{"id":"https://openalex.org/W4401428193","doi":"https://doi.org/10.1080/17568919.2024.2383165","title":"Design, synthesis and evaluation of novel norfloxacin analogs as potent anticancer and antioxidant agents","display_name":"Design, synthesis and evaluation of novel norfloxacin analogs as potent anticancer and antioxidant agents","publication_year":2024,"publication_date":"2024-08-08","ids":{"openalex":"https://openalex.org/W4401428193","doi":"https://doi.org/10.1080/17568919.2024.2383165","pmid":"https://pubmed.ncbi.nlm.nih.gov/39115052","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11457674"},"language":"en","primary_location":{"id":"doi:10.1080/17568919.2024.2383165","doi":"https://doi.org/10.1080/17568919.2024.2383165","is_oa":false,"landing_page_url":"https://doi.org/10.1080/17568919.2024.2383165","pdf_url":null,"source":{"id":"https://openalex.org/S122867665","display_name":"Future Medicinal Chemistry","issn_l":"1756-8919","issn":["1756-8919","1756-8927"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320316","host_organization_name":"Future Science Ltd","host_organization_lineage":["https://openalex.org/P4310320316"],"host_organization_lineage_names":["Future Science Ltd"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Future Medicinal Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11457674/pdf/IFMC_16_2383165.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5106360085","display_name":"Faraz Qurban","orcid":"https://orcid.org/0009-0007-2320-1891","observed_orcids":["https://orcid.org/0009-0007-2320-1891"]},"institutions":[{"id":"https://openalex.org/I16076960","display_name":"COMSATS University Islamabad","ror":"https://ror.org/00nqqvk19","country_code":"PK","type":"education","lineage":["https://openalex.org/I16076960"]},{"id":"https://openalex.org/I4405259367","display_name":"People's University of Medical and Health Sciences for Women","ror":"https://ror.org/024m1xa82","country_code":"PK","type":"education","lineage":["https://openalex.org/I4405259367"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Faraz Qurban","raw_affiliation_strings":["Department of Pharmacy, COMSATS University Islamabad, Abbottabad Campus, Abbottabad, 22060, Pakistan","Institute of Pharmaceutical Sciences, Peoples University of Medical & Health Sciences for Women, Nawabshah \u2013 Shaheed Benazirabad, Sindh, 67480, Pakistan"],"raw_orcid":"https://orcid.org/0009-0007-2320-1891","affiliations":[{"raw_affiliation_string":"Department of Pharmacy, COMSATS University Islamabad, Abbottabad Campus, Abbottabad, 22060, Pakistan","institution_ids":["https://openalex.org/I16076960"]},{"raw_affiliation_string":"Institute of Pharmaceutical Sciences, Peoples University of Medical & Health Sciences for Women, Nawabshah \u2013 Shaheed Benazirabad, Sindh, 67480, Pakistan","institution_ids":["https://openalex.org/I4405259367"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073152904","display_name":"Sohail Anjum Shahzad","orcid":"https://orcid.org/0000-0002-4226-3023","observed_orcids":["https://orcid.org/0000-0002-4226-3023"]},"institutions":[{"id":"https://openalex.org/I16076960","display_name":"COMSATS University Islamabad","ror":"https://ror.org/00nqqvk19","country_code":"PK","type":"education","lineage":["https://openalex.org/I16076960"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Sohail Anjum Shahzad","raw_affiliation_strings":["Department of Chemistry, COMSATS University Islamabad, Abbottabad Campus, Abbottabad, 22060, Pakistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, COMSATS University Islamabad, Abbottabad Campus, Abbottabad, 22060, Pakistan","institution_ids":["https://openalex.org/I16076960"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030321877","display_name":"Muhammad Saleh Khaskheli","orcid":"https://orcid.org/0000-0001-9699-2152","observed_orcids":["https://orcid.org/0000-0001-9699-2152"]},"institutions":[{"id":"https://openalex.org/I4405259367","display_name":"People's University of Medical and Health Sciences for Women","ror":"https://ror.org/024m1xa82","country_code":"PK","type":"education","lineage":["https://openalex.org/I4405259367"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Muhammad Saleh Khaskheli","raw_affiliation_strings":["Department of Anesthesiology, Peoples University of Medical & Health Sciences for Women, Nawab Shah \u2013 Shaheed Benazirabad, Sindh, 67480, Pakistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, Peoples University of Medical & Health Sciences for Women, Nawab Shah \u2013 Shaheed Benazirabad, Sindh, 67480, Pakistan","institution_ids":["https://openalex.org/I4405259367"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071910046","display_name":"Shafi Ullah Khan","orcid":"https://orcid.org/0000-0001-9231-1831","observed_orcids":["https://orcid.org/0000-0001-9231-1831","https://orcid.org/0000-0003-1305-4334"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I16076960","display_name":"COMSATS University Islamabad","ror":"https://ror.org/00nqqvk19","country_code":"PK","type":"education","lineage":["https://openalex.org/I16076960"]},{"id":"https://openalex.org/I4210105918","display_name":"Normandie Universit\u00e9","ror":"https://ror.org/01k40cz91","country_code":"FR","type":"education","lineage":["https://openalex.org/I4210105918"]},{"id":"https://openalex.org/I4210121964","display_name":"Centre Fran\u00e7ois Baclesse","ror":"https://ror.org/02x9y0j10","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210121964"]},{"id":"https://openalex.org/I4210133993","display_name":"Cancers et Pr\u00e9ventions","ror":"https://ror.org/03v83q278","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I4210105918","https://openalex.org/I4210114068","https://openalex.org/I4210133993","https://openalex.org/I4210139802","https://openalex.org/I4210139971","https://openalex.org/I4210141925","https://openalex.org/I98702875"]},{"id":"https://openalex.org/I4392021178","display_name":"Unit\u00e9 de recherche interdisciplinaire pour la pr\u00e9vention et le traitement des cancers","ror":"https://ror.org/04b8tg719","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I4210105918","https://openalex.org/I4392021178","https://openalex.org/I98702875"]},{"id":"https://openalex.org/I98702875","display_name":"Universit\u00e9 de Caen Normandie","ror":"https://ror.org/051kpcy16","country_code":"FR","type":"education","lineage":["https://openalex.org/I4210105918","https://openalex.org/I98702875"]}],"countries":["FR","PK"],"is_corresponding":false,"raw_author_name":"Shafi ullah Khan","raw_affiliation_strings":["Department of Pharmacy, COMSATS University Islamabad, Abbottabad Campus, Abbottabad, 22060, Pakistan","Normandie University, UNICAEN, INSERM U1086 \u201cANTICIPE\u201d (Interdisciplinary Research Unit for Cancers Prevention & Treatment), Centre Fran\u00e7ois Baclesse, 3 avenue G\u00e9n\u00e9ral Harris, Caen, 14000, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, COMSATS University Islamabad, Abbottabad Campus, Abbottabad, 22060, Pakistan","institution_ids":["https://openalex.org/I16076960"]},{"raw_affiliation_string":"Normandie University, UNICAEN, INSERM U1086 \u201cANTICIPE\u201d (Interdisciplinary Research Unit for Cancers Prevention & Treatment), Centre Fran\u00e7ois Baclesse, 3 avenue G\u00e9n\u00e9ral Harris, Caen, 14000, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210105918","https://openalex.org/I4210121964","https://openalex.org/I4210133993","https://openalex.org/I4392021178","https://openalex.org/I98702875"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082563651","display_name":"Shujaat Ali Khan","orcid":"https://orcid.org/0000-0001-7514-1308","observed_orcids":["https://orcid.org/0000-0001-7514-1308"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I16076960","display_name":"COMSATS University Islamabad","ror":"https://ror.org/00nqqvk19","country_code":"PK","type":"education","lineage":["https://openalex.org/I16076960"]},{"id":"https://openalex.org/I4210105918","display_name":"Normandie Universit\u00e9","ror":"https://ror.org/01k40cz91","country_code":"FR","type":"education","lineage":["https://openalex.org/I4210105918"]},{"id":"https://openalex.org/I4210121964","display_name":"Centre Fran\u00e7ois Baclesse","ror":"https://ror.org/02x9y0j10","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210121964"]},{"id":"https://openalex.org/I4210133993","display_name":"Cancers et Pr\u00e9ventions","ror":"https://ror.org/03v83q278","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I4210105918","https://openalex.org/I4210114068","https://openalex.org/I4210133993","https://openalex.org/I4210139802","https://openalex.org/I4210139971","https://openalex.org/I4210141925","https://openalex.org/I98702875"]},{"id":"https://openalex.org/I4392021178","display_name":"Unit\u00e9 de recherche interdisciplinaire pour la pr\u00e9vention et le traitement des cancers","ror":"https://ror.org/04b8tg719","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I4210105918","https://openalex.org/I4392021178","https://openalex.org/I98702875"]},{"id":"https://openalex.org/I98702875","display_name":"Universit\u00e9 de Caen Normandie","ror":"https://ror.org/051kpcy16","country_code":"FR","type":"education","lineage":["https://openalex.org/I4210105918","https://openalex.org/I98702875"]}],"countries":["FR","PK"],"is_corresponding":false,"raw_author_name":"Shujaat Ali Khan","raw_affiliation_strings":["Department of Pharmacy, COMSATS University Islamabad, Abbottabad Campus, Abbottabad, 22060, Pakistan","Normandie University, UNICAEN, INSERM U1086 \u201cANTICIPE\u201d (Interdisciplinary Research Unit for Cancers Prevention & Treatment), Centre Fran\u00e7ois Baclesse, 3 avenue G\u00e9n\u00e9ral Harris, Caen, 14000, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, COMSATS University Islamabad, Abbottabad Campus, Abbottabad, 22060, Pakistan","institution_ids":["https://openalex.org/I16076960"]},{"raw_affiliation_string":"Normandie University, UNICAEN, INSERM U1086 \u201cANTICIPE\u201d (Interdisciplinary Research Unit for Cancers Prevention & Treatment), Centre Fran\u00e7ois Baclesse, 3 avenue G\u00e9n\u00e9ral Harris, Caen, 14000, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210105918","https://openalex.org/I4210121964","https://openalex.org/I4210133993","https://openalex.org/I4392021178","https://openalex.org/I98702875"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082271687","display_name":"Waqar Rauf","orcid":"https://orcid.org/0000-0003-2853-3493","observed_orcids":["https://orcid.org/0000-0003-2853-3493"]},"institutions":[{"id":"https://openalex.org/I1308171952","display_name":"National Institute for Biotechnology and Genetic Engineering","ror":"https://ror.org/01bh91531","country_code":"PK","type":"education","lineage":["https://openalex.org/I1308171952"]},{"id":"https://openalex.org/I134276161","display_name":"Pakistan Institute of Engineering and Applied Sciences","ror":"https://ror.org/04d4mbk19","country_code":"PK","type":"education","lineage":["https://openalex.org/I134276161"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Waqar Rauf","raw_affiliation_strings":["Pakistan Institute of Engineering & Applied Sciences, Health Biotechnology Division, National Institute for Biotechnology & Genetic Engineering (NIBGE-C, PIEAS), Faisalabad, 38000, Pakistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pakistan Institute of Engineering & Applied Sciences, Health Biotechnology Division, National Institute for Biotechnology & Genetic Engineering (NIBGE-C, PIEAS), Faisalabad, 38000, Pakistan","institution_ids":["https://openalex.org/I1308171952","https://openalex.org/I134276161"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100729741","display_name":"Shamsul Islam","orcid":"https://orcid.org/0000-0002-5009-256X","observed_orcids":["https://orcid.org/0000-0002-5009-256X"]},"institutions":[{"id":"https://openalex.org/I16076960","display_name":"COMSATS University Islamabad","ror":"https://ror.org/00nqqvk19","country_code":"PK","type":"education","lineage":["https://openalex.org/I16076960"]}],"countries":["PK"],"is_corresponding":true,"raw_author_name":"Shamsul Islam","raw_affiliation_strings":["Department of Pharmacy, COMSATS University Islamabad, Abbottabad Campus, Abbottabad, 22060, Pakistan"],"raw_orcid":"https://orcid.org/0000-0002-4226-3023","affiliations":[{"raw_affiliation_string":"Department of Pharmacy, COMSATS University Islamabad, Abbottabad Campus, Abbottabad, 22060, Pakistan","institution_ids":["https://openalex.org/I16076960"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5081140948","display_name":"Abdul Mannan","orcid":"https://orcid.org/0000-0001-9964-2633","observed_orcids":["https://orcid.org/0000-0001-9964-2633"]},"institutions":[{"id":"https://openalex.org/I16076960","display_name":"COMSATS University Islamabad","ror":"https://ror.org/00nqqvk19","country_code":"PK","type":"education","lineage":["https://openalex.org/I16076960"]}],"countries":["PK"],"is_corresponding":true,"raw_author_name":"Abdul Mannan","raw_affiliation_strings":["Department of Pharmacy, COMSATS University Islamabad, Abbottabad Campus, Abbottabad, 22060, Pakistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, COMSATS University Islamabad, Abbottabad Campus, Abbottabad, 22060, Pakistan","institution_ids":["https://openalex.org/I16076960"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":10,"corresponding_author_ids":["https://openalex.org/A5081140948","https://openalex.org/A5100729741"],"corresponding_institution_ids":["https://openalex.org/I16076960"],"apc_list":null,"apc_paid":null,"fwci":0.6871,"has_fulltext":true,"cited_by_count":5,"citation_normalized_percentile":{"value":0.55339762,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":97},"biblio":{"volume":"16","issue":"17","first_page":"1777","last_page":"1789"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10274","display_name":"Heterocyclic Compound Synthesis and Bioactivity","score":0.7768999934196472,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10274","display_name":"Heterocyclic Compound Synthesis and Bioactivity","score":0.7768999934196472,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T13160","display_name":"Synthesis and Biological Evaluation","score":0.13779999315738678,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T14099","display_name":"Synthesis and Characterization of Heterocyclic Compounds","score":0.05939999967813492,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fluoroquinolones","display_name":"fluoroquinolones","score":0.8040000200271606},{"id":"https://openalex.org/keywords/anticancer-agents","display_name":"anticancer agents","score":0.9729999899864197},{"id":"https://openalex.org/keywords/antioxidant-activity","display_name":"antioxidant activity","score":0.9229999780654907},{"id":"https://openalex.org/keywords/antiproliferative-activity","display_name":"antiproliferative activity","score":0.9350000023841858},{"id":"https://openalex.org/keywords/hela-cells","display_name":"HeLa cells","score":0.9900000095367432},{"id":"https://openalex.org/keywords/bcl-2","display_name":"Bcl-2","score":0.8009999990463257},{"id":"https://openalex.org/keywords/tyrosinase","display_name":"tyrosinase","score":0.968999981880188},{"id":"https://openalex.org/keywords/molecular-docking","display_name":"molecular docking","score":0.8460000157356262},{"id":"https://openalex.org/keywords/adme-prediction","display_name":"ADME prediction","score":0.7799999713897705},{"id":"https://openalex.org/keywords/drug-likeness","display_name":"drug-likeness","score":0.5910000205039978},{"id":"https://openalex.org/keywords/gastrointestinal-absorption","display_name":"gastrointestinal absorption","score":0.5440000295639038},{"id":"https://openalex.org/keywords/structure-activity-relationship","display_name":"structure-activity relationship","score":0.6769999861717224}],"concepts":[{"id":"https://openalex.org/C2778746504","wikidata":"https://www.wikidata.org/wiki/Q417897","display_name":"Norfloxacin","level":4,"score":0.8808820843696594},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.6103223562240601},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5775148868560791},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5395808219909668},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.46808725595474243},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.2526005506515503},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.22539547085762024},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.22174805402755737},{"id":"https://openalex.org/C2778512257","wikidata":"https://www.wikidata.org/wiki/Q256602","display_name":"Ciprofloxacin","level":3,"score":0.07604768872261047}],"mesh":[{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D000975","descriptor_name":"Antioxidants","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D000975","descriptor_name":"Antioxidants","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000975","descriptor_name":"Antioxidants","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004354","descriptor_name":"Drug Screening Assays, Antitumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006367","descriptor_name":"HeLa Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009643","descriptor_name":"Norfloxacin","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D009643","descriptor_name":"Norfloxacin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015195","descriptor_name":"Drug Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015394","descriptor_name":"Molecular Structure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D062105","descriptor_name":"Molecular Docking Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1080/17568919.2024.2383165","doi":"https://doi.org/10.1080/17568919.2024.2383165","is_oa":false,"landing_page_url":"https://doi.org/10.1080/17568919.2024.2383165","pdf_url":null,"source":{"id":"https://openalex.org/S122867665","display_name":"Future Medicinal Chemistry","issn_l":"1756-8919","issn":["1756-8919","1756-8927"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320316","host_organization_name":"Future Science Ltd","host_organization_lineage":["https://openalex.org/P4310320316"],"host_organization_lineage_names":["Future Science Ltd"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Future Medicinal Chemistry","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11457674","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11457674","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11457674/pdf/IFMC_16_2383165.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Future Med Chem","raw_type":"Text"},{"id":"pmid:39115052","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39115052","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Future medicinal chemistry","raw_type":"Journal Article"},{"id":"pmh:oai:HAL:hal-05559985v1","doi":null,"is_oa":false,"landing_page_url":"https://normandie-univ.hal.science/hal-05559985","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Future Medicinal Chemistry, 2024, 16 (17), pp.1777-1789. &#x27E8;10.1080/17568919.2024.2383165&#x27E9;","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:11457674","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11457674","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11457674/pdf/IFMC_16_2383165.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Future Med Chem","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320310725","display_name":"University of Karachi","ror":"https://ror.org/05bbbc791"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4401428193.pdf","grobid_xml":"https://content.openalex.org/works/W4401428193.grobid-xml"},"referenced_works_count":25,"referenced_works":["https://openalex.org/W1990766453","https://openalex.org/W2009119070","https://openalex.org/W2012087756","https://openalex.org/W2016761141","https://openalex.org/W2094156327","https://openalex.org/W2115545129","https://openalex.org/W2498876603","https://openalex.org/W2553039496","https://openalex.org/W2593436234","https://openalex.org/W2769426045","https://openalex.org/W2891634759","https://openalex.org/W2982689983","https://openalex.org/W3019686017","https://openalex.org/W3024577764","https://openalex.org/W3036318564","https://openalex.org/W3093860382","https://openalex.org/W3124020797","https://openalex.org/W3210404717","https://openalex.org/W4206516945","https://openalex.org/W4210850478","https://openalex.org/W4214806713","https://openalex.org/W4236463097","https://openalex.org/W4281968445","https://openalex.org/W4388833208","https://openalex.org/W4392596288"],"related_works":["https://openalex.org/W3168428297","https://openalex.org/W3095322137","https://openalex.org/W2035219947","https://openalex.org/W1720414770","https://openalex.org/W4312333425","https://openalex.org/W2911432729","https://openalex.org/W2037327393","https://openalex.org/W4281616359","https://openalex.org/W4410146940","https://openalex.org/W2980010113"],"abstract_inverted_index":{"Aim:":[0],"To":[1],"synthesize":[2],"a":[3,116],"novel":[4,117],"series":[5],"of":[6,44,67,86,95],"norfloxacin":[7,15,112],"analogs":[8,16,113],"and":[9,19,23,27,74,83,100],"to":[10,57],"evaluate":[11],"biological":[12,106],"activity.Methodology:":[13],"Novel":[14],"were":[17,30],"synthesized":[18,90,111],"characterized":[20],"by":[21],"NMR":[22],"mass":[24],"spectrometry.":[25],"Antiproliferative":[26],"antioxidant":[28,59,76],"properties":[29],"studied.Results:":[31],"Compound":[32],"2f":[33],"was":[34],"the":[35,110],"most":[36],"potent":[37],"against":[38],"HeLa":[39],"cell-line":[40],"with":[41,69],"100%":[42],"inhibition":[43],"cell":[45],"viability":[46],"IC50":[47],"=":[48],"3.1":[49],"\u00b1":[50],"0.2":[51],"\u03bcM.":[52],"All":[53],"compounds":[54,68,87,91],"exhibit":[55],"moderate":[56],"excellent":[58],"properties.":[60],"Docking":[61],"study":[62],"demonstrates":[63],"higher":[64],"binding":[65],"affinity":[66],"respective":[70],"anticancer":[71,121],"(B-cell":[72],"lymphoma-2)":[73],"(tyrosinase)":[75],"targets.":[77],"In":[78],"silico":[79],"absorption,":[80],"distribution,":[81],"metabolism":[82],"excretion":[84],"profile":[85,107],"proves":[88],"all":[89],"follow":[92],"Lipinski\u2019s":[93],"rule":[94],"drug":[96,122],"likeness,":[97],"non":[98],"toxic":[99],"possess":[101],"passive":[102],"gastrointestinal":[103],"absorption.Conclusion:":[104],"The":[105],"suggest":[108],"that":[109],"can":[114],"be":[115],"scaffold":[118],"for":[119],"future":[120],"development.":[123]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":3}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2024-08-09T00:00:00"}
