{"id":"https://openalex.org/W4401575552","doi":"https://doi.org/10.1007/s40618-024-02441-z","title":"The real-world safety profile of tirzepatide: pharmacovigilance analysis of the FDA Adverse Event Reporting System (FAERS) database","display_name":"The real-world safety profile of tirzepatide: pharmacovigilance analysis of the FDA Adverse Event Reporting System (FAERS) database","publication_year":2024,"publication_date":"2024-08-14","ids":{"openalex":"https://openalex.org/W4401575552","doi":"https://doi.org/10.1007/s40618-024-02441-z","pmid":"https://pubmed.ncbi.nlm.nih.gov/39141075","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11473560"},"language":"en","primary_location":{"id":"doi:10.1007/s40618-024-02441-z","doi":"https://doi.org/10.1007/s40618-024-02441-z","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s40618-024-02441-z","pdf_url":"https://link.springer.com/content/pdf/10.1007/s40618-024-02441-z.pdf","source":{"id":"https://openalex.org/S207799248","display_name":"Journal of Endocrinological Investigation","issn_l":"0391-4097","issn":["0391-4097","1720-8386"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Endocrinological Investigation","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://link.springer.com/content/pdf/10.1007/s40618-024-02441-z.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103115613","display_name":"Irene Caruso","orcid":"https://orcid.org/0000-0002-5891-269X","observed_orcids":["https://orcid.org/0000-0002-5891-269X"]},"institutions":[{"id":"https://openalex.org/I5561750","display_name":"University of Bari Aldo Moro","ror":"https://ror.org/027ynra39","country_code":"IT","type":"education","lineage":["https://openalex.org/I5561750"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"I. Caruso","raw_affiliation_strings":["Department of Precision and Regenerative Medicine and Ionian Area, Section of Internal Medicine, Endocrinology, Andrology and Metabolic Diseases, University of Bari Aldo Moro, Bari, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Precision and Regenerative Medicine and Ionian Area, Section of Internal Medicine, Endocrinology, Andrology and Metabolic Diseases, University of Bari Aldo Moro, Bari, Italy","institution_ids":["https://openalex.org/I5561750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060481695","display_name":"Ludovico Di Gioia","orcid":"https://orcid.org/0009-0006-8165-7531","observed_orcids":["https://orcid.org/0009-0006-8165-7531"]},"institutions":[{"id":"https://openalex.org/I5561750","display_name":"University of Bari Aldo Moro","ror":"https://ror.org/027ynra39","country_code":"IT","type":"education","lineage":["https://openalex.org/I5561750"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"L. Di Gioia","raw_affiliation_strings":["Department of Precision and Regenerative Medicine and Ionian Area, Section of Internal Medicine, Endocrinology, Andrology and Metabolic Diseases, University of Bari Aldo Moro, Bari, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Precision and Regenerative Medicine and Ionian Area, Section of Internal Medicine, Endocrinology, Andrology and Metabolic Diseases, University of Bari Aldo Moro, Bari, Italy","institution_ids":["https://openalex.org/I5561750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056650933","display_name":"Sergio Di Molfetta","orcid":"https://orcid.org/0000-0003-3454-7330","observed_orcids":["https://orcid.org/0000-0003-3454-7330"]},"institutions":[{"id":"https://openalex.org/I5561750","display_name":"University of Bari Aldo Moro","ror":"https://ror.org/027ynra39","country_code":"IT","type":"education","lineage":["https://openalex.org/I5561750"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"S. Di Molfetta","raw_affiliation_strings":["Department of Precision and Regenerative Medicine and Ionian Area, Section of Internal Medicine, Endocrinology, Andrology and Metabolic Diseases, University of Bari Aldo Moro, Bari, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Precision and Regenerative Medicine and Ionian Area, Section of Internal Medicine, Endocrinology, Andrology and Metabolic Diseases, University of Bari Aldo Moro, Bari, Italy","institution_ids":["https://openalex.org/I5561750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061744685","display_name":"Mariangela Caporusso","orcid":"https://orcid.org/0009-0008-7331-3936","observed_orcids":["https://orcid.org/0009-0008-7331-3936"]},"institutions":[{"id":"https://openalex.org/I5561750","display_name":"University of Bari Aldo Moro","ror":"https://ror.org/027ynra39","country_code":"IT","type":"education","lineage":["https://openalex.org/I5561750"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"M. Caporusso","raw_affiliation_strings":["Department of Precision and Regenerative Medicine and Ionian Area, Section of Internal Medicine, Endocrinology, Andrology and Metabolic Diseases, University of Bari Aldo Moro, Bari, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Precision and Regenerative Medicine and Ionian Area, Section of Internal Medicine, Endocrinology, Andrology and Metabolic Diseases, University of Bari Aldo Moro, Bari, Italy","institution_ids":["https://openalex.org/I5561750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010465088","display_name":"Angelo Cignarelli","orcid":"https://orcid.org/0000-0001-6477-9031","observed_orcids":["https://orcid.org/0000-0001-6477-9031"]},"institutions":[{"id":"https://openalex.org/I5561750","display_name":"University of Bari Aldo Moro","ror":"https://ror.org/027ynra39","country_code":"IT","type":"education","lineage":["https://openalex.org/I5561750"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"A. Cignarelli","raw_affiliation_strings":["Department of Precision and Regenerative Medicine and Ionian Area, Section of Internal Medicine, Endocrinology, Andrology and Metabolic Diseases, University of Bari Aldo Moro, Bari, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Precision and Regenerative Medicine and Ionian Area, Section of Internal Medicine, Endocrinology, Andrology and Metabolic Diseases, University of Bari Aldo Moro, Bari, Italy","institution_ids":["https://openalex.org/I5561750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035542322","display_name":"Gian Pio Sorice","orcid":"https://orcid.org/0000-0001-9489-1534","observed_orcids":["https://orcid.org/0000-0001-9489-1534"]},"institutions":[{"id":"https://openalex.org/I5561750","display_name":"University of Bari Aldo Moro","ror":"https://ror.org/027ynra39","country_code":"IT","type":"education","lineage":["https://openalex.org/I5561750"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"G. P. Sorice","raw_affiliation_strings":["Department of Precision and Regenerative Medicine and Ionian Area, Section of Internal Medicine, Endocrinology, Andrology and Metabolic Diseases, University of Bari Aldo Moro, Bari, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Precision and Regenerative Medicine and Ionian Area, Section of Internal Medicine, Endocrinology, Andrology and Metabolic Diseases, University of Bari Aldo Moro, Bari, Italy","institution_ids":["https://openalex.org/I5561750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038077594","display_name":"Luigi Laviola","orcid":"https://orcid.org/0000-0001-8860-5845","observed_orcids":["https://orcid.org/0000-0001-8860-5845"]},"institutions":[{"id":"https://openalex.org/I5561750","display_name":"University of Bari Aldo Moro","ror":"https://ror.org/027ynra39","country_code":"IT","type":"education","lineage":["https://openalex.org/I5561750"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"L. Laviola","raw_affiliation_strings":["Department of Precision and Regenerative Medicine and Ionian Area, Section of Internal Medicine, Endocrinology, Andrology and Metabolic Diseases, University of Bari Aldo Moro, Bari, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Precision and Regenerative Medicine and Ionian Area, Section of Internal Medicine, Endocrinology, Andrology and Metabolic Diseases, University of Bari Aldo Moro, Bari, Italy","institution_ids":["https://openalex.org/I5561750"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5064872622","display_name":"Francesco Giorgino","orcid":"https://orcid.org/0000-0001-7372-2678","observed_orcids":["https://orcid.org/0000-0001-7372-2678"]},"institutions":[{"id":"https://openalex.org/I5561750","display_name":"University of Bari Aldo Moro","ror":"https://ror.org/027ynra39","country_code":"IT","type":"education","lineage":["https://openalex.org/I5561750"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"F. Giorgino","raw_affiliation_strings":["Department of Precision and Regenerative Medicine and Ionian Area, Section of Internal Medicine, Endocrinology, Andrology and Metabolic Diseases, University of Bari Aldo Moro, Bari, Italy. francesco.giorgino@uniba.it","Department of Precision and Regenerative Medicine and Ionian Area, Section of Internal Medicine, Endocrinology, Andrology and Metabolic Diseases, University of Bari Aldo Moro, Bari, Italy"],"raw_orcid":"https://orcid.org/0000-0001-7372-2678","affiliations":[{"raw_affiliation_string":"Department of Precision and Regenerative Medicine and Ionian Area, Section of Internal Medicine, Endocrinology, Andrology and Metabolic Diseases, University of Bari Aldo Moro, Bari, Italy. francesco.giorgino@uniba.it","institution_ids":["https://openalex.org/I5561750"]},{"raw_affiliation_string":"Department of Precision and Regenerative Medicine and Ionian Area, Section of Internal Medicine, Endocrinology, Andrology and Metabolic Diseases, University of Bari Aldo Moro, Bari, Italy","institution_ids":["https://openalex.org/I5561750"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5064872622"],"corresponding_institution_ids":["https://openalex.org/I5561750"],"apc_list":{"value":4590,"currency":"USD","value_usd":4590},"apc_paid":{"value":4590,"currency":"USD","value_usd":4590},"fwci":14.4675,"has_fulltext":true,"cited_by_count":61,"citation_normalized_percentile":{"value":0.99756583,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":100},"biblio":{"volume":"47","issue":"11","first_page":"2671","last_page":"2678"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11943","display_name":"Pharmacovigilance and Adverse Drug Reactions","score":0.9883000254631042,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11943","display_name":"Pharmacovigilance and Adverse Drug Reactions","score":0.9883000254631042,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":0.009399999864399433,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12539","display_name":"Pharmacology and Obesity Treatment","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tirzepatide","display_name":"tirzepatide","score":1.0},{"id":"https://openalex.org/keywords/drug-safety","display_name":"drug safety","score":0.7919999957084656},{"id":"https://openalex.org/keywords/adverse-events","display_name":"adverse events","score":0.6230000257492065},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.6790000200271606},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.9990000128746033},{"id":"https://openalex.org/keywords/glp-1-receptor-agonists","display_name":"GLP-1 receptor agonists","score":0.9279999732971191},{"id":"https://openalex.org/keywords/gastrointestinal-side-effects","display_name":"gastrointestinal adverse effects","score":0.8450000286102295},{"id":"https://openalex.org/keywords/nausea","display_name":"nausea","score":0.5950000286102295},{"id":"https://openalex.org/keywords/pancreatitis","display_name":"pancreatitis","score":0.9729999899864197},{"id":"https://openalex.org/keywords/diabetic-retinopathy","display_name":"diabetic retinopathy","score":0.9980000257492065},{"id":"https://openalex.org/keywords/medullary-thyroid-carcinoma","display_name":"medullary thyroid carcinoma","score":0.9990000128746033},{"id":"https://openalex.org/keywords/post-marketing-surveillance","display_name":"post-marketing surveillance","score":0.8180000185966492},{"id":"https://openalex.org/keywords/fda-adverse-event-reporting-system","display_name":"FDA Adverse Event Reporting System","score":0.5490000247955322}],"concepts":[{"id":"https://openalex.org/C2777105317","wikidata":"https://www.wikidata.org/wiki/Q4686710","display_name":"Adverse Event Reporting System","level":3,"score":0.9379428625106812},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8904082775115967},{"id":"https://openalex.org/C57658597","wikidata":"https://www.wikidata.org/wiki/Q1550789","display_name":"Pharmacovigilance","level":3,"score":0.6525897979736328},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.6094714999198914},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5367993116378784},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.4673108756542206},{"id":"https://openalex.org/C199475168","wikidata":"https://www.wikidata.org/wiki/Q1539689","display_name":"MedDRA","level":4,"score":0.4538728594779968},{"id":"https://openalex.org/C2779829184","wikidata":"https://www.wikidata.org/wiki/Q631361","display_name":"Diabetic retinopathy","level":3,"score":0.4435039162635803},{"id":"https://openalex.org/C77088390","wikidata":"https://www.wikidata.org/wiki/Q8513","display_name":"Database","level":1,"score":0.4284564256668091},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.4238562285900116},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.3755098879337311},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.2955286502838135},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007004","descriptor_name":"Hypoglycemic Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013964","descriptor_name":"Thyroid Neoplasms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014481","descriptor_name":"United States","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D014486","descriptor_name":"United States Food and Drug Administration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016208","descriptor_name":"Databases, Factual","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016907","descriptor_name":"Adverse Drug Reaction Reporting Systems","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":true},{"descriptor_ui":"D018278","descriptor_name":"Carcinoma, Neuroendocrine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060735","descriptor_name":"Pharmacovigilance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D064420","descriptor_name":"Drug-Related Side Effects and Adverse Reactions","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D064420","descriptor_name":"Drug-Related Side Effects and Adverse Reactions","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1007/s40618-024-02441-z","doi":"https://doi.org/10.1007/s40618-024-02441-z","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s40618-024-02441-z","pdf_url":"https://link.springer.com/content/pdf/10.1007/s40618-024-02441-z.pdf","source":{"id":"https://openalex.org/S207799248","display_name":"Journal of Endocrinological Investigation","issn_l":"0391-4097","issn":["0391-4097","1720-8386"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Endocrinological Investigation","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11473560","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11473560","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11473560/pdf/40618_2024_Article_2441.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Endocrinol Invest","raw_type":"Text"},{"id":"pmid:39141075","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39141075","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of endocrinological investigation","raw_type":"Journal Article"},{"id":"pmh:oai:ricerca.uniba.it:11586/519871","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/11586/519871","pdf_url":null,"source":{"id":"https://openalex.org/S4377196296","display_name":"CINECA IRIS Institutional Research Information System (University of Bari Aldo Moro)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I5561750","host_organization_name":"University of Bari Aldo Moro","host_organization_lineage":["https://openalex.org/I5561750"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1007/s40618-024-02441-z","doi":"https://doi.org/10.1007/s40618-024-02441-z","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s40618-024-02441-z","pdf_url":"https://link.springer.com/content/pdf/10.1007/s40618-024-02441-z.pdf","source":{"id":"https://openalex.org/S207799248","display_name":"Journal of Endocrinological Investigation","issn_l":"0391-4097","issn":["0391-4097","1720-8386"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Endocrinological Investigation","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320325953","display_name":"Fondazione per la Ricerca Biomedica","ror":"https://ror.org/005w6dd37"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4401575552.pdf","grobid_xml":"https://content.openalex.org/works/W4401575552.grobid-xml"},"referenced_works_count":35,"referenced_works":["https://openalex.org/W1988100739","https://openalex.org/W2082213840","https://openalex.org/W2462118923","https://openalex.org/W2519510391","https://openalex.org/W2735763507","https://openalex.org/W2787584324","https://openalex.org/W2901921552","https://openalex.org/W2910325484","https://openalex.org/W3004172664","https://openalex.org/W3007650583","https://openalex.org/W3034133160","https://openalex.org/W3086646659","https://openalex.org/W3114565741","https://openalex.org/W3177122952","https://openalex.org/W3177393241","https://openalex.org/W3187492301","https://openalex.org/W3191712049","https://openalex.org/W3205201678","https://openalex.org/W4210940103","https://openalex.org/W4220768125","https://openalex.org/W4220972902","https://openalex.org/W4221056231","https://openalex.org/W4288735703","https://openalex.org/W4288740467","https://openalex.org/W4308701204","https://openalex.org/W4366712080","https://openalex.org/W4378212143","https://openalex.org/W4386691506","https://openalex.org/W4387296976","https://openalex.org/W4387670410","https://openalex.org/W4387764698","https://openalex.org/W4388485257","https://openalex.org/W4389571899","https://openalex.org/W4391752441","https://openalex.org/W4392589483"],"related_works":["https://openalex.org/W4400652998","https://openalex.org/W7203536876","https://openalex.org/W7168164006","https://openalex.org/W4399525881","https://openalex.org/W4404532022","https://openalex.org/W4412151760","https://openalex.org/W4408130309","https://openalex.org/W7119493285","https://openalex.org/W7204726598","https://openalex.org/W4404735076"],"abstract_inverted_index":{"PURPOSE:":[0],"Randomized":[1],"controlled":[2],"trials":[3],"with":[4,17,121,202],"tirzepatide":[5],"(TZP)":[6],"displayed":[7],"unprecedented":[8],"glucose":[9],"and":[10,23,50,81,100,114,131,145,162,181,185,193,227],"body":[11],"weight":[12],"lowering":[13],"efficacy":[14],"in":[15],"individuals":[16],"type":[18],"2":[19],"diabetes":[20],"and/or":[21],"obesity":[22],"a":[24,175,186],"safety":[25,64,211],"profile":[26,212],"similar":[27,176,214],"to":[28,59,87,125,215],"that":[29,216],"of":[30,93,136,178,189,206,217,222],"glucagon-like":[31],"peptide-1":[32],"receptor":[33],"agonists":[34],"(GLP-1RA),":[35],"mainly":[36],"characterized":[37],"by":[38],"gastrointestinal":[39],"(GI)":[40],"adverse":[41],"events":[42],"(AE).":[43],"Concerns":[44],"on":[45],"diabetic":[46,96,155,194,225],"retinopathy,":[47,97,226],"pancreato-biliary":[48,98,146,191,223],"disorders,":[49,99],"medullary":[51,101,163,182,228],"thyroid":[52,102,164,183,229],"cancer":[53,103,165,184],"were":[54,85,104],"also":[55],"addressed.":[56],"We":[57],"aimed":[58],"investigate":[60],"whether":[61],"the":[62,68,89],"same":[63],"issues":[65],"emerged":[66],"from":[67],"FDA":[69],"Adverse":[70],"Event":[71],"Reporting":[72],"System":[73],"(FAERS)":[74],"post-marketing":[75],"surveillance":[76],"database.":[77,91],"METHODS:":[78],"OpenVigil":[79],"2.1-MedDRA-v24":[80],"AERSMine":[82],"(data":[83],"2004Q1-2023Q3)":[84],"used":[86],"query":[88],"FAERS":[90],"Reports":[92],"GI":[94,137,179],"AE,":[95,224],"investigated.":[105],"The":[106],"analysis":[107],"was":[108,123,171,200,213],"then":[109],"filtered":[110],"for":[111],"age,":[112],"gender,":[113],"designation":[115],"as":[116],"primary":[117],"suspect.":[118],"AE":[119,180,192],"occurrence":[120],"TZP":[122,173,199],"compared":[124],"insulin,":[126],"sodium-glucose":[127],"cotransporter-2":[128],"inhibitors,":[129],"metformin,":[130],"GLP-1RA.":[132,197],"RESULTS:":[133],"Disproportionate":[134],"reporting":[135],"[i.e.,":[138,148],"nausea":[139],"(ROR":[140,150,157,166],"4.01,":[141],"95%":[142,152,159,168],"CI":[143,153,160,169],"3.85-4.19)]":[144],"disorders":[147],"pancreatitis":[149],"3.63,":[151],"3.15-4.19)],":[154],"retinopathy":[156,195],"4.14,":[158],"2.34-7.30),":[161],"13.67,":[167],"4.35-42.96)":[170],"detected.":[172],"exhibited":[174],"risk":[177,188,205,221],"lower":[187],"most":[190],"vs.":[196],"CONCLUSIONS:":[198],"associated":[201],"an":[203],"increased":[204,220],"specific":[207],"AE.":[208],"However,":[209],"its":[210],"GLP-1RA,":[218],"without":[219],"cancer.":[230]},"counts_by_year":[{"year":2026,"cited_by_count":24},{"year":2025,"cited_by_count":34},{"year":2024,"cited_by_count":3}],"updated_date":"2026-11-13T13:42:25.865203","created_date":"2024-08-15T00:00:00"}