{"id":"https://openalex.org/W4401617850","doi":"https://doi.org/10.4236/jbm.2024.128010","title":"The Combination Effect of Daphne Extract and Imatinib on the Antiproliferative Activity of the K562 Cell Line","display_name":"The Combination Effect of Daphne Extract and Imatinib on the Antiproliferative Activity of the K562 Cell Line","publication_year":2024,"publication_date":"2024-01-01","ids":{"openalex":"https://openalex.org/W4401617850","doi":"https://doi.org/10.4236/jbm.2024.128010"},"language":"en","primary_location":{"id":"doi:10.4236/jbm.2024.128010","doi":"https://doi.org/10.4236/jbm.2024.128010","is_oa":true,"landing_page_url":"http://dx.doi.org/10.4236/jbm.2024.128010","pdf_url":"https://www.scirp.org/pdf/jbm_2024081515371739.pdf","source":{"id":"https://openalex.org/S2764372278","display_name":"Journal of Biosciences and Medicines","issn_l":"2327-5081","issn":["2327-5081","2327-509X"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biosciences and Medicines","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://www.scirp.org/pdf/jbm_2024081515371739.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5067003491","display_name":"Alireza Khorshid","orcid":"https://orcid.org/0000-0003-0345-1862","observed_orcids":["https://orcid.org/0000-0003-0345-1862"]},"institutions":[{"id":"https://openalex.org/I55302922","display_name":"The University of Texas Medical Branch at Galveston","ror":"https://ror.org/016tfm930","country_code":"US","type":"education","lineage":["https://openalex.org/I55302922"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alireza Khorshid","raw_affiliation_strings":["Department of Clinical Laboratory Sciences , University of Texas Medical Branch at Galveston , Galveston , TX , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Laboratory Sciences , University of Texas Medical Branch at Galveston , Galveston , TX , USA","institution_ids":["https://openalex.org/I55302922"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054297448","display_name":"Jafar Nouri Nojadeh","orcid":"https://orcid.org/0000-0002-2468-2996","observed_orcids":["https://orcid.org/0000-0002-2468-2996"]},"institutions":[{"id":"https://openalex.org/I163205636","display_name":"Tabriz University of Medical Sciences","ror":"https://ror.org/04krpx645","country_code":"IR","type":"education","lineage":["https://openalex.org/I163205636"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Jafar Nouri Nojadeh","raw_affiliation_strings":["Department of Medical Genetics , Faculty of Medicine , Tabriz University of Medical Sciences , Tabriz , Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Genetics , Faculty of Medicine , Tabriz University of Medical Sciences , Tabriz , Iran","institution_ids":["https://openalex.org/I163205636"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025222496","display_name":"Javid Sabour Takanlu","orcid":"https://orcid.org/0009-0003-9817-6249","observed_orcids":["https://orcid.org/0009-0003-9817-6249"]},"institutions":[{"id":"https://openalex.org/I188760350","display_name":"Ollscoil na Gaillimhe \u2013 University of Galway","ror":"https://ror.org/03bea9k73","country_code":"IE","type":"education","lineage":["https://openalex.org/I188760350"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"Javid Sabour Takanlu","raw_affiliation_strings":["Apoptosis Research Centre , Department of Biochemistry , School of Natural Sciences , National University of Ireland Galway , Galway , Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Apoptosis Research Centre , Department of Biochemistry , School of Natural Sciences , National University of Ireland Galway , Galway , Ireland","institution_ids":["https://openalex.org/I188760350"]}]},{"author_position":"last","author":{"id":null,"display_name":"Alireza Tavasoli","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210161235","display_name":"Fasa University of Medical Sciences","ror":"https://ror.org/05bh0zx16","country_code":"IR","type":"education","lineage":["https://openalex.org/I4210161235"]},{"id":"https://openalex.org/I4400600978","display_name":"Fasa University","ror":"https://ror.org/03a77cf20","country_code":"IR","type":"education","lineage":["https://openalex.org/I4400600978"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Alireza Tavasoli","raw_affiliation_strings":["Department of Pathology , School of Medicine , Fasa University of Medical Science , Fasa , Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology , School of Medicine , Fasa University of Medical Science , Fasa , Iran","institution_ids":["https://openalex.org/I4210161235","https://openalex.org/I4400600978"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2074,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.42988494,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":93},"biblio":{"volume":"12","issue":"08","first_page":"141","last_page":"153"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T14521","display_name":"Medicinal Plant Research","score":0.5756999850273132,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T14521","display_name":"Medicinal Plant Research","score":0.5756999850273132,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12215","display_name":"Phytochemical Studies and Bioactivities","score":0.2777999937534332,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12530","display_name":"Bioactive Natural Diterpenoids Research","score":0.024700000882148743,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/daphne-mucronata","display_name":"Daphne mucronata","score":1.0},{"id":"https://openalex.org/keywords/imatinib","display_name":"imatinib","score":0.968999981880188},{"id":"https://openalex.org/keywords/k562-cells","display_name":"K562 cells","score":0.9549999833106995},{"id":"https://openalex.org/keywords/chronic-myeloid-leukemia","display_name":"chronic myeloid leukemia","score":0.9539999961853027},{"id":"https://openalex.org/keywords/herbal-medicine","display_name":"herbal medicine","score":0.6349999904632568},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.6499999761581421},{"id":"https://openalex.org/keywords/antiproliferative-activity","display_name":"antiproliferative activity","score":0.9470000267028809},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.8960000276565552},{"id":"https://openalex.org/keywords/necrosis","display_name":"necrosis","score":0.7749999761581421},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9779999852180481},{"id":"https://openalex.org/keywords/bcl-2","display_name":"Bcl-2","score":0.8510000109672546},{"id":"https://openalex.org/keywords/bax","display_name":"Bax","score":0.9290000200271606},{"id":"https://openalex.org/keywords/dichloromethane-extract","display_name":"dichloromethane extract","score":0.8610000014305115},{"id":"https://openalex.org/keywords/anticancer-medicinal-plants","display_name":"anticancer medicinal plants","score":0.8100000023841858}],"concepts":[{"id":"https://openalex.org/C2777583451","wikidata":"https://www.wikidata.org/wiki/Q177094","display_name":"Imatinib","level":3,"score":0.6210898756980896},{"id":"https://openalex.org/C171122931","wikidata":"https://www.wikidata.org/wiki/Q6324626","display_name":"K562 cells","level":3,"score":0.5821684002876282},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.538888692855835},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.4476187527179718},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3743959069252014},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.34463319182395935},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3445095717906952},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3437635004520416},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.10456478595733643},{"id":"https://openalex.org/C2778729363","wikidata":"https://www.wikidata.org/wiki/Q11688946","display_name":"Myeloid leukemia","level":2,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.4236/jbm.2024.128010","doi":"https://doi.org/10.4236/jbm.2024.128010","is_oa":true,"landing_page_url":"http://dx.doi.org/10.4236/jbm.2024.128010","pdf_url":"https://www.scirp.org/pdf/jbm_2024081515371739.pdf","source":{"id":"https://openalex.org/S2764372278","display_name":"Journal of Biosciences and Medicines","issn_l":"2327-5081","issn":["2327-5081","2327-509X"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biosciences and Medicines","raw_type":"journal-article"},{"id":"doi:10.21203/rs.3.rs-4694814/v1","doi":"https://doi.org/10.21203/rs.3.rs-4694814/v1","is_oa":true,"landing_page_url":"http://dx.doi.org/10.21203/rs.3.rs-4694814/v1","pdf_url":"https://www.researchsquare.com/article/rs-4694814/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},{"id":"doi:10.21203/rs.3.rs-1735212/v1","doi":"https://doi.org/10.21203/rs.3.rs-1735212/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-1735212/v1","pdf_url":"https://www.researchsquare.com/article/rs-1735212/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.4236/jbm.2024.128010","doi":"https://doi.org/10.4236/jbm.2024.128010","is_oa":true,"landing_page_url":"http://dx.doi.org/10.4236/jbm.2024.128010","pdf_url":"https://www.scirp.org/pdf/jbm_2024081515371739.pdf","source":{"id":"https://openalex.org/S2764372278","display_name":"Journal of Biosciences and Medicines","issn_l":"2327-5081","issn":["2327-5081","2327-509X"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biosciences and Medicines","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4401617850.pdf","grobid_xml":"https://content.openalex.org/works/W4401617850.grobid-xml"},"referenced_works_count":21,"referenced_works":["https://openalex.org/W1571504690","https://openalex.org/W1990995713","https://openalex.org/W1993032039","https://openalex.org/W2005129871","https://openalex.org/W2008757142","https://openalex.org/W2026274798","https://openalex.org/W2027437771","https://openalex.org/W2037600121","https://openalex.org/W2063346783","https://openalex.org/W2090092477","https://openalex.org/W2095491679","https://openalex.org/W2108251338","https://openalex.org/W2141369840","https://openalex.org/W2157017203","https://openalex.org/W2188699404","https://openalex.org/W2260029135","https://openalex.org/W2587436825","https://openalex.org/W2618254711","https://openalex.org/W3014303139","https://openalex.org/W3082361221","https://openalex.org/W3160376776"],"related_works":["https://openalex.org/W4286632926","https://openalex.org/W2122396535","https://openalex.org/W2034686395","https://openalex.org/W2010015363","https://openalex.org/W1926598551","https://openalex.org/W2299652269","https://openalex.org/W2546613575","https://openalex.org/W4388293877","https://openalex.org/W340710041","https://openalex.org/W2369335690"],"abstract_inverted_index":{"Background:":[0],"Herbal":[1],"medicine":[2,43,63,68],"is":[3,38],"well-known":[4,40],"among":[5],"the":[6,28,45,57,70,89,104,130,153,156,162,167,177,186,194,197,204,207,221,230,233,241,250,261,272],"ancient":[7],"medical":[8],"sciences.":[9],"Healing":[10],"properties":[11],"have":[12],"been":[13,33],"observed":[14,256],"in":[15,83,129,139,170,176,189,196,203,249,257],"some":[16,79],"species":[17,80],"of":[18,23,47,60,78,81,92,103,107,155,166,172,199,206,220,232,240,253,266,275],"Daphne":[19,24,82,93,108,168,226,242,262,267],"plant.":[20],"The":[21,76,100,150,237,264],"effect":[22,91,239,274],"plant":[25],"extract":[26,106,158,169,187,213,227,243],"on":[27,69,95],"K562":[29,71,234],"cell":[30,72,131,179,235],"line":[31,73],"has":[32],"previously":[34],"studied,":[35],"and":[36,41,52,64,126,141,152,161,164,193,201,246],"Gleevec":[37],"a":[39,65,111,190],"effective":[42],"for":[44],"treatment":[46],"chronic":[48],"myelogenous":[49],"leukemia.":[50],"Material":[51],"Methods:":[53],"In":[54],"this":[55],"study,":[56],"simultaneous":[58],"effects":[59],"using":[61,135,147],"herbal":[62],"target":[66],"therapy":[67],"were":[74,133,145,159,174],"investigated.":[75],"presence":[77],"Iran":[84],"motivated":[85],"us":[86],"to":[87,185,260],"evaluate":[88],"cytotoxic":[90,273],"mucronata":[94],"human":[96],"leukemia":[97],"cancer":[98],"cells.":[99],"antiproliferative":[101],"activity":[102],"dichloromethane":[105],"mucronate":[109],"(Thymelaeaceae),":[110],"new":[112],"anticancer":[113],"medicinal":[114],"plant,":[115],"was":[116,120,244,255],"evaluated.":[117],"Cell":[118],"viability":[119,231],"quantitated":[121],"by":[122],"MTT":[123],"assay.":[124],"Apoptotic":[125],"necrotic":[127,238],"changes":[128],"membrane":[132],"examined":[134],"flow":[136],"cytometry.":[137],"Changes":[138],"Bax":[140,208],"Bcl2":[142,200,254],"gene":[143,209,251],"expression":[144,198,205,252],"investigated":[146],"real-time":[148],"PCR.":[149],"MIC":[151,163],"IC50":[154,165],"crude":[157],"calculated,":[160],"combination":[171,265],"imatinib":[173,270],"tested":[175],"K-562":[178,182],"line.":[180,236],"Results:":[181],"cells":[183,222,258],"responded":[184],"treatments":[188],"dose-dependent":[191],"manner,":[192],"increase":[195,248],"decrease":[202],"intensified":[210],"with":[211,269],"increasing":[212],"concentration.":[214],"Flow":[215],"cytometry":[216],"revealed":[217],"that":[218],"most":[219],"underwent":[223],"necrosis.":[224],"Conclusion:":[225],"effectively":[228],"decreased":[229],"evaluated,":[245],"an":[247],"exposed":[259],"extract.":[263],"extracts":[268],"enhances":[271],"imatinib.":[276]},"counts_by_year":[{"year":2025,"cited_by_count":1}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2024-08-16T00:00:00"}