{"id":"https://openalex.org/W4401688461","doi":"https://doi.org/10.1101/2024.08.15.608141","title":"ClearScope: a fully integrated light sheet theta microscope for sub-cellular resolution imaging without lateral size constraints","display_name":"ClearScope: a fully integrated light sheet theta microscope for sub-cellular resolution imaging without lateral size constraints","publication_year":2024,"publication_date":"2024-08-19","ids":{"openalex":"https://openalex.org/W4401688461","doi":"https://doi.org/10.1101/2024.08.15.608141","pmid":"https://pubmed.ncbi.nlm.nih.gov/39229056","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11370359"},"language":"en","primary_location":{"id":"doi:10.1101/2024.08.15.608141","doi":"https://doi.org/10.1101/2024.08.15.608141","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2024.08.15.608141","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.1101/2024.08.15.608141","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102551275","display_name":"Matthew G. Fay","orcid":"https://orcid.org/0009-0009-2439-8045","observed_orcids":["https://orcid.org/0009-0009-2439-8045"]},"institutions":[{"id":"https://openalex.org/I4210130942","display_name":"MBF Bioscience (United States)","ror":"https://ror.org/02zynam48","country_code":"US","type":"company","lineage":["https://openalex.org/I4210130942"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matthew G. Fay","raw_affiliation_strings":["MBF Bioscience, Williston, VT 05495, USA"],"raw_orcid":"https://orcid.org/0009-0009-2439-8045","affiliations":[{"raw_affiliation_string":"MBF Bioscience, Williston, VT 05495, USA","institution_ids":["https://openalex.org/I4210130942"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Peter J. Lang","orcid":"https://orcid.org/0009-0007-1876-4104","observed_orcids":["https://orcid.org/0009-0007-1876-4104"]},"institutions":[{"id":"https://openalex.org/I4210130942","display_name":"MBF Bioscience (United States)","ror":"https://ror.org/02zynam48","country_code":"US","type":"company","lineage":["https://openalex.org/I4210130942"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peter J. Lang","raw_affiliation_strings":["MBF Bioscience, Williston, VT 05495, USA"],"raw_orcid":"https://orcid.org/0009-0007-1876-4104","affiliations":[{"raw_affiliation_string":"MBF Bioscience, Williston, VT 05495, USA","institution_ids":["https://openalex.org/I4210130942"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5106602376","display_name":"David S. Denu","orcid":"https://orcid.org/0009-0006-4374-3711","observed_orcids":["https://orcid.org/0009-0006-4374-3711"]},"institutions":[{"id":"https://openalex.org/I4210130942","display_name":"MBF Bioscience (United States)","ror":"https://ror.org/02zynam48","country_code":"US","type":"company","lineage":["https://openalex.org/I4210130942"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David S. Denu","raw_affiliation_strings":["MBF Bioscience, Williston, VT 05495, USA"],"raw_orcid":"https://orcid.org/0009-0006-4374-3711","affiliations":[{"raw_affiliation_string":"MBF Bioscience, Williston, VT 05495, USA","institution_ids":["https://openalex.org/I4210130942"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012287678","display_name":"Nathan O\u2019Connor","orcid":"https://orcid.org/0009-0000-5928-8692","observed_orcids":["https://orcid.org/0009-0000-5928-8692"]},"institutions":[{"id":"https://openalex.org/I4210130942","display_name":"MBF Bioscience (United States)","ror":"https://ror.org/02zynam48","country_code":"US","type":"company","lineage":["https://openalex.org/I4210130942"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nathan J. O'Connor","raw_affiliation_strings":["MBF Bioscience, Williston, VT 05495, USA"],"raw_orcid":"https://orcid.org/0009-0000-5928-8692","affiliations":[{"raw_affiliation_string":"MBF Bioscience, Williston, VT 05495, USA","institution_ids":["https://openalex.org/I4210130942"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5106602377","display_name":"Benjamin W. Haydock","orcid":"https://orcid.org/0009-0005-0168-9190","observed_orcids":["https://orcid.org/0009-0005-0168-9190"]},"institutions":[{"id":"https://openalex.org/I4210130942","display_name":"MBF Bioscience (United States)","ror":"https://ror.org/02zynam48","country_code":"US","type":"company","lineage":["https://openalex.org/I4210130942"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Benjamin W. Haydock","raw_affiliation_strings":["MBF Bioscience, Williston, VT 05495, USA"],"raw_orcid":"https://orcid.org/0009-0005-0168-9190","affiliations":[{"raw_affiliation_string":"MBF Bioscience, Williston, VT 05495, USA","institution_ids":["https://openalex.org/I4210130942"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5106058218","display_name":"Jeffrey O. Blaisdell","orcid":"https://orcid.org/0009-0004-0565-9872","observed_orcids":["https://orcid.org/0009-0004-0565-9872"]},"institutions":[{"id":"https://openalex.org/I4210130942","display_name":"MBF Bioscience (United States)","ror":"https://ror.org/02zynam48","country_code":"US","type":"company","lineage":["https://openalex.org/I4210130942"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeffrey O. Blaisdell","raw_affiliation_strings":["MBF Bioscience, Williston, VT 05495, USA"],"raw_orcid":"https://orcid.org/0009-0004-0565-9872","affiliations":[{"raw_affiliation_string":"MBF Bioscience, Williston, VT 05495, USA","institution_ids":["https://openalex.org/I4210130942"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5106602378","display_name":"Nicolas Roussel","orcid":"https://orcid.org/0009-0003-7441-9496","observed_orcids":["https://orcid.org/0009-0003-7441-9496"]},"institutions":[{"id":"https://openalex.org/I4210130942","display_name":"MBF Bioscience (United States)","ror":"https://ror.org/02zynam48","country_code":"US","type":"company","lineage":["https://openalex.org/I4210130942"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nicolas Roussel","raw_affiliation_strings":["MBF Bioscience, Williston, VT 05495, USA"],"raw_orcid":"https://orcid.org/0009-0003-7441-9496","affiliations":[{"raw_affiliation_string":"MBF Bioscience, Williston, VT 05495, USA","institution_ids":["https://openalex.org/I4210130942"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114210496","display_name":"Alissa L. Wilson","orcid":"https://orcid.org/0009-0004-3698-1784","observed_orcids":["https://orcid.org/0009-0004-3698-1784"]},"institutions":[{"id":"https://openalex.org/I4210086933","display_name":"NYU Langone Health","ror":"https://ror.org/005dvqh91","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210086933"]},{"id":"https://openalex.org/I4210130942","display_name":"MBF Bioscience (United States)","ror":"https://ror.org/02zynam48","country_code":"US","type":"company","lineage":["https://openalex.org/I4210130942"]},{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]},{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alissa L. Wilson","raw_affiliation_strings":["Center for Neural Science, New York University, New York, NY 10003, USA","Comprehensive Epilepsy Center, Department of Neurology, New York University Grossman School of Medicine; New York City, 10016, USA","Department of Biological Sciences, Columbia University, New York, NY 10027, USA","Department of Biomedical Engineering, Columbia University, New York, NY 10027, USA","Department of Neuroscience and Physiology, New York University Grossman School of Medicine; New York City, 10016, USA","Department of Neurosurgery, New York University Grossman School of Medicine; New York City, 10016, USA","Department of Psychiatry, New York University Grossman School of Medicine; New York City, 10016, USA","MBF Bioscience, Williston, VT 05495, USA","Neuroscience Institute, New York University Langone Health, New York, NY 10016, USA","MBF Bioscience 185 Allen Brook Lane Suite 101 Williston VT 05495 USA"],"raw_orcid":"https://orcid.org/0009-0004-3698-1784","affiliations":[{"raw_affiliation_string":"Center for Neural Science, New York University, New York, NY 10003, USA","institution_ids":["https://openalex.org/I57206974"]},{"raw_affiliation_string":"Comprehensive Epilepsy Center, Department of Neurology, New York University Grossman School of Medicine; New York City, 10016, USA","institution_ids":["https://openalex.org/I57206974"]},{"raw_affiliation_string":"Department of Biological Sciences, Columbia University, New York, NY 10027, USA","institution_ids":["https://openalex.org/I78577930"]},{"raw_affiliation_string":"Department of Biomedical Engineering, Columbia University, New York, NY 10027, USA","institution_ids":["https://openalex.org/I78577930"]},{"raw_affiliation_string":"Department of Neuroscience and Physiology, New York University Grossman School of Medicine; New York City, 10016, USA","institution_ids":["https://openalex.org/I57206974"]},{"raw_affiliation_string":"Department of Neurosurgery, New York University Grossman School of Medicine; New York City, 10016, USA","institution_ids":["https://openalex.org/I57206974"]},{"raw_affiliation_string":"Department of Psychiatry, New York University Grossman School of Medicine; New York City, 10016, USA","institution_ids":["https://openalex.org/I57206974"]},{"raw_affiliation_string":"MBF Bioscience, Williston, VT 05495, USA","institution_ids":["https://openalex.org/I4210130942"]},{"raw_affiliation_string":"Neuroscience Institute, New York University Langone Health, New York, NY 10016, USA","institution_ids":["https://openalex.org/I4210086933","https://openalex.org/I57206974"]},{"raw_affiliation_string":"MBF Bioscience 185 Allen Brook Lane Suite 101 Williston VT 05495 USA","institution_ids":["https://openalex.org/I4210130942"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5106602379","display_name":"Sage R. Aronson","orcid":"https://orcid.org/0009-0004-5284-1087","observed_orcids":["https://orcid.org/0009-0004-5284-1087"]},"institutions":[{"id":"https://openalex.org/I4210130942","display_name":"MBF Bioscience (United States)","ror":"https://ror.org/02zynam48","country_code":"US","type":"company","lineage":["https://openalex.org/I4210130942"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sage R. Aronson","raw_affiliation_strings":["MBF Bioscience, Williston, VT 05495, USA"],"raw_orcid":"https://orcid.org/0009-0004-5284-1087","affiliations":[{"raw_affiliation_string":"MBF Bioscience, Williston, VT 05495, USA","institution_ids":["https://openalex.org/I4210130942"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018138809","display_name":"Paul J. Angstman","orcid":"https://orcid.org/0009-0009-8144-0115","observed_orcids":["https://orcid.org/0009-0009-8144-0115"]},"institutions":[{"id":"https://openalex.org/I4210130942","display_name":"MBF Bioscience (United States)","ror":"https://ror.org/02zynam48","country_code":"US","type":"company","lineage":["https://openalex.org/I4210130942"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paul J. Angstman","raw_affiliation_strings":["MBF Bioscience, Williston, VT 05495, USA"],"raw_orcid":"https://orcid.org/0009-0009-8144-0115","affiliations":[{"raw_affiliation_string":"MBF Bioscience, Williston, VT 05495, USA","institution_ids":["https://openalex.org/I4210130942"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033624524","display_name":"Cheng Gong","orcid":"https://orcid.org/0000-0002-0026-2006","observed_orcids":["https://orcid.org/0000-0002-0026-2006"]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cheng Gong","raw_affiliation_strings":["Department of Biological Sciences, Columbia University, New York, NY 10027, USA","Department of Biomedical Engineering, Columbia University, New York, NY 10027, USA","Department of Biomedical Engineering, Columbia University, New York, NY 1007, USA"],"raw_orcid":"https://orcid.org/0000-0002-0026-2006","affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, Columbia University, New York, NY 10027, USA","institution_ids":["https://openalex.org/I78577930"]},{"raw_affiliation_string":"Department of Biomedical Engineering, Columbia University, New York, NY 10027, USA","institution_ids":["https://openalex.org/I78577930"]},{"raw_affiliation_string":"Department of Biomedical Engineering, Columbia University, New York, NY 1007, USA","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000599932","display_name":"Tanvi Butola","orcid":"https://orcid.org/0000-0003-4350-0569","observed_orcids":["https://orcid.org/0000-0003-4350-0569"]},"institutions":[{"id":"https://openalex.org/I4210086933","display_name":"NYU Langone Health","ror":"https://ror.org/005dvqh91","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210086933"]},{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tanvi Butola","raw_affiliation_strings":["Comprehensive Epilepsy Center, Department of Neurology, New York University Grossman School of Medicine; New York City, 10016, USA","Department of Neuroscience and Physiology, New York University Grossman School of Medicine; New York City, 10016, USA","Neuroscience Institute, New York University Langone Health, New York, NY 10016, USA","Comprehensive Epilepsy Center, Department of Neurology, New York University Grossman School of Medicine","Department of Neuroscience and Physiology, New York University Grossman School of Medicine","New York City, 10016, USA"],"raw_orcid":"https://orcid.org/0000-0003-4350-0569","affiliations":[{"raw_affiliation_string":"Comprehensive Epilepsy Center, Department of Neurology, New York University Grossman School of Medicine; New York City, 10016, USA","institution_ids":["https://openalex.org/I57206974"]},{"raw_affiliation_string":"Department of Neuroscience and Physiology, New York University Grossman School of Medicine; New York City, 10016, USA","institution_ids":["https://openalex.org/I57206974"]},{"raw_affiliation_string":"Neuroscience Institute, New York University Langone Health, New York, NY 10016, USA","institution_ids":["https://openalex.org/I4210086933","https://openalex.org/I57206974"]},{"raw_affiliation_string":"Comprehensive Epilepsy Center, Department of Neurology, New York University Grossman School of Medicine","institution_ids":["https://openalex.org/I57206974"]},{"raw_affiliation_string":"Department of Neuroscience and Physiology, New York University Grossman School of Medicine","institution_ids":["https://openalex.org/I57206974"]},{"raw_affiliation_string":"New York City, 10016, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001041177","display_name":"Orrin Devinsky","orcid":"https://orcid.org/0000-0003-0044-4632","observed_orcids":["https://orcid.org/0000-0003-0044-4632"]},"institutions":[{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Orrin Devinsky","raw_affiliation_strings":["Comprehensive Epilepsy Center, Department of Neurology, New York University Grossman School of Medicine; New York City, 10016, USA","Department of Neuroscience and Physiology, New York University Grossman School of Medicine; New York City, 10016, USA","Department of Neurosurgery, New York University Grossman School of Medicine; New York City, 10016, USA","Department of Psychiatry, New York University Grossman School of Medicine; New York City, 10016, USA","Comprehensive Epilepsy Center, Department of Neurology, New York University Grossman School of Medicine","Department of Neuroscience and Physiology, New York University Grossman School of Medicine","Department of Neurosurgery, New York University Grossman School of Medicine","Department of Psychiatry, New York University Grossman School of Medicine","New York City, 1001, USA","New York City, 10016, USA"],"raw_orcid":"https://orcid.org/0000-0003-0044-4632","affiliations":[{"raw_affiliation_string":"Comprehensive Epilepsy Center, Department of Neurology, New York University Grossman School of Medicine; New York City, 10016, USA","institution_ids":["https://openalex.org/I57206974"]},{"raw_affiliation_string":"Department of Neuroscience and Physiology, New York University Grossman School of Medicine; New York City, 10016, USA","institution_ids":["https://openalex.org/I57206974"]},{"raw_affiliation_string":"Department of Neurosurgery, New York University Grossman School of Medicine; New York City, 10016, USA","institution_ids":["https://openalex.org/I57206974"]},{"raw_affiliation_string":"Department of Psychiatry, New York University Grossman School of Medicine; New York City, 10016, USA","institution_ids":["https://openalex.org/I57206974"]},{"raw_affiliation_string":"Comprehensive Epilepsy Center, Department of Neurology, New York University Grossman School of Medicine","institution_ids":["https://openalex.org/I57206974"]},{"raw_affiliation_string":"Department of Neuroscience and Physiology, New York University Grossman School of Medicine","institution_ids":["https://openalex.org/I57206974"]},{"raw_affiliation_string":"Department of Neurosurgery, New York University Grossman School of Medicine","institution_ids":["https://openalex.org/I57206974"]},{"raw_affiliation_string":"Department of Psychiatry, New York University Grossman School of Medicine","institution_ids":["https://openalex.org/I57206974"]},{"raw_affiliation_string":"New York City, 1001, USA","institution_ids":[]},{"raw_affiliation_string":"New York City, 10016, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001044140","display_name":"Jayeeta Basu","orcid":"https://orcid.org/0000-0002-7559-0936","observed_orcids":["https://orcid.org/0000-0002-7559-0936"]},"institutions":[{"id":"https://openalex.org/I4210086933","display_name":"NYU Langone Health","ror":"https://ror.org/005dvqh91","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210086933"]},{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jayeeta Basu","raw_affiliation_strings":["Center for Neural Science, New York University, New York, NY 10003, USA","Department of Neuroscience and Physiology, New York University Grossman School of Medicine; New York City, 10016, USA","Neuroscience Institute, New York University Langone Health, New York, NY 10016, USA","Department of Neuroscience and Physiology, New York University Grossman School of Medicine","New York City, 10016, USA"],"raw_orcid":"https://orcid.org/0000-0002-7559-0936","affiliations":[{"raw_affiliation_string":"Center for Neural Science, New York University, New York, NY 10003, USA","institution_ids":["https://openalex.org/I57206974"]},{"raw_affiliation_string":"Department of Neuroscience and Physiology, New York University Grossman School of Medicine; New York City, 10016, USA","institution_ids":["https://openalex.org/I57206974"]},{"raw_affiliation_string":"Neuroscience Institute, New York University Langone Health, New York, NY 10016, USA","institution_ids":["https://openalex.org/I4210086933","https://openalex.org/I57206974"]},{"raw_affiliation_string":"Department of Neuroscience and Physiology, New York University Grossman School of Medicine","institution_ids":["https://openalex.org/I57206974"]},{"raw_affiliation_string":"New York City, 10016, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085712951","display_name":"Raju Tomer","orcid":"https://orcid.org/0000-0002-4229-2860","observed_orcids":["https://orcid.org/0000-0002-4229-2860"]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Raju Tomer","raw_affiliation_strings":["Department of Biological Sciences, Columbia University, New York, NY 10027, USA","Department of Biomedical Engineering, Columbia University, New York, NY 10027, USA","Department of Biomedical Engineering, Columbia University, New York, NY 1007, USA"],"raw_orcid":"https://orcid.org/0000-0002-4229-2860","affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, Columbia University, New York, NY 10027, USA","institution_ids":["https://openalex.org/I78577930"]},{"raw_affiliation_string":"Department of Biomedical Engineering, Columbia University, New York, NY 10027, USA","institution_ids":["https://openalex.org/I78577930"]},{"raw_affiliation_string":"Department of Biomedical Engineering, Columbia University, New York, NY 1007, USA","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5066141902","display_name":"Jacob R. Glaser","orcid":"https://orcid.org/0000-0003-4463-207X","observed_orcids":["https://orcid.org/0000-0003-4463-207X"]},"institutions":[{"id":"https://openalex.org/I4210130942","display_name":"MBF Bioscience (United States)","ror":"https://ror.org/02zynam48","country_code":"US","type":"company","lineage":["https://openalex.org/I4210130942"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jacob R. Glaser","raw_affiliation_strings":["MBF Bioscience, Williston, VT 05495, USA"],"raw_orcid":"https://orcid.org/0000-0003-4463-207X","affiliations":[{"raw_affiliation_string":"MBF Bioscience, Williston, VT 05495, USA","institution_ids":["https://openalex.org/I4210130942"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5066141902"],"corresponding_institution_ids":["https://openalex.org/I4210130942"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10540","display_name":"Advanced Fluorescence Microscopy Techniques","score":0.9535999894142151,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10540","display_name":"Advanced Fluorescence Microscopy Techniques","score":0.9535999894142151,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.029100000858306885,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10977","display_name":"Optical Imaging and Spectroscopy Techniques","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/light-sheet-microscopy","display_name":"light-sheet microscopy","score":0.7519999742507935},{"id":"https://openalex.org/keywords/brain-clearing","display_name":"brain clearing","score":0.5849999785423279},{"id":"https://openalex.org/keywords/vessel-reconstruction","display_name":"vessel reconstruction","score":0.9729999899864197},{"id":"https://openalex.org/keywords/design-based-stereology","display_name":"design-based stereology","score":0.9399999976158142},{"id":"https://openalex.org/keywords/3d-brain-imaging","display_name":"3D brain imaging","score":0.7409999966621399},{"id":"https://openalex.org/keywords/mouse-brain","display_name":"mouse brain","score":0.7549999952316284},{"id":"https://openalex.org/keywords/human-brain","display_name":"human brain","score":0.5210000276565552},{"id":"https://openalex.org/keywords/neuropsychiatric-disorders","display_name":"neuropsychiatric disorders","score":0.6880000233650208},{"id":"https://openalex.org/keywords/neurological-disorders","display_name":"neurological disorders","score":0.6420000195503235}],"concepts":[{"id":"https://openalex.org/C113976765","wikidata":"https://www.wikidata.org/wiki/Q1823502","display_name":"Light sheet fluorescence microscopy","level":4,"score":0.8320773243904114},{"id":"https://openalex.org/C147080431","wikidata":"https://www.wikidata.org/wiki/Q1074953","display_name":"Microscopy","level":2,"score":0.6393148303031921},{"id":"https://openalex.org/C138944611","wikidata":"https://www.wikidata.org/wiki/Q1163287","display_name":"Clearance","level":2,"score":0.5808557271957397},{"id":"https://openalex.org/C205372480","wikidata":"https://www.wikidata.org/wiki/Q210521","display_name":"Image resolution","level":2,"score":0.47137415409088135},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.45987170934677124},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.44739922881126404},{"id":"https://openalex.org/C138268822","wikidata":"https://www.wikidata.org/wiki/Q1051925","display_name":"Resolution (logic)","level":2,"score":0.41273796558380127},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.3911049962043762},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.37199264764785767},{"id":"https://openalex.org/C31972630","wikidata":"https://www.wikidata.org/wiki/Q844240","display_name":"Computer vision","level":1,"score":0.3466756343841553},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.340875506401062},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.19290480017662048},{"id":"https://openalex.org/C187921700","wikidata":"https://www.wikidata.org/wiki/Q7430074","display_name":"Scanning confocal electron microscopy","level":3,"score":0.12685087323188782},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.09349030256271362},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1101/2024.08.15.608141","doi":"https://doi.org/10.1101/2024.08.15.608141","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2024.08.15.608141","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmid:39229056","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39229056","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"bioRxiv : the preprint server for biology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11370359","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11370359","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11370359/pdf/nihpp-2024.08.15.608141v1.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1101/2024.08.15.608141","doi":"https://doi.org/10.1101/2024.08.15.608141","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2024.08.15.608141","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G7485629529","display_name":"ClearScope","funder_award_id":"R44MH116827","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G9000881928","display_name":"Clinical and Translational Science Award","funder_award_id":"UL1TR001445","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337346","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":36,"referenced_works":["https://openalex.org/W1487216741","https://openalex.org/W1540070193","https://openalex.org/W2009275634","https://openalex.org/W2010114799","https://openalex.org/W2010460856","https://openalex.org/W2016277672","https://openalex.org/W2030224529","https://openalex.org/W2040870938","https://openalex.org/W2051036306","https://openalex.org/W2052003865","https://openalex.org/W2056942342","https://openalex.org/W2076507262","https://openalex.org/W2078677652","https://openalex.org/W2167279371","https://openalex.org/W2217108923","https://openalex.org/W2511563072","https://openalex.org/W2512571444","https://openalex.org/W2519039761","https://openalex.org/W2598427385","https://openalex.org/W2807523344","https://openalex.org/W2951285637","https://openalex.org/W2966422204","https://openalex.org/W3021105102","https://openalex.org/W3134482516","https://openalex.org/W3137491994","https://openalex.org/W3153719656","https://openalex.org/W3193928964","https://openalex.org/W3195544055","https://openalex.org/W3206830784","https://openalex.org/W3212846998","https://openalex.org/W4224214682","https://openalex.org/W4280562732","https://openalex.org/W4318401332","https://openalex.org/W4376132502","https://openalex.org/W4389305409","https://openalex.org/W4391428375"],"related_works":["https://openalex.org/W7134828522","https://openalex.org/W2902493446","https://openalex.org/W3135139881","https://openalex.org/W2920880693","https://openalex.org/W6921041835","https://openalex.org/W4414845344","https://openalex.org/W6977193382","https://openalex.org/W2902981599","https://openalex.org/W4206920958","https://openalex.org/W2993468371"],"abstract_inverted_index":{"imaging":[0,44,49,133,173],"of":[1,5,50,58,70,91,106,120,174,210,215,220],"cleared":[2,52],"intact":[3,175],"brains":[4,177],"animal":[6],"models":[7],"and":[8,11,27,33,60,125,159,162,178,182,192,201,212],"large":[9,51,137,222],"human":[10,179],"non-human":[12],"primate":[13],"postmortem":[14],"brain":[15,180],"specimens":[16],"is":[17],"important":[18],"for":[19,46,129,153],"understanding":[20],"the":[21,28,55,68,98,107,113,141,167],"physiological":[22],"neural":[23],"network":[24],"connectivity":[25],"patterns":[26],"pathological":[29],"alterations":[30],"underlying":[31],"neuropsychiatric":[32],"neurological":[34],"disorders.":[35],"Light-sheet":[36],"microscopy":[37,66,81],"has":[38],"emerged":[39],"as":[40],"a":[41,88,121,136,149],"highly":[42],"effective":[43],"modality":[45],"rapid":[47,130,207],"high-resolution":[48,171],"samples.":[53,223],"However,":[54],"orthogonal":[56],"arrangements":[57],"illumination":[59,93],"detection":[61,99,108],"optics":[62],"in":[63,196,217],"light":[64,78,94,100,109],"sheet":[65,79],"limits":[67],"size":[69],"specimen":[71,114,138],"that":[72],"can":[73],"be":[74],"imaged.":[75],"Recently":[76],"developed":[77],"theta":[80],"(LSTM)":[82],"technology":[83],"addressed":[84],"this":[85],"by":[86,170],"utilizing":[87],"unique":[89],"arrangement":[90,105],"two":[92],"paths":[95],"oblique":[96],"to":[97,112],"path,":[101],"while":[102],"allowing":[103],"perpendicular":[104],"path":[110],"relative":[111],"surface.":[115],"Here,":[116],"we":[117,147],"report":[118],"development":[119],"next-generation,":[122],"fully":[123],"integrated,":[124],"user-friendly":[126,202],"LSTM":[127,203],"system":[128,168],"sub-cellular":[131],"resolution":[132],"uniformly":[134],"throughout":[135],"without":[139],"constraining":[140],"lateral":[142],"(XY)":[143],"size.":[144],"In":[145],"addition,":[146],"provide":[148],"seamlessly":[150],"integrated":[151],"workflow":[152],"image":[154],"acquisition,":[155],"data":[156,184],"storage,":[157],"pre-":[158],"post-processing,":[160],"enhancement,":[161],"quantitative":[163,208],"analysis.":[164],"We":[165],"demonstrate":[166],"performance":[169],"3D":[172],"mouse":[176],"samples,":[181],"complete":[183],"analysis":[185,195],"including":[186],"digital":[187],"neuron":[188],"tracing,":[189],"vessel":[190],"reconstruction":[191],"design-based":[193],"stereological":[194],"3D.":[197],"This":[198],"technically":[199],"enhanced":[200],"implementation":[204],"will":[205],"enable":[206],"mapping":[209],"molecular":[211],"cellular":[213],"features":[214],"interests":[216],"diverse":[218],"types":[219],"very":[221]},"counts_by_year":[{"year":2025,"cited_by_count":1}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2024-08-19T00:00:00"}