{"id":"https://openalex.org/W4401635950","doi":"https://doi.org/10.23857/pc.v9i8.7811","title":"Cannabinoides y c\u00e1ncer de mama HER2 positivo: una revisi\u00f3n sistem\u00e1tica de los estudios in vivo e in vitro","display_name":"Cannabinoides y c\u00e1ncer de mama HER2 positivo: una revisi\u00f3n sistem\u00e1tica de los estudios in vivo e in vitro","publication_year":2024,"publication_date":"2024-08-01","ids":{"openalex":"https://openalex.org/W4401635950","doi":"https://doi.org/10.23857/pc.v9i8.7811"},"language":"es","primary_location":{"id":"doi:10.23857/pc.v9i8.7811","doi":"https://doi.org/10.23857/pc.v9i8.7811","is_oa":true,"landing_page_url":"http://dx.doi.org/10.23857/pc.v9i8.7811","pdf_url":"https://polodelconocimiento.com/ojs/index.php/es/article/download/7811/pdf","source":{"id":"https://openalex.org/S4210240955","display_name":"Polo del Conocimiento","issn_l":"2550-682X","issn":["2550-682X"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["erih-plus"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Polo del Conocimiento","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://polodelconocimiento.com/ojs/index.php/es/article/download/7811/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5106561766","display_name":"Melania Nicole Alba Naranjo","orcid":"https://orcid.org/0009-0001-5302-8432","observed_orcids":["https://orcid.org/0009-0001-5302-8432"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Melania Nicole Alba Naranjo","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0001-5302-8432","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5045441695","display_name":"Cesar David Guerra Naranjo","orcid":"https://orcid.org/0000-0001-6651-9591","observed_orcids":["https://orcid.org/0000-0001-6651-9591"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Cesar David Guerra Naranjo","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-6651-9591","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"9","issue":"8","first_page":"2065","last_page":"2082"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10414","display_name":"Cannabis and Cannabinoid Research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10414","display_name":"Cannabis and Cannabinoid Research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12626","display_name":"Cancer, Stress, Anesthesia, and Immune Response","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cannabinoids","display_name":"cannabinoids","score":0.8989999890327454},{"id":"https://openalex.org/keywords/her2-positive-breast-cancer","display_name":"HER2-positive breast cancer","score":0.921999990940094},{"id":"https://openalex.org/keywords/cannabinoid-receptors","display_name":"cannabinoid receptors","score":0.9100000262260437},{"id":"https://openalex.org/keywords/cb1-receptor","display_name":"CB1 receptor","score":0.9660000205039978},{"id":"https://openalex.org/keywords/cb2-receptor","display_name":"CB2 receptor","score":1.0},{"id":"https://openalex.org/keywords/endocannabinoid-system","display_name":"endocannabinoid system","score":0.9610000252723694},{"id":"https://openalex.org/keywords/tetrahydrocannabinol","display_name":"tetrahydrocannabinol","score":0.9049999713897705},{"id":"https://openalex.org/keywords/receptor-heterodimers","display_name":"receptor heterodimers","score":0.609000027179718},{"id":"https://openalex.org/keywords/anticancer-activity","display_name":"anticancer activity","score":0.8220000267028809},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.44200000166893005},{"id":"https://openalex.org/keywords/prognosis","display_name":"prognosis","score":0.33899998664855957}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3262142241001129}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.23857/pc.v9i8.7811","doi":"https://doi.org/10.23857/pc.v9i8.7811","is_oa":true,"landing_page_url":"http://dx.doi.org/10.23857/pc.v9i8.7811","pdf_url":"https://polodelconocimiento.com/ojs/index.php/es/article/download/7811/pdf","source":{"id":"https://openalex.org/S4210240955","display_name":"Polo del Conocimiento","issn_l":"2550-682X","issn":["2550-682X"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["erih-plus"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Polo del Conocimiento","raw_type":"journal-article"},{"id":"pmh:oai:ojs.polodelconocimiento.com:article/7811","doi":null,"is_oa":true,"landing_page_url":"https://polodelconocimiento.com/ojs/index.php/es/article/view/7811","pdf_url":null,"source":{"id":"https://openalex.org/S4210240955","display_name":"Polo del Conocimiento","issn_l":"2550-682X","issn":["2550-682X"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["erih-plus"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"10.23857/pc.v9i8","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.23857/pc.v9i8.7811","doi":"https://doi.org/10.23857/pc.v9i8.7811","is_oa":true,"landing_page_url":"http://dx.doi.org/10.23857/pc.v9i8.7811","pdf_url":"https://polodelconocimiento.com/ojs/index.php/es/article/download/7811/pdf","source":{"id":"https://openalex.org/S4210240955","display_name":"Polo del Conocimiento","issn_l":"2550-682X","issn":["2550-682X"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["erih-plus"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Polo del Conocimiento","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4401635950.pdf","grobid_xml":"https://content.openalex.org/works/W4401635950.grobid-xml"},"referenced_works_count":23,"referenced_works":["https://openalex.org/W1821794896","https://openalex.org/W1964856587","https://openalex.org/W2037232827","https://openalex.org/W2054961000","https://openalex.org/W2065184600","https://openalex.org/W2072110438","https://openalex.org/W2082886056","https://openalex.org/W2097255042","https://openalex.org/W2128652347","https://openalex.org/W2144403540","https://openalex.org/W2299045691","https://openalex.org/W2401948043","https://openalex.org/W2800218694","https://openalex.org/W2912747255","https://openalex.org/W2944367807","https://openalex.org/W2999795626","https://openalex.org/W3138026279","https://openalex.org/W3142425130","https://openalex.org/W3160356862","https://openalex.org/W4251681721","https://openalex.org/W4283386720","https://openalex.org/W4300690596","https://openalex.org/W4318033714"],"related_works":["https://openalex.org/W2979898272","https://openalex.org/W6990845002","https://openalex.org/W4413315920","https://openalex.org/W4416407130","https://openalex.org/W2162572959","https://openalex.org/W7071632710","https://openalex.org/W3189311848","https://openalex.org/W7107990941","https://openalex.org/W2912747255","https://openalex.org/W7160860217"],"abstract_inverted_index":{"El":[0,64],"c\u00e1ncer":[1,45,57],"de":[2,8,12,16,26,38,46,56,58,73,75,87,92,100,106,119,140,143,147],"mama":[3,47],"comprende":[4],"un":[5,111,137],"trascendente":[6],"enigma":[7],"salud":[9],"y":[10,30,36,79,90,94,117],"una":[11,39],"las":[13],"importantes":[14],"causas":[15],"mortalidad":[17],"a":[18,71],"nivel":[19],"mundial.":[20],"Este":[21],"art\u00edculo":[22],"analiza":[23],"el":[24,34,44,54,61,104,128],"papel":[25],"los":[27],"receptores":[28,76,102,123],"cannabinoides":[29,51,77,124],"sus":[31],"heter\u00f3meros":[32],"en":[33,103,135],"pron\u00f3stico":[35],"descubrimiento":[37],"nueva":[40],"diana":[41],"terap\u00e9utica":[42],"para":[43,53,127],"HER2":[48,144],"positivo,":[49],"discutiendo":[50],"espec\u00edficos":[52],"tratamiento":[55],"mama,":[59],"esencialmente":[60],"9-tetrahidrocannabinol":[62],"(THC).":[63],"mismo":[65],"que":[66,109,133],"posee":[67],"efectos":[68],"antitumorales,":[69],"induciendo":[70],"mecanismos":[72],"activaci\u00f3n":[74],"(CB1R":[78],"CB2R),":[80],"implicaci\u00f3n":[81],"del":[82,130],"sistema":[83],"endocannabinoide":[84],"(SEC),":[85],"acci\u00f3n":[86],"ligandos":[88],"end\u00f3genos":[89],"enzimas":[91],"s\u00edntesis":[93],"degradaci\u00f3n.":[95],"Se":[96],"recalca":[97],"la":[98,120,148],"importancia":[99],"estos":[101],"\u00e1rea":[105],"investigaci\u00f3n,":[107],"ya":[108,132],"permiten":[110],"diagn\u00f3stico":[112],"m\u00e1s":[113],"preciso,":[114],"tratamientos":[115],"minuciosos":[116],"seguimiento":[118],"enfermedad.":[121],"Los":[122],"son":[125],"sustanciales":[126],"manejo":[129],"c\u00e1ncer,":[131],"ponen":[134],"evidencia":[136],"nuevo":[138],"mecanismo":[139],"regulaci\u00f3n":[141],"oncog\u00e9nica":[142],"por":[145],"medio":[146],"heterodimerizaci\u00f3n.":[149]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2024-08-17T00:00:00"}
