{"id":"https://openalex.org/W4401684787","doi":"https://doi.org/10.1007/s00228-024-03744-z","title":"Evaluation of SLC6A2 and CYP2D6 polymorphisms\u2019 effects on atomoxetine treatment in attention deficit and hyperactivity disorder","display_name":"Evaluation of SLC6A2 and CYP2D6 polymorphisms\u2019 effects on atomoxetine treatment in attention deficit and hyperactivity disorder","publication_year":2024,"publication_date":"2024-08-19","ids":{"openalex":"https://openalex.org/W4401684787","doi":"https://doi.org/10.1007/s00228-024-03744-z","pmid":"https://pubmed.ncbi.nlm.nih.gov/39158690"},"language":"en","primary_location":{"id":"doi:10.1007/s00228-024-03744-z","doi":"https://doi.org/10.1007/s00228-024-03744-z","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s00228-024-03744-z","pdf_url":null,"source":{"id":"https://openalex.org/S31780008","display_name":"European Journal of Clinical Pharmacology","issn_l":"0031-6970","issn":["0031-6970","1432-1041"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Clinical Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://dx.doi.org/10.21203/rs.3.rs-4402227/v1","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5052612834","display_name":"\u0130smail Hasan K\u00f6le","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I131835042","display_name":"Bursa Uluda\u011f \u00dcni\u0307versi\u0307tesi\u0307","ror":"https://ror.org/03tg3eb07","country_code":"TR","type":"education","lineage":["https://openalex.org/I131835042"]}],"countries":["TR"],"is_corresponding":true,"raw_author_name":"Ismail Hasan Kole","raw_affiliation_strings":["Department of Child and Adolescent Psychiatry, Faculty of Medicine, Bursa Uludag University, Bursa, T\u00fcrkiye. hasankole@uludag.edu.tr","Department of Child and Adolescent Psychiatry, Faculty of Medicine, Bursa Uludag University, Bursa, T\u00fcrkiye"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Child and Adolescent Psychiatry, Faculty of Medicine, Bursa Uludag University, Bursa, T\u00fcrkiye. hasankole@uludag.edu.tr","institution_ids":["https://openalex.org/I131835042"]},{"raw_affiliation_string":"Department of Child and Adolescent Psychiatry, Faculty of Medicine, Bursa Uludag University, Bursa, T\u00fcrkiye","institution_ids":["https://openalex.org/I131835042"]}]},{"author_position":"middle","author":{"id":null,"display_name":"P\u0131nar Vural","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210146544","display_name":"Fatih Sultan Mehmet Waqf University","ror":"https://ror.org/04mma4681","country_code":"TR","type":"education","lineage":["https://openalex.org/I4210146544"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"P\u0131nar Vural","raw_affiliation_strings":["Department of Psychology, Faculty of Humanities and Social Sciences, Fatih Sultan Mehmet Vakif University, Istanbul, T\u00fcrkiye"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychology, Faculty of Humanities and Social Sciences, Fatih Sultan Mehmet Vakif University, Istanbul, T\u00fcrkiye","institution_ids":["https://openalex.org/I4210146544"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081849032","display_name":"Beste Yurdacan","orcid":"https://orcid.org/0000-0003-0937-4394","observed_orcids":["https://orcid.org/0000-0003-0937-4394"]},"institutions":[{"id":"https://openalex.org/I131835042","display_name":"Bursa Uluda\u011f \u00dcni\u0307versi\u0307tesi\u0307","ror":"https://ror.org/03tg3eb07","country_code":"TR","type":"education","lineage":["https://openalex.org/I131835042"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Beste Yurdacan","raw_affiliation_strings":["Department of Medical Biology, Faculty of Medicine, Bursa Uludag University, 16059, Bursa, T\u00fcrkiye"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Biology, Faculty of Medicine, Bursa Uludag University, 16059, Bursa, T\u00fcrkiye","institution_ids":["https://openalex.org/I131835042"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038058574","display_name":"Adem Alemdar","orcid":"https://orcid.org/0000-0003-3070-9224","observed_orcids":["https://orcid.org/0000-0003-3070-9224"]},"institutions":[{"id":"https://openalex.org/I131835042","display_name":"Bursa Uluda\u011f \u00dcni\u0307versi\u0307tesi\u0307","ror":"https://ror.org/03tg3eb07","country_code":"TR","type":"education","lineage":["https://openalex.org/I131835042"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Adem Alemdar","raw_affiliation_strings":["Department of Medical Biology, Faculty of Medicine, Bursa Uludag University, 16059, Bursa, T\u00fcrkiye"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Biology, Faculty of Medicine, Bursa Uludag University, 16059, Bursa, T\u00fcrkiye","institution_ids":["https://openalex.org/I131835042"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5065443234","display_name":"Caner Mutlu","orcid":"https://orcid.org/0000-0001-6507-8042","observed_orcids":["https://orcid.org/0000-0001-6507-8042"]},"institutions":[{"id":"https://openalex.org/I131835042","display_name":"Bursa Uluda\u011f \u00dcni\u0307versi\u0307tesi\u0307","ror":"https://ror.org/03tg3eb07","country_code":"TR","type":"education","lineage":["https://openalex.org/I131835042"]}],"countries":["TR"],"is_corresponding":true,"raw_author_name":"Caner Mutlu","raw_affiliation_strings":["Department of Child and Adolescent Psychiatry, Faculty of Medicine, Bursa Uludag University, Bursa, T\u00fcrkiye. canermutlu@uludag.edu.tr","Department of Child and Adolescent Psychiatry, Faculty of Medicine, Bursa Uludag University, Bursa, T\u00fcrkiye"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Child and Adolescent Psychiatry, Faculty of Medicine, Bursa Uludag University, Bursa, T\u00fcrkiye. canermutlu@uludag.edu.tr","institution_ids":["https://openalex.org/I131835042"]},{"raw_affiliation_string":"Department of Child and Adolescent Psychiatry, Faculty of Medicine, Bursa Uludag University, Bursa, T\u00fcrkiye","institution_ids":["https://openalex.org/I131835042"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5052612834","https://openalex.org/A5065443234"],"corresponding_institution_ids":["https://openalex.org/I131835042"],"apc_list":{"value":4590,"currency":"USD","value_usd":4590},"apc_paid":null,"fwci":0.8774,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.74135335,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":97},"biblio":{"volume":"80","issue":"11","first_page":"1773","last_page":"1785"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10537","display_name":"Attention Deficit Hyperactivity Disorder","score":0.9434000253677368,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10537","display_name":"Attention Deficit Hyperactivity Disorder","score":0.9434000253677368,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.054999999701976776,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/atomoxetine","display_name":"atomoxetine","score":0.9279999732971191},{"id":"https://openalex.org/keywords/attention-deficit-hyperactivity-disorder","display_name":"attention deficit hyperactivity disorder","score":0.9549999833106995},{"id":"https://openalex.org/keywords/norepinephrine-transporter","display_name":"norepinephrine transporter","score":0.9769999980926514},{"id":"https://openalex.org/keywords/cyp2d6","display_name":"CYP2D6","score":0.9990000128746033},{"id":"https://openalex.org/keywords/single-nucleotide-polymorphisms","display_name":"single nucleotide polymorphisms","score":0.9769999980926514},{"id":"https://openalex.org/keywords/pharmacogenetics","display_name":"pharmacogenetics","score":0.878000020980835},{"id":"https://openalex.org/keywords/treatment-response","display_name":"treatment response","score":0.921999990940094},{"id":"https://openalex.org/keywords/adverse-drug-reactions","display_name":"adverse drug reactions","score":0.7720000147819519},{"id":"https://openalex.org/keywords/genotype-phenotype-correlation","display_name":"genotype-phenotype correlation","score":0.7269999980926514}],"concepts":[{"id":"https://openalex.org/C2778781522","wikidata":"https://www.wikidata.org/wiki/Q417240","display_name":"Atomoxetine","level":4,"score":0.9439716339111328},{"id":"https://openalex.org/C33664856","wikidata":"https://www.wikidata.org/wiki/Q3271142","display_name":"CYP2D6","level":4,"score":0.8053476810455322},{"id":"https://openalex.org/C2780783007","wikidata":"https://www.wikidata.org/wiki/Q181923","display_name":"Attention deficit hyperactivity disorder","level":2,"score":0.6845604181289673},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.6565840840339661},{"id":"https://openalex.org/C2777112843","wikidata":"https://www.wikidata.org/wiki/Q422112","display_name":"Methylphenidate","level":3,"score":0.488944411277771},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4736291766166687},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4548916518688202},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3894685208797455},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.28380951285362244},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.26339322328567505},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.25585025548934937},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.18276455998420715},{"id":"https://openalex.org/C526171541","wikidata":"https://www.wikidata.org/wiki/Q407693","display_name":"Cytochrome P450","level":3,"score":0.09708723425865173},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.09480005502700806},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000069445","descriptor_name":"Atomoxetine Hydrochloride","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D000069445","descriptor_name":"Atomoxetine Hydrochloride","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001289","descriptor_name":"Attention Deficit Disorder with Hyperactivity","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D001289","descriptor_name":"Attention Deficit Disorder with Hyperactivity","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018759","descriptor_name":"Adrenergic Uptake Inhibitors","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D018759","descriptor_name":"Adrenergic Uptake Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D019389","descriptor_name":"Cytochrome P-450 CYP2D6","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D050484","descriptor_name":"Norepinephrine Plasma Membrane Transport Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1007/s00228-024-03744-z","doi":"https://doi.org/10.1007/s00228-024-03744-z","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s00228-024-03744-z","pdf_url":null,"source":{"id":"https://openalex.org/S31780008","display_name":"European Journal of Clinical Pharmacology","issn_l":"0031-6970","issn":["0031-6970","1432-1041"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Clinical Pharmacology","raw_type":"journal-article"},{"id":"doi:10.21203/rs.3.rs-4402227/v1","doi":"https://doi.org/10.21203/rs.3.rs-4402227/v1","is_oa":true,"landing_page_url":"http://dx.doi.org/10.21203/rs.3.rs-4402227/v1","pdf_url":null,"source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},{"id":"pmid:39158690","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39158690","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European journal of clinical pharmacology","raw_type":"Journal Article"},{"id":"pmh:oai:acikerisim.fsm.edu.tr:11352/4995","doi":null,"is_oa":true,"landing_page_url":"https://orcid.org/0000-0002-9896-6836","pdf_url":null,"source":{"id":"https://openalex.org/S4306400556","display_name":"DSpace@FSM (FSM Vakif University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210146544","host_organization_name":"Fatih Sultan Mehmet Waqf University","host_organization_lineage":["https://openalex.org/I4210146544"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"}],"best_oa_location":{"id":"doi:10.21203/rs.3.rs-4402227/v1","doi":"https://doi.org/10.21203/rs.3.rs-4402227/v1","is_oa":true,"landing_page_url":"http://dx.doi.org/10.21203/rs.3.rs-4402227/v1","pdf_url":null,"source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9922999739646912}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":50,"referenced_works":["https://openalex.org/W63074263","https://openalex.org/W1493305388","https://openalex.org/W1495850955","https://openalex.org/W1591596980","https://openalex.org/W1896744728","https://openalex.org/W1964309132","https://openalex.org/W1976295504","https://openalex.org/W1981330536","https://openalex.org/W1987326269","https://openalex.org/W2000595776","https://openalex.org/W2007086168","https://openalex.org/W2013038434","https://openalex.org/W2018913332","https://openalex.org/W2025655489","https://openalex.org/W2027451644","https://openalex.org/W2066906758","https://openalex.org/W2089459114","https://openalex.org/W2089690498","https://openalex.org/W2102693202","https://openalex.org/W2114290463","https://openalex.org/W2120036296","https://openalex.org/W2133062189","https://openalex.org/W2138357739","https://openalex.org/W2149164700","https://openalex.org/W2154662266","https://openalex.org/W2157475667","https://openalex.org/W2189823828","https://openalex.org/W2212816893","https://openalex.org/W2269370722","https://openalex.org/W2313756458","https://openalex.org/W2549853041","https://openalex.org/W2587631464","https://openalex.org/W2752587112","https://openalex.org/W2772773692","https://openalex.org/W2791741161","https://openalex.org/W2917080169","https://openalex.org/W2935530445","https://openalex.org/W3080171054","https://openalex.org/W3112850414","https://openalex.org/W3158381382","https://openalex.org/W3168541352","https://openalex.org/W3182471402","https://openalex.org/W4213226435","https://openalex.org/W4225123819","https://openalex.org/W4254230094","https://openalex.org/W4309809252","https://openalex.org/W4316469865","https://openalex.org/W4366549485","https://openalex.org/W4389509027","https://openalex.org/W4392964099"],"related_works":["https://openalex.org/W2120036296","https://openalex.org/W2917080169","https://openalex.org/W3158381382","https://openalex.org/W4297460151","https://openalex.org/W4403306975","https://openalex.org/W4294200711","https://openalex.org/W7112748401","https://openalex.org/W4225123819","https://openalex.org/W2170862812","https://openalex.org/W2000595776"],"abstract_inverted_index":{"Abstract":[0],"Background":[1],"There":[2],"is":[3],"insufficient":[4],"replicated":[5],"data":[6],"to":[7,64,140],"establish":[8],"a":[9],"relationship":[10,67],"between":[11,68,87,155],"the":[12,17,27,40,59,66,85,92,105,126,161,181,194],"polymorphisms":[13,33,120,179],"of":[14,19,29,70,74,78,89,94,114,129,134,147,164,172,178,196],"NET/SLC6A2":[15],"and":[16,37,46,76,80,91,109,160,183],"efficacy":[18],"Atomoxetine":[20],"(ATX)":[21],"treatment.":[22],"We":[23,151],"focused":[24],"on":[25,39],"evaluating":[26],"effect":[28],"top-line":[30],"single":[31],"nucleotide":[32],"(SNPs)":[34],"in":[35,44,101,121,142,167,190,201],"SLC6A2":[36,75,122,182],"CYP2D6":[38,90,184],"ATX":[41,81,98,141,200],"treatment":[42,82,127,191],"response":[43,128,192],"Attention-Deficit":[45],"Hyperactivity":[47],"Disorder":[48],"(ADHD).":[49],"Methods":[50],"Of":[51],"160":[52],"patient":[53],"records,":[54],"thirty-four":[55],"patients":[56,111,148],"who":[57],"met":[58],"inclusion":[60],"criteria":[61],"were":[62,123],"evaluated":[63],"determine":[65],"genotypes":[69,177],"ten":[71],"SNPs":[72,88],"(six":[73],"four":[77],"CYP2D6)":[79],"response.":[83],"Additionally,":[84],"connection":[86],"severity":[93,158,195],"side-effects":[95,197],"associated":[96,124,198],"with":[97,125,138,149,199],"was":[99,136],"analyzed":[100],"37":[102],"patients,":[103,108],"including":[104],"34":[106],"study":[107,174],"three":[110],"discontinued":[112],"because":[113],"ATX-dependent":[115],"side-effects.":[116],"Results":[117],"All":[118],"six":[119],"ATX.":[130],"The":[131,170],"\u201cT\u201d":[132],"allele":[133],"rs3785143":[135],"linked":[137],"unresponsiveness":[139],"treating":[143],"oppositional":[144],"defiant":[145],"symptoms":[146],"ADHD.":[150],"detected":[152],"an":[153,187],"association":[154],"higher":[156],"CGI-side-effect":[157],"scores":[159],"\u201cTT\u201d":[162],"genotype":[163],"rs1065852":[165],"polymorphism":[166],"CYP2D6.":[168],"Conclusions":[169],"findings":[171],"this":[173],"suggest":[175],"that":[176],"within":[180],"may":[185],"play":[186],"influential":[188],"role":[189],"or":[193],"ADHD":[202],"patients.":[203]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1}],"updated_date":"2026-11-01T11:40:01.658920","created_date":"2024-08-19T00:00:00"}