{"id":"https://openalex.org/W4401503100","doi":"https://doi.org/10.1248/bpb.b24-00311","title":"FXR Antagonist FLG249 Lowers Hepatic Triacylglycerol and Serum Cholesterol Level in High-Fat Diet-Induced Obese Mice","display_name":"FXR Antagonist FLG249 Lowers Hepatic Triacylglycerol and Serum Cholesterol Level in High-Fat Diet-Induced Obese Mice","publication_year":2024,"publication_date":"2024-08-12","ids":{"openalex":"https://openalex.org/W4401503100","doi":"https://doi.org/10.1248/bpb.b24-00311","pmid":"https://pubmed.ncbi.nlm.nih.gov/39135238"},"language":"en","primary_location":{"id":"doi:10.1248/bpb.b24-00311","doi":"https://doi.org/10.1248/bpb.b24-00311","is_oa":true,"landing_page_url":"https://doi.org/10.1248/bpb.b24-00311","pdf_url":"https://www.jstage.jst.go.jp/article/bpb/47/8/47_b24-00311/_pdf","source":{"id":"https://openalex.org/S165235614","display_name":"Biological and Pharmaceutical Bulletin","issn_l":"0918-6158","issn":["0918-6158","1347-5215"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310313382","host_organization_name":"Pharmaceutical Society of Japan","host_organization_lineage":["https://openalex.org/P4310313382"],"host_organization_lineage_names":["Pharmaceutical Society of Japan"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biological and Pharmaceutical Bulletin","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://www.jstage.jst.go.jp/article/bpb/47/8/47_b24-00311/_pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103071114","display_name":"Yusuke Iguchi","orcid":"https://orcid.org/0009-0007-4910-095X","observed_orcids":["https://orcid.org/0009-0007-4910-095X"]},"institutions":[{"id":"https://openalex.org/I4210131401","display_name":"Hiroshima International University","ror":"https://ror.org/03dk6an77","country_code":"JP","type":"education","lineage":["https://openalex.org/I4210131401"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yusuke Iguchi","raw_affiliation_strings":["Faculty of Pharmaceutical Sciences, Hiroshima International University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Pharmaceutical Sciences, Hiroshima International University","institution_ids":["https://openalex.org/I4210131401"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Yukiko Yamashita","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210131401","display_name":"Hiroshima International University","ror":"https://ror.org/03dk6an77","country_code":"JP","type":"education","lineage":["https://openalex.org/I4210131401"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yukiko Yamashita","raw_affiliation_strings":["Faculty of Pharmaceutical Sciences, Hiroshima International University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Pharmaceutical Sciences, Hiroshima International University","institution_ids":["https://openalex.org/I4210131401"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009468301","display_name":"Keigo Gohda","orcid":"https://orcid.org/0000-0002-9345-2377","observed_orcids":["https://orcid.org/0000-0002-9345-2377"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Keigo Gohda","raw_affiliation_strings":["Computer-Aided Molecular Modeling Research Center, Kansai (CAMM-Kansai)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Computer-Aided Molecular Modeling Research Center, Kansai (CAMM-Kansai)","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014929401","display_name":"Keisuke Oda","orcid":"https://orcid.org/0000-0002-3230-4901","observed_orcids":["https://orcid.org/0000-0002-3230-4901"]},"institutions":[{"id":"https://openalex.org/I4210131401","display_name":"Hiroshima International University","ror":"https://ror.org/03dk6an77","country_code":"JP","type":"education","lineage":["https://openalex.org/I4210131401"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Keisuke Oda","raw_affiliation_strings":["Faculty of Pharmaceutical Sciences, Hiroshima International University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Pharmaceutical Sciences, Hiroshima International University","institution_ids":["https://openalex.org/I4210131401"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069381935","display_name":"Ko Fujimori","orcid":"https://orcid.org/0000-0002-2506-0769","observed_orcids":["https://orcid.org/0000-0002-2506-0769"]},"institutions":[{"id":"https://openalex.org/I205143321","display_name":"Osaka Medical and Pharmaceutical University","ror":"https://ror.org/01y2kdt21","country_code":"JP","type":"education","lineage":["https://openalex.org/I205143321"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Ko Fujimori","raw_affiliation_strings":["Department of Pathobiochemistry, Faculty of Pharmacy, Osaka Medical and Pharmaceutical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathobiochemistry, Faculty of Pharmacy, Osaka Medical and Pharmaceutical University","institution_ids":["https://openalex.org/I205143321"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055556928","display_name":"Yukihiro Sera","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210131401","display_name":"Hiroshima International University","ror":"https://ror.org/03dk6an77","country_code":"JP","type":"education","lineage":["https://openalex.org/I4210131401"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yukihiro Sera","raw_affiliation_strings":["Faculty of Pharmaceutical Sciences, Hiroshima International University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Pharmaceutical Sciences, Hiroshima International University","institution_ids":["https://openalex.org/I4210131401"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075259952","display_name":"Tsuneo Imanaka","orcid":"https://orcid.org/0000-0003-4677-1356","observed_orcids":["https://orcid.org/0000-0003-4677-1356"]},"institutions":[{"id":"https://openalex.org/I4210131401","display_name":"Hiroshima International University","ror":"https://ror.org/03dk6an77","country_code":"JP","type":"education","lineage":["https://openalex.org/I4210131401"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tsuneo Imanaka","raw_affiliation_strings":["Faculty of Pharmaceutical Sciences, Hiroshima International University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Pharmaceutical Sciences, Hiroshima International University","institution_ids":["https://openalex.org/I4210131401"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Masafumi Yamaguchi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210131401","display_name":"Hiroshima International University","ror":"https://ror.org/03dk6an77","country_code":"JP","type":"education","lineage":["https://openalex.org/I4210131401"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masafumi Yamaguchi","raw_affiliation_strings":["Faculty of Pharmaceutical Sciences, Hiroshima International University","Graduate School of Pharmaceutical Sciences, Hiroshima International University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Pharmaceutical Sciences, Hiroshima International University","institution_ids":["https://openalex.org/I4210131401"]},{"raw_affiliation_string":"Graduate School of Pharmaceutical Sciences, Hiroshima International University","institution_ids":["https://openalex.org/I4210131401"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082175124","display_name":"Mizuho Une","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210131401","display_name":"Hiroshima International University","ror":"https://ror.org/03dk6an77","country_code":"JP","type":"education","lineage":["https://openalex.org/I4210131401"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Mizuho Une","raw_affiliation_strings":["Faculty of Pharmaceutical Sciences, Hiroshima International University","Graduate School of Pharmaceutical Sciences, Hiroshima International University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Pharmaceutical Sciences, Hiroshima International University","institution_ids":["https://openalex.org/I4210131401"]},{"raw_affiliation_string":"Graduate School of Pharmaceutical Sciences, Hiroshima International University","institution_ids":["https://openalex.org/I4210131401"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5034188197","display_name":"Naoki Teno","orcid":"https://orcid.org/0000-0002-3940-5473","observed_orcids":["https://orcid.org/0000-0002-3940-5473"]},"institutions":[{"id":"https://openalex.org/I4210131401","display_name":"Hiroshima International University","ror":"https://ror.org/03dk6an77","country_code":"JP","type":"education","lineage":["https://openalex.org/I4210131401"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Naoki Teno","raw_affiliation_strings":["Faculty of Clinical Nutrition, Hiroshima International University","Graduate School of Pharmaceutical Sciences, Hiroshima International University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Clinical Nutrition, Hiroshima International University","institution_ids":["https://openalex.org/I4210131401"]},{"raw_affiliation_string":"Graduate School of Pharmaceutical Sciences, Hiroshima International University","institution_ids":["https://openalex.org/I4210131401"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.0269,"has_fulltext":true,"cited_by_count":6,"citation_normalized_percentile":{"value":0.76463507,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"47","issue":"8","first_page":"1429","last_page":"1436"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.7656000256538391,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.7656000256538391,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11618","display_name":"Cholesterol and Lipid Metabolism","score":0.1696999967098236,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13430","display_name":"Lipid metabolism and disorders","score":0.0142000000923872,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/farnesoid-x-receptor","display_name":"farnesoid X receptor","score":0.8859999775886536},{"id":"https://openalex.org/keywords/fxr-antagonists","display_name":"FXR antagonists","score":0.9359999895095825},{"id":"https://openalex.org/keywords/high-fat-diet-induced-obesity","display_name":"high-fat diet-induced obesity","score":0.8320000171661377},{"id":"https://openalex.org/keywords/hepatic-triglycerides","display_name":"hepatic triglycerides","score":0.9620000123977661},{"id":"https://openalex.org/keywords/serum-cholesterol","display_name":"serum cholesterol","score":0.996999979019165},{"id":"https://openalex.org/keywords/bile-acid-metabolism","display_name":"bile acid metabolism","score":0.9610000252723694},{"id":"https://openalex.org/keywords/enterohepatic-circulation","display_name":"enterohepatic circulation","score":0.9380000233650208},{"id":"https://openalex.org/keywords/ceramide-synthesis","display_name":"ceramide synthesis","score":0.9580000042915344},{"id":"https://openalex.org/keywords/fatty-acid-beta-oxidation","display_name":"fatty acid beta-oxidation","score":0.9639999866485596},{"id":"https://openalex.org/keywords/ileum","display_name":"ileum","score":0.7630000114440918},{"id":"https://openalex.org/keywords/lipid-metabolism","display_name":"lipid metabolism","score":0.8130000233650208}],"concepts":[{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.8102484941482544},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7992085814476013},{"id":"https://openalex.org/C2776885963","wikidata":"https://www.wikidata.org/wiki/Q245204","display_name":"Antagonist","level":3,"score":0.6263197064399719},{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.5453847646713257},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.5343496203422546},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.43538570404052734},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.37902504205703735},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.22975674271583557}],"mesh":[{"descriptor_ui":"D000099150","descriptor_name":"Receptor, Farnesoid X-Activated","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001647","descriptor_name":"Bile Acids and Salts","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002784","descriptor_name":"Cholesterol","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D007082","descriptor_name":"Ileum","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D007082","descriptor_name":"Ileum","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008820","descriptor_name":"Mice, Obese","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014280","descriptor_name":"Triglycerides","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D018160","descriptor_name":"Receptors, Cytoplasmic and Nuclear","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D018160","descriptor_name":"Receptors, Cytoplasmic and Nuclear","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D050356","descriptor_name":"Lipid Metabolism","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059305","descriptor_name":"Diet, High-Fat","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1248/bpb.b24-00311","doi":"https://doi.org/10.1248/bpb.b24-00311","is_oa":true,"landing_page_url":"https://doi.org/10.1248/bpb.b24-00311","pdf_url":"https://www.jstage.jst.go.jp/article/bpb/47/8/47_b24-00311/_pdf","source":{"id":"https://openalex.org/S165235614","display_name":"Biological and Pharmaceutical Bulletin","issn_l":"0918-6158","issn":["0918-6158","1347-5215"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310313382","host_organization_name":"Pharmaceutical Society of Japan","host_organization_lineage":["https://openalex.org/P4310313382"],"host_organization_lineage_names":["Pharmaceutical Society of Japan"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biological and Pharmaceutical Bulletin","raw_type":"journal-article"},{"id":"pmid:39135238","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39135238","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biological & pharmaceutical bulletin","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1248/bpb.b24-00311","doi":"https://doi.org/10.1248/bpb.b24-00311","is_oa":true,"landing_page_url":"https://doi.org/10.1248/bpb.b24-00311","pdf_url":"https://www.jstage.jst.go.jp/article/bpb/47/8/47_b24-00311/_pdf","source":{"id":"https://openalex.org/S165235614","display_name":"Biological and Pharmaceutical Bulletin","issn_l":"0918-6158","issn":["0918-6158","1347-5215"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310313382","host_organization_name":"Pharmaceutical Society of Japan","host_organization_lineage":["https://openalex.org/P4310313382"],"host_organization_lineage_names":["Pharmaceutical Society of Japan"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biological and Pharmaceutical Bulletin","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.979200005531311,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G6433433877","display_name":"Elucidation of the Hepatitis B Virus Entry Mechanism and Infection Control via Entry Inhibitors","funder_award_id":"23K24323","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"}],"funders":[{"id":"https://openalex.org/F4320327572","display_name":"Promotion and Mutual Aid Corporation for Private Schools of Japan","ror":"https://ror.org/05h2t6865"},{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4401503100.pdf","grobid_xml":"https://content.openalex.org/works/W4401503100.grobid-xml"},"referenced_works_count":35,"referenced_works":["https://openalex.org/W2020814081","https://openalex.org/W2024431513","https://openalex.org/W2065147071","https://openalex.org/W2078010480","https://openalex.org/W2078220726","https://openalex.org/W2093406272","https://openalex.org/W2122478167","https://openalex.org/W2123561714","https://openalex.org/W2124025733","https://openalex.org/W2134897177","https://openalex.org/W2146012023","https://openalex.org/W2182954198","https://openalex.org/W2193344030","https://openalex.org/W2236340720","https://openalex.org/W2551836896","https://openalex.org/W2562858475","https://openalex.org/W2584971722","https://openalex.org/W2592437910","https://openalex.org/W2736217848","https://openalex.org/W2781916466","https://openalex.org/W2883359071","https://openalex.org/W2936424787","https://openalex.org/W2988012250","https://openalex.org/W3003165739","https://openalex.org/W3010649284","https://openalex.org/W3027037887","https://openalex.org/W3132913744","https://openalex.org/W3155404950","https://openalex.org/W3155857567","https://openalex.org/W3217186767","https://openalex.org/W4281710331","https://openalex.org/W4295907472","https://openalex.org/W4360602369","https://openalex.org/W4388013971","https://openalex.org/W4389060282"],"related_works":["https://openalex.org/W4412402252","https://openalex.org/W4392919425","https://openalex.org/W2736217848","https://openalex.org/W4379276546","https://openalex.org/W2139039119","https://openalex.org/W2792154419","https://openalex.org/W2805741858","https://openalex.org/W2073424962","https://openalex.org/W2416957212","https://openalex.org/W2047664305"],"abstract_inverted_index":{"Farnesoid":[0],"X":[1],"receptor":[2,7],"(FXR)":[3],"is":[4],"a":[5,41,78,131,140],"nuclear":[6],"that":[8,48,124],"regulates":[9,21],"the":[10,54,62,68,95,113,127],"synthesis":[11,104],"and":[12,23,46,105,115,136],"enterohepatic":[13],"circulation":[14],"of":[15,43,51,56,70,97],"bile":[16],"acids":[17],"(BAs).":[18],"It":[19],"also":[20],"lipid":[22,73,110,146],"carbohydrate":[24],"metabolism,":[25,102],"making":[26],"FXR":[27,44,58,142],"ligands":[28],"potential":[29,128],"therapeutic":[30],"agents":[31],"for":[32,86],"systemic":[33],"and/or":[34],"hepatic":[35],"metabolic":[36],"disorders.":[37,148],"We":[38],"previously":[39],"synthesized":[40],"series":[42],"antagonists":[45],"showed":[47],"oral":[49],"administration":[50],"FLG249":[52,71,83,125],"reduced":[53],"expression":[55,96],"several":[57],"target":[59],"genes":[60,98],"in":[61,75,112],"mouse":[63],"ileum.":[64],"Here,":[65],"we":[66],"investigated":[67],"effects":[69],"on":[72],"metabolism":[74,111,147],"mice":[76],"fed":[77],"high-fat":[79],"diet":[80],"(HFD).":[81],"When":[82],"was":[84],"administered":[85],"4":[87],"weeks":[88],"to":[89,100,129,144],"HFD-induced":[90],"obese":[91],"mice,":[92],"it":[93],"altered":[94],"related":[99],"BA":[101],"ceramide":[103],"fatty":[106],"acid":[107],"\u03b2-oxidation,":[108],"improving":[109],"liver":[114],"ileum":[116],"without":[117],"decreasing":[118],"body":[119],"weight.":[120],"These":[121],"findings":[122],"suggest":[123],"has":[126],"be":[130],"low":[132],"toxicity":[133],"pharmaceutical":[134],"compound":[135],"likely":[137],"acts":[138],"as":[139],"nonsteroidal":[141],"antagonist":[143],"improve":[145]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2024-08-13T00:00:00"}