{"id":"https://openalex.org/W4401626914","doi":"https://doi.org/10.1016/j.cobme.2024.100555","title":"Perspectives on synthetic protein circuits in mammalian cells","display_name":"Perspectives on synthetic protein circuits in mammalian cells","publication_year":2024,"publication_date":"2024-08-14","ids":{"openalex":"https://openalex.org/W4401626914","doi":"https://doi.org/10.1016/j.cobme.2024.100555","pmid":"https://pubmed.ncbi.nlm.nih.gov/39372446","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11448451"},"language":"en","primary_location":{"id":"doi:10.1016/j.cobme.2024.100555","doi":"https://doi.org/10.1016/j.cobme.2024.100555","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.cobme.2024.100555","pdf_url":null,"source":{"id":"https://openalex.org/S2898133657","display_name":"Current Opinion in Biomedical Engineering","issn_l":"2468-4511","issn":["2468-4511"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","norway-1","poland-20","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Current Opinion in Biomedical Engineering","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://doi.org/10.1016/j.cobme.2024.100555","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5051754999","display_name":"Carlos A. Aldrete","orcid":"https://orcid.org/0000-0003-3795-4572","observed_orcids":["https://orcid.org/0000-0003-3795-4572"]},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carlos A. Aldrete","raw_affiliation_strings":["Department of Chemical Engineering, Stanford University, CA, USA, 94305"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical Engineering, Stanford University, CA, USA, 94305","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108970545","display_name":"Connie An","orcid":"https://orcid.org/0000-0003-3977-1497","observed_orcids":["https://orcid.org/0000-0003-3977-1497"]},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Connie An","raw_affiliation_strings":["Department of Chemical Engineering, Stanford University, CA, USA, 94305"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical Engineering, Stanford University, CA, USA, 94305","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055750689","display_name":"Connor C. Call","orcid":"https://orcid.org/0000-0003-2394-7523","observed_orcids":["https://orcid.org/0000-0003-2394-7523"]},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Connor C. Call","raw_affiliation_strings":["Department of Chemical Engineering, Stanford University, CA, USA, 94305"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical Engineering, Stanford University, CA, USA, 94305","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031411983","display_name":"Xiaojing J. Gao","orcid":"https://orcid.org/0000-0002-3094-1456","observed_orcids":["https://orcid.org/0000-0002-3094-1456"]},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Xiaojing J. Gao","raw_affiliation_strings":["Department of Chemical Engineering, Stanford University, CA, USA, 94305"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical Engineering, Stanford University, CA, USA, 94305","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5043943810","display_name":"Alexander E. Vlahos","orcid":"https://orcid.org/0000-0002-2154-8791","observed_orcids":["https://orcid.org/0000-0002-2154-8791"]},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Alexander E. Vlahos","raw_affiliation_strings":["Department of Chemical Engineering, Stanford University, CA, USA, 94305"],"raw_orcid":"https://orcid.org/0000-0002-2154-8791","affiliations":[{"raw_affiliation_string":"Department of Chemical Engineering, Stanford University, CA, USA, 94305","institution_ids":["https://openalex.org/I97018004"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5031411983","https://openalex.org/A5043943810"],"corresponding_institution_ids":["https://openalex.org/I97018004"],"apc_list":{"value":3670,"currency":"USD","value_usd":3670},"apc_paid":null,"fwci":0.2034,"has_fulltext":true,"cited_by_count":5,"citation_normalized_percentile":{"value":0.19062419,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":97},"biblio":{"volume":"32","issue":null,"first_page":"100555","last_page":"100555"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10878","display_name":"CRISPR and Genetic Engineering","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/post-translational-regulation","display_name":"post-translational regulation","score":0.7480000257492065},{"id":"https://openalex.org/keywords/proteolysis","display_name":"proteolysis","score":0.9660000205039978},{"id":"https://openalex.org/keywords/phosphorylation","display_name":"phosphorylation","score":0.9670000076293945},{"id":"https://openalex.org/keywords/protein-protein-interaction","display_name":"protein-protein interaction","score":0.6859999895095825},{"id":"https://openalex.org/keywords/transcriptional-circuits","display_name":"transcriptional circuits","score":0.6629999876022339},{"id":"https://openalex.org/keywords/gene-therapy","display_name":"gene therapy","score":0.6380000114440918},{"id":"https://openalex.org/keywords/cell-engineering","display_name":"cell engineering","score":0.6930000185966492},{"id":"https://openalex.org/keywords/cancer-immunotherapy","display_name":"cancer immunotherapy","score":0.7559999823570251},{"id":"https://openalex.org/keywords/cell-transplantation","display_name":"cell transplantation","score":0.9649999737739563}],"concepts":[{"id":"https://openalex.org/C191908910","wikidata":"https://www.wikidata.org/wiki/Q862838","display_name":"Synthetic biology","level":2,"score":0.7702139019966125},{"id":"https://openalex.org/C66782513","wikidata":"https://www.wikidata.org/wiki/Q864601","display_name":"Biomedicine","level":2,"score":0.552140474319458},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.43070730566978455},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.43035659193992615},{"id":"https://openalex.org/C87325107","wikidata":"https://www.wikidata.org/wiki/Q7251493","display_name":"Protein phosphorylation","level":4,"score":0.4119150638580322},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3826959729194641},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.37115511298179626},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.28121417760849},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.22881585359573364},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.12941902875900269}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1016/j.cobme.2024.100555","doi":"https://doi.org/10.1016/j.cobme.2024.100555","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.cobme.2024.100555","pdf_url":null,"source":{"id":"https://openalex.org/S2898133657","display_name":"Current Opinion in Biomedical Engineering","issn_l":"2468-4511","issn":["2468-4511"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","norway-1","poland-20","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Current Opinion in Biomedical Engineering","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11448451","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11448451/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11448451/pdf/nihms-2018901.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Curr Opin Biomed Eng","raw_type":"Text"},{"id":"pmid:39372446","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39372446","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current opinion in biomedical engineering","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/j.cobme.2024.100555","doi":"https://doi.org/10.1016/j.cobme.2024.100555","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.cobme.2024.100555","pdf_url":null,"source":{"id":"https://openalex.org/S2898133657","display_name":"Current Opinion in Biomedical Engineering","issn_l":"2468-4511","issn":["2468-4511"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","norway-1","poland-20","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Current Opinion in Biomedical Engineering","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G2289860940","display_name":"Graduate Research Fellowship Program (GRFP)","funder_award_id":"2146755","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G2911136643","display_name":null,"funder_award_id":"R00 EB027723","funder_id":"https://openalex.org/F4320337363","funder_display_name":"National Institute of Biomedical Imaging and Bioengineering"},{"id":"https://openalex.org/G3142106742","display_name":null,"funder_award_id":"NIH 5 T32","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G4227984967","display_name":"Cellular and Molecular Biology Training Program","funder_award_id":"T32GM007276","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G4577539952","display_name":null,"funder_award_id":"5 T32 GM007276","funder_id":"https://openalex.org/F4320320338","funder_display_name":"Human Frontier Science Program"},{"id":"https://openalex.org/G4728883355","display_name":"Synthetic DNA-free Circuits for \u201cScarless\u201d Programming of Mammalian Cells","funder_award_id":"4r00eb027723-02","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G5773896139","display_name":null,"funder_award_id":"5 T32 GM007276","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G7511721956","display_name":null,"funder_award_id":"LT000221/2021-L","funder_id":"https://openalex.org/F4320320338","funder_display_name":"Human Frontier Science Program"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320308507","display_name":"Stanford University","ror":"https://ror.org/00f54p054"},{"id":"https://openalex.org/F4320320338","display_name":"Human Frontier Science Program","ror":"https://ror.org/02ebx7v45"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337363","display_name":"National Institute of Biomedical Imaging and Bioengineering","ror":"https://ror.org/00372qc85"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":66,"referenced_works":["https://openalex.org/W1043004949","https://openalex.org/W1968831085","https://openalex.org/W1970586355","https://openalex.org/W1982409013","https://openalex.org/W2001831734","https://openalex.org/W2012175205","https://openalex.org/W2013971421","https://openalex.org/W2070961268","https://openalex.org/W2080874961","https://openalex.org/W2110193578","https://openalex.org/W2113802879","https://openalex.org/W2147524392","https://openalex.org/W2158243563","https://openalex.org/W2168979150","https://openalex.org/W2256857837","https://openalex.org/W2595201960","https://openalex.org/W2604556291","https://openalex.org/W2615853094","https://openalex.org/W2751002781","https://openalex.org/W2755866416","https://openalex.org/W2802363588","https://openalex.org/W2802432478","https://openalex.org/W2802915411","https://openalex.org/W2806001790","https://openalex.org/W2897380393","https://openalex.org/W2899563546","https://openalex.org/W2902888941","https://openalex.org/W2903102808","https://openalex.org/W2942604302","https://openalex.org/W2950183003","https://openalex.org/W2956084030","https://openalex.org/W2963418941","https://openalex.org/W2963671418","https://openalex.org/W2994825712","https://openalex.org/W2997938055","https://openalex.org/W3010819406","https://openalex.org/W3014096229","https://openalex.org/W3015800425","https://openalex.org/W3036774895","https://openalex.org/W3109746568","https://openalex.org/W3118161098","https://openalex.org/W3153508581","https://openalex.org/W3174242765","https://openalex.org/W3200308012","https://openalex.org/W4205285854","https://openalex.org/W4213361745","https://openalex.org/W4220866630","https://openalex.org/W4221109056","https://openalex.org/W4224056900","https://openalex.org/W4225151249","https://openalex.org/W4249558460","https://openalex.org/W4283269902","https://openalex.org/W4285043139","https://openalex.org/W4296248317","https://openalex.org/W4307031704","https://openalex.org/W4310251737","https://openalex.org/W4311551459","https://openalex.org/W4315865958","https://openalex.org/W4323924105","https://openalex.org/W4378212594","https://openalex.org/W4387372802","https://openalex.org/W4387880756","https://openalex.org/W4400356950","https://openalex.org/W4406019703","https://openalex.org/W4406412495","https://openalex.org/W6838949483"],"related_works":["https://openalex.org/W1993018547","https://openalex.org/W2781442782","https://openalex.org/W3153508581","https://openalex.org/W2697347174","https://openalex.org/W2087296862","https://openalex.org/W2511431006","https://openalex.org/W2007504406","https://openalex.org/W2535341543","https://openalex.org/W2947204666","https://openalex.org/W1557540215"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":3}],"updated_date":"2026-10-29T09:56:32.521200","created_date":"2024-08-16T00:00:00"}