{"id":"https://openalex.org/W4401467805","doi":"https://doi.org/10.1002/dad2.12623","title":"Circulating sphingolipids in relation to cognitive decline and incident dementia: The Cardiovascular Health Study","display_name":"Circulating sphingolipids in relation to cognitive decline and incident dementia: The Cardiovascular Health Study","publication_year":2024,"publication_date":"2024-07-01","ids":{"openalex":"https://openalex.org/W4401467805","doi":"https://doi.org/10.1002/dad2.12623","pmid":"https://pubmed.ncbi.nlm.nih.gov/39130802","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11310412"},"language":"en","primary_location":{"id":"doi:10.1002/dad2.12623","doi":"https://doi.org/10.1002/dad2.12623","is_oa":true,"landing_page_url":"https://doi.org/10.1002/dad2.12623","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/dad2.12623","source":{"id":"https://openalex.org/S2898482455","display_name":"Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring","issn_l":"2352-8729","issn":["2352-8729"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-2","norway-2","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer's &amp; Dementia: Diagnosis, Assessment &amp; Disease Monitoring","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/dad2.12623","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5065552139","display_name":"Kristine F. Moseholm","orcid":"https://orcid.org/0000-0002-8954-9846","observed_orcids":["https://orcid.org/0000-0002-8954-9846"]},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]}],"countries":["DK"],"is_corresponding":true,"raw_author_name":"Kristine F. Moseholm","raw_affiliation_strings":["Department of Public Health Section of Epidemiology University of Copenhagen  Copenhagen Denmark"],"raw_orcid":"https://orcid.org/0000-0002-8954-9846","affiliations":[{"raw_affiliation_string":"Department of Public Health Section of Epidemiology University of Copenhagen  Copenhagen Denmark","institution_ids":["https://openalex.org/I124055696"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031385776","display_name":"H\u00e9l\u00e9ne T. Cronj\u00e9","orcid":"https://orcid.org/0000-0001-6855-8324","observed_orcids":["https://orcid.org/0000-0001-6855-8324"]},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"H\u00e9l\u00e9ne T. Cronj\u00e9","raw_affiliation_strings":["Department of Public Health Section of Epidemiology University of Copenhagen  Copenhagen Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Public Health Section of Epidemiology University of Copenhagen  Copenhagen Denmark","institution_ids":["https://openalex.org/I124055696"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016741001","display_name":"Manja Koch","orcid":"https://orcid.org/0000-0002-4794-4821","observed_orcids":["https://orcid.org/0000-0002-4794-4821"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Manja Koch","raw_affiliation_strings":["Department of Nutrition Harvard T.H. Chan School of Public Health  Boston Massachusetts USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nutrition Harvard T.H. Chan School of Public Health  Boston Massachusetts USA","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107836541","display_name":"Annette L. Fitzpatrick","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Annette L. Fitzpatrick","raw_affiliation_strings":["Departments of Family Medicine and Epidemiology School of Public Health University of Washington  Seattle Washington USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Family Medicine and Epidemiology School of Public Health University of Washington  Seattle Washington USA","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100619838","display_name":"Oscar L. L\u00f3pez","orcid":"https://orcid.org/0000-0002-8546-8256","observed_orcids":["https://orcid.org/0000-0002-8546-8256"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Oscar L. Lopez","raw_affiliation_strings":["Department of Neurology School of Medicine University of Pittsburgh  Pittsburgh Pennsylvania USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology School of Medicine University of Pittsburgh  Pittsburgh Pennsylvania USA","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024693030","display_name":"Marcia C. de Oliveira Otto","orcid":"https://orcid.org/0000-0002-4585-0688","observed_orcids":["https://orcid.org/0000-0002-4585-0688"]},"institutions":[{"id":"https://openalex.org/I919571938","display_name":"The University of Texas Health Science Center at Houston","ror":"https://ror.org/03gds6c39","country_code":"US","type":"education","lineage":["https://openalex.org/I919571938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marcia C. de Oliveira Otto","raw_affiliation_strings":["Department of Epidemiology University of Texas Health Science Center  Houston Texas USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Epidemiology University of Texas Health Science Center  Houston Texas USA","institution_ids":["https://openalex.org/I919571938"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024956978","display_name":"W. T. Longstreth","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"W. T. Longstreth","raw_affiliation_strings":["Department of Neurology School of Medicine University of Washington  Seattle Washington USA","Departments of Family Medicine and Epidemiology School of Public Health University of Washington  Seattle Washington USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology School of Medicine University of Washington  Seattle Washington USA","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"Departments of Family Medicine and Epidemiology School of Public Health University of Washington  Seattle Washington USA","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031218554","display_name":"Andrew N. Hoofnagle","orcid":"https://orcid.org/0000-0002-6449-0243","observed_orcids":["https://orcid.org/0000-0002-6449-0243"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew N. Hoofnagle","raw_affiliation_strings":["Department of Laboratory Medicine and Pathology School of Medicine University of Washington  Seattle Washington USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine and Pathology School of Medicine University of Washington  Seattle Washington USA","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041104244","display_name":"Kenneth Jay Mukamal","orcid":"https://orcid.org/0000-0001-8450-6970","observed_orcids":["https://orcid.org/0000-0001-8450-6970"]},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kenneth J. Mukamal","raw_affiliation_strings":["Department of Medicine Beth Israel Deaconess Medical Center  Boston Massachusetts USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine Beth Israel Deaconess Medical Center  Boston Massachusetts USA","institution_ids":["https://openalex.org/I1316535847"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009270847","display_name":"Rozenn N. Lema\u00eetre","orcid":"https://orcid.org/0000-0002-7038-1844","observed_orcids":["https://orcid.org/0000-0002-7038-1844"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rozenn N. Lemaitre","raw_affiliation_strings":["Cardiovascular Health Research Unit, Department of Medicine University of Washington  Seattle Washington USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Health Research Unit, Department of Medicine University of Washington  Seattle Washington USA","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5086755641","display_name":"Majken K. Jensen","orcid":"https://orcid.org/0000-0003-4729-7545","observed_orcids":["https://orcid.org/0000-0003-4729-7545"]},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["DK","US"],"is_corresponding":false,"raw_author_name":"Majken K. Jensen","raw_affiliation_strings":["Department of Nutrition Harvard T.H. Chan School of Public Health  Boston Massachusetts USA","Department of Public Health Section of Epidemiology University of Copenhagen  Copenhagen Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nutrition Harvard T.H. Chan School of Public Health  Boston Massachusetts USA","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Department of Public Health Section of Epidemiology University of Copenhagen  Copenhagen Denmark","institution_ids":["https://openalex.org/I124055696"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5065552139"],"corresponding_institution_ids":["https://openalex.org/I124055696"],"apc_list":{"value":2310,"currency":"USD","value_usd":2310},"apc_paid":{"value":2310,"currency":"USD","value_usd":2310},"fwci":2.1636,"has_fulltext":true,"cited_by_count":8,"citation_normalized_percentile":{"value":0.87989137,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":99},"biblio":{"volume":"16","issue":"3","first_page":"e12623","last_page":"e12623"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.6431000232696533,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.6431000232696533,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11308","display_name":"Sphingolipid Metabolism and Signaling","score":0.34279999136924744,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10387","display_name":"Fatty Acid Research and Health","score":0.003000000026077032,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sphingolipids","display_name":"sphingolipids","score":0.9480000138282776},{"id":"https://openalex.org/keywords/cognitive-decline","display_name":"cognitive decline","score":0.8059999942779541},{"id":"https://openalex.org/keywords/dementia-risk","display_name":"dementia risk","score":0.9150000214576721},{"id":"https://openalex.org/keywords/sphingomyelin","display_name":"sphingomyelin","score":0.8870000243186951},{"id":"https://openalex.org/keywords/ceramide","display_name":"ceramide","score":0.9639999866485596},{"id":"https://openalex.org/keywords/palmitic-acid","display_name":"palmitic acid","score":0.7820000052452087},{"id":"https://openalex.org/keywords/fatty-acid-chain-length","display_name":"fatty acid chain length","score":0.8009999990463257},{"id":"https://openalex.org/keywords/plasma-lipids","display_name":"plasma lipids","score":0.7689999938011169},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.7310000061988831},{"id":"https://openalex.org/keywords/cardiovascular-health-study","display_name":"Cardiovascular Health Study","score":0.8880000114440918}],"concepts":[{"id":"https://openalex.org/C61705674","wikidata":"https://www.wikidata.org/wiki/Q410395","display_name":"Sphingolipid","level":2,"score":0.840573787689209},{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.8046334385871887},{"id":"https://openalex.org/C2984863031","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Cognitive decline","level":4,"score":0.7401116490364075},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.6197140216827393},{"id":"https://openalex.org/C3018284874","wikidata":"https://www.wikidata.org/wiki/Q389735","display_name":"Cardiovascular health","level":3,"score":0.5549104809761047},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5450295805931091},{"id":"https://openalex.org/C74909509","wikidata":"https://www.wikidata.org/wiki/Q10387","display_name":"Gerontology","level":1,"score":0.4616372287273407},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.33285951614379883},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3232914209365845},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.18134334683418274},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.14047876000404358},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1342099905014038},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.057114481925964355}],"mesh":[],"locations_count":7,"locations":[{"id":"doi:10.1002/dad2.12623","doi":"https://doi.org/10.1002/dad2.12623","is_oa":true,"landing_page_url":"https://doi.org/10.1002/dad2.12623","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/dad2.12623","source":{"id":"https://openalex.org/S2898482455","display_name":"Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring","issn_l":"2352-8729","issn":["2352-8729"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-2","norway-2","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer's &amp; Dementia: Diagnosis, Assessment &amp; Disease Monitoring","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11310412","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11310412","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11310412/pdf/DAD2-16-e12623.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimers Dement (Amst)","raw_type":"Text"},{"id":"pmid:39130802","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39130802","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer's & dementia (Amsterdam, Netherlands)","raw_type":"Journal Article"},{"id":"pmh:oai:pure.atira.dk:openaire/b13d2e0c-2d75-40cc-b52d-d49aca2a822b","doi":null,"is_oa":true,"landing_page_url":"https://researchprofiles.ku.dk/da/publications/b13d2e0c-2d75-40cc-b52d-d49aca2a822b","pdf_url":null,"source":{"id":"https://openalex.org/S4306401983","display_name":"Research at the University of Copenhagen (University of Copenhagen)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I124055696","host_organization_name":"University of Copenhagen","host_organization_lineage":["https://openalex.org/I124055696"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Moseholm, K F, Cronj\u00e9, H T, Koch, M, Fitzpatrick, A L, Lopez, O L, Otto, M C D O, Longstreth, W T, Hoofnagle, A N, Mukamal, K J, Lemaitre, R N & Jensen, M K 2024, 'Circulating sphingolipids in relation to cognitive decline and incident dementia : The Cardiovascular Health Study', Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring, vol. 16, no. 3, e12623. https://doi.org/10.1002/dad2.12623","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:digitalcommons.library.tmc.edu:uthsph_docs-2445","doi":null,"is_oa":true,"landing_page_url":"https://digitalcommons.library.tmc.edu/uthsph_docs/1484","pdf_url":"https://digitalcommons.library.tmc.edu/cgi/viewcontent.cgi?article=2445&context=uthsph_docs","source":{"id":"https://openalex.org/S4377196655","display_name":"Digital Commons-TMC (Texas Medical Center)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1337852284","host_organization_name":"Texas Medical Center","host_organization_lineage":["https://openalex.org/I1337852284"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Faculty, Staff and Student Publications","raw_type":"text"},{"id":"pmh:oai:digitalcommons.library.tmc.edu:uthsph_docs-1944","doi":null,"is_oa":false,"landing_page_url":"https://digitalcommons.library.tmc.edu/uthsph_docs/974","pdf_url":null,"source":{"id":"https://openalex.org/S4377196655","display_name":"Digital Commons-TMC (Texas Medical Center)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1337852284","host_organization_name":"Texas Medical Center","host_organization_lineage":["https://openalex.org/I1337852284"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Faculty, Staff and Student Publications","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:ebfe276994184a99bf0389a46a6ebb34","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/ebfe276994184a99bf0389a46a6ebb34","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Alzheimer\u2019s & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol 16, Iss 3, Pp n/a-n/a (2024)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1002/dad2.12623","doi":"https://doi.org/10.1002/dad2.12623","is_oa":true,"landing_page_url":"https://doi.org/10.1002/dad2.12623","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/dad2.12623","source":{"id":"https://openalex.org/S2898482455","display_name":"Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring","issn_l":"2352-8729","issn":["2352-8729"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-2","norway-2","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer's &amp; Dementia: Diagnosis, Assessment &amp; Disease Monitoring","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.979200005531311}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G1220223050","display_name":null,"funder_award_id":"N01 HC085086","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G1261314546","display_name":null,"funder_award_id":"75N 92021D00006","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G1270022350","display_name":"CORONARY HEART DISEASE AND STROKE","funder_award_id":"n01hc085082-026","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G1288641935","display_name":"CORONARY HEART DISEASE &STROKE IN PEOPLE AGED 65-84","funder_award_id":"n01hc085081-021","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G1386593725","display_name":null,"funder_award_id":"NNF17OC0027812","funder_id":"https://openalex.org/F4320325957","funder_display_name":"Novo Nordisk Fonden"},{"id":"https://openalex.org/G161289361","display_name":"CORONARY HEART DISEASE AND STROKE","funder_award_id":"n01hc085079-024","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G2194386449","display_name":null,"funder_award_id":"N01 HC085079","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G2240676382","display_name":"CORONARY HEART DISEASE &STROKE IN PEOPLE AGED 65-84","funder_award_id":"n01hc085083-027","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G2391884931","display_name":null,"funder_award_id":"N01 HC085083","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G2625768758","display_name":"CORONARY HEART DISEASE &STROKE IN THE ELDERLY","funder_award_id":"n01hc085080-026","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G3045517347","display_name":null,"funder_award_id":"N01 HC085080","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G3220743633","display_name":null,"funder_award_id":"HHSN 268200800007C","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G3256118428","display_name":null,"funder_award_id":"HHSN268201800001C","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G3528935637","display_name":"CHS research resources for the cardiovascular health of older adults","funder_award_id":"U01HL130114","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G3993082116","display_name":"CENTRAL BLOOD ANALYSIS LABORATORY FOR CHS","funder_award_id":"n01hc085086-022","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G438379627","display_name":null,"funder_award_id":"2019\u2010AARF\u2010644678","funder_id":"https://openalex.org/F4320306219","funder_display_name":"Alzheimer's Association"},{"id":"https://openalex.org/G4457992036","display_name":"Proteomics profiling and risk of dementia","funder_award_id":"K01AG066817","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G5358316673","display_name":"Mid-Career Research and Mentorship in Metabolic Aging","funder_award_id":"K24AG065525","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G5479317095","display_name":null,"funder_award_id":"HHSN268201200036C","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G581887176","display_name":null,"funder_award_id":"N01HC085082","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G6000838390","display_name":"CHS Events Follow-up Study","funder_award_id":"U01HL080295","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G6207795174","display_name":"Plasma sphingolipids and risk of cardiovascular disease","funder_award_id":"R01HL128575","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G6226795708","display_name":null,"funder_award_id":"N01 HC055222","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G6718202627","display_name":"CHS-Transition Phase","funder_award_id":"n01hc55222-0-0-0","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G7022638084","display_name":"Plasma Proteomics for Identification of Non-Invasive Dementia Risk Markers","funder_award_id":"AARF-21-851606","funder_id":"https://openalex.org/F4320306219","funder_display_name":"Alzheimer's Association"},{"id":"https://openalex.org/G7176672723","display_name":null,"funder_award_id":"N01 HC085081","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G7669931240","display_name":"Exceptional Survival: Trajectories to Functional Aging (CHS All Stars)","funder_award_id":"R01AG023629","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G9000874358","display_name":"Nutrition Obesity Research Center","funder_award_id":"P30DK035816","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320306219","display_name":"Alzheimer's Association","ror":"https://ror.org/0375f4d26"},{"id":"https://openalex.org/F4320325957","display_name":"Novo Nordisk Fonden","ror":"https://ror.org/04txyc737"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4401467805.pdf","grobid_xml":"https://content.openalex.org/works/W4401467805.grobid-xml"},"referenced_works_count":46,"referenced_works":["https://openalex.org/W1256777839","https://openalex.org/W1562946553","https://openalex.org/W1850582709","https://openalex.org/W1968537977","https://openalex.org/W1972686602","https://openalex.org/W1989294823","https://openalex.org/W1993868853","https://openalex.org/W1999160838","https://openalex.org/W2012374994","https://openalex.org/W2024430285","https://openalex.org/W2025607561","https://openalex.org/W2047487074","https://openalex.org/W2063131612","https://openalex.org/W2072543902","https://openalex.org/W2088941906","https://openalex.org/W2090140552","https://openalex.org/W2093816724","https://openalex.org/W2132495615","https://openalex.org/W2134810505","https://openalex.org/W2145669020","https://openalex.org/W2156220037","https://openalex.org/W2161197885","https://openalex.org/W2566039789","https://openalex.org/W2603228471","https://openalex.org/W2784429314","https://openalex.org/W2905435570","https://openalex.org/W2908002252","https://openalex.org/W2916749909","https://openalex.org/W2965475701","https://openalex.org/W2981166078","https://openalex.org/W2992771150","https://openalex.org/W2997449152","https://openalex.org/W2999667991","https://openalex.org/W3004531922","https://openalex.org/W3022486925","https://openalex.org/W3046275966","https://openalex.org/W3083472845","https://openalex.org/W3202232593","https://openalex.org/W3215066238","https://openalex.org/W4200487651","https://openalex.org/W4200595101","https://openalex.org/W4211238543","https://openalex.org/W4293572533","https://openalex.org/W4307044062","https://openalex.org/W4391107710","https://openalex.org/W6662021636"],"related_works":["https://openalex.org/W4324140487","https://openalex.org/W7127118644","https://openalex.org/W2980325778","https://openalex.org/W2000315424","https://openalex.org/W4200595101","https://openalex.org/W1703528746","https://openalex.org/W2091216838","https://openalex.org/W4406210014","https://openalex.org/W2088941906","https://openalex.org/W3047786219"],"abstract_inverted_index":{"INTRODUCTION:":[0],"Whether":[1],"circulating":[2],"levels":[3,56,73,91,137],"of":[4,44,57,74,92,118,138,163,166,180],"sphingolipids":[5,139],"are":[6],"prospectively":[7],"associated":[8,61,78,114,141,154],"with":[9,62,68,79,85,115,142,150,155],"cognitive":[10,65,130,143,158,181],"decline":[11,22,66,81,131,144,159],"and":[12,35,104,132,145,148,160],"dementia":[13,133,146],"risk":[14,117,162],"is":[15],"uncertain.":[16],"METHODS:":[17],"\u03b54":[18],"allele":[19],"carriers).":[20],"Cognitive":[21],"was":[23],"assessed":[24],"annually":[25],"across":[26],"6":[27],"years":[28],"using":[29],"modified":[30],"Mini-Mental":[31],"State":[32],"Examination":[33],"(3MSE)":[34],"Digital":[36],"Symbol":[37],"Substitution":[38],"Test":[39],"(DSST).":[40],"Additionally,":[41],"a":[42,63],"subset":[43],"3050":[45],"participants":[46],"were":[47,60,77,113,140,153],"followed":[48],"for":[49],"clinically":[50],"adjudicated":[51],"dementia.":[52,120],"RESULTS:":[53],"Higher":[54],"plasma":[55],"sphingomyelin-d18:1/16:0":[58],"(SM-16)":[59],"faster":[64,156],"measured":[67,84],"3MSE,":[69],"in":[70,82,129,178],"contrast,":[71],"higher":[72,90,116],"sphingomyelin-d18:1/22:0":[75],"(SM-22)":[76],"slower":[80],"cognition":[83],"DSST.":[86],"In":[87],"Cox":[88],"regression,":[89],"SM-16":[93],"(hazard":[94],"ration":[95],"[HR]":[96],"=":[97,108],"1.24":[98],"[95%":[99,110],"confidence":[100],"interval":[101],"[CI]:":[102],"1.08-1.44])":[103],"ceramide-d18:1/16:0":[105],"(Cer-16)":[106],"(HR":[107],"1.26":[109],"CI:":[111],"1.10-1.45])":[112],"incident":[119],"DISCUSSION:":[121],"Several":[122],"sphingolipid":[123],"species":[124],"appear":[125],"to":[126],"be":[127],"involved":[128],"risk.":[134],"Highlights:":[135],"Plasma":[136],"risk.Ceramides":[147],"sphingomyelins":[149],"palmitic":[151],"acid":[152,175],"annual":[157],"increased":[161],"dementia.The":[164],"direction":[165],"association":[167],"depended":[168],"on":[169],"the":[170],"covalently":[171],"bound":[172],"saturated":[173],"fatty":[174],"chain":[176],"length":[177],"analysis":[179],"decline.":[182]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":2}],"updated_date":"2026-11-02T09:45:03.842371","created_date":"2024-08-10T00:00:00"}
