{"id":"https://openalex.org/W4401463553","doi":"https://doi.org/10.22271/27069567.2024.v6.i3a.570","title":"Metastasis of cervical cancer cell line affected by probiotics in real-time PCR assay","display_name":"Metastasis of cervical cancer cell line affected by probiotics in real-time PCR assay","publication_year":2024,"publication_date":"2024-07-01","ids":{"openalex":"https://openalex.org/W4401463553","doi":"https://doi.org/10.22271/27069567.2024.v6.i3a.570"},"language":"en","primary_location":{"id":"doi:10.22271/27069567.2024.v6.i3a.570","doi":"https://doi.org/10.22271/27069567.2024.v6.i3a.570","is_oa":true,"landing_page_url":"https://doi.org/10.22271/27069567.2024.v6.i3a.570","pdf_url":"https://www.medicinepaper.net/article/570/6-3-9-979.pdf","source":{"id":"https://openalex.org/S4210226113","display_name":"International Journal of Advanced Research in Medicine","issn_l":"2706-9567","issn":["2706-9567","2706-9575"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Advanced Research in Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://www.medicinepaper.net/article/570/6-3-9-979.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5070246683","display_name":"Azher Adnan","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Azher Adnan","raw_affiliation_strings":["Department of Medical Biotechnology , Thi Qar Health Forensic Medicine , Iraq"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Biotechnology , Thi Qar Health Forensic Medicine , Iraq","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5074050523","display_name":"Zainab Mohammed Farhan","orcid":"https://orcid.org/0000-0001-7982-8203","observed_orcids":["https://orcid.org/0000-0001-7982-8203"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zainab M Farhan","raw_affiliation_strings":["Department of Dhi Qar Health , Imam Hussein Teaching Hospital , Iraq"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dhi Qar Health , Imam Hussein Teaching Hospital , Iraq","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.1637,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.39112393,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":93},"biblio":{"volume":"6","issue":"3","first_page":"48","last_page":"55"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10141","display_name":"Probiotics and Fermented Foods","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10141","display_name":"Probiotics and Fermented Foods","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12996","display_name":"Bacterial Cancer Therapy","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10428","display_name":"Reproductive tract infections research","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/probiotics","display_name":"probiotics","score":0.9200000166893005},{"id":"https://openalex.org/keywords/lactobacillus-crispatus","display_name":"Lactobacillus crispatus","score":0.9200000166893005},{"id":"https://openalex.org/keywords/cervical-cancer","display_name":"cervical cancer","score":0.9480000138282776},{"id":"https://openalex.org/keywords/hela-cells","display_name":"HeLa cells","score":0.9459999799728394},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.6830000281333923},{"id":"https://openalex.org/keywords/mmp-2","display_name":"MMP-2","score":0.9210000038146973},{"id":"https://openalex.org/keywords/mmp-9","display_name":"MMP-9","score":1.0},{"id":"https://openalex.org/keywords/matrix-metalloproteinases","display_name":"matrix metalloproteinases","score":0.8149999976158142},{"id":"https://openalex.org/keywords/antimetastatic-activity","display_name":"antimetastatic activity","score":0.7229999899864197},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.9470000267028809},{"id":"https://openalex.org/keywords/lactic-acid-bacteria","display_name":"lactic acid bacteria","score":0.7649999856948853},{"id":"https://openalex.org/keywords/gene-expression","display_name":"gene expression","score":0.4830000102519989}],"concepts":[{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.5685945153236389},{"id":"https://openalex.org/C2994372470","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell lines","level":4,"score":0.5505931973457336},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5459172129631042},{"id":"https://openalex.org/C48023723","wikidata":"https://www.wikidata.org/wiki/Q856198","display_name":"Real-time polymerase chain reaction","level":3,"score":0.5178261399269104},{"id":"https://openalex.org/C2778220009","wikidata":"https://www.wikidata.org/wiki/Q160105","display_name":"Cervical cancer","level":3,"score":0.5130754709243774},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.46579277515411377},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.44786542654037476},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4393092095851898},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4015422761440277},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.39309853315353394},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3872390389442444},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.3453288674354553},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.16786733269691467},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.16544213891029358},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.13201817870140076}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.22271/27069567.2024.v6.i3a.570","doi":"https://doi.org/10.22271/27069567.2024.v6.i3a.570","is_oa":true,"landing_page_url":"https://doi.org/10.22271/27069567.2024.v6.i3a.570","pdf_url":"https://www.medicinepaper.net/article/570/6-3-9-979.pdf","source":{"id":"https://openalex.org/S4210226113","display_name":"International Journal of Advanced Research in Medicine","issn_l":"2706-9567","issn":["2706-9567","2706-9575"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Advanced Research in Medicine","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.22271/27069567.2024.v6.i3a.570","doi":"https://doi.org/10.22271/27069567.2024.v6.i3a.570","is_oa":true,"landing_page_url":"https://doi.org/10.22271/27069567.2024.v6.i3a.570","pdf_url":"https://www.medicinepaper.net/article/570/6-3-9-979.pdf","source":{"id":"https://openalex.org/S4210226113","display_name":"International Journal of Advanced Research in Medicine","issn_l":"2706-9567","issn":["2706-9567","2706-9575"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Advanced Research in Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9922999739646912,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4401463553.pdf","grobid_xml":"https://content.openalex.org/works/W4401463553.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2511294876","https://openalex.org/W164581281","https://openalex.org/W4391182608","https://openalex.org/W2000836424","https://openalex.org/W4210430650","https://openalex.org/W3202771395","https://openalex.org/W2765650037","https://openalex.org/W4296618928","https://openalex.org/W4318824161","https://openalex.org/W4390906741"],"abstract_inverted_index":{"Objective:":[0],"The":[1],"term":[2],"\"probiotic\"":[3],"refers":[4],"to":[5,12,61,66,95,244,248,253,259],"live":[6],"microorganisms":[7],"that":[8,24,162,184,211],"have":[9,209],"been":[10,141],"linked":[11],"advantageous":[13],"outcomes":[14],"for":[15],"the":[16,68,86,101,104,109,113,126,129,138,165,174,177,203,216,264,271],"host.Nonetheless,":[17],"a":[18,116,171,212],"large":[19],"body":[20],"of":[21,70,108,115,128,176,205,218,273],"research":[22,64,182],"suggests":[23],"probiotic":[25,46,213],"lactic":[26],"acid":[27],"bacteria":[28],"(LAB)":[29],"may":[30,48],"be":[31,96],"helpful":[32],"in":[33,37,54,170,173,190,257,276],"preventing":[34],"colon":[35],"cancer":[36,53,220,240,266],"its":[38],"early":[39],"stages.However,":[40],"nothing":[41],"is":[42,251],"known":[43],"about":[44],"how":[45],"LAB":[47],"affect":[49,155],"colorectal":[50],"and":[51,99,131,179,197,222,232],"cervical":[52,76,239],"their":[55,206],"later":[56],"phases,":[57],"particularly":[58],"with":[59,164],"regard":[60],"metastasis.The":[62],"present":[63],"sought":[65],"examine":[67],"impact":[69,107],"Lactobacillus":[71,145],"crispatus":[72,146],"supernatant":[73,147],"(LCS)":[74],"on":[75,85,226,235,263],"cell":[77,88,227,237,267],"lines":[78,268],"derived":[79],"from":[80],"human":[81],"tissue,":[82],"specifically":[83],"focusing":[84],"HeLa":[87,150,191,236],"line.Throughout":[89],"our":[90,261],"inquiry,":[91],"this":[92],"was":[93,111,134,160],"going":[94],"executed.":[97],"Materials":[98],"Methods:Using":[100],"MTT":[102],"test,":[103],"experiment's":[105],"activities":[106],"LCS":[110,152,185],"ascertained.Through":[112],"utilization":[114],"quantitative":[117],"reverse":[118],"transcriptase-polymerase":[119],"chain":[120],"reaction":[121],"(qRT-PCR),":[122],"an":[123],"investigation":[124],"into":[125],"expression":[127,175,199,204],"MMP2":[130,178,196],"MMP9":[132,180,198],"genes":[133],"carried":[135],"out":[136],"after":[137],"cells":[139,157,192,241],"had":[140],"synchronized.Results:":[142],"Probiotics":[143],"called":[144],"cytotoxically":[148],"affected":[149],"cells.Furthermore,":[151],"did":[153],"not":[154],"normal":[156],"adversely.Additionally,":[158],"it":[159],"demonstrated":[161],"treatment":[163],"lactobacilli":[166],"under":[167],"study":[168],"resulted":[169],"decrease":[172],"genes.Our":[181],"indicates":[183],"effectively":[186],"inhibits":[187],"metastatic":[188],"potency":[189],"by":[193],"down":[194],"regulating":[195,202],"while":[200],"up":[201],"inhibitors.":[207],"Conclusion:We":[208],"shown":[210],"can":[214],"delay":[215],"progression":[217],"late-stage":[219],"illness":[221],"has":[223],"anti-metastasis":[224],"effects":[225,234],"lines.LCS":[228],"exhibited":[229],"both":[230],"cytotoxic":[231],"anti-metastatic":[233],"lines.HeLa":[238],"are":[242],"resistant":[243],"proliferation":[245],"when":[246],"exposed":[247],"L.":[249],"crispatus.It":[250],"required":[252],"conduct":[254],"additional":[255],"evaluations":[256],"order":[258],"assess":[260],"findings":[262],"other":[265],"before":[269],"considering":[270],"use":[272],"these":[274],"probiotics":[275],"larger":[277],"trial":[278],"studies.":[279]},"counts_by_year":[{"year":2025,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2024-08-10T00:00:00"}