{"id":"https://openalex.org/W4401705672","doi":"https://doi.org/10.1038/s41598-024-69431-2","title":"The protective effect of vinpocetine against Estradiol-benzoate induced cervical hyperkeratosis in female rats via modulation of SIRT1/Nrf2, and NLRP3 inflammasome","display_name":"The protective effect of vinpocetine against Estradiol-benzoate induced cervical hyperkeratosis in female rats via modulation of SIRT1/Nrf2, and NLRP3 inflammasome","publication_year":2024,"publication_date":"2024-08-19","ids":{"openalex":"https://openalex.org/W4401705672","doi":"https://doi.org/10.1038/s41598-024-69431-2","pmid":"https://pubmed.ncbi.nlm.nih.gov/39160173","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11333625"},"language":"en","primary_location":{"id":"doi:10.1038/s41598-024-69431-2","doi":"https://doi.org/10.1038/s41598-024-69431-2","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-024-69431-2","pdf_url":"https://www.nature.com/articles/s41598-024-69431-2.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41598-024-69431-2.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5051649412","display_name":"Remon Roshdy Rofaeil","orcid":"https://orcid.org/0000-0002-0159-5937","observed_orcids":["https://orcid.org/0000-0002-0159-5937"]},"institutions":[{"id":"https://openalex.org/I4401727001","display_name":"Deraya University","ror":"https://ror.org/05252fg05","country_code":"EG","type":"education","lineage":["https://openalex.org/I4401727001"]},{"id":"https://openalex.org/I89466785","display_name":"Minia University","ror":"https://ror.org/02hcv4z63","country_code":"EG","type":"education","lineage":["https://openalex.org/I89466785"]}],"countries":["EG"],"is_corresponding":true,"raw_author_name":"Remon R. Rofaeil","raw_affiliation_strings":["Department of Medical Pharmacology, Faculty of Medicine, Minia University, Minia, 61519, Egypt. remon.roufeal@mu.edu.eg","Department of Pharmacology & Toxicology, Faculty of Pharmacy, Deraya University, Minia, 61111, Egypt. remon.roufeal@mu.edu.eg","Department of Medical Pharmacology, Faculty of Medicine, Minia University, Minia, 61519, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Pharmacology, Faculty of Medicine, Minia University, Minia, 61519, Egypt. remon.roufeal@mu.edu.eg","institution_ids":["https://openalex.org/I89466785"]},{"raw_affiliation_string":"Department of Pharmacology & Toxicology, Faculty of Pharmacy, Deraya University, Minia, 61111, Egypt. remon.roufeal@mu.edu.eg","institution_ids":["https://openalex.org/I4401727001"]},{"raw_affiliation_string":"Department of Medical Pharmacology, Faculty of Medicine, Minia University, Minia, 61519, Egypt","institution_ids":["https://openalex.org/I89466785"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058286068","display_name":"Reham H. Mohyeldin","orcid":"https://orcid.org/0000-0003-3749-2427","observed_orcids":["https://orcid.org/0000-0003-3749-2427"]},"institutions":[{"id":"https://openalex.org/I4401727001","display_name":"Deraya University","ror":"https://ror.org/05252fg05","country_code":"EG","type":"education","lineage":["https://openalex.org/I4401727001"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Reham H. Mohyeldin","raw_affiliation_strings":["Department of Pharmacology & Toxicology, Faculty of Pharmacy, Deraya University, Minia, 61111, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology & Toxicology, Faculty of Pharmacy, Deraya University, Minia, 61111, Egypt","institution_ids":["https://openalex.org/I4401727001"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091966197","display_name":"Ehab E Sharata","orcid":"https://orcid.org/0009-0002-6517-7221","observed_orcids":["https://orcid.org/0009-0002-6517-7221"]},"institutions":[{"id":"https://openalex.org/I4401727001","display_name":"Deraya University","ror":"https://ror.org/05252fg05","country_code":"EG","type":"education","lineage":["https://openalex.org/I4401727001"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Ehab E. Sharata","raw_affiliation_strings":["Department of Pharmacology & Toxicology, Faculty of Pharmacy, Deraya University, Minia, 61111, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology & Toxicology, Faculty of Pharmacy, Deraya University, Minia, 61111, Egypt","institution_ids":["https://openalex.org/I4401727001"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059778120","display_name":"Mina Ezzat Attya","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I89466785","display_name":"Minia University","ror":"https://ror.org/02hcv4z63","country_code":"EG","type":"education","lineage":["https://openalex.org/I89466785"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Mina Ezzat Attya","raw_affiliation_strings":["Department of Pathology, Faculty of Medicine, Minia University, Minia, 61519, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Faculty of Medicine, Minia University, Minia, 61519, Egypt","institution_ids":["https://openalex.org/I89466785"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5095040524","display_name":"Hany Gaber Essawy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I89466785","display_name":"Minia University","ror":"https://ror.org/02hcv4z63","country_code":"EG","type":"education","lineage":["https://openalex.org/I89466785"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Hany Essawy","raw_affiliation_strings":["Department of Obstetrics & Gynecology, Faculty of Medicine, Minia University, Minia, 61519, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics & Gynecology, Faculty of Medicine, Minia University, Minia, 61519, Egypt","institution_ids":["https://openalex.org/I89466785"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Osama A. Ibrahim","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I89466785","display_name":"Minia University","ror":"https://ror.org/02hcv4z63","country_code":"EG","type":"education","lineage":["https://openalex.org/I89466785"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Osama A. Ibrahim","raw_affiliation_strings":["Department of Obstetrics & Gynecology, Faculty of Medicine, Minia University, Minia, 61519, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics & Gynecology, Faculty of Medicine, Minia University, Minia, 61519, Egypt","institution_ids":["https://openalex.org/I89466785"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5073536869","display_name":"Walaa Yehia Abdelzaher","orcid":"https://orcid.org/0000-0001-6511-1797","observed_orcids":["https://orcid.org/0000-0001-6511-1797"]},"institutions":[{"id":"https://openalex.org/I89466785","display_name":"Minia University","ror":"https://ror.org/02hcv4z63","country_code":"EG","type":"education","lineage":["https://openalex.org/I89466785"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Walaa Yehia Abdelzaher","raw_affiliation_strings":["Department of Medical Pharmacology, Faculty of Medicine, Minia University, Minia, 61519, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Pharmacology, Faculty of Medicine, Minia University, Minia, 61519, Egypt","institution_ids":["https://openalex.org/I89466785"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5051649412"],"corresponding_institution_ids":["https://openalex.org/I4401727001","https://openalex.org/I89466785"],"apc_list":{"value":2590,"currency":"USD","value_usd":2590},"apc_paid":{"value":2590,"currency":"USD","value_usd":2590},"fwci":1.8905,"has_fulltext":true,"cited_by_count":17,"citation_normalized_percentile":{"value":0.86304687,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":98,"max":99},"biblio":{"volume":"14","issue":"1","first_page":"19171","last_page":"19171"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11078","display_name":"Inflammasome and immune disorders","score":0.9545999765396118,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11078","display_name":"Inflammasome and immune disorders","score":0.9545999765396118,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11332","display_name":"Genomics, phytochemicals, and oxidative stress","score":0.0203000009059906,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13026","display_name":"Natural Compounds in Disease Treatment","score":0.0031999999191612005,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/vinpocetine","display_name":"vinpocetine","score":0.9990000128746033},{"id":"https://openalex.org/keywords/estradiol-benzoate","display_name":"estradiol benzoate","score":0.9879999756813049},{"id":"https://openalex.org/keywords/nlrp3-inflammasome","display_name":"NLRP3 inflammasome","score":1.0},{"id":"https://openalex.org/keywords/pyroptosis","display_name":"pyroptosis","score":0.9760000109672546},{"id":"https://openalex.org/keywords/gasdermin-d","display_name":"gasdermin D","score":0.8629999756813049},{"id":"https://openalex.org/keywords/caspase-1","display_name":"caspase-1","score":0.9139999747276306},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.9760000109672546},{"id":"https://openalex.org/keywords/cytokines","display_name":"cytokines","score":0.6010000109672546},{"id":"https://openalex.org/keywords/cervical-tissue","display_name":"cervical tissue","score":0.31200000643730164},{"id":"https://openalex.org/keywords/chemoprevention","display_name":"chemoprevention","score":0.7429999709129333}],"concepts":[{"id":"https://openalex.org/C2778788455","wikidata":"https://www.wikidata.org/wiki/Q420288","display_name":"Vinpocetine","level":2,"score":0.6665730476379395},{"id":"https://openalex.org/C2777209026","wikidata":"https://www.wikidata.org/wiki/Q412405","display_name":"Inflammasome","level":3,"score":0.6544971466064453},{"id":"https://openalex.org/C2779915019","wikidata":"https://www.wikidata.org/wiki/Q1640998","display_name":"Hyperkeratosis","level":2,"score":0.6488314867019653},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.46553221344947815},{"id":"https://openalex.org/C123079801","wikidata":"https://www.wikidata.org/wiki/Q750240","display_name":"Modulation (music)","level":2,"score":0.43237677216529846},{"id":"https://openalex.org/C2778506572","wikidata":"https://www.wikidata.org/wiki/Q11450699","display_name":"Estradiol benzoate","level":4,"score":0.4272823631763458},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3872871994972229},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3743175268173218},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.24442201852798462},{"id":"https://openalex.org/C2777164284","wikidata":"https://www.wikidata.org/wiki/Q277954","display_name":"Estrogen","level":2,"score":0.21808630228042603},{"id":"https://openalex.org/C16005928","wikidata":"https://www.wikidata.org/wiki/Q171171","display_name":"Dermatology","level":1,"score":0.18032968044281006},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.08249232172966003},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.07106095552444458},{"id":"https://openalex.org/C8264082","wikidata":"https://www.wikidata.org/wiki/Q7113259","display_name":"Ovariectomized rat","level":3,"score":0.0},{"id":"https://openalex.org/C24890656","wikidata":"https://www.wikidata.org/wiki/Q82811","display_name":"Acoustics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000071199","descriptor_name":"NLR Family, Pyrin Domain-Containing 3 Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002584","descriptor_name":"Cervix Uteri","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D002584","descriptor_name":"Cervix Uteri","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002584","descriptor_name":"Cervix Uteri","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D004958","descriptor_name":"Estradiol","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D004958","descriptor_name":"Estradiol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014748","descriptor_name":"Vinca Alkaloids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D014748","descriptor_name":"Vinca Alkaloids","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D051267","descriptor_name":"NF-E2-Related Factor 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056564","descriptor_name":"Sirtuin 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D058847","descriptor_name":"Inflammasomes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D058847","descriptor_name":"Inflammasomes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1038/s41598-024-69431-2","doi":"https://doi.org/10.1038/s41598-024-69431-2","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-024-69431-2","pdf_url":"https://www.nature.com/articles/s41598-024-69431-2.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11333625","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11333625","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11333625/pdf/41598_2024_Article_69431.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sci Rep","raw_type":"Text"},{"id":"pmid:39160173","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39160173","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific reports","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:6f272664867d4d5cb61a007f923829ab","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/6f272664867d4d5cb61a007f923829ab","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Scientific Reports, Vol 14, Iss 1, Pp 1-8 (2024)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1038/s41598-024-69431-2","doi":"https://doi.org/10.1038/s41598-024-69431-2","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-024-69431-2","pdf_url":"https://www.nature.com/articles/s41598-024-69431-2.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321655","display_name":"Science and Technology Development Fund","ror":"https://ror.org/044vr6g03"},{"id":"https://openalex.org/F4320327648","display_name":"Minia University","ror":"https://ror.org/02hcv4z63"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4401705672.pdf","grobid_xml":"https://content.openalex.org/works/W4401705672.grobid-xml"},"referenced_works_count":54,"referenced_works":["https://openalex.org/W8335157","https://openalex.org/W145724542","https://openalex.org/W311440096","https://openalex.org/W1094547483","https://openalex.org/W1571010590","https://openalex.org/W1732475031","https://openalex.org/W1791762728","https://openalex.org/W1970094250","https://openalex.org/W2005373107","https://openalex.org/W2007272934","https://openalex.org/W2023752098","https://openalex.org/W2048853752","https://openalex.org/W2063496703","https://openalex.org/W2071110150","https://openalex.org/W2076743940","https://openalex.org/W2080675024","https://openalex.org/W2091093079","https://openalex.org/W2098618805","https://openalex.org/W2104831422","https://openalex.org/W2121754708","https://openalex.org/W2125297437","https://openalex.org/W2125385377","https://openalex.org/W2142238400","https://openalex.org/W2327359649","https://openalex.org/W2585450890","https://openalex.org/W2604030747","https://openalex.org/W2745256990","https://openalex.org/W2756210704","https://openalex.org/W2971124378","https://openalex.org/W2995540455","https://openalex.org/W2996623827","https://openalex.org/W2998625568","https://openalex.org/W3007492121","https://openalex.org/W3024189585","https://openalex.org/W3036664601","https://openalex.org/W3039374476","https://openalex.org/W3098960721","https://openalex.org/W3116523068","https://openalex.org/W3131145093","https://openalex.org/W3153759288","https://openalex.org/W3199160495","https://openalex.org/W3202438914","https://openalex.org/W4220875495","https://openalex.org/W4318019182","https://openalex.org/W4323830543","https://openalex.org/W4376879251","https://openalex.org/W4379618762","https://openalex.org/W4380876096","https://openalex.org/W4385620143","https://openalex.org/W4385660707","https://openalex.org/W4387924978","https://openalex.org/W4388023311","https://openalex.org/W4390519742","https://openalex.org/W4390950337"],"related_works":["https://openalex.org/W2392854639","https://openalex.org/W3092060185","https://openalex.org/W3169511623","https://openalex.org/W4321375427","https://openalex.org/W4391276742","https://openalex.org/W4229052329","https://openalex.org/W2981760086","https://openalex.org/W2796499199","https://openalex.org/W2138667246","https://openalex.org/W4391448532"],"abstract_inverted_index":{"The":[0,85],"current":[1],"study":[2],"was":[3,24,44,91,98],"assigned":[4],"to":[5,39],"determine":[6],"the":[7,59],"putative":[8],"preventive":[9],"role":[10],"of":[11,50,61,64,87],"vinpocetine":[12],"(VIN)":[13],"in":[14,18,26,47,58,82,123],"cervical":[15,41,83,124,138],"hyperkeratosis":[16,139],"(CHK)":[17],"female":[19],"rats.":[20],"Estradiol":[21],"Benzoate":[22],"(EB)":[23],"utilized":[25],"a":[27,48],"dose":[28,49],"f":[29],"(60":[30],"\u03bcg/100":[31],"g,":[32],"i.m)":[33],"three":[34],"times/week":[35],"for":[36,54],"4":[37,55],"weeks":[38,56],"induce":[40],"hyperkeratosis.":[42],"VIN":[43,126,134],"administered":[45],"alone":[46],"(10":[51],"mg/kg/day,":[52],"orally)":[53],"and":[57,89,109,111,118,131,143],"presence":[60],"EB.":[62],"Levels":[63],"malondialdehyde":[65],"(MDA),":[66],"total":[67],"nitrites":[68],"(NOx),":[69],"reduced":[70,122],"glutathione":[71],"(GSH),":[72],"interleukin-18":[73],"(IL-18),":[74],"IL-1\u03b2,":[75,108],"tumor":[76],"necrosis":[77],"factor-alpha":[78],"(TNF-\u03b1)":[79],"were":[80,121],"measured":[81],"tissue.":[84,125],"expression":[86],"NLRP3/GSDMD/Caspase-1,":[88],"SIRT1/Nrf2":[90,144],"determined":[92],"using":[93],"ELISA.":[94],"Cervical":[95],"histopathological":[96,132],"examination":[97],"also":[99],"done.":[100],"EB":[101],"significantly":[102,127],"raised":[103],"MDA,":[104],"NOx,":[105],"TNF-\u03b1,":[106],"IL-18,":[107],"GSDMD":[110],"up-regulated":[112],"NLRP3/Caspase-1":[113],"proteins.":[114],"However,":[115],"GSH,":[116],"SIRT1,":[117],"Nrf2":[119],"levels":[120],"alleviates":[128],"all":[129],"biochemical":[130],"abnormalities.":[133],"considerably":[135],"mitigates":[136],"EB-induced":[137],"via":[140],"NLRP3-induced":[141],"pyroptosis":[142],"signaling":[145],"pathway.":[146]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":11}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2024-08-20T00:00:00"}