{"id":"https://openalex.org/W4401559809","doi":"https://doi.org/10.1016/j.scp.2024.101715","title":"Could natural-complex therapeutic products be useful for preserving biodiversity? UHPLC-qToF approaches to study the ready-biodegradability of a loperamide-based-drug and Lenodiar-Pediatric\u00ae","display_name":"Could natural-complex therapeutic products be useful for preserving biodiversity? UHPLC-qToF approaches to study the ready-biodegradability of a loperamide-based-drug and Lenodiar-Pediatric\u00ae","publication_year":2024,"publication_date":"2024-08-14","ids":{"openalex":"https://openalex.org/W4401559809","doi":"https://doi.org/10.1016/j.scp.2024.101715"},"language":"en","primary_location":{"id":"doi:10.1016/j.scp.2024.101715","doi":"https://doi.org/10.1016/j.scp.2024.101715","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.scp.2024.101715","pdf_url":null,"source":{"id":"https://openalex.org/S2898513339","display_name":"Sustainable Chemistry and Pharmacy","issn_l":"2352-5541","issn":["2352-5541"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","norway-1","poland-40","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sustainable Chemistry and Pharmacy","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1016/j.scp.2024.101715","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5001995416","display_name":"Luisa Mattoli","orcid":"https://orcid.org/0000-0002-5566-8919","observed_orcids":["https://orcid.org/0000-0002-5566-8919"]},"institutions":[{"id":"https://openalex.org/I4210125802","display_name":"Aboca (Italy)","ror":"https://ror.org/03f5nqa05","country_code":"IT","type":"company","lineage":["https://openalex.org/I4210125802"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Luisa Mattoli","raw_affiliation_strings":["Metabolomics & Analytical Sciences, Aboca SpA, Sansepolcro, AR, Italy"],"raw_orcid":"https://orcid.org/0000-0002-5566-8919","affiliations":[{"raw_affiliation_string":"Metabolomics & Analytical Sciences, Aboca SpA, Sansepolcro, AR, Italy","institution_ids":["https://openalex.org/I4210125802"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076896433","display_name":"Giada Fodaroni","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210125802","display_name":"Aboca (Italy)","ror":"https://ror.org/03f5nqa05","country_code":"IT","type":"company","lineage":["https://openalex.org/I4210125802"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Giada Fodaroni","raw_affiliation_strings":["Metabolomics & Analytical Sciences, Aboca SpA, Sansepolcro, AR, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Metabolomics & Analytical Sciences, Aboca SpA, Sansepolcro, AR, Italy","institution_ids":["https://openalex.org/I4210125802"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011703107","display_name":"Michela Burico","orcid":"https://orcid.org/0000-0002-6243-9073","observed_orcids":["https://orcid.org/0000-0002-6243-9073"]},"institutions":[{"id":"https://openalex.org/I4210125802","display_name":"Aboca (Italy)","ror":"https://ror.org/03f5nqa05","country_code":"IT","type":"company","lineage":["https://openalex.org/I4210125802"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Michela Burico","raw_affiliation_strings":["Metabolomics & Analytical Sciences, Aboca SpA, Sansepolcro, AR, Italy"],"raw_orcid":"https://orcid.org/0000-0002-6243-9073","affiliations":[{"raw_affiliation_string":"Metabolomics & Analytical Sciences, Aboca SpA, Sansepolcro, AR, Italy","institution_ids":["https://openalex.org/I4210125802"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078412382","display_name":"Sara Tamimi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210125802","display_name":"Aboca (Italy)","ror":"https://ror.org/03f5nqa05","country_code":"IT","type":"company","lineage":["https://openalex.org/I4210125802"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Sara Tamimi","raw_affiliation_strings":["Metabolomics & Analytical Sciences, Aboca SpA, Sansepolcro, AR, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Metabolomics & Analytical Sciences, Aboca SpA, Sansepolcro, AR, Italy","institution_ids":["https://openalex.org/I4210125802"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065130498","display_name":"Claudio Marzio Quintiero","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210125802","display_name":"Aboca (Italy)","ror":"https://ror.org/03f5nqa05","country_code":"IT","type":"company","lineage":["https://openalex.org/I4210125802"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Claudio Marzio Quintiero","raw_affiliation_strings":["Metabolomics & Analytical Sciences, Aboca SpA, Sansepolcro, AR, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Metabolomics & Analytical Sciences, Aboca SpA, Sansepolcro, AR, Italy","institution_ids":["https://openalex.org/I4210125802"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5098809095","display_name":"Beatrice Marzio Gironi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210125802","display_name":"Aboca (Italy)","ror":"https://ror.org/03f5nqa05","country_code":"IT","type":"company","lineage":["https://openalex.org/I4210125802"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Beatrice Gironi","raw_affiliation_strings":["Metabolomics & Analytical Sciences, Aboca SpA, Sansepolcro, AR, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Metabolomics & Analytical Sciences, Aboca SpA, Sansepolcro, AR, Italy","institution_ids":["https://openalex.org/I4210125802"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5098809096","display_name":"Vitalia Murgia","orcid":"https://orcid.org/0009-0006-7592-607X","observed_orcids":["https://orcid.org/0009-0006-7592-607X"]},"institutions":[{"id":"https://openalex.org/I25217355","display_name":"University of Pavia","ror":"https://ror.org/00s6t1f81","country_code":"IT","type":"education","lineage":["https://openalex.org/I25217355"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Vitalia Murgia","raw_affiliation_strings":["International Society of Doctors for the Environment, ISDE, Italian Section, Arezzo, Italy","Pediatric Unit, Department of Clinical, Surgical, Diagnostic and Pediatric Sciences, University of Pavia, Pavia, Italy"],"raw_orcid":"https://orcid.org/0009-0006-7592-607X","affiliations":[{"raw_affiliation_string":"International Society of Doctors for the Environment, ISDE, Italian Section, Arezzo, Italy","institution_ids":[]},{"raw_affiliation_string":"Pediatric Unit, Department of Clinical, Surgical, Diagnostic and Pediatric Sciences, University of Pavia, Pavia, Italy","institution_ids":["https://openalex.org/I25217355"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059222867","display_name":"Emiliano Giovagnoni","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210125802","display_name":"Aboca (Italy)","ror":"https://ror.org/03f5nqa05","country_code":"IT","type":"company","lineage":["https://openalex.org/I4210125802"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Emiliano Giovagnoni","raw_affiliation_strings":["Metabolomics & Analytical Sciences, Aboca SpA, Sansepolcro, AR, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Metabolomics & Analytical Sciences, Aboca SpA, Sansepolcro, AR, Italy","institution_ids":["https://openalex.org/I4210125802"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5026384685","display_name":"Mattia Gianni","orcid":"https://orcid.org/0009-0004-2955-8240","observed_orcids":["https://orcid.org/0009-0004-2955-8240"]},"institutions":[{"id":"https://openalex.org/I4210125802","display_name":"Aboca (Italy)","ror":"https://ror.org/03f5nqa05","country_code":"IT","type":"company","lineage":["https://openalex.org/I4210125802"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Mattia Gianni","raw_affiliation_strings":["Metabolomics & Analytical Sciences, Aboca SpA, Sansepolcro, AR, Italy"],"raw_orcid":"https://orcid.org/0009-0004-2955-8240","affiliations":[{"raw_affiliation_string":"Metabolomics & Analytical Sciences, Aboca SpA, Sansepolcro, AR, Italy","institution_ids":["https://openalex.org/I4210125802"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5001995416"],"corresponding_institution_ids":["https://openalex.org/I4210125802"],"apc_list":{"value":2500,"currency":"USD","value_usd":2500},"apc_paid":{"value":2500,"currency":"USD","value_usd":2500},"fwci":0.277,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.38468641,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":97},"biblio":{"volume":"41","issue":null,"first_page":"101715","last_page":"101715"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10419","display_name":"Pharmaceutical and Antibiotic Environmental Impacts","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2310","display_name":"Pollution"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10419","display_name":"Pharmaceutical and Antibiotic Environmental Impacts","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2310","display_name":"Pollution"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T13092","display_name":"Environmental Chemistry and Analysis","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2304","display_name":"Environmental Chemistry"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11460","display_name":"Analytical Methods in Pharmaceuticals","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/loperamide","display_name":"loperamide","score":0.8259999752044678},{"id":"https://openalex.org/keywords/ready-biodegradability","display_name":"ready biodegradability","score":0.9210000038146973},{"id":"https://openalex.org/keywords/biodiversity-conservation","display_name":"biodiversity conservation","score":0.5619999766349792},{"id":"https://openalex.org/keywords/one-health","display_name":"One Health","score":0.6980000138282776},{"id":"https://openalex.org/keywords/ecopharmacovigilance","display_name":"ecopharmacovigilance","score":0.9879999756813049},{"id":"https://openalex.org/keywords/pharmaceutical-excipients","display_name":"pharmaceutical excipients","score":0.4950000047683716}],"concepts":[{"id":"https://openalex.org/C2777573665","wikidata":"https://www.wikidata.org/wiki/Q423751","display_name":"Loperamide","level":3,"score":0.7625439167022705},{"id":"https://openalex.org/C157021035","wikidata":"https://www.wikidata.org/wiki/Q696715","display_name":"Biodegradation","level":2,"score":0.4400516450405121},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.41855230927467346},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3307094871997833},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.2652934193611145},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.22572535276412964},{"id":"https://openalex.org/C2779802037","wikidata":"https://www.wikidata.org/wiki/Q40878","display_name":"Diarrhea","level":2,"score":0.10331517457962036},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.09396037459373474},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0906137228012085}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1016/j.scp.2024.101715","doi":"https://doi.org/10.1016/j.scp.2024.101715","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.scp.2024.101715","pdf_url":null,"source":{"id":"https://openalex.org/S2898513339","display_name":"Sustainable Chemistry and Pharmacy","issn_l":"2352-5541","issn":["2352-5541"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","norway-1","poland-40","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sustainable Chemistry and Pharmacy","raw_type":"journal-article"},{"id":"doi:10.2139/ssrn.4835421","doi":"https://doi.org/10.2139/ssrn.4835421","is_oa":true,"landing_page_url":"https://doi.org/10.2139/ssrn.4835421","pdf_url":null,"source":{"id":"https://openalex.org/S4210172589","display_name":"SSRN Electronic Journal","issn_l":"1556-5068","issn":["1556-5068"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1318003438","host_organization_name":"RELX Group (Netherlands)","host_organization_lineage":["https://openalex.org/I1318003438"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1016/j.scp.2024.101715","doi":"https://doi.org/10.1016/j.scp.2024.101715","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.scp.2024.101715","pdf_url":null,"source":{"id":"https://openalex.org/S2898513339","display_name":"Sustainable Chemistry and Pharmacy","issn_l":"2352-5541","issn":["2352-5541"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","norway-1","poland-40","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sustainable Chemistry and Pharmacy","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.7811999917030334,"id":"https://metadata.un.org/sdg/12","display_name":"Responsible consumption and production"},{"score":0.7246000170707703,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":56,"referenced_works":["https://openalex.org/W387573856","https://openalex.org/W601636511","https://openalex.org/W1611854178","https://openalex.org/W1966206163","https://openalex.org/W1969873955","https://openalex.org/W1970073243","https://openalex.org/W1971503506","https://openalex.org/W1973097679","https://openalex.org/W1982372154","https://openalex.org/W1985610365","https://openalex.org/W1989402496","https://openalex.org/W2001025616","https://openalex.org/W2002695325","https://openalex.org/W2012200658","https://openalex.org/W2013623962","https://openalex.org/W2024495965","https://openalex.org/W2030219777","https://openalex.org/W2035749709","https://openalex.org/W2038464298","https://openalex.org/W2040577900","https://openalex.org/W2057530277","https://openalex.org/W2064375438","https://openalex.org/W2070835429","https://openalex.org/W2076288335","https://openalex.org/W2082003688","https://openalex.org/W2118588291","https://openalex.org/W2303445783","https://openalex.org/W2322580831","https://openalex.org/W2326873227","https://openalex.org/W2613980613","https://openalex.org/W2640707900","https://openalex.org/W2778025055","https://openalex.org/W2805735596","https://openalex.org/W2896881392","https://openalex.org/W2897993790","https://openalex.org/W3090673888","https://openalex.org/W3115588179","https://openalex.org/W3168956483","https://openalex.org/W3196868117","https://openalex.org/W4210696246","https://openalex.org/W4214932927","https://openalex.org/W4225882752","https://openalex.org/W4281709240","https://openalex.org/W4306986298","https://openalex.org/W4324366414","https://openalex.org/W4367603061","https://openalex.org/W4380360344","https://openalex.org/W4380370702","https://openalex.org/W4381620518","https://openalex.org/W4385875457","https://openalex.org/W4386409496","https://openalex.org/W4388600976","https://openalex.org/W4390501919","https://openalex.org/W4392563166","https://openalex.org/W4401482540","https://openalex.org/W6701498964"],"related_works":["https://openalex.org/W2921954416","https://openalex.org/W4399359339","https://openalex.org/W7168333079","https://openalex.org/W2573827282","https://openalex.org/W4405650800","https://openalex.org/W7100666749","https://openalex.org/W3093699735","https://openalex.org/W4290803480","https://openalex.org/W4248553304","https://openalex.org/W1881579618"],"abstract_inverted_index":{"Pharmaceutical":[0],"products":[1,224],"have":[2,29,234],"contributed":[3],"to":[4,42,51,102,164,169,188,238],"improving":[5],"the":[6,43,67,74,77,86,90,93,96,100,111,120,136,158,175,181,189,194,203,206,214,217],"expectancy":[7],"and":[8,16,38,45,54,69,109,124,144,208,232],"quality":[9],"of":[10,12,14,79,89,114,122,139,149,191,205,226],"life":[11],"millions":[13],"patients":[15],"their":[17],"role":[18,245],"in":[19,32,129,213,246],"our":[20],"society":[21],"is":[22,49,63,72,209],"undisputed.":[23],"However,":[24],"many":[25],"active":[26],"pharmaceutical":[27],"ingredients":[28],"been":[30,118,235],"found":[31,168],"rivers,":[33],"lakes,":[34],"seas,":[35],"drinking":[36],"water":[37],"can":[39],"cause":[40],"damage":[41],"environment":[44,68],"ecosystems.":[46,70],"Environmental":[47],"contamination":[48],"known":[50],"affect":[52],"biodiversity":[53,104],"health.":[55],"From":[56],"a":[57,140,145],"\"One":[58],"Health\"":[59],"perspective,":[60],"human":[61],"health":[62],"safeguarded":[64],"by":[65,105],"preserving":[66],"Italy":[71],"at":[73,202],"forefront":[75],"on":[76,135,142,183],"issue":[78],"protecting":[80],"biodiversity,":[81],"having":[82],"included":[83],"it":[84,116,185],"among":[85],"fundamental":[87],"principles":[88],"Constitution.":[91],"At":[92],"same":[94],"time":[95],"European":[97],"Commission":[98],"launched":[99],"strategy":[101],"protect":[103],"2030.":[106],"To":[107],"map":[108],"limit":[110],"environmental":[112],"effect":[113],"drugs,":[115],"has":[117],"proposed":[119],"topic":[121],"ecopharmacovigilance":[123],"eco-directed":[125],"sustainable":[126],"prescribing.":[127],"It's":[128],"this":[130,133],"context":[131],"that":[132,198],"work":[134],"ready":[137],"biodegradability":[138],"drug-based":[141,182],"loperamide":[143,184,199],"medical":[146],"device":[147],"made":[148,225],"complex":[150,228],"natural":[151,227],"matrix,":[152],"Lenodiar-Pediatric\u00ae,":[153],"was":[154,186,200],"carried":[155],"out":[156],"for":[157,180],"first":[159],"time.":[160],"The":[161],"products,":[162],"indicated":[163],"treat":[165],"diarrhoea,":[166],"were":[167],"be":[170],"readily":[171],"biodegradable.":[172],"For":[173],"Lenodiar-Pediatric\u00ae":[174],"biodegradation":[176],"isn't":[177],"surprising,":[178],"while":[179],"due":[187],"degradation":[190],"excipients.":[192],"Indeed,":[193],"UHPLC-qToF":[195],"investigation":[196],"highlighted":[197],"present":[201],"end":[204],"test":[207],"therefore":[210],"potentially":[211],"persistent":[212],"environment,":[215],"confirming":[216],"most":[218],"relevant":[219],"literature.":[220],"In":[221],"conclusion,":[222],"therapeutic":[223],"matrix":[229],"which":[230],"efficacy":[231],"safety":[233],"proven":[236],"according":[237],"Evidence-Based":[239],"Standards":[240],"may":[241],"play":[242],"an":[243],"important":[244],"safeguarding":[247],"biodiversity.":[248]},"counts_by_year":[{"year":2025,"cited_by_count":3}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2024-08-15T00:00:00"}