{"id":"https://openalex.org/W4401714979","doi":"https://doi.org/10.1007/s12325-024-02951-5","title":"Tapering and Sustained Remission of Thrombopoietin Receptor Agonists (TPO-RAs): Is it Time for Paediatric ITP?","display_name":"Tapering and Sustained Remission of Thrombopoietin Receptor Agonists (TPO-RAs): Is it Time for Paediatric ITP?","publication_year":2024,"publication_date":"2024-08-20","ids":{"openalex":"https://openalex.org/W4401714979","doi":"https://doi.org/10.1007/s12325-024-02951-5","pmid":"https://pubmed.ncbi.nlm.nih.gov/39162982"},"language":"en","primary_location":{"id":"doi:10.1007/s12325-024-02951-5","doi":"https://doi.org/10.1007/s12325-024-02951-5","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s12325-024-02951-5","pdf_url":null,"source":{"id":"https://openalex.org/S27230875","display_name":"Advances in Therapy","issn_l":"0741-238X","issn":["0741-238X","1865-8652"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320330","host_organization_name":"Adis, Springer Healthcare","host_organization_lineage":["https://openalex.org/P4310320330","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Adis, Springer Healthcare","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advances in Therapy","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5018380503","display_name":"Susana Marcos Pe\u00f1a","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Susana Marcos-Pe\u00f1a","raw_affiliation_strings":["San Agust\u00edn Health Center, Burgos Primary Care Management, Burgos, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"San Agust\u00edn Health Center, Burgos Primary Care Management, Burgos, Spain","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023707691","display_name":"Beatriz Fern\u00e1ndez Pern\u00eda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210115949","display_name":"Hospital Universitario de Burgos","ror":"https://ror.org/01j5v0d02","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210115949"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Beatriz Fern\u00e1ndez-Pernia","raw_affiliation_strings":["Hospital Universitario de Burgos, Burgos, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital Universitario de Burgos, Burgos, Spain","institution_ids":["https://openalex.org/I4210115949"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074438534","display_name":"Drew Provan","orcid":"https://orcid.org/0000-0002-5110-8455","observed_orcids":["https://orcid.org/0000-0002-5110-8455"]},"institutions":[{"id":"https://openalex.org/I166337079","display_name":"Queen Mary University of London","ror":"https://ror.org/026zzn846","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I166337079"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Drew Provan","raw_affiliation_strings":["Department of Haematology, Barts and The London School of Medicine, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Haematology, Barts and The London School of Medicine, London, UK","institution_ids":["https://openalex.org/I166337079"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5068600380","display_name":"Tom\u00e1s Jos\u00e9 Gonz\u00e1lez\u2010L\u00f3pez","orcid":"https://orcid.org/0000-0001-9575-1816","observed_orcids":["https://orcid.org/0000-0001-9575-1816","https://orcid.org/0000-0003-2458-2554"]},"institutions":[{"id":"https://openalex.org/I4210115949","display_name":"Hospital Universitario de Burgos","ror":"https://ror.org/01j5v0d02","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210115949"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Tom\u00e1s Jos\u00e9 Gonz\u00e1lez-L\u00f3pez","raw_affiliation_strings":["Hematology Department, Hospital Universitario de Burgos, Avenida Islas Baleares, 3, 09006, Burgos, Spain. tjgonzalez@saludcastillayleon.es","Hematology Department, Hospital Universitario de Burgos, Avenida Islas Baleares, 3, 09006, Burgos, Spain"],"raw_orcid":"https://orcid.org/0000-0003-2458-2554","affiliations":[{"raw_affiliation_string":"Hematology Department, Hospital Universitario de Burgos, Avenida Islas Baleares, 3, 09006, Burgos, Spain. tjgonzalez@saludcastillayleon.es","institution_ids":["https://openalex.org/I4210115949"]},{"raw_affiliation_string":"Hematology Department, Hospital Universitario de Burgos, Avenida Islas Baleares, 3, 09006, Burgos, Spain","institution_ids":["https://openalex.org/I4210115949"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5068600380"],"corresponding_institution_ids":["https://openalex.org/I4210115949"],"apc_list":{"value":4590,"currency":"USD","value_usd":4590},"apc_paid":null,"fwci":0.0776,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.14347984,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":93},"biblio":{"volume":"41","issue":"10","first_page":"3771","last_page":"3777"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12352","display_name":"Heparin-Induced Thrombocytopenia and Thrombosis","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10693","display_name":"Blood transfusion and management","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/thrombopoietin-receptor-agonists","display_name":"thrombopoietin receptor agonists","score":0.9769999980926514},{"id":"https://openalex.org/keywords/romiplostim","display_name":"romiplostim","score":0.7850000262260437},{"id":"https://openalex.org/keywords/eltrombopag","display_name":"eltrombopag","score":1.0},{"id":"https://openalex.org/keywords/avatrombopag","display_name":"avatrombopag","score":0.9959999918937683},{"id":"https://openalex.org/keywords/treatment-tapering","display_name":"treatment tapering","score":0.8920000195503235},{"id":"https://openalex.org/keywords/treatment-discontinuation","display_name":"treatment discontinuation","score":0.8399999737739563},{"id":"https://openalex.org/keywords/spontaneous-regression","display_name":"spontaneous regression","score":0.8169999718666077},{"id":"https://openalex.org/keywords/platelet-count-response","display_name":"platelet count response","score":0.578000009059906}],"concepts":[{"id":"https://openalex.org/C2776915898","wikidata":"https://www.wikidata.org/wiki/Q1235195","display_name":"Romiplostim","level":5,"score":0.952523946762085},{"id":"https://openalex.org/C2780588981","wikidata":"https://www.wikidata.org/wiki/Q411588","display_name":"Eltrombopag","level":4,"score":0.9477534294128418},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9411866664886475},{"id":"https://openalex.org/C2778715236","wikidata":"https://www.wikidata.org/wiki/Q55622662","display_name":"Discontinuation","level":2,"score":0.827823281288147},{"id":"https://openalex.org/C2777863708","wikidata":"https://www.wikidata.org/wiki/Q424519","display_name":"Thrombopoietin","level":4,"score":0.7683835625648499},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5380415916442871},{"id":"https://openalex.org/C2778713057","wikidata":"https://www.wikidata.org/wiki/Q18029261","display_name":"Thrombopoietin receptor","level":5,"score":0.4626499116420746},{"id":"https://openalex.org/C2779384505","wikidata":"https://www.wikidata.org/wiki/Q17007513","display_name":"Concomitant","level":2,"score":0.43421199917793274},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.38887298107147217},{"id":"https://openalex.org/C2993327898","wikidata":"https://www.wikidata.org/wiki/Q638729","display_name":"Immune thrombocytopenia","level":3,"score":0.21173977851867676},{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.18625721335411072},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.0},{"id":"https://openalex.org/C109159458","wikidata":"https://www.wikidata.org/wiki/Q919283","display_name":"Haematopoiesis","level":3,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D001565","descriptor_name":"Benzoates","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004334","descriptor_name":"Drug Administration Schedule","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006834","descriptor_name":"Hydrazines","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D010976","descriptor_name":"Platelet Count","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011720","descriptor_name":"Pyrazoles","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D011961","descriptor_name":"Receptors, Fc","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D012074","descriptor_name":"Remission Induction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013844","descriptor_name":"Thiazoles","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D013876","descriptor_name":"Thiophenes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013926","descriptor_name":"Thrombopoietin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D016553","descriptor_name":"Purpura, Thrombocytopenic, Idiopathic","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053628","descriptor_name":"Receptors, Thrombopoietin","qualifier_ui":"Q000819","qualifier_name":"agonists","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1007/s12325-024-02951-5","doi":"https://doi.org/10.1007/s12325-024-02951-5","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s12325-024-02951-5","pdf_url":null,"source":{"id":"https://openalex.org/S27230875","display_name":"Advances in Therapy","issn_l":"0741-238X","issn":["0741-238X","1865-8652"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320330","host_organization_name":"Adis, Springer Healthcare","host_organization_lineage":["https://openalex.org/P4310320330","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Adis, Springer Healthcare","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advances in Therapy","raw_type":"journal-article"},{"id":"pmid:39162982","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39162982","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advances in therapy","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9940000176429749,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":34,"referenced_works":["https://openalex.org/W1530742578","https://openalex.org/W1940859004","https://openalex.org/W1974829928","https://openalex.org/W1980002878","https://openalex.org/W1984073642","https://openalex.org/W2010176345","https://openalex.org/W2098728471","https://openalex.org/W2130017206","https://openalex.org/W2139745353","https://openalex.org/W2151165602","https://openalex.org/W2153670291","https://openalex.org/W2156817733","https://openalex.org/W2328749309","https://openalex.org/W2414381444","https://openalex.org/W2466020015","https://openalex.org/W2765458598","https://openalex.org/W2781224426","https://openalex.org/W2891044782","https://openalex.org/W2907960088","https://openalex.org/W2969481077","https://openalex.org/W3047896951","https://openalex.org/W3080501275","https://openalex.org/W3133048368","https://openalex.org/W3139319767","https://openalex.org/W3207464851","https://openalex.org/W4323353705","https://openalex.org/W4323655680","https://openalex.org/W4367669506","https://openalex.org/W4386944124","https://openalex.org/W4389083949","https://openalex.org/W4389683657","https://openalex.org/W4391881634","https://openalex.org/W4394770437","https://openalex.org/W4401911169"],"related_works":["https://openalex.org/W4389232439","https://openalex.org/W2342531607","https://openalex.org/W3206222204","https://openalex.org/W2023093390","https://openalex.org/W4410480135","https://openalex.org/W1891479302","https://openalex.org/W4225282319","https://openalex.org/W4404423033","https://openalex.org/W376014369","https://openalex.org/W3212095802"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2024-08-21T00:00:00"}