":"https://openalex.org/I4210135737","display_name":"Jesse Brown VA Medical Center","ror":"https://ror.org/049qtwc86","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210115976","https://openalex.org/I4210135737"]},{"id":"https://openalex.org/I4390039227","display_name":"Robert H. Lurie Comprehensive Cancer Center of Northwestern University","ror":"https://ror.org/02p4far57","country_code":null,"type":"healthcare","lineage":["https://openalex.org/I4210147348","https://openalex.org/I4390039227"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David J. Bentrem","raw_affiliation_strings":["2The Robert H. Lurie Comprehensive Cancer Center, Chicago, Illinois","3Jesse Brown VA Medical Center, Chicago, Illinois","4Department of Surgery, Feinberg School of Medicine, Northwestern University, Chicago, Illinois","Department of Surgery, Feinberg School of Medicine, Northwestern University, Chicago, Illinois. 4","Jesse Brown VA Medical Center, Chicago, Illinois. 3","The Robert H. Lurie Comprehensive Cancer Center, Chicago, Illinois. 2"],"raw_orcid":"https://orcid.org/0009-0007-2506-6187","affiliations":[{"raw_affiliation_string":"2The Robert H. Lurie Comprehensive Cancer Center, Chicago, Illinois","institution_ids":["https://openalex.org/I4390039227"]},{"raw_affiliation_string":"3Jesse Brown VA Medical Center, Chicago, Illinois","institution_ids":["https://openalex.org/I4210135737"]},{"raw_affiliation_string":"4Department of Surgery, Feinberg School of Medicine, Northwestern University, Chicago, Illinois","institution_ids":["https://openalex.org/I111979921"]},{"raw_affiliation_string":"Department of Surgery, Feinberg School of Medicine, Northwestern University, Chicago, Illinois. 4","institution_ids":["https://openalex.org/I111979921"]},{"raw_affiliation_string":"Jesse Brown VA Medical Center, Chicago, Illinois. 3","institution_ids":["https://openalex.org/I4210135737"]},{"raw_affiliation_string":"The Robert H. Lurie Comprehensive Cancer Center, Chicago, Illinois. 2","institution_ids":["https://openalex.org/I4390039227"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5001372566","display_name":"Hidayatullah G. Munshi","orcid":"https://orcid.org/0000-0002-9552-0775","observed_orcids":["https://orcid.org/0000-0002-9552-0775"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]},{"id":"https://openalex.org/I4210135737","display_name":"Jesse Brown VA Medical Center","ror":"https://ror.org/049qtwc86","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210115976","https://openalex.org/I4210135737"]},{"id":"https://openalex.org/I4390039227","display_name":"Robert H. Lurie Comprehensive Cancer Center of Northwestern University","ror":"https://ror.org/02p4far57","country_code":null,"type":"healthcare","lineage":["https://openalex.org/I4210147348","https://openalex.org/I4390039227"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hidayatullah G. Munshi","raw_affiliation_strings":["1Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois","2The Robert H. Lurie Comprehensive Cancer Center, Chicago, Illinois","3Jesse Brown VA Medical Center, Chicago, Illinois","Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois. 1","Jesse Brown VA Medical Center, Chicago, Illinois. 3","The Robert H. Lurie Comprehensive Cancer Center, Chicago, Illinois. 2"],"raw_orcid":"https://orcid.org/0000-0002-9552-0775","affiliations":[{"raw_affiliation_string":"1Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois","institution_ids":["https://openalex.org/I111979921"]},{"raw_affiliation_string":"2The Robert H. Lurie Comprehensive Cancer Center, Chicago, Illinois","institution_ids":["https://openalex.org/I4390039227"]},{"raw_affiliation_string":"3Jesse Brown VA Medical Center, Chicago, Illinois","institution_ids":["https://openalex.org/I4210135737"]},{"raw_affiliation_string":"Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois. 1","institution_ids":["https://openalex.org/I111979921"]},{"raw_affiliation_string":"Jesse Brown VA Medical Center, Chicago, Illinois. 3","institution_ids":["https://openalex.org/I4210135737"]},{"raw_affiliation_string":"The Robert H. Lurie Comprehensive Cancer Center, Chicago, Illinois. 2","institution_ids":["https://openalex.org/I4390039227"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.3725,"has_fulltext":true,"cited_by_count":9,"citation_normalized_percentile":{"value":0.83644211,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"23","issue":"12","first_page":"1854","last_page":"1865"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.8511000275611877,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.8511000275611877,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.13819999992847443,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11533","display_name":"Melanoma and MAPK Pathways","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/trametinib","display_name":"trametinib","score":0.972000002861023},{"id":"https://openalex.org/keywords/anti-pd-1-antibody","display_name":"anti-PD-1","score":0.875},{"id":"https://openalex.org/keywords/pancreatic-ductal-adenocarcinoma","display_name":"pancreatic ductal adenocarcinoma","score":0.9789999723434448},{"id":"https://openalex.org/keywords/folfirinox","display_name":"FOLFIRINOX","score":0.9190000295639038},{"id":"https://openalex.org/keywords/mek-erk-signaling","display_name":"MEK/ERK signaling","score":0.9769999980926514},{"id":"https://openalex.org/keywords/immune-checkpoint-inhibitors","display_name":"immune checkpoint inhibitors","score":0.6909999847412109},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.5789999961853027},{"id":"https://openalex.org/keywords/cd8-t-cell-infiltration","display_name":"CD8+ T cell infiltration","score":0.902999997138977},{"id":"https://openalex.org/keywords/tumor-immune-microenvironment","display_name":"tumor immune microenvironment","score":0.8059999942779541},{"id":"https://openalex.org/keywords/kpc-cells","display_name":"KPC cells","score":0.6079999804496765},{"id":"https://openalex.org/keywords/neoadjuvant-chemotherapy","display_name":"neoadjuvant chemotherapy","score":0.7799999713897705}],"concepts":[{"id":"https://openalex.org/C2778472372","wikidata":"https://www.wikidata.org/wiki/Q7833138","display_name":"Trametinib","level":4,"score":0.7914764285087585},{"id":"https://openalex.org/C2780210213","wikidata":"https://www.wikidata.org/wiki/Q212961","display_name":"Pancreatic cancer","level":3,"score":0.7441999912261963},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.6561231017112732},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5881697535514832},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5161155462265015},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4544042944908142},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3775530159473419},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3709396719932556},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2781428396701813},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.10794708132743835},{"id":"https://openalex.org/C57074206","wikidata":"https://www.wikidata.org/wiki/Q14197552","display_name":"MAPK/ERK pathway","level":3,"score":0.09930247068405151},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.06772306561470032}],"mesh":[{"descriptor_ui":"D000077146","descriptor_name":"Irinotecan","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000077146","descriptor_name":"Irinotecan","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000077146","descriptor_name":"Irinotecan","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000077146","descriptor_name":"Irinotecan","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000077146","descriptor_name":"Irinotecan","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000077146","descriptor_name":"Irinotecan","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000077146","descriptor_name":"Irinotecan","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000077146","descriptor_name":"Irinotecan","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000077146","descriptor_name":"Irinotecan","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000077146","descriptor_name":"Irinotecan","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000077146","descriptor_name":"Irinotecan","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000077146","descriptor_name":"Irinotecan","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000077146","descriptor_name":"Irinotecan","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000077146","descriptor_name":"Irinotecan","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000077150","descriptor_name":"Oxaliplatin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000077150","descriptor_name":"Oxaliplatin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000077150","descriptor_name":"Oxaliplatin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000077150","descriptor_name":"Oxaliplatin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000077150","descriptor_name":"Oxaliplatin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000077150","descriptor_name":"Oxaliplatin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000077150","descriptor_name":"Oxaliplatin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000077150","descriptor_name":"Oxaliplatin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000077150","descriptor_name":"Oxaliplatin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000077150","descriptor_name":"Oxaliplatin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000077150","descriptor_name":"Oxaliplatin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000077150","descriptor_name":"Oxaliplatin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000077150","descriptor_name":"Oxaliplatin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000077150","descriptor_name":"Oxaliplatin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D002955","descriptor_name":"Leucovorin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002955","descriptor_name":"Leucovorin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002955","descriptor_name":"Leucovorin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002955","descriptor_name":"Leucovorin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002955","descriptor_name":"Leucovorin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002955","descriptor_name":"Leucovorin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002955","descriptor_name":"Leucovorin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002955","descriptor_name":"Leucovorin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D002955","descriptor_name":"Leucovorin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D002955","descriptor_name":"Leucovorin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D002955","descriptor_name":"Leucovorin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D002955","descriptor_name":"Leucovorin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D002955","descriptor_name":"Leucovorin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D002955","descriptor_name":"Leucovorin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D004357","descriptor_name":"Drug Synergism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004357","descriptor_name":"Drug Synergism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004357","descriptor_name":"Drug Synergism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004357","descriptor_name":"Drug Synergism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004357","descriptor_name":"Drug Synergism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004357","descriptor_name":"Drug Synergism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004357","descriptor_name":"Drug Synergism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005472","descriptor_name":"Fluorouracil","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005472","descriptor_name":"Fluorouracil","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005472","descriptor_name":"Fluorouracil","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005472","descriptor_name":"Fluorouracil","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005472","descriptor_name":"Fluorouracil","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005472","descriptor_name":"Fluorouracil","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005472","descriptor_name":"Fluorouracil","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005472","descriptor_name":"Fluorouracil","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D005472","descriptor_name":"Fluorouracil","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D005472","descriptor_name":"Fluorouracil","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D005472","descriptor_name":"Fluorouracil","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D005472","descriptor_name":"Fluorouracil","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D005472","descriptor_name":"Fluorouracil","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D005472","descriptor_name":"Fluorouracil","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D011728","descriptor_name":"Pyridones","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D011728","descriptor_name":"Pyridones","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D011728","descriptor_name":"Pyridones","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D011728","descriptor_name":"Pyridones","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D011728","descriptor_name":"Pyridones","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D011728","descriptor_name":"Pyridones","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D011728","descriptor_name":"Pyridones","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D011728","descriptor_name":"Pyridones","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D011728","descriptor_name":"Pyridones","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D011728","descriptor_name":"Pyridones","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D011728","descriptor_name":"Pyridones","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D011728","descriptor_name":"Pyridones","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D011728","descriptor_name":"Pyridones","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D011728","descriptor_name":"Pyridones","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D011744","descriptor_name":"Pyrimidinones","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D011744","descriptor_name":"Pyrimidinones","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D011744","descriptor_name":"Pyrimidinones","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D011744","descriptor_name":"Pyrimidinones","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D011744","descriptor_name":"Pyrimidinones","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D011744","descriptor_name":"Pyrimidinones","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D011744","descriptor_name":"Pyrimidinones","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D021441","descriptor_name":"Carcinoma, Pancreatic Ductal","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D021441","descriptor_name":"Carcinoma, Pancreatic Ductal","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D021441","descriptor_name":"Carcinoma, Pancreatic Ductal","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D021441","descriptor_name":"Carcinoma, Pancreatic Ductal","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D021441","descriptor_name":"Carcinoma, Pancreatic Ductal","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D021441","descriptor_name":"Carcinoma, Pancreatic Ductal","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D021441","descriptor_name":"Carcinoma, Pancreatic Ductal","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D021441","descriptor_name":"Carcinoma, Pancreatic Ductal","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D021441","descriptor_name":"Carcinoma, Pancreatic Ductal","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D021441","descriptor_name":"Carcinoma, Pancreatic Ductal","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D021441","descriptor_name":"Carcinoma, Pancreatic Ductal","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D021441","descriptor_name":"Carcinoma, Pancreatic Ductal","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D021441","descriptor_name":"Carcinoma, Pancreatic Ductal","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D021441","descriptor_name":"Carcinoma, Pancreatic Ductal","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D023041","descriptor_name":"Xenograft Model Antitumor Assays","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023041","descriptor_name":"Xenograft Model Antitumor Assays","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023041","descriptor_name":"Xenograft Model Antitumor Assays","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023041","descriptor_name":"Xenograft Model Antitumor Assays","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023041","descriptor_name":"Xenograft Model Antitumor Assays","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023041","descriptor_name":"Xenograft Model Antitumor Assays","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023041","descriptor_name":"Xenograft Model Antitumor Assays","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D061026","descriptor_name":"Programmed Cell Death 1 Receptor","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D061026","descriptor_name":"Programmed Cell Death 1 Receptor","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D061026","descriptor_name":"Programmed Cell Death 1 Receptor","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D061026","descriptor_name":"Programmed Cell Death 1 Receptor","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D061026","descriptor_name":"Programmed Cell Death 1 Receptor","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D061026","descriptor_name":"Programmed Cell Death 1 Receptor","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D061026","descriptor_name":"Programmed Cell Death 1 Receptor","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1158/1535-7163.mct-23-0833","doi":"https://doi.org/10.1158/1535-7163.mct-23-0833","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1535-7163.mct-23-0833","pdf_url":null,"source":{"id":"https://openalex.org/S48437117","display_name":"Molecular Cancer Therapeutics","issn_l":"1535-7163","issn":["1535-7163","1538-8514"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Cancer Therapeutics","raw_type":"journal-article"},{"id":"pmid:39162011","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39162011","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular cancer therapeutics","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11614707","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11614707","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11614707/pdf/nihms-2019210.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Mol Cancer Ther","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:11614707","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11614707","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11614707/pdf/nihms-2019210.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Mol Cancer Ther","raw_type":"Text"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.800000011920929,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1164661550","display_name":null,"funder_award_id":"P30CA060553","funder_id":"https://openalex.org/F4320333106","funder_display_name":"Robert H. Lurie Comprehensive Cancer Center"},{"id":"https://openalex.org/G157389813","display_name":null,"funder_award_id":"T32 CA070085","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G1716881944","display_name":"Rapid evaluation of immunotherapy regimens in ex vivo human pancreatic tumor slice cultures.","funder_award_id":"R21CA255291","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G317886719","display_name":null,"funder_award_id":"P30CA060553","funder_id":"https://openalex.org/F4320309475","funder_display_name":"Northwestern University"},{"id":"https://openalex.org/G3966316300","display_name":null,"funder_award_id":"I01 BX005595","funder_id":"https://openalex.org/F4320306127","funder_display_name":"U.S. Department of Veterans Affairs"},{"id":"https://openalex.org/G4615614686","display_name":null,"funder_award_id":"I21BX005693","funder_id":"https://openalex.org/F4320306127","funder_display_name":"U.S. Department of Veterans Affairs"},{"id":"https://openalex.org/G4815087562","display_name":null,"funder_award_id":"IRG-21-144-270","funder_id":"https://openalex.org/F4320306095","funder_display_name":"American Cancer Society"},{"id":"https://openalex.org/G9000173131","display_name":null,"funder_award_id":"T32 CA070085","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000883447","display_name":"Co-targeting BET Bromodomain Proteins and MNK Kinases in Pancreatic Cancer","funder_award_id":"R01CA265997","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000891045","display_name":"The Robert H. Lurie Comprehensive Cancer Center","funder_award_id":"P30CA060553","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320306095","display_name":"American Cancer Society","ror":"https://ror.org/02e463172"},{"id":"https://openalex.org/F4320306127","display_name":"U.S. Department of Veterans Affairs","ror":"https://ror.org/05rsv9s98"},{"id":"https://openalex.org/F4320309475","display_name":"Northwestern University","ror":"https://ror.org/000e0be47"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320333106","display_name":"Robert H. Lurie Comprehensive Cancer Center","ror":"https://ror.org/000e0be47"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4401715744.pdf","grobid_xml":"https://content.openalex.org/works/W4401715744.grobid-xml"},"referenced_works_count":35,"referenced_works":["https://openalex.org/W1968812902","https://openalex.org/W2058554042","https://openalex.org/W2086262311","https://openalex.org/W2099044540","https://openalex.org/W2147924229","https://openalex.org/W2151253787","https://openalex.org/W2289851792","https://openalex.org/W2409856225","https://openalex.org/W2541831810","https://openalex.org/W2588812529","https://openalex.org/W2622499649","https://openalex.org/W2737010615","https://openalex.org/W2900560643","https://openalex.org/W2938645074","https://openalex.org/W2945942484","https://openalex.org/W2946040614","https://openalex.org/W2959096163","https://openalex.org/W2971939190","https://openalex.org/W2978682544","https://openalex.org/W3000532606","https://openalex.org/W3033893295","https://openalex.org/W3038798082","https://openalex.org/W3111256553","https://openalex.org/W3121841314","https://openalex.org/W3200708092","https://openalex.org/W3202028317","https://openalex.org/W4200098246","https://openalex.org/W4210426142","https://openalex.org/W4214751040","https://openalex.org/W4226063604","https://openalex.org/W4296711034","https://openalex.org/W4309497291","https://openalex.org/W4311425047","https://openalex.org/W4390946922","https://openalex.org/W6847393935"],"related_works":["https://openalex.org/W1968485788","https://openalex.org/W3094263385","https://openalex.org/W2323135942","https://openalex.org/W1982443780","https://openalex.org/W2103627259","https://openalex.org/W4200053557","https://openalex.org/W2236199583","https://openalex.org/W4311279708","https://openalex.org/W4391225521","https://openalex.org/W4281702260"],"abstract_inverted_index":{"Despite":[0],"advances":[1],"in":[2,45,55,63,88,138,141,191,206],"immune":[3,36,152],"checkpoint":[4,37],"inhibitors,":[5],"chemotherapy":[6],"remains":[7],"the":[8,19,24,108,144,167,181,186],"standard":[9],"therapy":[10],"for":[11,200],"patients":[12,46,64,207],"with":[13,47,65,98,120,149,208],"pancreatic":[14],"ductal":[15],"adenocarcinoma":[16],"(PDAC).":[17],"As":[18],"combinations":[20],"of":[21,101,115,125,174,188],"chemotherapy,":[22],"including":[23],"FOLFIRINOX":[25,161,214],"[5-fluorouracil,":[26],"F;":[27],"irinotecan,":[28],"I;":[29],"and":[30,35,94,131,140,184,203],"oxaliplatin,":[31],"O":[32],"(FIO)]":[33],"regimen,":[34],"inhibitors":[38],"have":[39],"failed":[40],"to":[41,59,122,135,155,216],"demonstrate":[42,132],"clinical":[43],"benefit":[44],"metastatic":[48],"PDAC":[49,76,91,117,157,209],"tumors,":[50],"there":[51],"is":[52],"increasing":[53],"interest":[54],"identifying":[56],"therapeutic":[57],"approaches":[58],"potentiate":[60],"ICI":[61],"efficacy":[62,187],"PDAC.":[66],"In":[67,103],"this":[68],"study,":[69],"we":[70,105,164],"report":[71],"that":[72,107,166],"neoadjuvant":[73,160,211],"FOLFIRINOX-treated":[74],"human":[75,156],"tumors":[77,148,158,183],"exhibit":[78],"increased":[79,133],"MEK/ERK":[80,86],"activation.":[81],"We":[82],"also":[83],"show":[84],"elevated":[85],"signaling":[87],"ex":[89],"vivo":[90],"slice":[92],"cultures":[93],"cell":[95,118],"lines":[96,119],"treated":[97],"a":[99,150,198],"combination":[100],"FIO.":[102],"addition,":[104],"find":[106],"KPC-FIO":[109,145,182],"cells,":[110],"established":[111],"from":[112],"repeated":[113],"treatment":[114,215],"mouse":[116,193],"six":[121],"eight":[123],"cycles":[124],"FIO,":[126],"display":[127],"enhanced":[128],"ERK":[129],"phosphorylation":[130],"sensitivity":[134],"MEK":[136,168],"inhibition":[137],"vitro":[139],"vivo.":[142],"Significantly,":[143],"cells":[146,179],"develop":[147],"proinflammatory":[151],"profile":[153],"similar":[154],"after":[159,210],"treatment.":[162],"Furthermore,":[163],"found":[165],"inhibitor":[169],"trametinib":[170,202],"enables":[171],"additional":[172],"infiltration":[173],"highly":[175],"functional":[176],"CD8+":[177],"T":[178],"into":[180],"potentiates":[185],"anti-PD-1":[189,204],"antibody":[190],"syngeneic":[192],"models.":[194],"Our":[195],"findings":[196],"provide":[197],"rationale":[199],"combining":[201],"antibodies":[205],"or":[212],"short-term":[213],"achieve":[217],"effective":[218],"antitumor":[219],"responses.":[220]},"counts_by_year":[{"year":2026,"cited_by_count":7},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2025-10-10T00:00:00"}