{"id":"https://openalex.org/W4401444476","doi":"https://doi.org/10.1242/jeb.249213","title":"A meta-analysis of whole-body and heart mass effect sizes from a long-term artificial selection experiment for high voluntary exercise","display_name":"A meta-analysis of whole-body and heart mass effect sizes from a long-term artificial selection experiment for high voluntary exercise","publication_year":2024,"publication_date":"2024-08-09","ids":{"openalex":"https://openalex.org/W4401444476","doi":"https://doi.org/10.1242/jeb.249213","pmid":"https://pubmed.ncbi.nlm.nih.gov/39119628"},"language":"en","primary_location":{"id":"doi:10.1242/jeb.249213","doi":"https://doi.org/10.1242/jeb.249213","is_oa":false,"landing_page_url":"https://doi.org/10.1242/jeb.249213","pdf_url":null,"source":{"id":"https://openalex.org/S20257348","display_name":"Journal of Experimental Biology","issn_l":"0022-0949","issn":["0022-0949","1477-9145"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311847","host_organization_name":"The Company of Biologists","host_organization_lineage":["https://openalex.org/P4310311847"],"host_organization_lineage_names":["The Company of Biologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Experimental Biology","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5043293321","display_name":"Nicole E. Schwartz","orcid":"https://orcid.org/0000-0002-7411-3011","observed_orcids":["https://orcid.org/0000-0002-7411-3011"]},"institutions":[{"id":"https://openalex.org/I103635307","display_name":"University of California, Riverside","ror":"https://ror.org/03nawhv43","country_code":"US","type":"education","lineage":["https://openalex.org/I103635307"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nicole E. Schwartz","raw_affiliation_strings":["University of California, Riverside Department of Evolution, Ecology, and Organismal Biology , , Riverside, CA 92521 , USA"],"raw_orcid":"https://orcid.org/0000-0002-7411-3011","affiliations":[{"raw_affiliation_string":"University of California, Riverside Department of Evolution, Ecology, and Organismal Biology , , Riverside, CA 92521 , USA","institution_ids":["https://openalex.org/I103635307"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5019388483","display_name":"Theodore Garland","orcid":"https://orcid.org/0000-0002-7916-3552","observed_orcids":["https://orcid.org/0000-0002-7916-3552"]},"institutions":[{"id":"https://openalex.org/I103635307","display_name":"University of California, Riverside","ror":"https://ror.org/03nawhv43","country_code":"US","type":"education","lineage":["https://openalex.org/I103635307"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Theodore Garland","raw_affiliation_strings":["University of California, Riverside Department of Evolution, Ecology, and Organismal Biology , , Riverside, CA 92521 , USA"],"raw_orcid":"https://orcid.org/0000-0002-7916-3552","affiliations":[{"raw_affiliation_string":"University of California, Riverside Department of Evolution, Ecology, and Organismal Biology , , Riverside, CA 92521 , USA","institution_ids":["https://openalex.org/I103635307"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I103635307"],"apc_list":null,"apc_paid":null,"fwci":0.2274,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.23177083,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"227","issue":"17","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10174","display_name":"Animal Behavior and Reproduction","score":0.490200012922287,"subfield":{"id":"https://openalex.org/subfields/1105","display_name":"Ecology, Evolution, Behavior and Systematics"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10174","display_name":"Animal Behavior and Reproduction","score":0.490200012922287,"subfield":{"id":"https://openalex.org/subfields/1105","display_name":"Ecology, Evolution, Behavior and Systematics"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10594","display_name":"Genetic and phenotypic traits in livestock","score":0.2937000095844269,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11764","display_name":"Evolution and Genetic Dynamics","score":0.05730000138282776,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/selective-breeding","display_name":"selective breeding","score":0.9789999723434448},{"id":"https://openalex.org/keywords/voluntary-wheel-running","display_name":"voluntary wheel running","score":0.8700000047683716},{"id":"https://openalex.org/keywords/body-mass","display_name":"body mass","score":0.9810000061988831},{"id":"https://openalex.org/keywords/selection-limits","display_name":"selection limits","score":0.6299999952316284},{"id":"https://openalex.org/keywords/correlated-response","display_name":"correlated response","score":0.6100000143051147},{"id":"https://openalex.org/keywords/comparative-physiology","display_name":"comparative physiology","score":0.4490000009536743},{"id":"https://openalex.org/keywords/evolutionary-physiology","display_name":"evolutionary physiology","score":0.5889999866485596}],"concepts":[{"id":"https://openalex.org/C61797465","wikidata":"https://www.wikidata.org/wiki/Q1188986","display_name":"Term (time)","level":2,"score":0.6609470844268799},{"id":"https://openalex.org/C81917197","wikidata":"https://www.wikidata.org/wiki/Q628760","display_name":"Selection (genetic algorithm)","level":2,"score":0.6304876208305359},{"id":"https://openalex.org/C26077564","wikidata":"https://www.wikidata.org/wiki/Q1910318","display_name":"Turnover","level":2,"score":0.4959903657436371},{"id":"https://openalex.org/C95190672","wikidata":"https://www.wikidata.org/wiki/Q815382","display_name":"Meta-analysis","level":2,"score":0.45437073707580566},{"id":"https://openalex.org/C99508421","wikidata":"https://www.wikidata.org/wiki/Q2678675","display_name":"Physical medicine and rehabilitation","level":1,"score":0.3926517963409424},{"id":"https://openalex.org/C1862650","wikidata":"https://www.wikidata.org/wiki/Q186005","display_name":"Physical therapy","level":1,"score":0.3262152671813965},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3120828866958618},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.22256529331207275},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.20359137654304504},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.13878768682479858},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0798192024230957},{"id":"https://openalex.org/C187736073","wikidata":"https://www.wikidata.org/wiki/Q2920921","display_name":"Management","level":1,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001835","descriptor_name":"Body Weight","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006321","descriptor_name":"Heart","qualifier_ui":"Q000033","qualifier_name":"anatomy & histology","is_major_topic":true},{"descriptor_ui":"D006321","descriptor_name":"Heart","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D006352","descriptor_name":"Heart Ventricles","qualifier_ui":"Q000033","qualifier_name":"anatomy & histology","is_major_topic":false},{"descriptor_ui":"D009929","descriptor_name":"Organ Size","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010805","descriptor_name":"Physical Conditioning, Animal","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D012420","descriptor_name":"Running","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D012641","descriptor_name":"Selection, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1242/jeb.249213","doi":"https://doi.org/10.1242/jeb.249213","is_oa":false,"landing_page_url":"https://doi.org/10.1242/jeb.249213","pdf_url":null,"source":{"id":"https://openalex.org/S20257348","display_name":"Journal of Experimental Biology","issn_l":"0022-0949","issn":["0022-0949","1477-9145"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311847","host_organization_name":"The Company of Biologists","host_organization_lineage":["https://openalex.org/P4310311847"],"host_organization_lineage_names":["The Company of Biologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Experimental Biology","raw_type":"journal-article"},{"id":"pmid:39119628","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39119628","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of experimental biology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[{"display_name":"Systematic Review","id":"https://openalex.org/study-designs/systematic-review"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":94,"referenced_works":["https://openalex.org/W96165550","https://openalex.org/W347685255","https://openalex.org/W850830564","https://openalex.org/W1548178315","https://openalex.org/W1548331719","https://openalex.org/W1589728983","https://openalex.org/W1940276190","https://openalex.org/W1940311765","https://openalex.org/W1963539360","https://openalex.org/W1965635919","https://openalex.org/W1968055211","https://openalex.org/W1968314159","https://openalex.org/W1980099417","https://openalex.org/W1982070737","https://openalex.org/W1984340024","https://openalex.org/W1986361512","https://openalex.org/W1990545199","https://openalex.org/W1991945749","https://openalex.org/W2000942130","https://openalex.org/W2006331688","https://openalex.org/W2007652699","https://openalex.org/W2013914899","https://openalex.org/W2017421512","https://openalex.org/W2040798713","https://openalex.org/W2041053664","https://openalex.org/W2044695803","https://openalex.org/W2046860385","https://openalex.org/W2047820724","https://openalex.org/W2048047184","https://openalex.org/W2057525967","https://openalex.org/W2058725004","https://openalex.org/W2064985760","https://openalex.org/W2068862116","https://openalex.org/W2075418882","https://openalex.org/W2105696044","https://openalex.org/W2105824687","https://openalex.org/W2106225750","https://openalex.org/W2107026277","https://openalex.org/W2109848597","https://openalex.org/W2118134392","https://openalex.org/W2126400785","https://openalex.org/W2127555093","https://openalex.org/W2130494722","https://openalex.org/W2134316915","https://openalex.org/W2137070227","https://openalex.org/W2148740602","https://openalex.org/W2152505303","https://openalex.org/W2154564154","https://openalex.org/W2162778907","https://openalex.org/W2163004304","https://openalex.org/W2165748801","https://openalex.org/W2166042832","https://openalex.org/W2170645444","https://openalex.org/W2172242021","https://openalex.org/W2180277885","https://openalex.org/W2293040502","https://openalex.org/W2323115401","https://openalex.org/W2340674923","https://openalex.org/W2415095469","https://openalex.org/W2429635823","https://openalex.org/W2465955090","https://openalex.org/W2480985474","https://openalex.org/W2527755291","https://openalex.org/W2551708352","https://openalex.org/W2588402133","https://openalex.org/W2593883258","https://openalex.org/W2625356483","https://openalex.org/W2743825580","https://openalex.org/W2791712542","https://openalex.org/W2945098413","https://openalex.org/W2971263241","https://openalex.org/W2982425965","https://openalex.org/W3087943677","https://openalex.org/W3094205424","https://openalex.org/W3115592149","https://openalex.org/W3136911058","https://openalex.org/W3156444734","https://openalex.org/W3199368890","https://openalex.org/W4213014407","https://openalex.org/W4229721809","https://openalex.org/W4232439667","https://openalex.org/W4236691294","https://openalex.org/W4245549186","https://openalex.org/W4300819187","https://openalex.org/W4300870773","https://openalex.org/W4307465049","https://openalex.org/W4384126599","https://openalex.org/W4386045829","https://openalex.org/W4392024100","https://openalex.org/W4396719943","https://openalex.org/W4398232070","https://openalex.org/W4401210899","https://openalex.org/W6721790244","https://openalex.org/W6722503554"],"related_works":["https://openalex.org/W2175843266","https://openalex.org/W7028041560","https://openalex.org/W2148740602","https://openalex.org/W2143081611","https://openalex.org/W2064473037","https://openalex.org/W2041011068","https://openalex.org/W298127785","https://openalex.org/W2017421512","https://openalex.org/W2902831041","https://openalex.org/W2126676149"],"abstract_inverted_index":{"Selection":[0],"experiments":[1,14],"play":[2],"an":[3],"increasingly":[4],"important":[5],"role":[6],"in":[7,23,143,194,211],"comparative":[8],"and":[9,80,175,203,244],"evolutionary":[10],"physiology.":[11],"However,":[12],"selection":[13,94,113,225,236],"can":[15],"be":[16,139],"limited":[17],"by":[18],"relatively":[19],"low":[20],"statistical":[21,161,192],"power,":[22],"part":[24],"because":[25],"replicate":[26,106],"line":[27],"is":[28,55,157],"the":[29,49,128,219,224,235],"experimental":[30],"unit":[31],"for":[32,61,96,154,214,227,241],"analyses":[33],"of":[34,42,59,179,191],"direct":[35],"or":[36],"correlated":[37,53],"responses":[38,54],"(rather":[39],"than":[40,127],"number":[41],"individuals":[43],"measured).":[44],"One":[45],"way":[46],"to":[47,51,75,121,141,150,207,253],"increase":[48],"ability":[50],"detect":[52],"through":[56],"a":[57,62,88,91,177,189],"meta-analysis":[58],"studies":[60,174],"given":[63],"trait":[64],"across":[65],"multiple":[66],"generations.":[67],"To":[68],"demonstrate":[69],"this,":[70],"we":[71],"applied":[72],"meta-analytic":[73],"techniques":[74],"two":[76],"traits":[77,136,216],"(body":[78],"mass":[79,86,156,243,247],"heart":[81,147,245],"ventricle":[82,246],"mass,":[83],"with":[84,218],"body":[85,155,242],"as":[87],"covariate)":[89],"from":[90,171],"long-term":[92],"artificial":[93],"experiment":[95],"high":[97],"voluntary":[98],"wheel-running":[99,228],"behavior.":[100],"In":[101],"this":[102],"experiment,":[103],"all":[104],"four":[105,129],"High":[107],"Runner":[108],"(HR)":[109],"lines":[110,145],"reached":[111],"apparent":[112],"limits":[114],"around":[115],"generations":[116],"17-27,":[117],"running":[118],"approximately":[119],"2.5-":[120],"3-fold":[122],"more":[123],"revolutions":[124],"per":[125],"day":[126],"non-selected":[130],"Control":[131],"(C)":[132],"lines.":[133],"Although":[134],"both":[135,215],"would":[137],"also":[138],"expected":[140,149,152],"change":[142],"HR":[144,197],"(relative":[146],"size":[148,181],"increase,":[151],"direction":[153],"less":[158],"clear),":[159],"their":[160],"significance":[162,193],"has":[163],"varied,":[164],"despite":[165,188],"repeated":[166],"measurements.":[167],"We":[168],"compiled":[169],"information":[170],"33":[172],"unique":[173],"calculated":[176],"measure":[178],"effect":[180,212,239],"(Pearson's":[182],"R).":[183],"Our":[184],"results":[185],"indicate":[186],"that,":[187],"lack":[190],"most":[195],"generations,":[196],"mice":[198],"have":[199,248],"evolved":[200],"larger":[201],"hearts":[202],"smaller":[204,250],"bodies":[205],"relative":[206],"controls.":[208],"Moreover,":[209],"plateaus":[210],"sizes":[213,240],"coincide":[217],"generational":[220],"range":[221],"during":[222],"which":[223],"limit":[226],"behavior":[229],"was":[230],"reached.":[231],"Finally,":[232],"since":[233],"reaching":[234],"limit,":[237],"absolute":[238],"become":[249],"(i.e.":[251],"closer":[252],"0).":[254]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2024-08-10T00:00:00"}