{"id":"https://openalex.org/W4401633299","doi":"https://doi.org/10.4088/jcp.23nr15240","title":"Rationale for Adjunctive Treatment Targeting Multiple Mechanisms in Schizophrenia","display_name":"Rationale for Adjunctive Treatment Targeting Multiple Mechanisms in Schizophrenia","publication_year":2024,"publication_date":"2024-08-16","ids":{"openalex":"https://openalex.org/W4401633299","doi":"https://doi.org/10.4088/jcp.23nr15240","pmid":"https://pubmed.ncbi.nlm.nih.gov/39196873"},"language":"en","primary_location":{"id":"doi:10.4088/jcp.23nr15240","doi":"https://doi.org/10.4088/jcp.23nr15240","is_oa":false,"landing_page_url":"https://doi.org/10.4088/jcp.23nr15240","pdf_url":null,"source":{"id":"https://openalex.org/S17992710","display_name":"The Journal of Clinical Psychiatry","issn_l":"0160-6689","issn":["0160-6689","1534-8628","1555-2101"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4322614534","host_organization_name":"Physicians Postgraduate Press, Inc.","host_organization_lineage":["https://openalex.org/P4322614534"],"host_organization_lineage_names":["Physicians Postgraduate Press, Inc."],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Clinical Psychiatry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5010145606","display_name":"Bruce J. Kinon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210091812","display_name":"Bristol-Myers Squibb (United States)","ror":"https://ror.org/00gtmwv55","country_code":"US","type":"company","lineage":["https://openalex.org/I4210091812"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bruce J. Kinon","raw_affiliation_strings":["Corresponding Author: Bruce J. Kinon, MD (bjkinon@sbcglobal.net), c/o Alicia Meli, MS, Bristol Myers Squibb Corporate Headquarters, Route 206 & Province Line Road, Princeton, NJ 08543","Karuna Therapeutics, Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Corresponding Author: Bruce J. Kinon, MD (bjkinon@sbcglobal.net), c/o Alicia Meli, MS, Bristol Myers Squibb Corporate Headquarters, Route 206 & Province Line Road, Princeton, NJ 08543","institution_ids":["https://openalex.org/I4210091812"]},{"raw_affiliation_string":"Karuna Therapeutics, Boston, Massachusetts","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002251483","display_name":"Stefan Leucht","orcid":"https://orcid.org/0000-0002-4934-4352","observed_orcids":["https://orcid.org/0000-0002-4934-4352"]},"institutions":[{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Stefan Leucht","raw_affiliation_strings":["Department of Psychiatry and Psychotherapy, TUM School of Medicine and Health, Technical University of Munich, Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry and Psychotherapy, TUM School of Medicine and Health, Technical University of Munich, Munich, Germany","institution_ids":["https://openalex.org/I62916508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023252875","display_name":"Carol A. Tamminga","orcid":"https://orcid.org/0000-0002-6366-5697","observed_orcids":["https://orcid.org/0000-0002-6366-5697"]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carol Tamminga","raw_affiliation_strings":["Department of Psychiatry, University of Texas Southwestern Medical School, Dallas, Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, University of Texas Southwestern Medical School, Dallas, Texas","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110607987","display_name":"Alan F. Breier","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alan Breier","raw_affiliation_strings":["Department of Psychiatry, Indiana University School of Medicine, Indianapolis, Indiana"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, Indiana University School of Medicine, Indianapolis, Indiana","institution_ids":["https://openalex.org/I4394709130"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000677832","display_name":"Ronald N. Marcus","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210091812","display_name":"Bristol-Myers Squibb (United States)","ror":"https://ror.org/00gtmwv55","country_code":"US","type":"company","lineage":["https://openalex.org/I4210091812"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ronald Marcus","raw_affiliation_strings":["Bristol Myers Squibb, Princeton, New Jersey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bristol Myers Squibb, Princeton, New Jersey","institution_ids":["https://openalex.org/I4210091812"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101815684","display_name":"Steven M. Paul","orcid":"https://orcid.org/0009-0009-2773-8025","observed_orcids":["https://orcid.org/0009-0009-2773-8025","https://orcid.org/0000-0002-8388-2023"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Steven M. Paul","raw_affiliation_strings":["Karuna Therapeutics, Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Karuna Therapeutics, Boston, Massachusetts","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.8004,"has_fulltext":false,"cited_by_count":13,"citation_normalized_percentile":{"value":0.94376052,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":99},"biblio":{"volume":"85","issue":"3","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10023","display_name":"Schizophrenia research and treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10023","display_name":"Schizophrenia research and treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11071","display_name":"Treatment of Major Depression","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/schizophrenia","display_name":"schizophrenia","score":0.9300000071525574},{"id":"https://openalex.org/keywords/adjunctive-therapy","display_name":"adjunctive therapy","score":0.890999972820282},{"id":"https://openalex.org/keywords/antipsychotic-side-effects","display_name":"antipsychotic adverse effects","score":0.7820000052452087},{"id":"https://openalex.org/keywords/dopaminergic-pathways","display_name":"dopaminergic pathways","score":0.7260000109672546},{"id":"https://openalex.org/keywords/glutamate-dysfunction","display_name":"glutamate dysfunction","score":0.6990000009536743},{"id":"https://openalex.org/keywords/acetylcholine","display_name":"acetylcholine","score":0.9649999737739563},{"id":"https://openalex.org/keywords/serotonin","display_name":"serotonin","score":0.9929999709129333},{"id":"https://openalex.org/keywords/gaba","display_name":"GABA","score":0.8859999775886536},{"id":"https://openalex.org/keywords/negative-symptoms","display_name":"negative symptoms","score":0.824999988079071},{"id":"https://openalex.org/keywords/cognitive-impairment","display_name":"cognitive impairment","score":0.9509999752044678},{"id":"https://openalex.org/keywords/treatment-adherence","display_name":"medication adherence","score":0.5320000052452087}],"concepts":[{"id":"https://openalex.org/C2776412080","wikidata":"https://www.wikidata.org/wiki/Q7431605","display_name":"Schizophrenia (object-oriented programming)","level":2,"score":0.7565644979476929},{"id":"https://openalex.org/C3018162438","wikidata":"https://www.wikidata.org/wiki/Q1304270","display_name":"Adjunctive treatment","level":2,"score":0.509458601474762},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.5048838257789612},{"id":"https://openalex.org/C542102704","wikidata":"https://www.wikidata.org/wiki/Q183257","display_name":"Psychotherapist","level":1,"score":0.47820115089416504},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.3873879313468933},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.31514373421669006},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.07924434542655945}],"mesh":[{"descriptor_ui":"D004359","descriptor_name":"Drug Therapy, Combination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012559","descriptor_name":"Schizophrenia","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D014150","descriptor_name":"Antipsychotic Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D014150","descriptor_name":"Antipsychotic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D014150","descriptor_name":"Antipsychotic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D065127","descriptor_name":"Dopamine D2 Receptor Antagonists","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D065127","descriptor_name":"Dopamine D2 Receptor Antagonists","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.4088/jcp.23nr15240","doi":"https://doi.org/10.4088/jcp.23nr15240","is_oa":false,"landing_page_url":"https://doi.org/10.4088/jcp.23nr15240","pdf_url":null,"source":{"id":"https://openalex.org/S17992710","display_name":"The Journal of Clinical Psychiatry","issn_l":"0160-6689","issn":["0160-6689","1534-8628","1555-2101"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4322614534","host_organization_name":"Physicians Postgraduate Press, Inc.","host_organization_lineage":["https://openalex.org/P4322614534"],"host_organization_lineage_names":["Physicians Postgraduate Press, Inc."],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Clinical Psychiatry","raw_type":"journal-article"},{"id":"pmid:39196873","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39196873","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of clinical psychiatry","raw_type":"Journal Article"},{"id":"pmh:oai:mediatum.ub.tum.de:node/1797010","doi":null,"is_oa":false,"landing_page_url":"https://mediatum.ub.tum.de/1797010","pdf_url":null,"source":{"id":"https://openalex.org/S4377196330","display_name":"mediaTUM  (Technical University of Munich)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I62916508","host_organization_name":"Technical University of Munich","host_organization_lineage":["https://openalex.org/I62916508"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2092271259","https://openalex.org/W2013555225","https://openalex.org/W2074169473","https://openalex.org/W157021211","https://openalex.org/W2888342366","https://openalex.org/W2010599721","https://openalex.org/W3035233583","https://openalex.org/W2323125985","https://openalex.org/W4327723526","https://openalex.org/W2958423778"],"abstract_inverted_index":{"receptor-blocking":[0,140],"antipsychotics":[1,49],"have":[2],"well-known":[3],"limitations,":[4],"including":[5,107],"ineffectively":[6],"treating":[7],"across":[8],"all":[9],"symptom":[10],"domains":[11],"and":[12,23,60,65,80,111],"generating":[13],"common":[14,76],"side":[15,73],"effects":[16,74],"such":[17],"as":[18,133],"motor":[19],"disturbances,":[20],"weight":[21],"gain,":[22],"metabolic":[24],"dysfunction.":[25],"New":[26],"approaches":[27],"are":[28,57,75,130],"sorely":[29],"needed":[30],"to":[31,83,87],"address":[32],"the":[33,96,115],"continued":[34],"unmet":[35,70],"treatment":[36,135],"needs":[37],"for":[38,136],"individuals":[39,137],"living":[40],"with":[41,77,122,138],"schizophrenia.":[42,139],"receptor":[43],"antagonists":[44],"or":[45],"partial":[46],"agonists.":[47],"While":[48,114],"primarily":[50],"relieve":[51],"positive":[52,55],"symptoms,":[53],"residual":[54],"symptoms":[56,64],"still":[58],"common,":[59],"management":[61],"of":[62,98,117,131],"negative":[63],"cognitive":[66],"impairment":[67],"remains":[68],"an":[69],"need.":[71],"Problematic":[72],"current":[78],"agents":[79],"can":[81],"contribute":[82],"nonadherence.":[84],"In":[85],"addition":[86],"alterations":[88],"in":[89,103],"dopaminergic":[90],"pathways,":[91],"increasing":[92],"evidence":[93],"indicates":[94],"that":[95,126],"pathophysiology":[97,116],"schizophrenia":[99,118],"also":[100],"includes":[101],"dysfunction":[102],"other":[104],"neurotransmitter":[105],"systems":[106,129],"glutamate,":[108],"acetylcholine,":[109],"serotonin,":[110],"\u03b3-aminobutyric":[112],"acid.":[113],"is":[119],"complex,":[120],"treatments":[121],"novel":[123],"pharmacologic":[124],"actions":[125],"target":[127],"these":[128],"interest":[132],"adjunctive":[134],"antipsychotics.":[141]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2024-08-17T00:00:00"}