{"id":"https://openalex.org/W4401435765","doi":"https://doi.org/10.3389/fmolb.2024.1401405","title":"Longitudinal evaluation of manufacturer-specific differences for high-sensitive CRP EQA results","display_name":"Longitudinal evaluation of manufacturer-specific differences for high-sensitive CRP EQA results","publication_year":2024,"publication_date":"2024-08-08","ids":{"openalex":"https://openalex.org/W4401435765","doi":"https://doi.org/10.3389/fmolb.2024.1401405","pmid":"https://pubmed.ncbi.nlm.nih.gov/39176390","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11338768"},"language":"en","primary_location":{"id":"doi:10.3389/fmolb.2024.1401405","doi":"https://doi.org/10.3389/fmolb.2024.1401405","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fmolb.2024.1401405","pdf_url":null,"source":{"id":"https://openalex.org/S2595797843","display_name":"Frontiers in Molecular Biosciences","issn_l":"2296-889X","issn":["2296-889X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-140","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Molecular Biosciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3389/fmolb.2024.1401405","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5070119445","display_name":"Nathalie Weiss","orcid":"https://orcid.org/0000-0002-1977-7931","observed_orcids":["https://orcid.org/0000-0002-1977-7931"]},"institutions":[{"id":"https://openalex.org/I4210106415","display_name":"Instand","ror":"https://ror.org/01n69pc33","country_code":"DE","type":"nonprofit","lineage":["https://openalex.org/I4210106415"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Nathalie Weiss","raw_affiliation_strings":["INSTAND e.V., Society for Promoting Quality Assurance in Medical Laboratories e.V., Duesseldorf, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INSTAND e.V., Society for Promoting Quality Assurance in Medical Laboratories e.V., Duesseldorf, Germany","institution_ids":["https://openalex.org/I4210106415"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015302819","display_name":"Laura Vierbaum","orcid":"https://orcid.org/0000-0002-3492-9796","observed_orcids":["https://orcid.org/0000-0002-3492-9796"]},"institutions":[{"id":"https://openalex.org/I4210106415","display_name":"Instand","ror":"https://ror.org/01n69pc33","country_code":"DE","type":"nonprofit","lineage":["https://openalex.org/I4210106415"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Laura Vierbaum","raw_affiliation_strings":["INSTAND e.V., Society for Promoting Quality Assurance in Medical Laboratories e.V., Duesseldorf, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INSTAND e.V., Society for Promoting Quality Assurance in Medical Laboratories e.V., Duesseldorf, Germany","institution_ids":["https://openalex.org/I4210106415"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049478976","display_name":"Marcel Kremser","orcid":"https://orcid.org/0000-0002-1174-3438","observed_orcids":["https://orcid.org/0000-0002-1174-3438"]},"institutions":[{"id":"https://openalex.org/I4210106415","display_name":"Instand","ror":"https://ror.org/01n69pc33","country_code":"DE","type":"nonprofit","lineage":["https://openalex.org/I4210106415"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Marcel Kremser","raw_affiliation_strings":["INSTAND e.V., Society for Promoting Quality Assurance in Medical Laboratories e.V., Duesseldorf, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INSTAND e.V., Society for Promoting Quality Assurance in Medical Laboratories e.V., Duesseldorf, Germany","institution_ids":["https://openalex.org/I4210106415"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5094260534","display_name":"Anne Kaufmann-Stoeck","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210106415","display_name":"Instand","ror":"https://ror.org/01n69pc33","country_code":"DE","type":"nonprofit","lineage":["https://openalex.org/I4210106415"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Anne Kaufmann-Stoeck","raw_affiliation_strings":["INSTAND e.V., Society for Promoting Quality Assurance in Medical Laboratories e.V., Duesseldorf, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INSTAND e.V., Society for Promoting Quality Assurance in Medical Laboratories e.V., Duesseldorf, Germany","institution_ids":["https://openalex.org/I4210106415"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5094260535","display_name":"Silke Kappler","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210106415","display_name":"Instand","ror":"https://ror.org/01n69pc33","country_code":"DE","type":"nonprofit","lineage":["https://openalex.org/I4210106415"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Silke Kappler","raw_affiliation_strings":["INSTAND e.V., Society for Promoting Quality Assurance in Medical Laboratories e.V., Duesseldorf, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INSTAND e.V., Society for Promoting Quality Assurance in Medical Laboratories e.V., Duesseldorf, Germany","institution_ids":["https://openalex.org/I4210106415"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017614616","display_name":"Silvia Ballert","orcid":"https://orcid.org/0000-0001-7092-2973","observed_orcids":["https://orcid.org/0000-0001-7092-2973"]},"institutions":[{"id":"https://openalex.org/I4210089758","display_name":"Anhalt University of Applied Sciences","ror":"https://ror.org/0076zct58","country_code":"DE","type":"education","lineage":["https://openalex.org/I4210089758"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Silvia Ballert","raw_affiliation_strings":["Institute of Bioanalytical Sciences (IBAS), Center of Life Sciences, Anhalt University of Applied Sciences, Bernburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Bioanalytical Sciences (IBAS), Center of Life Sciences, Anhalt University of Applied Sciences, Bernburg, Germany","institution_ids":["https://openalex.org/I4210089758"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035380955","display_name":"Kathrin Kabrodt","orcid":"https://orcid.org/0000-0002-9125-4887","observed_orcids":["https://orcid.org/0000-0002-9125-4887"]},"institutions":[{"id":"https://openalex.org/I4210089758","display_name":"Anhalt University of Applied Sciences","ror":"https://ror.org/0076zct58","country_code":"DE","type":"education","lineage":["https://openalex.org/I4210089758"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Kathrin Kabrodt","raw_affiliation_strings":["Institute of Bioanalytical Sciences (IBAS), Center of Life Sciences, Anhalt University of Applied Sciences, Bernburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Bioanalytical Sciences (IBAS), Center of Life Sciences, Anhalt University of Applied Sciences, Bernburg, Germany","institution_ids":["https://openalex.org/I4210089758"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032626470","display_name":"Klaus\u2010Peter Hunfeld","orcid":"https://orcid.org/0000-0001-6507-8608","observed_orcids":["https://orcid.org/0000-0001-6507-8608"]},"institutions":[{"id":"https://openalex.org/I114090438","display_name":"Goethe University Frankfurt","ror":"https://ror.org/04cvxnb49","country_code":"DE","type":"education","lineage":["https://openalex.org/I114090438"]},{"id":"https://openalex.org/I4210106415","display_name":"Instand","ror":"https://ror.org/01n69pc33","country_code":"DE","type":"nonprofit","lineage":["https://openalex.org/I4210106415"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Klaus-Peter Hunfeld","raw_affiliation_strings":["INSTAND e.V., Society for Promoting Quality Assurance in Medical Laboratories e.V., Duesseldorf, Germany","Medical Faculty, Northwest Medical Centre, Academic Teaching Hospital, Institute for Laboratory Medicine, Microbiology and Infection Control, Goethe University Frankfurt, Frankfurt, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INSTAND e.V., Society for Promoting Quality Assurance in Medical Laboratories e.V., Duesseldorf, Germany","institution_ids":["https://openalex.org/I4210106415"]},{"raw_affiliation_string":"Medical Faculty, Northwest Medical Centre, Academic Teaching Hospital, Institute for Laboratory Medicine, Microbiology and Infection Control, Goethe University Frankfurt, Frankfurt, Germany","institution_ids":["https://openalex.org/I114090438"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5024859522","display_name":"Ingo Schellenberg","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210089758","display_name":"Anhalt University of Applied Sciences","ror":"https://ror.org/0076zct58","country_code":"DE","type":"education","lineage":["https://openalex.org/I4210089758"]},{"id":"https://openalex.org/I4210106415","display_name":"Instand","ror":"https://ror.org/01n69pc33","country_code":"DE","type":"nonprofit","lineage":["https://openalex.org/I4210106415"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Ingo Schellenberg","raw_affiliation_strings":["INSTAND e.V., Society for Promoting Quality Assurance in Medical Laboratories e.V., Duesseldorf, Germany","Institute of Bioanalytical Sciences (IBAS), Center of Life Sciences, Anhalt University of Applied Sciences, Bernburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INSTAND e.V., Society for Promoting Quality Assurance in Medical Laboratories e.V., Duesseldorf, Germany","institution_ids":["https://openalex.org/I4210106415"]},{"raw_affiliation_string":"Institute of Bioanalytical Sciences (IBAS), Center of Life Sciences, Anhalt University of Applied Sciences, Bernburg, Germany","institution_ids":["https://openalex.org/I4210089758"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5070119445"],"corresponding_institution_ids":["https://openalex.org/I4210106415"],"apc_list":{"value":3295,"currency":"USD","value_usd":3295},"apc_paid":{"value":3295,"currency":"USD","value_usd":3295},"fwci":2.7253,"has_fulltext":true,"cited_by_count":5,"citation_normalized_percentile":{"value":0.88267193,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":97},"biblio":{"volume":"11","issue":null,"first_page":"1401405","last_page":"1401405"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11314","display_name":"Clinical Laboratory Practices and Quality Control","score":0.9810000061988831,"subfield":{"id":"https://openalex.org/subfields/3607","display_name":"Medical Laboratory Technology"},"field":{"id":"https://openalex.org/fields/36","display_name":"Health Professions"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11314","display_name":"Clinical Laboratory Practices and Quality Control","score":0.9810000061988831,"subfield":{"id":"https://openalex.org/subfields/3607","display_name":"Medical Laboratory Technology"},"field":{"id":"https://openalex.org/fields/36","display_name":"Health Professions"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":0.008299999870359898,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14245","display_name":"Biomarkers in Disease Mechanisms","score":0.0032999999821186066,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/high-sensitivity-c-reactive-protein","display_name":"high-sensitivity C-reactive protein","score":0.9810000061988831},{"id":"https://openalex.org/keywords/assay-harmonization","display_name":"assay harmonization","score":0.8640000224113464},{"id":"https://openalex.org/keywords/external-quality-assessment","display_name":"external quality assessment","score":0.9800000190734863},{"id":"https://openalex.org/keywords/cardiovascular-risk-stratification","display_name":"cardiovascular risk stratification","score":0.8429999947547913},{"id":"https://openalex.org/keywords/assay-bias","display_name":"assay bias","score":0.6060000061988831},{"id":"https://openalex.org/keywords/coefficient-of-variation","display_name":"coefficient of variation","score":0.8730000257492065},{"id":"https://openalex.org/keywords/cardiovascular-disease-risk-assessment","display_name":"cardiovascular disease risk assessment","score":0.703000009059906}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3613104224205017},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.32610899209976196},{"id":"https://openalex.org/C19527891","wikidata":"https://www.wikidata.org/wiki/Q1120908","display_name":"Medical physics","level":1,"score":0.3259258270263672}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.3389/fmolb.2024.1401405","doi":"https://doi.org/10.3389/fmolb.2024.1401405","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fmolb.2024.1401405","pdf_url":null,"source":{"id":"https://openalex.org/S2595797843","display_name":"Frontiers in Molecular Biosciences","issn_l":"2296-889X","issn":["2296-889X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-140","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Molecular Biosciences","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11338768","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11338768","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11338768/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Mol Biosci","raw_type":"Text"},{"id":"pmid:39176390","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39176390","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in molecular biosciences","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:5599a0040528466f92eb0aef8d8fde4a","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/5599a0040528466f92eb0aef8d8fde4a","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Molecular Biosciences, Vol 11 (2024)","raw_type":"article"},{"id":"pmh:oai:publikationen.ub.uni-frankfurt.de:87697","doi":null,"is_oa":true,"landing_page_url":"http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/87697","pdf_url":null,"source":{"id":"https://openalex.org/S4306400432","display_name":"Publication Server of Goethe University Frankfurt am Main (Goethe University Frankfurt)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I114090438","host_organization_name":"Goethe University Frankfurt","host_organization_lineage":["https://openalex.org/I114090438"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fmolb.2024.1401405","doi":"https://doi.org/10.3389/fmolb.2024.1401405","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fmolb.2024.1401405","pdf_url":null,"source":{"id":"https://openalex.org/S2595797843","display_name":"Frontiers in Molecular Biosciences","issn_l":"2296-889X","issn":["2296-889X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-140","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Molecular Biosciences","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4401435765.pdf","grobid_xml":"https://content.openalex.org/works/W4401435765.grobid-xml"},"referenced_works_count":36,"referenced_works":["https://openalex.org/W1569358024","https://openalex.org/W1972926621","https://openalex.org/W2024886564","https://openalex.org/W2026458419","https://openalex.org/W2061670942","https://openalex.org/W2066446780","https://openalex.org/W2104257769","https://openalex.org/W2130441942","https://openalex.org/W2137983259","https://openalex.org/W2149878320","https://openalex.org/W2159087408","https://openalex.org/W2161913081","https://openalex.org/W2402599050","https://openalex.org/W2567901815","https://openalex.org/W2586816621","https://openalex.org/W2599627323","https://openalex.org/W2748400555","https://openalex.org/W2755662129","https://openalex.org/W2771055636","https://openalex.org/W2852998865","https://openalex.org/W2886714802","https://openalex.org/W2967024862","https://openalex.org/W3021842026","https://openalex.org/W3198763602","https://openalex.org/W3200977026","https://openalex.org/W4229015026","https://openalex.org/W4243536911","https://openalex.org/W4308509933","https://openalex.org/W4362594885","https://openalex.org/W4378782109","https://openalex.org/W4380987757","https://openalex.org/W4386251618","https://openalex.org/W4391104889","https://openalex.org/W4395008381","https://openalex.org/W6801719172","https://openalex.org/W7214220068"],"related_works":["https://openalex.org/W4386660320","https://openalex.org/W2790533684","https://openalex.org/W2254552245","https://openalex.org/W2953110900","https://openalex.org/W2047953698","https://openalex.org/W2074688041","https://openalex.org/W1851605804","https://openalex.org/W2008239000","https://openalex.org/W1986480401","https://openalex.org/W2622552554"],"abstract_inverted_index":{"Background:":[0],"C-reactive":[1],"protein":[2],"(CRP)":[3],"is":[4,24,82],"an":[5,192],"established":[6],"serum":[7,128],"biomarker":[8],"for":[9,59,104,154,261],"different":[10,76,250,275],"pathologies":[11],"such":[12],"as":[13,159,161],"tissue":[14],"injury":[15],"and":[16,41,51,110],"inflammatory":[17],"events.":[18],"One":[19],"rising":[20],"area":[21],"of":[22,27,30,44,62,69,89,116,140,157,164,180,210,232,249],"interest":[23],"the":[25,38,52,60,66,86,122,137,150,162,196,208,224,236,262],"incorporation":[26],"low":[28],"concentrations":[29],"CRP,":[31,36],"so":[32],"called":[33],"high-sensitive":[34],"(hs-)":[35],"in":[37,65,174,223,266],"risk":[39,67],"assessment":[40,68,101],"treatment":[42],"monitoring":[43],"cardiovascular":[45],"diseases":[46],"(CVDs).":[47],"Many":[48],"research":[49],"projects":[50],"resulting":[53],"meta-analyses":[54],"have":[55,281],"reported":[56],"controversial":[57],"results":[58],"use":[61],"hs-CRP,":[63,80],"especially":[64],"CVDs.":[70],"However,":[71],"since":[72],"these":[73,221],"analyses":[74,168],"used":[75],"assays":[77,270],"to":[78,84,129,135,182,184,205,213,229,259,274],"detect":[79],"it":[81],"important":[83],"assess":[85,136],"current":[87,138],"level":[88],"assay":[90,141,237,258],"harmonization.":[91,287],"Methods:":[92],"This":[93],"paper":[94],"analyzes":[95],"data":[96],"from":[97,126,177,203],"17":[98],"external":[99],"quality":[100],"(EQA)":[102],"surveys":[103],"hs-CRP":[105,155],"conducted":[106],"worldwide":[107],"between":[108],"2018":[109],"2023.":[111],"Each":[112],"EQA":[113],"survey":[114],"consisted":[115],"two":[117],"blinded":[118],"samples.":[119,131],"In":[120],"2020":[121],"sample":[123,201],"material":[124],"changed":[125],"pooled":[127],"single-donor":[130,206],"The":[132],"aim":[133],"was":[134,242],"status":[139],"harmonization":[142,171],"by":[143,257],"a":[144,243,282],"manufacturer-based":[145],"approach,":[146],"taking":[147],"into":[148],"consideration":[149],"clinical":[151,225],"decision":[152],"limits":[153],"risk-stratification":[156],"CVDs":[158],"well":[160],"scatter":[163],"results.":[165],"Results:":[166],"Our":[167],"show":[169],"that":[170,190],"has":[172],"increased":[173],"recent":[175],"years":[176],"median":[178],"differences":[179,222,264],"up":[181],"50%":[183],"below":[185,214],"20%,":[186],"with":[187,216],"one":[188,217],"exception":[189],"showed":[191],"increasing":[193],"bias":[194],"throughout":[195],"observed":[197,265],"period.":[198],"After":[199],"changing":[200],"materials":[202],"pools":[204],"samples,":[207],"coefficient":[209],"variation":[211],"decreased":[212],"10%":[215],"exception.":[218],"Nevertheless,":[219],"even":[220],"setting":[226],"could":[227],"lead":[228],"disparate":[230],"classification":[231],"patients":[233],"depending":[234],"on":[235,285],"used.":[238],"Conclusion:":[239],"While":[240],"there":[241],"positive":[244],"trend":[245],"towards":[246],"harmonization,":[247],"meta-analysis":[248],"risk-score":[251],"publications":[252],"should":[253],"stratify":[254],"their":[255],"analysis":[256],"account":[260],"manufacturer-specific":[263],"this":[267],"paper.":[268],"Furthermore,":[269],"are":[271],"currently":[272],"traceable":[273],"international":[276],"standard":[277],"preparations,":[278],"which":[279],"might":[280],"negative":[283],"impact":[284],"future":[286]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":2}],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2024-08-09T00:00:00"}
