{"id":"https://openalex.org/W4401519611","doi":"https://doi.org/10.1007/s13402-024-00975-1","title":"Tertiary lymphoid structures and their therapeutic implications in cancer","display_name":"Tertiary lymphoid structures and their therapeutic implications in cancer","publication_year":2024,"publication_date":"2024-08-12","ids":{"openalex":"https://openalex.org/W4401519611","doi":"https://doi.org/10.1007/s13402-024-00975-1","pmid":"https://pubmed.ncbi.nlm.nih.gov/39133439","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/12974082"},"language":"en","primary_location":{"id":"doi:10.1007/s13402-024-00975-1","doi":"https://doi.org/10.1007/s13402-024-00975-1","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s13402-024-00975-1","pdf_url":null,"source":{"id":"https://openalex.org/S4210230201","display_name":"Cellular Oncology","issn_l":"1570-5870","issn":["1570-5870","1875-8606","2211-3428","2211-3436"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cellular Oncology","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1007/s13402-024-00975-1","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100451602","display_name":"Xun Chen","orcid":"https://orcid.org/0000-0002-4922-8116","observed_orcids":["https://orcid.org/0000-0002-4922-8116"]},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]},{"id":"https://openalex.org/I4210115624","display_name":"Hunan Cancer Hospital","ror":"https://ror.org/025020z88","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210115624"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xun Chen","raw_affiliation_strings":["Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute, Central South University, Changsha, Hunan, China","NHC Key Laboratory of Carcinogenesis and Hunan Key Laboratory of Cancer Metabolism, Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute, Central South University, Changsha, Hunan, China","institution_ids":["https://openalex.org/I139660479"]},{"raw_affiliation_string":"NHC Key Laboratory of Carcinogenesis and Hunan Key Laboratory of Cancer Metabolism, Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, China","institution_ids":["https://openalex.org/I139660479","https://openalex.org/I4210115624"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101473039","display_name":"Pan Wu","orcid":"https://orcid.org/0000-0003-3250-6770","observed_orcids":["https://orcid.org/0000-0003-3250-6770"]},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]},{"id":"https://openalex.org/I4210115624","display_name":"Hunan Cancer Hospital","ror":"https://ror.org/025020z88","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210115624"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Pan Wu","raw_affiliation_strings":["Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute, Central South University, Changsha, Hunan, China","NHC Key Laboratory of Carcinogenesis and Hunan Key Laboratory of Cancer Metabolism, Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute, Central South University, Changsha, Hunan, China","institution_ids":["https://openalex.org/I139660479"]},{"raw_affiliation_string":"NHC Key Laboratory of Carcinogenesis and Hunan Key Laboratory of Cancer Metabolism, Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, China","institution_ids":["https://openalex.org/I139660479","https://openalex.org/I4210115624"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100636820","display_name":"Ziqi Liu","orcid":"https://orcid.org/0000-0002-7201-3973","observed_orcids":["https://orcid.org/0000-0002-7201-3973","https://orcid.org/0000-0002-6546-0417"]},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]},{"id":"https://openalex.org/I4210115624","display_name":"Hunan Cancer Hospital","ror":"https://ror.org/025020z88","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210115624"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ziqi Liu","raw_affiliation_strings":["Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute, Central South University, Changsha, Hunan, China","NHC Key Laboratory of Carcinogenesis and Hunan Key Laboratory of Cancer Metabolism, Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute, Central South University, Changsha, Hunan, China","institution_ids":["https://openalex.org/I139660479"]},{"raw_affiliation_string":"NHC Key Laboratory of Carcinogenesis and Hunan Key Laboratory of Cancer Metabolism, Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, China","institution_ids":["https://openalex.org/I139660479","https://openalex.org/I4210115624"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027510597","display_name":"Tiansheng Li","orcid":"https://orcid.org/0000-0001-7972-7031","observed_orcids":["https://orcid.org/0000-0001-7972-7031"]},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]},{"id":"https://openalex.org/I4210115624","display_name":"Hunan Cancer Hospital","ror":"https://ror.org/025020z88","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210115624"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Tiansheng Li","raw_affiliation_strings":["Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute, Central South University, Changsha, Hunan, China","NHC Key Laboratory of Carcinogenesis and Hunan Key Laboratory of Cancer Metabolism, Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute, Central South University, Changsha, Hunan, China","institution_ids":["https://openalex.org/I139660479"]},{"raw_affiliation_string":"NHC Key Laboratory of Carcinogenesis and Hunan Key Laboratory of Cancer Metabolism, Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, China","institution_ids":["https://openalex.org/I139660479","https://openalex.org/I4210115624"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101721704","display_name":"Jie Wu","orcid":"https://orcid.org/0000-0003-2181-8971","observed_orcids":["https://orcid.org/0000-0003-2181-8971","https://orcid.org/0000-0001-5744-8840"]},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]},{"id":"https://openalex.org/I154093214","display_name":"Xinjiang Medical University","ror":"https://ror.org/01p455v08","country_code":"CN","type":"education","lineage":["https://openalex.org/I154093214"]},{"id":"https://openalex.org/I4210102015","display_name":"Tumor Hospital of Xinjiang Medical University","ror":"https://ror.org/015tqbb95","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210102015"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jie Wu","raw_affiliation_strings":["Departments of Cancer Research Institute, Affiliated Cancer Hospital of Xinjiang Medical University, Urumqi, China","Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute, Central South University, Changsha, Hunan, China","Xinjiang Key Laboratory of Translational Biomedical Engineering, Urumqi, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Cancer Research Institute, Affiliated Cancer Hospital of Xinjiang Medical University, Urumqi, China","institution_ids":["https://openalex.org/I154093214","https://openalex.org/I4210102015"]},{"raw_affiliation_string":"Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute, Central South University, Changsha, Hunan, China","institution_ids":["https://openalex.org/I139660479"]},{"raw_affiliation_string":"Xinjiang Key Laboratory of Translational Biomedical Engineering, Urumqi, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Zhaoyang Zeng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]},{"id":"https://openalex.org/I4210115624","display_name":"Hunan Cancer Hospital","ror":"https://ror.org/025020z88","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210115624"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhaoyang Zeng","raw_affiliation_strings":["Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute, Central South University, Changsha, Hunan, China","NHC Key Laboratory of Carcinogenesis and Hunan Key Laboratory of Cancer Metabolism, Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute, Central South University, Changsha, Hunan, China","institution_ids":["https://openalex.org/I139660479"]},{"raw_affiliation_string":"NHC Key Laboratory of Carcinogenesis and Hunan Key Laboratory of Cancer Metabolism, Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, China","institution_ids":["https://openalex.org/I139660479","https://openalex.org/I4210115624"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011160323","display_name":"Wenjia Guo","orcid":"https://orcid.org/0000-0002-4255-3135","observed_orcids":["https://orcid.org/0000-0002-4255-3135"]},"institutions":[{"id":"https://openalex.org/I154093214","display_name":"Xinjiang Medical University","ror":"https://ror.org/01p455v08","country_code":"CN","type":"education","lineage":["https://openalex.org/I154093214"]},{"id":"https://openalex.org/I4210102015","display_name":"Tumor Hospital of Xinjiang Medical University","ror":"https://ror.org/015tqbb95","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210102015"]},{"id":"https://openalex.org/I96908189","display_name":"Xinjiang University","ror":"https://ror.org/059gw8r13","country_code":"CN","type":"education","lineage":["https://openalex.org/I96908189"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Wenjia Guo","raw_affiliation_strings":["Departments of Cancer Research Institute, Affiliated Cancer Hospital of Xinjiang Medical University, Urumqi, China. wenjiaguo@xjmu.edu.cn","Xinjiang Key Laboratory of Translational Biomedical Engineering, Urumqi, China. wenjiaguo@xjmu.edu.cn","Departments of Cancer Research Institute, Affiliated Cancer Hospital of Xinjiang Medical University, Urumqi, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Cancer Research Institute, Affiliated Cancer Hospital of Xinjiang Medical University, Urumqi, China. wenjiaguo@xjmu.edu.cn","institution_ids":["https://openalex.org/I154093214","https://openalex.org/I4210102015"]},{"raw_affiliation_string":"Xinjiang Key Laboratory of Translational Biomedical Engineering, Urumqi, China. wenjiaguo@xjmu.edu.cn","institution_ids":["https://openalex.org/I96908189"]},{"raw_affiliation_string":"Departments of Cancer Research Institute, Affiliated Cancer Hospital of Xinjiang Medical University, Urumqi, China","institution_ids":["https://openalex.org/I154093214","https://openalex.org/I4210102015"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109736598","display_name":"Wei Xiong","orcid":"https://orcid.org/0009-0003-9673-522X","observed_orcids":["https://orcid.org/0009-0003-9673-522X","https://orcid.org/0000-0003-1635-8173"]},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]},{"id":"https://openalex.org/I4210115624","display_name":"Hunan Cancer Hospital","ror":"https://ror.org/025020z88","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210115624"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Wei Xiong","raw_affiliation_strings":["Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute, Central South University, Changsha, Hunan, China. xiongwei@csu.edu.cn","NHC Key Laboratory of Carcinogenesis and Hunan Key Laboratory of Cancer Metabolism, Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, China. xiongwei@csu.edu.cn","NHC Key Laboratory of Carcinogenesis and Hunan Key Laboratory of Cancer Metabolism, Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute, Central South University, Changsha, Hunan, China. xiongwei@csu.edu.cn","institution_ids":["https://openalex.org/I139660479"]},{"raw_affiliation_string":"NHC Key Laboratory of Carcinogenesis and Hunan Key Laboratory of Cancer Metabolism, Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, China. xiongwei@csu.edu.cn","institution_ids":["https://openalex.org/I139660479","https://openalex.org/I4210115624"]},{"raw_affiliation_string":"NHC Key Laboratory of Carcinogenesis and Hunan Key Laboratory of Cancer Metabolism, Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, China","institution_ids":["https://openalex.org/I139660479","https://openalex.org/I4210115624"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5011160323","https://openalex.org/A5109736598"],"corresponding_institution_ids":["https://openalex.org/I139660479","https://openalex.org/I154093214","https://openalex.org/I4210102015","https://openalex.org/I4210115624","https://openalex.org/I96908189"],"apc_list":{"value":4390,"currency":"USD","value_usd":4390},"apc_paid":{"value":4390,"currency":"USD","value_usd":4390},"fwci":0.5861,"has_fulltext":false,"cited_by_count":11,"citation_normalized_percentile":{"value":0.55781609,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"47","issue":"5","first_page":"1579","last_page":"1592"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.9818999767303467,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.9818999767303467,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.007600000128149986,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11313","display_name":"Immune cells in cancer","score":0.002400000113993883,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tertiary-lymphoid-structures","display_name":"tertiary lymphoid structures","score":1.0},{"id":"https://openalex.org/keywords/antitumor-immunity","display_name":"antitumor immunity","score":0.8040000200271606},{"id":"https://openalex.org/keywords/immune-infiltration","display_name":"immune cell infiltration","score":0.8090000152587891},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.8059999942779541},{"id":"https://openalex.org/keywords/immunotherapy","display_name":"immunotherapy","score":0.8510000109672546},{"id":"https://openalex.org/keywords/cancer-immunotherapy","display_name":"cancer immunotherapy","score":0.6579999923706055},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.5360000133514404},{"id":"https://openalex.org/keywords/b-cells","display_name":"B cells","score":0.7149999737739563},{"id":"https://openalex.org/keywords/t-cells","display_name":"T cells","score":0.9959999918937683}],"concepts":[{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.7602296471595764},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.6234372854232788},{"id":"https://openalex.org/C181152851","wikidata":"https://www.wikidata.org/wiki/Q712604","display_name":"Lymphatic system","level":2,"score":0.5573077201843262},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.5402234792709351},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5338128209114075},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5204434990882874},{"id":"https://openalex.org/C153400128","wikidata":"https://www.wikidata.org/wiki/Q3150731","display_name":"Infiltration (HVAC)","level":2,"score":0.4851697087287903},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.46884217858314514},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4347783625125885},{"id":"https://openalex.org/C2780674031","wikidata":"https://www.wikidata.org/wiki/Q2012719","display_name":"Cancer immunotherapy","level":4,"score":0.4272342920303345},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.38545462489128113},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3657975196838379},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.08687901496887207},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C97355855","wikidata":"https://www.wikidata.org/wiki/Q11473","display_name":"Thermodynamics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000072717","descriptor_name":"Tertiary Lymphoid Structures","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D000072717","descriptor_name":"Tertiary Lymphoid Structures","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007167","descriptor_name":"Immunotherapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D059016","descriptor_name":"Tumor Microenvironment","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1007/s13402-024-00975-1","doi":"https://doi.org/10.1007/s13402-024-00975-1","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s13402-024-00975-1","pdf_url":null,"source":{"id":"https://openalex.org/S4210230201","display_name":"Cellular Oncology","issn_l":"1570-5870","issn":["1570-5870","1875-8606","2211-3428","2211-3436"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cellular Oncology","raw_type":"journal-article"},{"id":"pmid:39133439","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39133439","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cellular oncology (Dordrecht, Netherlands)","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:12974082","doi":null,"is_oa":true,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39133439/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Oncol (Dordr)","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1007/s13402-024-00975-1","doi":"https://doi.org/10.1007/s13402-024-00975-1","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s13402-024-00975-1","pdf_url":null,"source":{"id":"https://openalex.org/S4210230201","display_name":"Cellular Oncology","issn_l":"1570-5870","issn":["1570-5870","1875-8606","2211-3428","2211-3436"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cellular Oncology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[{"id":"https://openalex.org/G444469553","display_name":null,"funder_award_id":"2022JJ30063","funder_id":"https://openalex.org/F4320322843","funder_display_name":"Natural Science Foundation of\u00a0Hunan Province"}],"funders":[{"id":"https://openalex.org/F4320322843","display_name":"Natural Science Foundation of\u00a0Hunan Province","ror":null}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":108,"referenced_works":["https://openalex.org/W1906698094","https://openalex.org/W1908442436","https://openalex.org/W1992988295","https://openalex.org/W2001634461","https://openalex.org/W2033511257","https://openalex.org/W2050571399","https://openalex.org/W2050603521","https://openalex.org/W2064273388","https://openalex.org/W2072715223","https://openalex.org/W2084338775","https://openalex.org/W2084598886","https://openalex.org/W2097995306","https://openalex.org/W2098578630","https://openalex.org/W2116576993","https://openalex.org/W2129702476","https://openalex.org/W2149668671","https://openalex.org/W2154999756","https://openalex.org/W2162449424","https://openalex.org/W2185780593","https://openalex.org/W2255455167","https://openalex.org/W2303799488","https://openalex.org/W2318250120","https://openalex.org/W2339442385","https://openalex.org/W2466343307","https://openalex.org/W2516767722","https://openalex.org/W2563046079","https://openalex.org/W2597573969","https://openalex.org/W2608885960","https://openalex.org/W2626585215","https://openalex.org/W2734928468","https://openalex.org/W2737082469","https://openalex.org/W2754092421","https://openalex.org/W2767198233","https://openalex.org/W2776272710","https://openalex.org/W2779312016","https://openalex.org/W2790255072","https://openalex.org/W2884102404","https://openalex.org/W2892334779","https://openalex.org/W2907564726","https://openalex.org/W2916141528","https://openalex.org/W2925736610","https://openalex.org/W2945057866","https://openalex.org/W2949851288","https://openalex.org/W2952904472","https://openalex.org/W2973659942","https://openalex.org/W2979575610","https://openalex.org/W2980866617","https://openalex.org/W2982132703","https://openalex.org/W3000282923","https://openalex.org/W3000311037","https://openalex.org/W3013536581","https://openalex.org/W3019967466","https://openalex.org/W3087687807","https://openalex.org/W3092138236","https://openalex.org/W3093216105","https://openalex.org/W3096715224","https://openalex.org/W3120538773","https://openalex.org/W3132042942","https://openalex.org/W3135973786","https://openalex.org/W3139219537","https://openalex.org/W3143562363","https://openalex.org/W3165251172","https://openalex.org/W3165303778","https://openalex.org/W3167727425","https://openalex.org/W3171465065","https://openalex.org/W3175540779","https://openalex.org/W3179999554","https://openalex.org/W3180646962","https://openalex.org/W3184050310","https://openalex.org/W3187890850","https://openalex.org/W3191177172","https://openalex.org/W3198613918","https://openalex.org/W3200003072","https://openalex.org/W3202268960","https://openalex.org/W3204530095","https://openalex.org/W3205213119","https://openalex.org/W3211204931","https://openalex.org/W3214330513","https://openalex.org/W3215544807","https://openalex.org/W4200371667","https://openalex.org/W4200418659","https://openalex.org/W4205511851","https://openalex.org/W4205878253","https://openalex.org/W4206799282","https://openalex.org/W4210277252","https://openalex.org/W4210285054","https://openalex.org/W4210484995","https://openalex.org/W4211220691","https://openalex.org/W4214620261","https://openalex.org/W4221125550","https://openalex.org/W4221135307","https://openalex.org/W4226106494","https://openalex.org/W4280605221","https://openalex.org/W4281490788","https://openalex.org/W4281563307","https://openalex.org/W4282913082","https://openalex.org/W4285386732","https://openalex.org/W4295993478","https://openalex.org/W4296047815","https://openalex.org/W4300690056","https://openalex.org/W4303501039","https://openalex.org/W4306167880","https://openalex.org/W4306393517","https://openalex.org/W4365482895","https://openalex.org/W4393040331","https://openalex.org/W4400002746","https://openalex.org/W4403042967","https://openalex.org/W6802231411"],"related_works":["https://openalex.org/W4315497997","https://openalex.org/W6959600383","https://openalex.org/W4410608472","https://openalex.org/W4414343156","https://openalex.org/W4385707981","https://openalex.org/W4406235475","https://openalex.org/W7214226467","https://openalex.org/W4401197203","https://openalex.org/W4400335601","https://openalex.org/W4205511851"],"abstract_inverted_index":{"Tertiary":[0],"lymphoid":[1,6],"structures":[2],"(TLSs)":[3],"are":[4,70,106],"ectopic":[5],"aggregates":[7],"formed":[8],"by":[9,27,64],"the":[10,38,120],"structured":[11],"accumulation":[12],"of":[13,83,123],"immune":[14,39,52,66],"cells":[15,19,22],"such":[16],"as":[17,80,94],"B":[18],"and":[20,30,69,125],"T":[21],"in":[23,37,42,75,129],"non-lymphoid":[24],"tissues":[25],"induced":[26],"infection,":[28],"inflammation,":[29],"tumors.":[31],"They":[32],"play":[33],"a":[34,95],"crucial":[35],"role":[36],"response,":[40],"particularly":[41],"association":[43],"with":[44,72],"tumor":[45,62],"development,":[46],"where":[47],"they":[48],"primarily":[49],"exert":[50],"anti-tumor":[51],"functions":[53],"during":[54],"tumorigenesis.":[55],"Current":[56],"research":[57],"suggests":[58],"that":[59],"TLSs":[60,90,104,124],"inhibit":[61],"growth":[63],"facilitating":[65],"cell":[67],"infiltration":[68],"correlated":[71],"favorable":[73],"prognosis":[74],"various":[76],"solid":[77],"tumors,":[78],"serving":[79],"an":[81],"indicator":[82],"immunotherapy":[84],"effectiveness":[85],"to":[86,102,108,112],"some":[87],"extent.":[88],"Therefore,":[89],"hold":[91],"great":[92],"promise":[93],"valuable":[96],"biomarker.":[97],"Most":[98],"importantly,":[99],"immunotherapies":[100],"aimed":[101],"prompting":[103],"formation":[105,121],"anticipated":[107],"be":[109],"potent":[110],"adjuncts":[111],"current":[113],"cancer":[114,130],"treatment.":[115],"This":[116],"review":[117],"focuses":[118],"on":[119],"process":[122],"their":[126],"potential":[127],"applications":[128],"therapy.":[131]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2024-08-13T00:00:00"}