{"id":"https://openalex.org/W4401435546","doi":"https://doi.org/10.1016/j.ijbiomac.2024.134600","title":"RETRACTED: FTO-overexpressing extracellular vesicles from BM-MSCs reverse cellular senescence and aging to ameliorate osteoarthritis by modulating METTL3/YTHDF2-mediated RNA m6A modifications","display_name":"RETRACTED: FTO-overexpressing extracellular vesicles from BM-MSCs reverse cellular senescence and aging to ameliorate osteoarthritis by modulating METTL3/YTHDF2-mediated RNA m6A modifications","publication_year":2024,"publication_date":"2024-08-08","ids":{"openalex":"https://openalex.org/W4401435546","doi":"https://doi.org/10.1016/j.ijbiomac.2024.134600","pmid":"https://pubmed.ncbi.nlm.nih.gov/39122063"},"language":"en","primary_location":{"id":"doi:10.1016/j.ijbiomac.2024.134600","doi":"https://doi.org/10.1016/j.ijbiomac.2024.134600","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.ijbiomac.2024.134600","pdf_url":null,"source":{"id":"https://openalex.org/S83853393","display_name":"International Journal of Biological Macromolecules","issn_l":"0141-8130","issn":["0141-8130","1879-0003"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","medline","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Biological Macromolecules","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W4401435546"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100333458","display_name":"Lei Chen","orcid":"https://orcid.org/0000-0002-2846-6211","observed_orcids":["https://orcid.org/0000-0002-2846-6211"]},"institutions":[{"id":"https://openalex.org/I116953780","display_name":"Tongji University","ror":"https://ror.org/03rc6as71","country_code":"CN","type":"education","lineage":["https://openalex.org/I116953780"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lei Chen","raw_affiliation_strings":["Department of Orthopedics, Tongji Hospital, School of Medicine, Tongji University, 389 Xincun Road, Shanghai 200065, PR China; Clinical Research Center, Tongji Hospital, School of Medicine, Tongji University, 389 Xincun Road, Shanghai 200065, PR China","Clinical Research Center, Tongji Hospital, School of Medicine, Tongji University, 389 Xincun Road, Shanghai 200065, PR China","Department of Orthopedics, Tongji Hospital, School of Medicine, Tongji University, 389 Xincun Road, Shanghai 200065, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedics, Tongji Hospital, School of Medicine, Tongji University, 389 Xincun Road, Shanghai 200065, PR China; Clinical Research Center, Tongji Hospital, School of Medicine, Tongji University, 389 Xincun Road, Shanghai 200065, PR China","institution_ids":["https://openalex.org/I116953780"]},{"raw_affiliation_string":"Clinical Research Center, Tongji Hospital, School of Medicine, Tongji University, 389 Xincun Road, Shanghai 200065, PR China","institution_ids":["https://openalex.org/I116953780"]},{"raw_affiliation_string":"Department of Orthopedics, Tongji Hospital, School of Medicine, Tongji University, 389 Xincun Road, Shanghai 200065, PR China","institution_ids":["https://openalex.org/I116953780"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113113719","display_name":"Jia Liu","orcid":"https://orcid.org/0000-0002-0226-1066","observed_orcids":["https://orcid.org/0000-0002-0226-1066"]},"institutions":[{"id":"https://openalex.org/I116953780","display_name":"Tongji University","ror":"https://ror.org/03rc6as71","country_code":"CN","type":"education","lineage":["https://openalex.org/I116953780"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jia Liu","raw_affiliation_strings":["Department of Orthopedics, Tongji Hospital, School of Medicine, Tongji University, 389 Xincun Road, Shanghai 200065, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedics, Tongji Hospital, School of Medicine, Tongji University, 389 Xincun Road, Shanghai 200065, PR China","institution_ids":["https://openalex.org/I116953780"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5087595282","display_name":"Zhitao Rao","orcid":"https://orcid.org/0000-0002-6053-1378","observed_orcids":["https://orcid.org/0000-0002-6053-1378"]},"institutions":[{"id":"https://openalex.org/I116953780","display_name":"Tongji University","ror":"https://ror.org/03rc6as71","country_code":"CN","type":"education","lineage":["https://openalex.org/I116953780"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Zhitao Rao","raw_affiliation_strings":["Department of Orthopedics, Tongji Hospital, School of Medicine, Tongji University, 389 Xincun Road, Shanghai 200065, PR China. Electronic address: raozht1980@126.com","Department of Orthopedics, Tongji Hospital, School of Medicine, Tongji University, 389 Xincun Road, Shanghai 200065, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedics, Tongji Hospital, School of Medicine, Tongji University, 389 Xincun Road, Shanghai 200065, PR China. Electronic address: raozht1980@126.com","institution_ids":["https://openalex.org/I116953780"]},{"raw_affiliation_string":"Department of Orthopedics, Tongji Hospital, School of Medicine, Tongji University, 389 Xincun Road, Shanghai 200065, PR China","institution_ids":["https://openalex.org/I116953780"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5087595282"],"corresponding_institution_ids":["https://openalex.org/I116953780"],"apc_list":{"value":4260,"currency":"USD","value_usd":4260},"apc_paid":null,"fwci":6.6576,"has_fulltext":false,"cited_by_count":27,"citation_normalized_percentile":{"value":0.976018,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"278","issue":"Pt 1","first_page":"134600","last_page":"134600"},"is_retracted":true,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.9071999788284302,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.9071999788284302,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10773","display_name":"Extracellular vesicles in disease","score":0.05829999968409538,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.017899999395012856,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/osteoarthritis","display_name":"osteoarthritis","score":0.8859999775886536},{"id":"https://openalex.org/keywords/extracellular-vesicles","display_name":"extracellular vesicles","score":0.9570000171661377},{"id":"https://openalex.org/keywords/bone-marrow-mesenchymal-stem-cells","display_name":"bone marrow mesenchymal stem cells","score":0.9900000095367432},{"id":"https://openalex.org/keywords/fto-gene","display_name":"FTO","score":0.984000027179718},{"id":"https://openalex.org/keywords/mettl3","display_name":"METTL3","score":0.8019999861717224},{"id":"https://openalex.org/keywords/ythdf2","display_name":"YTHDF2","score":0.9990000128746033},{"id":"https://openalex.org/keywords/m6a-methylation","display_name":"m6A RNA methylation","score":0.7599999904632568},{"id":"https://openalex.org/keywords/cellular-senescence","display_name":"cellular senescence","score":0.9480000138282776},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.7129999995231628},{"id":"https://openalex.org/keywords/autophagy","display_name":"autophagy","score":0.8619999885559082},{"id":"https://openalex.org/keywords/chondrocytes","display_name":"chondrocytes","score":0.8989999890327454},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.8330000042915344},{"id":"https://openalex.org/keywords/bnip3","display_name":"BNIP3","score":0.8109999895095825},{"id":"https://openalex.org/keywords/retraction","display_name":"retraction","score":0.37700000405311584}],"concepts":[{"id":"https://openalex.org/C203522944","wikidata":"https://www.wikidata.org/wiki/Q288322","display_name":"Autophagy","level":3,"score":0.7803430557250977},{"id":"https://openalex.org/C2781000418","wikidata":"https://www.wikidata.org/wiki/Q18034312","display_name":"ATG5","level":4,"score":0.774054765701294},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.678429126739502},{"id":"https://openalex.org/C173396325","wikidata":"https://www.wikidata.org/wiki/Q1501275","display_name":"Gene knockdown","level":3,"score":0.6650082468986511},{"id":"https://openalex.org/C198826908","wikidata":"https://www.wikidata.org/wiki/Q1922379","display_name":"Mesenchymal stem cell","level":2,"score":0.655463695526123},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.6547953486442566},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6293398141860962},{"id":"https://openalex.org/C522857546","wikidata":"https://www.wikidata.org/wiki/Q2070979","display_name":"Senescence","level":2,"score":0.5304391384124756},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.4785362184047699},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.35293322801589966},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.23053839802742004},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.11274740099906921},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.08502420783042908}],"mesh":[{"descriptor_ui":"D000067128","descriptor_name":"Extracellular Vesicles","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000071516","descriptor_name":"Alpha-Ketoglutarate-Dependent Dioxygenase FTO","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000071516","descriptor_name":"Alpha-Ketoglutarate-Dependent Dioxygenase FTO","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000097906","descriptor_name":"RNA Methylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000241","descriptor_name":"Adenosine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D000241","descriptor_name":"Adenosine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001343","descriptor_name":"Autophagy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008780","descriptor_name":"Methyltransferases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008780","descriptor_name":"Methyltransferases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010003","descriptor_name":"Osteoarthritis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D010003","descriptor_name":"Osteoarthritis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010003","descriptor_name":"Osteoarthritis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D010003","descriptor_name":"Osteoarthritis","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D012313","descriptor_name":"RNA","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012313","descriptor_name":"RNA","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016601","descriptor_name":"RNA-Binding Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D016601","descriptor_name":"RNA-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016922","descriptor_name":"Cellular Senescence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019902","descriptor_name":"Chondrocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D024101","descriptor_name":"Mitochondrial Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059630","descriptor_name":"Mesenchymal Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.ijbiomac.2024.134600","doi":"https://doi.org/10.1016/j.ijbiomac.2024.134600","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.ijbiomac.2024.134600","pdf_url":null,"source":{"id":"https://openalex.org/S83853393","display_name":"International Journal of Biological Macromolecules","issn_l":"0141-8130","issn":["0141-8130","1879-0003"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","medline","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Biological Macromolecules","raw_type":"journal-article"},{"id":"pmid:39122063","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39122063","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of biological macromolecules","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9476000070571899,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2443837076","display_name":null,"funder_award_id":"22Y11911900","funder_id":"https://openalex.org/F4320327786","funder_display_name":"Major Technology Innovation Projects of Jiangsu Province"},{"id":"https://openalex.org/G5641500620","display_name":null,"funder_award_id":"82271435","funder_id":"https://openalex.org/F4320326181","funder_display_name":"National Aerospace Science Foundation of China"},{"id":"https://openalex.org/G636653187","display_name":null,"funder_award_id":"82271435","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G6938739588","display_name":null,"funder_award_id":"2021PJD064","funder_id":"https://openalex.org/F4320329904","funder_display_name":"Yunan Ten Thousand Talents Plan Young and Elite Talents Project"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320326181","display_name":"National Aerospace Science Foundation of China","ror":null},{"id":"https://openalex.org/F4320327786","display_name":"Major Technology Innovation Projects of Jiangsu Province","ror":null},{"id":"https://openalex.org/F4320329904","display_name":"Yunan Ten Thousand Talents Plan Young and Elite Talents Project","ror":null}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":41,"referenced_works":["https://openalex.org/W2596302024","https://openalex.org/W2626721076","https://openalex.org/W2770892112","https://openalex.org/W2931058147","https://openalex.org/W2947165071","https://openalex.org/W2970578839","https://openalex.org/W3101423962","https://openalex.org/W3127756908","https://openalex.org/W3128585320","https://openalex.org/W3176734525","https://openalex.org/W3184664738","https://openalex.org/W3195742959","https://openalex.org/W3199406024","https://openalex.org/W3206218751","https://openalex.org/W3210206291","https://openalex.org/W3211034774","https://openalex.org/W3214563279","https://openalex.org/W3217347066","https://openalex.org/W4205419579","https://openalex.org/W4206368060","https://openalex.org/W4210939839","https://openalex.org/W4283156085","https://openalex.org/W4283808777","https://openalex.org/W4285403931","https://openalex.org/W4285489723","https://openalex.org/W4285677480","https://openalex.org/W4293230983","https://openalex.org/W4294939904","https://openalex.org/W4296401130","https://openalex.org/W4298396277","https://openalex.org/W4308891621","https://openalex.org/W4311662970","https://openalex.org/W4312066084","https://openalex.org/W4318985524","https://openalex.org/W4319080389","https://openalex.org/W4321018592","https://openalex.org/W4323654584","https://openalex.org/W4323971979","https://openalex.org/W4362523900","https://openalex.org/W4380893739","https://openalex.org/W6842277758"],"related_works":["https://openalex.org/W4404634023","https://openalex.org/W4324142114","https://openalex.org/W4403558567","https://openalex.org/W3154006597","https://openalex.org/W3163988616","https://openalex.org/W3175183767","https://openalex.org/W4396972875","https://openalex.org/W4406069803","https://openalex.org/W3211034774","https://openalex.org/W4416122649"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":16},{"year":2025,"cited_by_count":11}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2024-08-09T00:00:00"}