{"id":"https://openalex.org/W4401619267","doi":"https://doi.org/10.1158/0008-5472.c.7403479.v1","title":"Data from Large-Scale Alternative Polyadenylation-Wide Association Studies to Identify Putative Cancer Susceptibility Genes","display_name":"Data from Large-Scale Alternative Polyadenylation-Wide Association Studies to Identify Putative Cancer Susceptibility Genes","publication_year":2024,"publication_date":"2024-08-15","ids":{"openalex":"https://openalex.org/W4401619267","doi":"https://doi.org/10.1158/0008-5472.c.7403479.v1"},"language":"en","primary_location":{"id":"doi:10.1158/0008-5472.c.7403479.v1","doi":"https://doi.org/10.1158/0008-5472.c.7403479.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.c.7403479.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/0008-5472.c.7403479.v1","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5086299976","display_name":"Xingyi Guo","orcid":"https://orcid.org/0000-0001-5269-1294","observed_orcids":["https://orcid.org/0000-0001-5269-1294"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xingyi Guo","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-5269-1294","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041664384","display_name":"Jie Ping","orcid":"https://orcid.org/0000-0001-9907-5819","observed_orcids":["https://orcid.org/0000-0001-9907-5819","https://orcid.org/0000-0002-9455-6012"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jie Ping","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-9907-5819","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027886468","display_name":"Yaohua Yang","orcid":"https://orcid.org/0000-0002-3815-7172","observed_orcids":["https://orcid.org/0000-0002-3815-7172"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yaohua Yang","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-3815-7172","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088717502","display_name":"Xinwan Su","orcid":"https://orcid.org/0000-0002-7257-1860","observed_orcids":["https://orcid.org/0000-0002-7257-1860"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xinwan Su","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-7257-1860","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085657415","display_name":"Xiao\u2010Ou Shu","orcid":"https://orcid.org/0000-0002-0711-8314","observed_orcids":["https://orcid.org/0000-0002-0711-8314"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xiao-Ou Shu","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-0711-8314","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086118402","display_name":"Wanqing Wen","orcid":"https://orcid.org/0000-0002-3004-5168","observed_orcids":["https://orcid.org/0000-0002-3004-5168"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wanqing Wen","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-3004-5168","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022038908","display_name":"Zhishan Chen","orcid":"https://orcid.org/0000-0002-5893-8048","observed_orcids":["https://orcid.org/0000-0002-5893-8048"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zhishan Chen","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-5893-8048","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007901381","display_name":"Yunjing Zhang","orcid":"https://orcid.org/0000-0002-8773-428X","observed_orcids":["https://orcid.org/0000-0002-8773-428X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yunjing Zhang","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-8773-428X","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087325326","display_name":"Ran Tao","orcid":"https://orcid.org/0000-0002-1106-2923","observed_orcids":["https://orcid.org/0000-0002-1106-2923"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ran Tao","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-1106-2923","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026156414","display_name":"Guochong Jia","orcid":"https://orcid.org/0000-0002-8455-1832","observed_orcids":["https://orcid.org/0000-0002-8455-1832"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Guochong Jia","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-8455-1832","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100567102","display_name":"Jingni He","orcid":"https://orcid.org/0000-0001-8049-9734","observed_orcids":["https://orcid.org/0000-0001-8049-9734"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jingni He","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-8049-9734","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005513706","display_name":"Qiuyin Cai","orcid":"https://orcid.org/0000-0002-9384-5648","observed_orcids":["https://orcid.org/0000-0002-9384-5648"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Qiuyin Cai","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-9384-5648","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062572974","display_name":"Qingrun Zhang","orcid":"https://orcid.org/0000-0003-2701-0711","observed_orcids":["https://orcid.org/0000-0003-2701-0711"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Qingrun Zhang","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-2701-0711","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019133187","display_name":"Graham G. Giles","orcid":"https://orcid.org/0000-0003-4946-9099","observed_orcids":["https://orcid.org/0000-0003-4946-9099"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Graham G. Giles","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-4946-9099","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067713698","display_name":"Rachel Pearlman","orcid":"https://orcid.org/0000-0002-9293-5860","observed_orcids":["https://orcid.org/0000-0002-9293-5860"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rachel Pearlman","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-9293-5860","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082547550","display_name":"Gad Rennert","orcid":"https://orcid.org/0000-0002-8512-068X","observed_orcids":["https://orcid.org/0000-0002-8512-068X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gad Rennert","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-8512-068X","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004651940","display_name":"Pavel Vodi\u010dka","orcid":"https://orcid.org/0000-0003-2376-1243","observed_orcids":["https://orcid.org/0000-0003-2376-1243"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Pavel Vodicka","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-2376-1243","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019158614","display_name":"Amanda I. Phipps","orcid":"https://orcid.org/0000-0002-1446-2201","observed_orcids":["https://orcid.org/0000-0002-1446-2201"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Amanda Phipps","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-1446-2201","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070703103","display_name":"Stephen B. Gruber","orcid":"https://orcid.org/0000-0001-8656-7822","observed_orcids":["https://orcid.org/0000-0001-8656-7822"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Stephen B. Gruber","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-8656-7822","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101976827","display_name":"Graham Casey","orcid":"https://orcid.org/0000-0003-1584-5551","observed_orcids":["https://orcid.org/0000-0003-1584-5551"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Graham Casey","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-1584-5551","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053681099","display_name":"Ulrike Peters","orcid":"https://orcid.org/0000-0001-5666-9318","observed_orcids":["https://orcid.org/0000-0001-5666-9318"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ulrike Peters","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-5666-9318","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101592761","display_name":"Jirong Long","orcid":"https://orcid.org/0000-0002-7433-9766","observed_orcids":["https://orcid.org/0000-0002-7433-9766"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jirong Long","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-7433-9766","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086822947","display_name":"Weiqiang Lin","orcid":"https://orcid.org/0000-0002-2171-8009","observed_orcids":["https://orcid.org/0000-0002-2171-8009"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Weiqiang Lin","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-2171-8009","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5100401143","display_name":"Wei Zheng","orcid":"https://orcid.org/0000-0003-1226-070X","observed_orcids":["https://orcid.org/0000-0003-1226-070X","https://orcid.org/0000-0003-1034-0757","https://orcid.org/0009-0008-5993-0647"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wei Zheng","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-1226-070X","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.9761000275611877,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.9761000275611877,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.021299999207258224,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alternative-polyadenylation","display_name":"alternative polyadenylation","score":1.0},{"id":"https://openalex.org/keywords/cancer-susceptibility-genes","display_name":"cancer susceptibility genes","score":0.8460000157356262},{"id":"https://openalex.org/keywords/3-untranslated-region","display_name":"3' untranslated region","score":0.9070000052452087},{"id":"https://openalex.org/keywords/post-transcriptional-regulation","display_name":"post-transcriptional regulation","score":0.7210000157356262},{"id":"https://openalex.org/keywords/quantitative-trait-loci","display_name":"quantitative trait loci","score":0.7009999752044678},{"id":"https://openalex.org/keywords/colocalization-analysis","display_name":"colocalization analysis","score":0.6330000162124634},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.734000027179718},{"id":"https://openalex.org/keywords/ovarian-cancer","display_name":"ovarian cancer","score":0.9850000143051147},{"id":"https://openalex.org/keywords/prostate-cancer","display_name":"prostate cancer","score":0.9929999709129333},{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"colorectal cancer","score":1.0},{"id":"https://openalex.org/keywords/lung-cancer","display_name":"lung cancer","score":1.0},{"id":"https://openalex.org/keywords/pancreatic-cancer","display_name":"pancreatic cancer","score":1.0},{"id":"https://openalex.org/keywords/stat6","display_name":"STAT6","score":0.7009999752044678},{"id":"https://openalex.org/keywords/ldha","display_name":"LDHA","score":0.9940000176429749},{"id":"https://openalex.org/keywords/mrna-stability","display_name":"mRNA stability","score":0.597000002861023},{"id":"https://openalex.org/keywords/cell-proliferation-and-migration","display_name":"cell proliferation and migration","score":0.746999979019165}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6384952068328857},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5491597056388855},{"id":"https://openalex.org/C22667442","wikidata":"https://www.wikidata.org/wiki/Q3272830","display_name":"Three prime untranslated region","level":5,"score":0.5296729803085327},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.5005495548248291},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.48981592059135437},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.43955445289611816},{"id":"https://openalex.org/C89604277","wikidata":"https://www.wikidata.org/wiki/Q424345","display_name":"Untranslated region","level":4,"score":0.4319859445095062},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4271528422832489},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.42364150285720825},{"id":"https://openalex.org/C186413461","wikidata":"https://www.wikidata.org/wiki/Q744727","display_name":"Genetic association","level":5,"score":0.4204569160938263},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.4083758294582367},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3570408225059509},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.16846755146980286}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/0008-5472.c.7403479.v1","doi":"https://doi.org/10.1158/0008-5472.c.7403479.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.c.7403479.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/0008-5472.c.7403479.v1","doi":"https://doi.org/10.1158/0008-5472.c.7403479.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.c.7403479.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4396999564","https://openalex.org/W4388449625","https://openalex.org/W4392157338","https://openalex.org/W4386461923","https://openalex.org/W4388131899","https://openalex.org/W6949046682","https://openalex.org/W4412784745","https://openalex.org/W2982225121","https://openalex.org/W4409626957","https://openalex.org/W4236385169"],"abstract_inverted_index":{"Abstract":[0],"Alternative":[1],"polyadenylation":[2,242,258],"(APA)":[3],"modulates":[4],"mRNA":[5,14],"processing":[6],"in":[7,59,228],"the":[8,25,72,89,145,176,193,207,224,229,252],"3\u2032-untranslated":[9],"regions":[10],"(3\u2032":[11],"UTR),":[12],"affecting":[13],"stability":[15],"and":[16,48,64,112,150,160,188,216],"translation":[17],"efficiency.":[18],"Research":[19],"into":[20,30,223],"genetically":[21,78,255],"regulated":[22,256],"APA":[23,46,57,80,124,156,227],"has":[24],"potential":[26],"to":[27,42,55,92,122,141,213,232,261,264],"provide":[28],"insights":[29,222],"cancer":[31,49,83,142,244],"risk.":[32,50],"In":[33],"this":[34,219],"study,":[35],"we":[36],"conducted":[37],"large":[38,95],"APA-wide":[39],"association":[40,97],"studies":[41,98],"investigate":[43],"associations":[44,239],"between":[45],"levels":[47,58,81],"Genetic":[51],"models":[52,91],"were":[53,85,126,152],"built":[54],"predict":[56],"multiple":[60],"tissues":[61],"using":[62],"genotype":[63],"RNA":[65],"sequencing":[66],"data":[67,93],"from":[68,71,94],"1,337":[69],"samples":[70],"Genotype-Tissue":[73],"Expression":[74],"project.":[75],"Associations":[76],"of":[77,99,117,133,179,196,206,226,238,240,254,259],"predicted":[79],"with":[82,128,201,243],"risk":[84,119,147,177,245],"assessed":[86],"by":[87,154],"applying":[88],"prediction":[90],"genome-wide":[96],"six":[100],"common":[101,233],"cancers":[102],"among":[103],"European":[104],"ancestry":[105],"populations:":[106],"breast,":[107],"ovarian,":[108],"prostate,":[109],"colorectal,":[110],"lung,":[111],"pancreatic":[113],"cancers.":[114,234],"A":[115],"total":[116],"58":[118,247],"genes":[120,137,199,209],"(corresponding":[121],"76":[123],"sites)":[125],"associated":[127],"at":[129],"least":[130],"one":[131],"type":[132],"cancer,":[134],"including":[135],"25":[136],"previously":[138],"not":[139],"linked":[140],"susceptibility.":[143],"Of":[144],"identified":[146],"APAs,":[148],"97.4%":[149],"26.3%":[151],"supported":[153],"3\u2032-UTR":[155,172,180],"quantitative":[157],"trait":[158],"loci":[159],"colocalization":[161],"analyses,":[162],"respectively.":[163],"Luciferase":[164],"reporter":[165],"assays":[166],"for":[167],"four":[168],"selected":[169],"putative":[170,248],"regulatory":[171],"variants":[173],"demonstrated":[174],"that":[175],"alleles":[178],"variants,":[181],"rs324015":[182],"(STAT6),":[183],"rs2280503":[184],"(DIP2B),":[185],"rs1128450":[186],"(FBXO38),":[187],"rs145220637":[189],"(LDHA),":[190],"significantly":[191],"increased":[192],"posttranscriptional":[194],"activities":[195],"their":[197,211],"target":[198,208],"compared":[200],"reference":[202],"alleles.":[203],"Furthermore,":[204],"knockdown":[205],"confirmed":[210],"ability":[212],"promote":[214],"proliferation":[215],"migration.":[217],"Overall,":[218],"study":[220],"provides":[221],"role":[225],"genetic":[230,262],"susceptibility":[231,249,263],"Significance:":[235],"Systematic":[236],"evaluation":[237],"alternative":[241,257],"reveals":[246],"genes,":[250],"highlighting":[251],"contribution":[253],"3\u2032UTRs":[260],"cancer.":[265]},"counts_by_year":[],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2024-08-16T00:00:00"}
