{"id":"https://openalex.org/W4401596259","doi":"https://doi.org/10.1002/glia.24603","title":"Astrocytic centrin\u20102 expression in entorhinal cortex correlates with Alzheimer's disease severity","display_name":"Astrocytic centrin\u20102 expression in entorhinal cortex correlates with Alzheimer's disease severity","publication_year":2024,"publication_date":"2024-08-15","ids":{"openalex":"https://openalex.org/W4401596259","doi":"https://doi.org/10.1002/glia.24603","pmid":"https://pubmed.ncbi.nlm.nih.gov/39145525","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13058879"},"language":"en","primary_location":{"id":"doi:10.1002/glia.24603","doi":"https://doi.org/10.1002/glia.24603","is_oa":true,"landing_page_url":"https://doi.org/10.1002/glia.24603","pdf_url":null,"source":{"id":"https://openalex.org/S147407642","display_name":"Glia","issn_l":"0894-1491","issn":["0894-1491","1098-1136"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Glia","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1002/glia.24603","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5072664288","display_name":"Elisa Degl\u2019Innocenti","orcid":"https://orcid.org/0000-0002-3819-0116","observed_orcids":["https://orcid.org/0000-0002-3819-0116"]},"institutions":[{"id":"https://openalex.org/I108290504","display_name":"University of Pisa","ror":"https://ror.org/03ad39j10","country_code":"IT","type":"education","lineage":["https://openalex.org/I108290504"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Elisa Degl'Innocenti","raw_affiliation_strings":["Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy","Fondazione Pisana per la Scienza ONLUS, San Giuliano Terme, Italy"],"raw_orcid":"https://orcid.org/0000-0002-3819-0116","affiliations":[{"raw_affiliation_string":"Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy","institution_ids":["https://openalex.org/I108290504"]},{"raw_affiliation_string":"Fondazione Pisana per la Scienza ONLUS, San Giuliano Terme, Italy","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049787394","display_name":"Tino Emanuele Poloni","orcid":"https://orcid.org/0000-0002-8463-6879","observed_orcids":["https://orcid.org/0000-0002-8463-6879"]},"institutions":[{"id":"https://openalex.org/I4210110921","display_name":"Fondazione Golgi Cenci","ror":"https://ror.org/017b91861","country_code":"IT","type":"other","lineage":["https://openalex.org/I4210110921"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Tino Emanuele Poloni","raw_affiliation_strings":["Department of Neurology and Neuropathology Golgi\u2010Cenci Foundation & ASP Golgi\u2010Redaelli Abbiategrasso Italy"],"raw_orcid":"https://orcid.org/0000-0002-8463-6879","affiliations":[{"raw_affiliation_string":"Department of Neurology and Neuropathology Golgi\u2010Cenci Foundation & ASP Golgi\u2010Redaelli Abbiategrasso Italy","institution_ids":["https://openalex.org/I4210110921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072516497","display_name":"Valentina Medici","orcid":"https://orcid.org/0000-0001-9385-3384","observed_orcids":["https://orcid.org/0000-0001-9385-3384"]},"institutions":[{"id":"https://openalex.org/I4210110921","display_name":"Fondazione Golgi Cenci","ror":"https://ror.org/017b91861","country_code":"IT","type":"other","lineage":["https://openalex.org/I4210110921"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Valentina Medici","raw_affiliation_strings":["Department of Neurology and Neuropathology Golgi\u2010Cenci Foundation & ASP Golgi\u2010Redaelli Abbiategrasso Italy"],"raw_orcid":"https://orcid.org/0000-0001-9385-3384","affiliations":[{"raw_affiliation_string":"Department of Neurology and Neuropathology Golgi\u2010Cenci Foundation & ASP Golgi\u2010Redaelli Abbiategrasso Italy","institution_ids":["https://openalex.org/I4210110921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035181498","display_name":"Francesco Olimpico","orcid":"https://orcid.org/0009-0003-0392-2983","observed_orcids":["https://orcid.org/0009-0003-0392-2983"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Francesco Olimpico","raw_affiliation_strings":["Fondazione Pisana per la Scienza ONLUS, San Giuliano Terme, Italy"],"raw_orcid":"https://orcid.org/0009-0003-0392-2983","affiliations":[{"raw_affiliation_string":"Fondazione Pisana per la Scienza ONLUS, San Giuliano Terme, Italy","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062847907","display_name":"Francesco Finamore","orcid":"https://orcid.org/0009-0005-7875-662X","observed_orcids":["https://orcid.org/0009-0005-7875-662X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Francesco Finamore","raw_affiliation_strings":["Fondazione Pisana per la Scienza ONLUS, San Giuliano Terme, Italy"],"raw_orcid":"https://orcid.org/0009-0005-7875-662X","affiliations":[{"raw_affiliation_string":"Fondazione Pisana per la Scienza ONLUS, San Giuliano Terme, Italy","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5093579617","display_name":"Xhulja Profka","orcid":"https://orcid.org/0000-0002-5785-3325","observed_orcids":["https://orcid.org/0000-0002-5785-3325"]},"institutions":[{"id":"https://openalex.org/I4210110921","display_name":"Fondazione Golgi Cenci","ror":"https://ror.org/017b91861","country_code":"IT","type":"other","lineage":["https://openalex.org/I4210110921"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Xhulja Profka","raw_affiliation_strings":["Department of Neurology and Neuropathology Golgi\u2010Cenci Foundation & ASP Golgi\u2010Redaelli Abbiategrasso Italy"],"raw_orcid":"https://orcid.org/0000-0002-5785-3325","affiliations":[{"raw_affiliation_string":"Department of Neurology and Neuropathology Golgi\u2010Cenci Foundation & ASP Golgi\u2010Redaelli Abbiategrasso Italy","institution_ids":["https://openalex.org/I4210110921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5106521370","display_name":"Karouna Bascarane","orcid":"https://orcid.org/0009-0005-5764-8275","observed_orcids":["https://orcid.org/0009-0005-5764-8275"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I2738703131","display_name":"Commissariat \u00e0 l'\u00c9nergie Atomique et aux \u00c9nergies Alternatives","ror":"https://ror.org/00jjx8s55","country_code":"FR","type":"government","lineage":["https://openalex.org/I2738703131"]},{"id":"https://openalex.org/I277688954","display_name":"Universit\u00e9 Paris-Saclay","ror":"https://ror.org/03xjwb503","country_code":"FR","type":"education","lineage":["https://openalex.org/I277688954"]},{"id":"https://openalex.org/I4387152877","display_name":"Laboratoire des Maladies Neurod\u00e9g\u00e9n\u00e9ratives","ror":"https://ror.org/00az7j379","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I2738703131","https://openalex.org/I277688954","https://openalex.org/I4210113668","https://openalex.org/I4387152877"]},{"id":"https://openalex.org/I4405258682","display_name":"Molecular Imaging Research Center","ror":"https://ror.org/012bkhy33","country_code":"FR","type":"facility","lineage":["https://openalex.org/I2738703131","https://openalex.org/I277688954","https://openalex.org/I4210113668","https://openalex.org/I4405258682","https://openalex.org/I4405259120"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Karouna Bascarane","raw_affiliation_strings":["Laboratoire des Maladies Neurod\u00e9g\u00e9n\u00e9ratives Universit\u00e9 Paris\u2010Saclay, CEA, CNRS, MIRCen  Fontenay\u2010aux\u2010Roses France"],"raw_orcid":"https://orcid.org/0009-0005-5764-8275","affiliations":[{"raw_affiliation_string":"Laboratoire des Maladies Neurod\u00e9g\u00e9n\u00e9ratives Universit\u00e9 Paris\u2010Saclay, CEA, CNRS, MIRCen  Fontenay\u2010aux\u2010Roses France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I2738703131","https://openalex.org/I277688954","https://openalex.org/I4387152877","https://openalex.org/I4405258682"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061426290","display_name":"Castrese Morrone","orcid":"https://orcid.org/0000-0002-3993-7306","observed_orcids":["https://orcid.org/0000-0002-3993-7306"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Castrese Morrone","raw_affiliation_strings":["Fondazione Pisana per la Scienza ONLUS, San Giuliano Terme, Italy"],"raw_orcid":"https://orcid.org/0000-0002-3993-7306","affiliations":[{"raw_affiliation_string":"Fondazione Pisana per la Scienza ONLUS, San Giuliano Terme, Italy","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085794456","display_name":"Aldo Pastore","orcid":"https://orcid.org/0009-0007-3037-0474","observed_orcids":["https://orcid.org/0009-0007-3037-0474"]},"institutions":[{"id":"https://openalex.org/I157210198","display_name":"Scuola Normale Superiore","ror":"https://ror.org/03aydme10","country_code":"IT","type":"education","lineage":["https://openalex.org/I157210198"]},{"id":"https://openalex.org/I4210108356","display_name":"National Enterprise for NanoScience and NanoTechnology","ror":"https://ror.org/01sgfhb12","country_code":"IT","type":"facility","lineage":["https://openalex.org/I157210198","https://openalex.org/I162290304","https://openalex.org/I30771326","https://openalex.org/I4210087815","https://openalex.org/I4210108356","https://openalex.org/I4210155236"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Aldo Pastore","raw_affiliation_strings":["Fondazione Pisana per la Scienza ONLUS, San Giuliano Terme, Italy","Laboratorio NEST, Scuola Normale Superiore, Pisa, Italy"],"raw_orcid":"https://orcid.org/0009-0007-3037-0474","affiliations":[{"raw_affiliation_string":"Fondazione Pisana per la Scienza ONLUS, San Giuliano Terme, Italy","institution_ids":[]},{"raw_affiliation_string":"Laboratorio NEST, Scuola Normale Superiore, Pisa, Italy","institution_ids":["https://openalex.org/I157210198","https://openalex.org/I4210108356"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004430637","display_name":"Carole Escartin","orcid":"https://orcid.org/0000-0003-3613-4118","observed_orcids":["https://orcid.org/0000-0003-3613-4118"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I2738703131","display_name":"Commissariat \u00e0 l'\u00c9nergie Atomique et aux \u00c9nergies Alternatives","ror":"https://ror.org/00jjx8s55","country_code":"FR","type":"government","lineage":["https://openalex.org/I2738703131"]},{"id":"https://openalex.org/I277688954","display_name":"Universit\u00e9 Paris-Saclay","ror":"https://ror.org/03xjwb503","country_code":"FR","type":"education","lineage":["https://openalex.org/I277688954"]},{"id":"https://openalex.org/I4387152877","display_name":"Laboratoire des Maladies Neurod\u00e9g\u00e9n\u00e9ratives","ror":"https://ror.org/00az7j379","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I2738703131","https://openalex.org/I277688954","https://openalex.org/I4210113668","https://openalex.org/I4387152877"]},{"id":"https://openalex.org/I4405258682","display_name":"Molecular Imaging Research Center","ror":"https://ror.org/012bkhy33","country_code":"FR","type":"facility","lineage":["https://openalex.org/I2738703131","https://openalex.org/I277688954","https://openalex.org/I4210113668","https://openalex.org/I4405258682","https://openalex.org/I4405259120"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Carole Escartin","raw_affiliation_strings":["Laboratoire des Maladies Neurod\u00e9g\u00e9n\u00e9ratives Universit\u00e9 Paris\u2010Saclay, CEA, CNRS, MIRCen  Fontenay\u2010aux\u2010Roses France"],"raw_orcid":"https://orcid.org/0000-0003-3613-4118","affiliations":[{"raw_affiliation_string":"Laboratoire des Maladies Neurod\u00e9g\u00e9n\u00e9ratives Universit\u00e9 Paris\u2010Saclay, CEA, CNRS, MIRCen  Fontenay\u2010aux\u2010Roses France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I2738703131","https://openalex.org/I277688954","https://openalex.org/I4387152877","https://openalex.org/I4405258682"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087234831","display_name":"Liam Andrew McDonnell","orcid":"https://orcid.org/0000-0003-0595-9491","observed_orcids":["https://orcid.org/0000-0003-0595-9491"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Liam A. McDonnell","raw_affiliation_strings":["Fondazione Pisana per la Scienza ONLUS, San Giuliano Terme, Italy"],"raw_orcid":"https://orcid.org/0000-0003-0595-9491","affiliations":[{"raw_affiliation_string":"Fondazione Pisana per la Scienza ONLUS, San Giuliano Terme, Italy","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5073257998","display_name":"Maria Teresa Dell\u2019Anno","orcid":"https://orcid.org/0000-0003-1825-671X","observed_orcids":["https://orcid.org/0000-0003-1825-671X"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Maria Teresa Dell'Anno","raw_affiliation_strings":["Fondazione Pisana per la Scienza ONLUS, San Giuliano Terme, Italy"],"raw_orcid":"https://orcid.org/0000-0003-1825-671X","affiliations":[{"raw_affiliation_string":"Fondazione Pisana per la Scienza ONLUS, San Giuliano Terme, Italy","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":9,"corresponding_author_ids":["https://openalex.org/A5073257998"],"corresponding_institution_ids":[],"apc_list":{"value":5190,"currency":"USD","value_usd":5190},"apc_paid":{"value":5190,"currency":"USD","value_usd":5190},"fwci":0.2685,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":{"value":0.42973009,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":95},"biblio":{"volume":"72","issue":"12","first_page":"2158","last_page":"2177"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.8320000171661377,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.8320000171661377,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.16419999301433563,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/centrin-2","display_name":"centrin 2","score":0.9750000238418579},{"id":"https://openalex.org/keywords/astrocytes","display_name":"astrocytes","score":0.8309999704360962},{"id":"https://openalex.org/keywords/astrocyte-activation","display_name":"astrocyte activation","score":0.9409999847412109},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9890000224113464},{"id":"https://openalex.org/keywords/entorhinal-cortex","display_name":"entorhinal cortex","score":0.9990000128746033},{"id":"https://openalex.org/keywords/astrocyte-calcium-signaling","display_name":"astrocyte calcium signaling","score":0.8410000205039978},{"id":"https://openalex.org/keywords/amyloid-beta","display_name":"amyloid-beta","score":0.6710000038146973},{"id":"https://openalex.org/keywords/neurofibrillary-tangles","display_name":"neurofibrillary tangles","score":0.847000002861023},{"id":"https://openalex.org/keywords/disease-severity","display_name":"disease severity","score":0.6830000281333923},{"id":"https://openalex.org/keywords/neurocognitive-impairment","display_name":"neurocognitive impairment","score":0.847000002861023},{"id":"https://openalex.org/keywords/stat3","display_name":"STAT3","score":0.8259999752044678},{"id":"https://openalex.org/keywords/nfatc3","display_name":"NFATc3","score":0.9980000257492065},{"id":"https://openalex.org/keywords/ykl-40","display_name":"YKL-40","score":0.9850000143051147},{"id":"https://openalex.org/keywords/reactive-astrocytes","display_name":"reactive astrocytes","score":0.6819999814033508}],"concepts":[{"id":"https://openalex.org/C2779965356","wikidata":"https://www.wikidata.org/wiki/Q4811564","display_name":"Astrogliosis","level":3,"score":0.8452646732330322},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7402251958847046},{"id":"https://openalex.org/C2777542381","wikidata":"https://www.wikidata.org/wiki/Q502961","display_name":"Astrocyte","level":3,"score":0.7141287326812744},{"id":"https://openalex.org/C2780715579","wikidata":"https://www.wikidata.org/wiki/Q2603645","display_name":"Entorhinal cortex","level":3,"score":0.6773180961608887},{"id":"https://openalex.org/C2780495277","wikidata":"https://www.wikidata.org/wiki/Q905442","display_name":"Glial fibrillary acidic protein","level":3,"score":0.6494394540786743},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.49085885286331177},{"id":"https://openalex.org/C87753298","wikidata":"https://www.wikidata.org/wiki/Q17157137","display_name":"Neuroinflammation","level":3,"score":0.48938196897506714},{"id":"https://openalex.org/C68026918","wikidata":"https://www.wikidata.org/wiki/Q1970256","display_name":"Senile plaques","level":4,"score":0.47809669375419617},{"id":"https://openalex.org/C122229402","wikidata":"https://www.wikidata.org/wiki/Q5018802","display_name":"Calcium-binding protein","level":3,"score":0.4776631295681},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.4669339060783386},{"id":"https://openalex.org/C2776925932","wikidata":"https://www.wikidata.org/wiki/Q1755122","display_name":"Neurodegeneration","level":3,"score":0.44641315937042236},{"id":"https://openalex.org/C31705614","wikidata":"https://www.wikidata.org/wiki/Q423510","display_name":"Amyloid precursor protein","level":4,"score":0.4393322169780731},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4209066331386566},{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.3937353193759918},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.34398406744003296},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.2157788872718811},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.19839534163475037},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.1940421760082245},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.18785825371742249},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.14783141016960144},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1302107572555542},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.1201845109462738},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.10910049080848694}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D001253","descriptor_name":"Astrocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001253","descriptor_name":"Astrocytes","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D002135","descriptor_name":"Calcium-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018728","descriptor_name":"Entorhinal Cortex","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018728","descriptor_name":"Entorhinal Cortex","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1002/glia.24603","doi":"https://doi.org/10.1002/glia.24603","is_oa":true,"landing_page_url":"https://doi.org/10.1002/glia.24603","pdf_url":null,"source":{"id":"https://openalex.org/S147407642","display_name":"Glia","issn_l":"0894-1491","issn":["0894-1491","1098-1136"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Glia","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13058879","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13058879/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13058879/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Glia","raw_type":"Text"},{"id":"pmid:39145525","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39145525","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Glia","raw_type":"Journal Article"},{"id":"pmh:oai:HAL:hal-04780616v1","doi":null,"is_oa":true,"landing_page_url":"https://hal.science/hal-04780616","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Glia, 2024, 72 (12), pp.2158-2177. &#x27E8;10.1002/glia.24603&#x27E9;","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1002/glia.24603","doi":"https://doi.org/10.1002/glia.24603","is_oa":true,"landing_page_url":"https://doi.org/10.1002/glia.24603","pdf_url":null,"source":{"id":"https://openalex.org/S147407642","display_name":"Glia","issn_l":"0894-1491","issn":["0894-1491","1098-1136"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Glia","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G213802806","display_name":null,"funder_award_id":"#ANR21\u2010CE17\u20100047\u201002","funder_id":"https://openalex.org/F7400742617","funder_display_name":"Vermont Agency of Natural Resources"},{"id":"https://openalex.org/G2967493662","display_name":"TAGLN3 as a new regulator of neuroinflammation: from a biomarker to a biotarget in Alzheimer\u2019s disease","funder_award_id":"ANR-21-CE17-0047","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"}],"funders":[{"id":"https://openalex.org/F4320320883","display_name":"Agence Nationale de la Recherche","ror":"https://ror.org/00rbzpz17"},{"id":"https://openalex.org/F7400742617","display_name":"Vermont Agency of Natural Resources","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4401596259.pdf","grobid_xml":"https://content.openalex.org/works/W4401596259.grobid-xml"},"referenced_works_count":84,"referenced_works":["https://openalex.org/W10604852","https://openalex.org/W1507013865","https://openalex.org/W1523922157","https://openalex.org/W1545961204","https://openalex.org/W1569924411","https://openalex.org/W1594747697","https://openalex.org/W1599277155","https://openalex.org/W1966720891","https://openalex.org/W1967464880","https://openalex.org/W1967823816","https://openalex.org/W1975372045","https://openalex.org/W1986229796","https://openalex.org/W1988278010","https://openalex.org/W1993573917","https://openalex.org/W1994857072","https://openalex.org/W1995111570","https://openalex.org/W2000225222","https://openalex.org/W2001618696","https://openalex.org/W2007926323","https://openalex.org/W2013354290","https://openalex.org/W2033456903","https://openalex.org/W2044694742","https://openalex.org/W2052870901","https://openalex.org/W2058914023","https://openalex.org/W2071221524","https://openalex.org/W2073363749","https://openalex.org/W2090620788","https://openalex.org/W2093650784","https://openalex.org/W2094286956","https://openalex.org/W2128228199","https://openalex.org/W2128846883","https://openalex.org/W2136250824","https://openalex.org/W2142943752","https://openalex.org/W2146729934","https://openalex.org/W2154780300","https://openalex.org/W2155009321","https://openalex.org/W2165092386","https://openalex.org/W2171835565","https://openalex.org/W2191292005","https://openalex.org/W2213006009","https://openalex.org/W2292817482","https://openalex.org/W2510930296","https://openalex.org/W2607517472","https://openalex.org/W2610760715","https://openalex.org/W2624641603","https://openalex.org/W2738888781","https://openalex.org/W2752317246","https://openalex.org/W2771680129","https://openalex.org/W2774835162","https://openalex.org/W2791430979","https://openalex.org/W2801244110","https://openalex.org/W2886053020","https://openalex.org/W2888257210","https://openalex.org/W2893741908","https://openalex.org/W2897601491","https://openalex.org/W2897675136","https://openalex.org/W2907017802","https://openalex.org/W2917194175","https://openalex.org/W2943828894","https://openalex.org/W2946201788","https://openalex.org/W2950930837","https://openalex.org/W3011906605","https://openalex.org/W3012240755","https://openalex.org/W3025955412","https://openalex.org/W3033211903","https://openalex.org/W3046615650","https://openalex.org/W3085066201","https://openalex.org/W3089126593","https://openalex.org/W3101789682","https://openalex.org/W3132240972","https://openalex.org/W3198052269","https://openalex.org/W4200565516","https://openalex.org/W4206337645","https://openalex.org/W4221125598","https://openalex.org/W4225159621","https://openalex.org/W4247665917","https://openalex.org/W4247759744","https://openalex.org/W4308451957","https://openalex.org/W4313477105","https://openalex.org/W4378219872","https://openalex.org/W4378229525","https://openalex.org/W4391743929","https://openalex.org/W4393898985","https://openalex.org/W6959047540"],"related_works":["https://openalex.org/W7065924143","https://openalex.org/W2292817482","https://openalex.org/W2980811666","https://openalex.org/W2980864115","https://openalex.org/W1972816016","https://openalex.org/W2229426556","https://openalex.org/W3185758573","https://openalex.org/W4200565516","https://openalex.org/W2030924879","https://openalex.org/W4401931122"],"abstract_inverted_index":{"Astrogliosis":[0],"is":[1,213],"a":[2,46,101,144,166,184,198,235],"condition":[3],"shared":[4],"by":[5,123],"acute":[6],"and":[7,11,15,29,85,118,132,139,151,161,172,187,195,224],"chronic":[8,63],"neurological":[9],"diseases":[10],"includes":[12],"morphological,":[13],"proteomic,":[14],"functional":[16,47],"rearrangements":[17,221],"of":[18,37,62,68,87,158,215,230],"astroglia.":[19],"In":[20],"Alzheimer's":[21],"disease":[22,238],"(AD),":[23],"reactive":[24,190],"astrocytes":[25,176],"frame":[26],"amyloid":[27,49,159],"deposits":[28],"exhibit":[30],"structural":[31],"changes":[32],"associated":[33],"with":[34,155,183,189],"the":[35,60,66,80,95,106,156,180,208,216,228],"overexpression":[36],"specific":[38],"proteins,":[39],"mostly":[40],"belonging":[41],"to":[42,59,112,227],"intermediate":[43],"filaments.":[44],"At":[45],"level,":[48],"beta":[50],"triggers":[51],"dysfunctional":[52],"calcium":[53,75,218],"signaling":[54,76],"in":[55,73,89,105,110,130,179,201,222,237],"astrocytes,":[56],"which":[57],"contributes":[58],"maintenance":[61],"neuroinflammation.":[64],"Therefore,":[65],"identification":[67],"intracellular":[69],"players":[70],"that":[71,211,232],"participate":[72],"astrocyte":[74,83,103],"can":[77],"help":[78],"unveil":[79],"mechanisms":[81],"underlying":[82],"reactivity":[84],"loss":[86],"function":[88],"AD.":[90],"We":[91],"have":[92],"recently":[93],"identified":[94],"calcium-binding":[96],"protein":[97],"centrin-2":[98],"(CETN2)":[99],"as":[100],"novel":[102],"marker":[104],"human":[107],"brain":[108],"and,":[109],"order":[111],"determine":[113],"whether":[114],"astrocytic":[115,217],"CETN2":[116,149,170,212,226],"expression":[117,171],"distribution":[119],"could":[120,233],"be":[121],"affected":[122],"neurodegenerative":[124],"conditions,":[125],"we":[126,142],"examined":[127],"its":[128],"pattern":[129,186],"control":[131],"sporadic":[133],"AD":[134,173,223],"patients.":[135],"By":[136],"immunoblot,":[137],"immunohistochemistry,":[138],"targeted-mass":[140],"spectrometry,":[141],"report":[143],"positive":[145],"correlation":[146],"between":[147,169],"entorhinal":[148,181],"immunoreactivity":[150],"neurocognitive":[152],"impairment,":[153],"along":[154],"abundance":[157],"depositions":[160],"neurofibrillary":[162],"tangles,":[163],"thus":[164],"highlighting":[165],"linear":[167],"relationship":[168],"progression.":[174],"CETN2-positive":[175],"were":[177],"dispersed":[178],"cortex":[182],"clustered":[185],"colocalized":[188],"glia":[191],"markers":[192],"STAT3,":[193],"NFATc3,":[194],"YKL-40,":[196],"indicating":[197],"human-specific":[199],"role":[200,236],"AD-induced":[202],"astrogliosis.":[203],"Collectively,":[204],"our":[205],"data":[206],"provide":[207],"first":[209],"evidence":[210],"part":[214],"toolkit":[219],"undergoing":[220],"adds":[225],"list":[229],"proteins":[231],"play":[234],"evolution.":[239]},"counts_by_year":[{"year":2025,"cited_by_count":2}],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2024-08-15T00:00:00"}
