{"id":"https://openalex.org/W4401425201","doi":"https://doi.org/10.1007/s11033-024-09840-8","title":"Harnessing the power of clustered regularly interspaced short palindromic repeats (CRISPR) based microfluidics for next-generation molecular diagnostics","display_name":"Harnessing the power of clustered regularly interspaced short palindromic repeats (CRISPR) based microfluidics for next-generation molecular diagnostics","publication_year":2024,"publication_date":"2024-08-08","ids":{"openalex":"https://openalex.org/W4401425201","doi":"https://doi.org/10.1007/s11033-024-09840-8","pmid":"https://pubmed.ncbi.nlm.nih.gov/39115550"},"language":"en","primary_location":{"id":"doi:10.1007/s11033-024-09840-8","doi":"https://doi.org/10.1007/s11033-024-09840-8","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s11033-024-09840-8","pdf_url":null,"source":{"id":"https://openalex.org/S197962172","display_name":"Molecular Biology Reports","issn_l":"0301-4851","issn":["0301-4851","1573-4978"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Biology Reports","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108830870","display_name":"Rasanpreet Kaur","orcid":"https://orcid.org/0000-0001-6535-9311","observed_orcids":["https://orcid.org/0000-0001-6535-9311"]},"institutions":[{"id":"https://openalex.org/I82571370","display_name":"GLA University","ror":"https://ror.org/05fnxgv12","country_code":"IN","type":"education","lineage":["https://openalex.org/I82571370"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Rasanpreet Kaur","raw_affiliation_strings":["Department of Biotechnology, Institute of Applied Sciences & Humanities, GLA University, Chaumuhan, 281406, Mathura, Uttar Pradesh, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biotechnology, Institute of Applied Sciences & Humanities, GLA University, Chaumuhan, 281406, Mathura, Uttar Pradesh, India","institution_ids":["https://openalex.org/I82571370"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101417549","display_name":"Saurabh Kumar Gupta","orcid":"https://orcid.org/0000-0003-4671-9144","observed_orcids":["https://orcid.org/0000-0003-4671-9144"]},"institutions":[{"id":"https://openalex.org/I82571370","display_name":"GLA University","ror":"https://ror.org/05fnxgv12","country_code":"IN","type":"education","lineage":["https://openalex.org/I82571370"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Saurabh Gupta","raw_affiliation_strings":["Department of Biotechnology, Institute of Applied Sciences & Humanities, GLA University, Chaumuhan, 281406, Mathura, Uttar Pradesh, India. saurabh.gupta@gla.ac.in","Department of Biotechnology, Institute of Applied Sciences & Humanities, GLA University, Chaumuhan, 281406, Mathura, Uttar Pradesh, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biotechnology, Institute of Applied Sciences & Humanities, GLA University, Chaumuhan, 281406, Mathura, Uttar Pradesh, India. saurabh.gupta@gla.ac.in","institution_ids":["https://openalex.org/I82571370"]},{"raw_affiliation_string":"Department of Biotechnology, Institute of Applied Sciences & Humanities, GLA University, Chaumuhan, 281406, Mathura, Uttar Pradesh, India","institution_ids":["https://openalex.org/I82571370"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024211918","display_name":"Arjun Chauhan","orcid":"https://orcid.org/0000-0003-1188-8386","observed_orcids":["https://orcid.org/0000-0003-1188-8386"]},"institutions":[{"id":"https://openalex.org/I82571370","display_name":"GLA University","ror":"https://ror.org/05fnxgv12","country_code":"IN","type":"education","lineage":["https://openalex.org/I82571370"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Arjun Chauhan","raw_affiliation_strings":["Department of Biotechnology, Institute of Applied Sciences & Humanities, GLA University, Chaumuhan, 281406, Mathura, Uttar Pradesh, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biotechnology, Institute of Applied Sciences & Humanities, GLA University, Chaumuhan, 281406, Mathura, Uttar Pradesh, India","institution_ids":["https://openalex.org/I82571370"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101288804","display_name":"Vidhi Mishra","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I82571370","display_name":"GLA University","ror":"https://ror.org/05fnxgv12","country_code":"IN","type":"education","lineage":["https://openalex.org/I82571370"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Vidhi Mishra","raw_affiliation_strings":["Department of Biotechnology, Institute of Applied Sciences & Humanities, GLA University, Chaumuhan, 281406, Mathura, Uttar Pradesh, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biotechnology, Institute of Applied Sciences & Humanities, GLA University, Chaumuhan, 281406, Mathura, Uttar Pradesh, India","institution_ids":["https://openalex.org/I82571370"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100643912","display_name":"Manish Kumar Sharma","orcid":"https://orcid.org/0000-0002-1574-565X","observed_orcids":["https://orcid.org/0000-0002-1574-565X"]},"institutions":[{"id":"https://openalex.org/I1337315214","display_name":"Dr. Ram Manohar Lohia Avadh University","ror":"https://ror.org/02797hn66","country_code":"IN","type":"education","lineage":["https://openalex.org/I1337315214"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Manish Kumar Sharma","raw_affiliation_strings":["Department of Biotechnology, Dr. Rammanohar Lohia Avadh University, Ayodhya, 224001, Uttar Pradesh, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biotechnology, Dr. Rammanohar Lohia Avadh University, Ayodhya, 224001, Uttar Pradesh, India","institution_ids":["https://openalex.org/I1337315214"]}]},{"author_position":"last","author":{"id":null,"display_name":"Jitendra Singh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210106490","display_name":"All India Institute of Medical Sciences Bhopal","ror":"https://ror.org/01rs0zz87","country_code":"IN","type":"education","lineage":["https://openalex.org/I4210106490"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Jitendra Singh","raw_affiliation_strings":["Department of Translational Medicine, All India Institute of Medical Sciences Bhopal, Saket Nagar, Bhopal, 462020, Madhya Pradesh, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Translational Medicine, All India Institute of Medical Sciences Bhopal, Saket Nagar, Bhopal, 462020, Madhya Pradesh, India","institution_ids":["https://openalex.org/I4210106490"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5101417549"],"corresponding_institution_ids":["https://openalex.org/I82571370"],"apc_list":{"value":3990,"currency":"USD","value_usd":3990},"apc_paid":null,"fwci":0.524,"has_fulltext":false,"cited_by_count":18,"citation_normalized_percentile":{"value":0.44366868,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"51","issue":"1","first_page":"896","last_page":"896"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11393","display_name":"Biosensors and Analytical Detection","score":0.6592000126838684,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11393","display_name":"Biosensors and Analytical Detection","score":0.6592000126838684,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10412","display_name":"Microfluidic and Capillary Electrophoresis Applications","score":0.1607999950647354,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10878","display_name":"CRISPR and Genetic Engineering","score":0.15309999883174896,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/crispr-based-diagnostics","display_name":"CRISPR-based diagnostics","score":0.8809999823570251},{"id":"https://openalex.org/keywords/microfluidics","display_name":"microfluidics","score":0.8059999942779541},{"id":"https://openalex.org/keywords/point-of-care-testing","display_name":"point-of-care testing","score":0.8379999995231628},{"id":"https://openalex.org/keywords/cas9","display_name":"Cas9","score":0.7680000066757202},{"id":"https://openalex.org/keywords/cas12","display_name":"Cas12","score":0.9980000257492065},{"id":"https://openalex.org/keywords/cas13","display_name":"Cas13","score":0.9990000128746033},{"id":"https://openalex.org/keywords/pathogen-detection","display_name":"pathogen detection","score":0.7730000019073486},{"id":"https://openalex.org/keywords/rna-biomarkers","display_name":"RNA biomarkers","score":0.7599999904632568},{"id":"https://openalex.org/keywords/dna-biomarkers","display_name":"DNA biomarkers","score":0.9399999976158142},{"id":"https://openalex.org/keywords/portable-diagnostic-device","display_name":"portable diagnostic device","score":0.796999990940094},{"id":"https://openalex.org/keywords/cross-contamination","display_name":"cross-contamination","score":0.6420000195503235},{"id":"https://openalex.org/keywords/quantification","display_name":"quantification","score":0.4690000116825104},{"id":"https://openalex.org/keywords/personalized-medicine","display_name":"personalized medicine","score":0.9409999847412109}],"concepts":[{"id":"https://openalex.org/C98108389","wikidata":"https://www.wikidata.org/wiki/Q412563","display_name":"CRISPR","level":3,"score":0.9270666241645813},{"id":"https://openalex.org/C8673954","wikidata":"https://www.wikidata.org/wiki/Q138845","display_name":"Microfluidics","level":2,"score":0.6924078464508057},{"id":"https://openalex.org/C132455925","wikidata":"https://www.wikidata.org/wiki/Q16965677","display_name":"Cas9","level":4,"score":0.6537436842918396},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.48870304226875305},{"id":"https://openalex.org/C144501496","wikidata":"https://www.wikidata.org/wiki/Q5533489","display_name":"Genome editing","level":4,"score":0.4815581142902374},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.4656916856765747},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.445349782705307},{"id":"https://openalex.org/C32220436","wikidata":"https://www.wikidata.org/wiki/Q2072214","display_name":"Personalized medicine","level":2,"score":0.42979252338409424},{"id":"https://openalex.org/C179786068","wikidata":"https://www.wikidata.org/wiki/Q16257937","display_name":"Molecular diagnostics","level":2,"score":0.4179506301879883},{"id":"https://openalex.org/C2522767166","wikidata":"https://www.wikidata.org/wiki/Q2374463","display_name":"Data science","level":1,"score":0.3262391686439514},{"id":"https://openalex.org/C201995342","wikidata":"https://www.wikidata.org/wiki/Q682496","display_name":"Systems engineering","level":1,"score":0.32601404190063477},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.3088160753250122},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2952561378479004},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.21139740943908691},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.11344203352928162},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.07841461896896362},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000072669","descriptor_name":"Gene Editing","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D025202","descriptor_name":"Molecular Diagnostic Techniques","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D044085","descriptor_name":"Microfluidics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D056656","descriptor_name":"Lab-On-A-Chip Devices","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057089","descriptor_name":"Pathology, Molecular","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D064112","descriptor_name":"Clustered Regularly Interspaced Short Palindromic Repeats","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D064113","descriptor_name":"CRISPR-Cas Systems","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1007/s11033-024-09840-8","doi":"https://doi.org/10.1007/s11033-024-09840-8","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s11033-024-09840-8","pdf_url":null,"source":{"id":"https://openalex.org/S197962172","display_name":"Molecular Biology Reports","issn_l":"0301-4851","issn":["0301-4851","1573-4978"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Biology Reports","raw_type":"journal-article"},{"id":"pmid:39115550","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39115550","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular biology reports","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":159,"referenced_works":["https://openalex.org/W1987027200","https://openalex.org/W1990487336","https://openalex.org/W2001721477","https://openalex.org/W2035669572","https://openalex.org/W2045435533","https://openalex.org/W2047032063","https://openalex.org/W2067080805","https://openalex.org/W2121099951","https://openalex.org/W2163241233","https://openalex.org/W2238012416","https://openalex.org/W2346028445","https://openalex.org/W2418040526","https://openalex.org/W2606915822","https://openalex.org/W2785904295","https://openalex.org/W2787024379","https://openalex.org/W2800905921","https://openalex.org/W2801783434","https://openalex.org/W2807307953","https://openalex.org/W2895823148","https://openalex.org/W2901473950","https://openalex.org/W2901478147","https://openalex.org/W2901552404","https://openalex.org/W2902246058","https://openalex.org/W2920964100","https://openalex.org/W2969221202","https://openalex.org/W2970290674","https://openalex.org/W2970391528","https://openalex.org/W2973445868","https://openalex.org/W2974223043","https://openalex.org/W2974267223","https://openalex.org/W2978292797","https://openalex.org/W2982454227","https://openalex.org/W2989883799","https://openalex.org/W2994621268","https://openalex.org/W2997842553","https://openalex.org/W3004806486","https://openalex.org/W3006168659","https://openalex.org/W3008550746","https://openalex.org/W3011496369","https://openalex.org/W3017027667","https://openalex.org/W3017334101","https://openalex.org/W3020077371","https://openalex.org/W3021211921","https://openalex.org/W3021896513","https://openalex.org/W3023764677","https://openalex.org/W3028883492","https://openalex.org/W3035764705","https://openalex.org/W3039751730","https://openalex.org/W3043693625","https://openalex.org/W3046568100","https://openalex.org/W3047719754","https://openalex.org/W3049161425","https://openalex.org/W3049443028","https://openalex.org/W3049762119","https://openalex.org/W3080327845","https://openalex.org/W3080614324","https://openalex.org/W3080708411","https://openalex.org/W3084605330","https://openalex.org/W3084605929","https://openalex.org/W3085955925","https://openalex.org/W3087332812","https://openalex.org/W3089965698","https://openalex.org/W3092653154","https://openalex.org/W3092952465","https://openalex.org/W3097419470","https://openalex.org/W3103998356","https://openalex.org/W3104540940","https://openalex.org/W3108711749","https://openalex.org/W3108961574","https://openalex.org/W3110194374","https://openalex.org/W3111292947","https://openalex.org/W3112329071","https://openalex.org/W3112638533","https://openalex.org/W3115403348","https://openalex.org/W3118236943","https://openalex.org/W3119666167","https://openalex.org/W3120767630","https://openalex.org/W3123486922","https://openalex.org/W3126789423","https://openalex.org/W3127388554","https://openalex.org/W3129426035","https://openalex.org/W3129470634","https://openalex.org/W3130365044","https://openalex.org/W3132767577","https://openalex.org/W3133577546","https://openalex.org/W3135005312","https://openalex.org/W3145032960","https://openalex.org/W3145908384","https://openalex.org/W3152649722","https://openalex.org/W3155521739","https://openalex.org/W3156849398","https://openalex.org/W3157305514","https://openalex.org/W3157675340","https://openalex.org/W3158848144","https://openalex.org/W3159246176","https://openalex.org/W3159606037","https://openalex.org/W3160312461","https://openalex.org/W3162164881","https://openalex.org/W3162451617","https://openalex.org/W3163909596","https://openalex.org/W3165793603","https://openalex.org/W3167937267","https://openalex.org/W3169841655","https://openalex.org/W3170948381","https://openalex.org/W3175119564","https://openalex.org/W3178418858","https://openalex.org/W3181270618","https://openalex.org/W3183397623","https://openalex.org/W3185485316","https://openalex.org/W3186756286","https://openalex.org/W3187978141","https://openalex.org/W3188079964","https://openalex.org/W3189188210","https://openalex.org/W3194018776","https://openalex.org/W3205691628","https://openalex.org/W3205756117","https://openalex.org/W3211092355","https://openalex.org/W4200120010","https://openalex.org/W4200289441","https://openalex.org/W4200619760","https://openalex.org/W4210752017","https://openalex.org/W4210780188","https://openalex.org/W4211132599","https://openalex.org/W4211246989","https://openalex.org/W4214648784","https://openalex.org/W4220738252","https://openalex.org/W4220917387","https://openalex.org/W4220930347","https://openalex.org/W4224299753","https://openalex.org/W4232987846","https://openalex.org/W4242913343","https://openalex.org/W4280565528","https://openalex.org/W4283694761","https://openalex.org/W4284962143","https://openalex.org/W4285392438","https://openalex.org/W4286229202","https://openalex.org/W4290672784","https://openalex.org/W4292209988","https://openalex.org/W4306737047","https://openalex.org/W4308809949","https://openalex.org/W4313545742","https://openalex.org/W4318542645","https://openalex.org/W4318754840","https://openalex.org/W4319068078","https://openalex.org/W4366236754","https://openalex.org/W4366824220","https://openalex.org/W4367839071","https://openalex.org/W4377694845","https://openalex.org/W4387580807","https://openalex.org/W4388457445","https://openalex.org/W4390766035","https://openalex.org/W4390790579","https://openalex.org/W4391655853","https://openalex.org/W4392549562","https://openalex.org/W4392595486","https://openalex.org/W4396821059","https://openalex.org/W4399029979","https://openalex.org/W4399040549","https://openalex.org/W6602989878"],"related_works":["https://openalex.org/W4306737047","https://openalex.org/W4308147830","https://openalex.org/W4399944072","https://openalex.org/W7123356033","https://openalex.org/W4396742719","https://openalex.org/W4200265245","https://openalex.org/W4407380031","https://openalex.org/W4414746465","https://openalex.org/W4408122839","https://openalex.org/W4407117092"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":9},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":2}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2024-08-09T00:00:00"}