{"id":"https://openalex.org/W4401523491","doi":"https://doi.org/10.4103/ijdt.ijdt_24_24","title":"Vildagliptin Sustained-release and Dapagliflozin Fixed-dose Combination in the Management of Type 2 Diabetes Mellitus: A Comprehensive Review","display_name":"Vildagliptin Sustained-release and Dapagliflozin Fixed-dose Combination in the Management of Type 2 Diabetes Mellitus: A Comprehensive Review","publication_year":2024,"publication_date":"2024-04-01","ids":{"openalex":"https://openalex.org/W4401523491","doi":"https://doi.org/10.4103/ijdt.ijdt_24_24"},"language":"en","primary_location":{"id":"doi:10.4103/ijdt.ijdt_24_24","doi":"https://doi.org/10.4103/ijdt.ijdt_24_24","is_oa":true,"landing_page_url":"https://doi.org/10.4103/ijdt.ijdt_24_24","pdf_url":null,"source":{"id":"https://openalex.org/S4387287924","display_name":"International Journal of Diabetes and Technology","issn_l":"2949-8457","issn":["2949-8457"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj"],"host_organization":"https://openalex.org/P4310320448","host_organization_name":"Medknow","host_organization_lineage":["https://openalex.org/P4310320448","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Medknow","Wolters Kluwer"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Diabetes and Technology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://doi.org/10.4103/ijdt.ijdt_24_24","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5028083563","display_name":"Subhajyoti Ghosh","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Subhajyoti Ghosh","raw_affiliation_strings":["Apollo Clinic, Dibrugarh, Assam, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Apollo Clinic, Dibrugarh, Assam, India","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Mainak Mukhopadhyay","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I46827455","display_name":"AMRI Hospitals","ror":"https://ror.org/006p8df44","country_code":"IN","type":"healthcare","lineage":["https://openalex.org/I46827455"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Mainak Mukhopadhyay","raw_affiliation_strings":["Department of Diabetology, AMRI Hospital, Kolkata, West Bengal, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Diabetology, AMRI Hospital, Kolkata, West Bengal, India","institution_ids":["https://openalex.org/I46827455"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102074007","display_name":"Mayur Bhikulal Agrawal","orcid":"https://orcid.org/0000-0002-7172-3690","observed_orcids":["https://orcid.org/0000-0002-7172-3690"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mayur Agrawal","raw_affiliation_strings":["Hormone India Diabetes and Endocrine Centre, Bhopal, Madhya Pradesh, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hormone India Diabetes and Endocrine Centre, Bhopal, Madhya Pradesh, India","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Mohammad Shahid","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mohammad Shahid","raw_affiliation_strings":["Department of Cardiology, Moti Lal Nehru Medical College, Prayagraj, Uttar Pradesh, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Moti Lal Nehru Medical College, Prayagraj, Uttar Pradesh, India","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082489082","display_name":"Mahak Lamba","orcid":"https://orcid.org/0009-0008-9403-9331","observed_orcids":["https://orcid.org/0009-0008-9403-9331"]},"institutions":[{"id":"https://openalex.org/I280994","display_name":"King George's Medical University","ror":"https://ror.org/00gvw6327","country_code":"IN","type":"education","lineage":["https://openalex.org/I280994"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Mahak Lamba","raw_affiliation_strings":["Department of Medicine, King George Medical College, Lucknow, Uttar Pradesh, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, King George Medical College, Lucknow, Uttar Pradesh, India","institution_ids":["https://openalex.org/I280994"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110335661","display_name":"Sudeep Jain","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sudeep Jain","raw_affiliation_strings":["Dr. Sudeep Jain Counsultant Clinic, Chattarpur, Madhya Pradesh, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dr. Sudeep Jain Counsultant Clinic, Chattarpur, Madhya Pradesh, India","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Ashish Prasad","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210119848","display_name":"USV (India)","ror":"https://ror.org/02kq47078","country_code":"IN","type":"company","lineage":["https://openalex.org/I4210119848"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Ashish Prasad","raw_affiliation_strings":["USV Private Limited, Arvind Vithal Gandhi Chowk, BSD Marg, Station Road, Govandi East, Mumbai, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"USV Private Limited, Arvind Vithal Gandhi Chowk, BSD Marg, Station Road, Govandi East, Mumbai, India","institution_ids":["https://openalex.org/I4210119848"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Amit Gupta","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210119848","display_name":"USV (India)","ror":"https://ror.org/02kq47078","country_code":"IN","type":"company","lineage":["https://openalex.org/I4210119848"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Amit Gupta","raw_affiliation_strings":["USV Private Limited, Arvind Vithal Gandhi Chowk, BSD Marg, Station Road, Govandi East, Mumbai, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"USV Private Limited, Arvind Vithal Gandhi Chowk, BSD Marg, Station Road, Govandi East, Mumbai, India","institution_ids":["https://openalex.org/I4210119848"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036810923","display_name":"Rohan Narayan Kesarkar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210119848","display_name":"USV (India)","ror":"https://ror.org/02kq47078","country_code":"IN","type":"company","lineage":["https://openalex.org/I4210119848"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Rohan Kesarkar","raw_affiliation_strings":["USV Private Limited, Arvind Vithal Gandhi Chowk, BSD Marg, Station Road, Govandi East, Mumbai, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"USV Private Limited, Arvind Vithal Gandhi Chowk, BSD Marg, Station Road, Govandi East, Mumbai, India","institution_ids":["https://openalex.org/I4210119848"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078545136","display_name":"Sona B. Warrier","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210119848","display_name":"USV (India)","ror":"https://ror.org/02kq47078","country_code":"IN","type":"company","lineage":["https://openalex.org/I4210119848"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Sona Warrier","raw_affiliation_strings":["USV Private Limited, Arvind Vithal Gandhi Chowk, BSD Marg, Station Road, Govandi East, Mumbai, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"USV Private Limited, Arvind Vithal Gandhi Chowk, BSD Marg, Station Road, Govandi East, Mumbai, India","institution_ids":["https://openalex.org/I4210119848"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113331270","display_name":"Abhijeet Pednekar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210119848","display_name":"USV (India)","ror":"https://ror.org/02kq47078","country_code":"IN","type":"company","lineage":["https://openalex.org/I4210119848"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Abhijeet Pednekar","raw_affiliation_strings":["USV Private Limited, Arvind Vithal Gandhi Chowk, BSD Marg, Station Road, Govandi East, Mumbai, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"USV Private Limited, Arvind Vithal Gandhi Chowk, BSD Marg, Station Road, Govandi East, Mumbai, India","institution_ids":["https://openalex.org/I4210119848"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5078545136"],"corresponding_institution_ids":["https://openalex.org/I4210119848"],"apc_list":null,"apc_paid":null,"fwci":0.6597,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.72387199,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":96},"biblio":{"volume":"3","issue":"2","first_page":"49","last_page":"54"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10560","display_name":"Diabetes Management and Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12539","display_name":"Pharmacology and Obesity Treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.9679999947547913},{"id":"https://openalex.org/keywords/dapagliflozin","display_name":"dapagliflozin","score":1.0},{"id":"https://openalex.org/keywords/fixed-dose-combination","display_name":"fixed-dose combination","score":0.9919999837875366},{"id":"https://openalex.org/keywords/dpp-4-inhibitors","display_name":"DPP-4 inhibitors","score":0.9470000267028809},{"id":"https://openalex.org/keywords/sglt2-inhibitors","display_name":"SGLT2 inhibitors","score":0.8830000162124634},{"id":"https://openalex.org/keywords/glycemic-control","display_name":"glycemic control","score":0.9200000166893005},{"id":"https://openalex.org/keywords/hypoglycemia-risk","display_name":"hypoglycemia risk","score":0.843999981880188},{"id":"https://openalex.org/keywords/weight-loss","display_name":"weight loss","score":0.7059999704360962},{"id":"https://openalex.org/keywords/pill-burden","display_name":"medication burden","score":0.9089999794960022},{"id":"https://openalex.org/keywords/indian-patients","display_name":"Indian patients","score":0.5759999752044678},{"id":"https://openalex.org/keywords/treatment-adherence","display_name":"medication adherence","score":0.3479999899864197}],"concepts":[{"id":"https://openalex.org/C2777422806","wikidata":"https://www.wikidata.org/wiki/Q409898","display_name":"Dapagliflozin","level":4,"score":0.9890542030334473},{"id":"https://openalex.org/C2776453732","wikidata":"https://www.wikidata.org/wiki/Q421042","display_name":"Vildagliptin","level":4,"score":0.9722120761871338},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.775368332862854},{"id":"https://openalex.org/C2910068830","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 Diabetes Mellitus","level":3,"score":0.5943666696548462},{"id":"https://openalex.org/C2780668416","wikidata":"https://www.wikidata.org/wiki/Q202758","display_name":"Hypoglycemia","level":3,"score":0.5233494639396667},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.4860706627368927},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4759873151779175},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.4239833950996399},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.3390413820743561},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3285660743713379},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3083968758583069}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.4103/ijdt.ijdt_24_24","doi":"https://doi.org/10.4103/ijdt.ijdt_24_24","is_oa":true,"landing_page_url":"https://doi.org/10.4103/ijdt.ijdt_24_24","pdf_url":null,"source":{"id":"https://openalex.org/S4387287924","display_name":"International Journal of Diabetes and Technology","issn_l":"2949-8457","issn":["2949-8457"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj"],"host_organization":"https://openalex.org/P4310320448","host_organization_name":"Medknow","host_organization_lineage":["https://openalex.org/P4310320448","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Medknow","Wolters Kluwer"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Diabetes and Technology","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:4a2beb0bbdf2452a87763c1bcf94411b","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/4a2beb0bbdf2452a87763c1bcf94411b","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"International Journal of Diabetes and Technology, Vol 3, Iss 2, Pp 49-54 (2024)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.4103/ijdt.ijdt_24_24","doi":"https://doi.org/10.4103/ijdt.ijdt_24_24","is_oa":true,"landing_page_url":"https://doi.org/10.4103/ijdt.ijdt_24_24","pdf_url":null,"source":{"id":"https://openalex.org/S4387287924","display_name":"International Journal of Diabetes and Technology","issn_l":"2949-8457","issn":["2949-8457"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj"],"host_organization":"https://openalex.org/P4310320448","host_organization_name":"Medknow","host_organization_lineage":["https://openalex.org/P4310320448","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Medknow","Wolters Kluwer"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Diabetes and Technology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":43,"referenced_works":["https://openalex.org/W1846464686","https://openalex.org/W1998401806","https://openalex.org/W2020364588","https://openalex.org/W2033493723","https://openalex.org/W2050003893","https://openalex.org/W2050350823","https://openalex.org/W2076985396","https://openalex.org/W2101865653","https://openalex.org/W2116254891","https://openalex.org/W2123862315","https://openalex.org/W2124020657","https://openalex.org/W2143916766","https://openalex.org/W2148328779","https://openalex.org/W2154277743","https://openalex.org/W2167245776","https://openalex.org/W2489697890","https://openalex.org/W2600487630","https://openalex.org/W2604040271","https://openalex.org/W2731496504","https://openalex.org/W2737015170","https://openalex.org/W2753932519","https://openalex.org/W2755476177","https://openalex.org/W2806181300","https://openalex.org/W2900413769","https://openalex.org/W2910179486","https://openalex.org/W2955781565","https://openalex.org/W2974260792","https://openalex.org/W2983229458","https://openalex.org/W2983437395","https://openalex.org/W3014409190","https://openalex.org/W3014927250","https://openalex.org/W3016841284","https://openalex.org/W3042485772","https://openalex.org/W3088173406","https://openalex.org/W3089094100","https://openalex.org/W3179748924","https://openalex.org/W3202330513","https://openalex.org/W4220863195","https://openalex.org/W4311406873","https://openalex.org/W4311408914","https://openalex.org/W4324100267","https://openalex.org/W4377098108","https://openalex.org/W6852287725"],"related_works":["https://openalex.org/W4411023343","https://openalex.org/W4398218295","https://openalex.org/W4399261221","https://openalex.org/W4412872421","https://openalex.org/W4396781974","https://openalex.org/W2984807943","https://openalex.org/W6893955277","https://openalex.org/W1929011608","https://openalex.org/W4400149505","https://openalex.org/W7117659132"],"abstract_inverted_index":{"Type":[0],"2":[1,44],"diabetes":[2],"mellitus":[3],"(T2DM)":[4],"is":[5,54],"a":[6,16,28,40,55,120,130],"complex":[7],"disease":[8,79],"with":[9,61,88],"multiple":[10],"pathophysiological":[11],"defects":[12],"and":[13,39,74,82,102,107,110,158,166,177,190],"generally":[14,85],"requires":[15],"combination":[17,30,138],"of":[18,32,67,133,151,187],"antidiabetic":[19],"agents":[20],"to":[21,48],"achieve":[22],"glycemic":[23],"targets.":[24],"In":[25],"this":[26,137],"context,":[27],"fixed-dose":[29],"(FDC)":[31],"dipeptidyl":[33],"peptidase-4":[34],"inhibitors":[35,45],"vildagliptin":[36,60,152,164,188],"sustained-release":[37],"(SR)":[38],"sodium-glucose":[41],"cotransporter":[42],"type":[43],"dapagliflozin":[46,83,167,191],"appear":[47],"be":[49,140],"an":[50,115,141],"attractive":[51],"approach.":[52],"There":[53],"strong":[56],"rationale":[57],"for":[58,118,156,182],"combining":[59],"dapagliflozin.":[62],"They":[63],"have":[64,129],"complementary":[65],"mechanisms":[66],"action":[68],"that":[69],"address":[70],"several":[71],"pathological":[72],"pathways":[73],"are":[75,84,169],"effective":[76],"at":[77],"all":[78],"stages.":[80],"Vildagliptin":[81],"well":[86],"tolerated,":[87],"low":[89],"hypoglycemia":[90],"risk.":[91],"Moreover,":[92],"they":[93],"exert":[94],"beneficial":[95],"pleiotropic":[96],"actions":[97],"on":[98,162],"the":[99,145,154,163,174,183],"cardiovascular":[100],"system":[101],"kidneys,":[103],"lower":[104],"body":[105],"weight,":[106],"blood":[108],"pressure":[109],"reduce":[111],"pill":[112],"burden,":[113],"providing":[114],"important":[116],"option":[117],"managing":[119],"broad":[121],"patient":[122],"population.":[123],"For":[124],"Indian":[125],"T2DM":[126,194],"patients,":[127],"who":[128],"high":[131],"prevalence":[132],"cardiometabolic":[134],"risk":[135],"factors,":[136],"would":[139],"appropriate":[142],"choice.":[143],"Furthermore,":[144],"once-daily":[146],"100":[147],"mg":[148],"SR":[149,165,189],"dosage":[150],"meets":[153],"requirements":[155],"compliance":[157],"adherence.":[159],"However,":[160],"data":[161],"FDC":[168],"limited.":[170],"This":[171],"review":[172],"summarizes":[173],"available":[175],"evidence":[176],"provides":[178],"rational,":[179],"practical":[180],"guidance":[181],"optimal":[184],"clinical":[185],"use":[186],"FDCs":[192],"in":[193],"patients.":[195]},"counts_by_year":[{"year":2025,"cited_by_count":2}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2024-08-13T00:00:00"}
