{"id":"https://openalex.org/W4401422287","doi":"https://doi.org/10.1039/d4bm00688g","title":"Controlling cellular packing and hypoxia in 3D tumor spheroids via DNA interactions","display_name":"Controlling cellular packing and hypoxia in 3D tumor spheroids via DNA interactions","publication_year":2024,"publication_date":"2024-01-01","ids":{"openalex":"https://openalex.org/W4401422287","doi":"https://doi.org/10.1039/d4bm00688g","pmid":"https://pubmed.ncbi.nlm.nih.gov/39136101","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11320176"},"language":"en","primary_location":{"id":"doi:10.1039/d4bm00688g","doi":"https://doi.org/10.1039/d4bm00688g","is_oa":true,"landing_page_url":"https://doi.org/10.1039/d4bm00688g","pdf_url":"https://pubs.rsc.org/en/content/articlepdf/2024/bm/d4bm00688g","source":{"id":"https://openalex.org/S2494179437","display_name":"Biomaterials Science","issn_l":"2047-4830","issn":["2047-4830","2047-4849"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomaterials Science","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://pubs.rsc.org/en/content/articlepdf/2024/bm/d4bm00688g","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5064523766","display_name":"Sven A. Saemundsson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I188538660","display_name":"University of Colorado Boulder","ror":"https://ror.org/02ttsq026","country_code":"US","type":"education","lineage":["https://openalex.org/I188538660"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sven A. Saemundsson","raw_affiliation_strings":["Department of Chemical and Biological Engineering, University of Colorado, Boulder, 596 UCB, Boulder, CO, 80303, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical and Biological Engineering, University of Colorado, Boulder, 596 UCB, Boulder, CO, 80303, USA","institution_ids":["https://openalex.org/I188538660"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054558148","display_name":"Shane D. Curry","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I188538660","display_name":"University of Colorado Boulder","ror":"https://ror.org/02ttsq026","country_code":"US","type":"education","lineage":["https://openalex.org/I188538660"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shane D. Curry","raw_affiliation_strings":["Department of Chemical and Biological Engineering, University of Colorado, Boulder, 596 UCB, Boulder, CO, 80303, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical and Biological Engineering, University of Colorado, Boulder, 596 UCB, Boulder, CO, 80303, USA","institution_ids":["https://openalex.org/I188538660"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111284479","display_name":"Bryce M. Bower","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I188538660","display_name":"University of Colorado Boulder","ror":"https://ror.org/02ttsq026","country_code":"US","type":"education","lineage":["https://openalex.org/I188538660"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bryce M. Bower","raw_affiliation_strings":["Department of Chemical and Biological Engineering, University of Colorado, Boulder, 596 UCB, Boulder, CO, 80303, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical and Biological Engineering, University of Colorado, Boulder, 596 UCB, Boulder, CO, 80303, USA","institution_ids":["https://openalex.org/I188538660"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5106358441","display_name":"Ethan J. DeBoo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I188538660","display_name":"University of Colorado Boulder","ror":"https://ror.org/02ttsq026","country_code":"US","type":"education","lineage":["https://openalex.org/I188538660"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ethan J. DeBoo","raw_affiliation_strings":["Department of Chemical and Biological Engineering, University of Colorado, Boulder, 596 UCB, Boulder, CO, 80303, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical and Biological Engineering, University of Colorado, Boulder, 596 UCB, Boulder, CO, 80303, USA","institution_ids":["https://openalex.org/I188538660"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073481717","display_name":"Andrew P. Goodwin","orcid":"https://orcid.org/0000-0002-7284-4005","observed_orcids":["https://orcid.org/0000-0002-7284-4005"]},"institutions":[{"id":"https://openalex.org/I188538660","display_name":"University of Colorado Boulder","ror":"https://ror.org/02ttsq026","country_code":"US","type":"education","lineage":["https://openalex.org/I188538660"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew P. Goodwin","raw_affiliation_strings":["Department of Chemical and Biological Engineering, University of Colorado, Boulder, 596 UCB, Boulder, CO, 80303, USA","Materials Science and Engineering Program, University of Colorado, Boulder, 596 UCB, Boulder, CO, 80303, USA"],"raw_orcid":"https://orcid.org/0000-0002-7284-4005","affiliations":[{"raw_affiliation_string":"Department of Chemical and Biological Engineering, University of Colorado, Boulder, 596 UCB, Boulder, CO, 80303, USA","institution_ids":["https://openalex.org/I188538660"]},{"raw_affiliation_string":"Materials Science and Engineering Program, University of Colorado, Boulder, 596 UCB, Boulder, CO, 80303, USA","institution_ids":["https://openalex.org/I188538660"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5022214757","display_name":"Jennifer N. Cha","orcid":"https://orcid.org/0000-0002-2840-1653","observed_orcids":["https://orcid.org/0000-0002-2840-1653"]},"institutions":[{"id":"https://openalex.org/I188538660","display_name":"University of Colorado Boulder","ror":"https://ror.org/02ttsq026","country_code":"US","type":"education","lineage":["https://openalex.org/I188538660"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jennifer N. Cha","raw_affiliation_strings":["Biomedical Engineering Program, University of Colorado, Boulder, 596 UCB, Boulder, CO, 80303, USA","Department of Chemical and Biological Engineering, University of Colorado, Boulder, 596 UCB, Boulder, CO, 80303, USA","Materials Science and Engineering Program, University of Colorado, Boulder, 596 UCB, Boulder, CO, 80303, USA"],"raw_orcid":"https://orcid.org/0000-0002-2840-1653","affiliations":[{"raw_affiliation_string":"Biomedical Engineering Program, University of Colorado, Boulder, 596 UCB, Boulder, CO, 80303, USA","institution_ids":["https://openalex.org/I188538660"]},{"raw_affiliation_string":"Department of Chemical and Biological Engineering, University of Colorado, Boulder, 596 UCB, Boulder, CO, 80303, USA","institution_ids":["https://openalex.org/I188538660"]},{"raw_affiliation_string":"Materials Science and Engineering Program, University of Colorado, Boulder, 596 UCB, Boulder, CO, 80303, USA","institution_ids":["https://openalex.org/I188538660"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5022214757"],"corresponding_institution_ids":["https://openalex.org/I188538660"],"apc_list":null,"apc_paid":null,"fwci":0.7651,"has_fulltext":true,"cited_by_count":7,"citation_normalized_percentile":{"value":0.63316546,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":97,"max":98},"biblio":{"volume":"12","issue":"18","first_page":"4759","last_page":"4769"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11190","display_name":"3D Printing in Biomedical Research","score":0.6323000192642212,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11190","display_name":"3D Printing in Biomedical Research","score":0.6323000192642212,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.09669999778270721,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.07460000365972519,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tumor-spheroids","display_name":"tumor spheroids","score":0.9160000085830688},{"id":"https://openalex.org/keywords/hypoxia","display_name":"hypoxia","score":0.6970000267028809},{"id":"https://openalex.org/keywords/biotinylated-dna","display_name":"biotinylated DNA","score":0.9259999990463257},{"id":"https://openalex.org/keywords/spheroid-formation","display_name":"spheroid formation","score":0.6819999814033508},{"id":"https://openalex.org/keywords/cell-adhesion-molecules","display_name":"adhesion molecules","score":0.7710000276565552},{"id":"https://openalex.org/keywords/fibronectin","display_name":"fibronectin","score":0.9739999771118164},{"id":"https://openalex.org/keywords/e-cadherin","display_name":"E-cadherin","score":0.9160000085830688},{"id":"https://openalex.org/keywords/4t1-cells","display_name":"4T1 cells","score":0.972000002861023},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.949999988079071}],"concepts":[{"id":"https://openalex.org/C175369904","wikidata":"https://www.wikidata.org/wiki/Q208395","display_name":"Spheroid","level":3,"score":0.867007851600647},{"id":"https://openalex.org/C7836513","wikidata":"https://www.wikidata.org/wiki/Q1641506","display_name":"Hypoxia (environmental)","level":3,"score":0.6347781419754028},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.5922431349754333},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.53294837474823},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.5187821388244629},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5104357600212097},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.26053109765052795},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.20957517623901367},{"id":"https://openalex.org/C540031477","wikidata":"https://www.wikidata.org/wiki/Q629","display_name":"Oxygen","level":2,"score":0.15452134609222412},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.10582023859024048},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015687","descriptor_name":"Cell Hypoxia","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018874","descriptor_name":"Spheroids, Cellular","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018874","descriptor_name":"Spheroids, Cellular","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059016","descriptor_name":"Tumor Microenvironment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1039/d4bm00688g","doi":"https://doi.org/10.1039/d4bm00688g","is_oa":true,"landing_page_url":"https://doi.org/10.1039/d4bm00688g","pdf_url":"https://pubs.rsc.org/en/content/articlepdf/2024/bm/d4bm00688g","source":{"id":"https://openalex.org/S2494179437","display_name":"Biomaterials Science","issn_l":"2047-4830","issn":["2047-4830","2047-4849"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomaterials Science","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11320176","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11320176","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomater Sci","raw_type":"Text"},{"id":"pmid:39136101","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39136101","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomaterials science","raw_type":"Journal Article"},{"id":"pmh:oai:cuscholar:37720f407","doi":null,"is_oa":true,"landing_page_url":"https://scholar.colorado.edu/concern/articles/37720f407","pdf_url":"https://scholar.colorado.edu/downloads/9w032472x","source":{"id":"https://openalex.org/S4306401957","display_name":"CU Scholar (University of Colorado Boulder)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I188538660","host_organization_name":"University of Colorado Boulder","host_organization_lineage":["https://openalex.org/I188538660"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"},{"id":"pmh:oai:frl.publisso.de:frl:6486002","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11320176","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/instance/11320176/bin/BM-012-D4BM00688G-s001.pdf","source":{"id":"https://openalex.org/S4306402606","display_name":"Informationszentrum Lebenswissenschaften (ZB MED)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210112663","host_organization_name":"ZB MED - Information Centre for Life Sciences","host_organization_lineage":["https://openalex.org/I4210112663"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Biomaterials science, 12(18):4759-4769","raw_type":"Zeitschriftenartikel"}],"best_oa_location":{"id":"doi:10.1039/d4bm00688g","doi":"https://doi.org/10.1039/d4bm00688g","is_oa":true,"landing_page_url":"https://doi.org/10.1039/d4bm00688g","pdf_url":"https://pubs.rsc.org/en/content/articlepdf/2024/bm/d4bm00688g","source":{"id":"https://openalex.org/S2494179437","display_name":"Biomaterials Science","issn_l":"2047-4830","issn":["2047-4830","2047-4849"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomaterials Science","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.6000000238418579}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2916879868","display_name":"Design of Nanostructures for Light-Mediated Propulsion for Molecular Delivery into Tissue","funder_award_id":"2025547","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G353655726","display_name":null,"funder_award_id":"SCR_018302","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G4235965494","display_name":"Laser Scanning Confocal Microscope","funder_award_id":"1s10od034320-01","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G4415789564","display_name":"Acquisition of multi-mode, high-resolution, high-sensitivity imaging platform","funder_award_id":"1s10od034218-01","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G526627292","display_name":null,"funder_award_id":"SCR_018302","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G536846052","display_name":"Mechanisms of p27Kipl Proteolysis in Cancer Cells","funder_award_id":"R01CA107098","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4401422287.pdf","grobid_xml":"https://content.openalex.org/works/W4401422287.grobid-xml"},"referenced_works_count":39,"referenced_works":["https://openalex.org/W1506680628","https://openalex.org/W1656731888","https://openalex.org/W1741548448","https://openalex.org/W1751530372","https://openalex.org/W1860070660","https://openalex.org/W1976815031","https://openalex.org/W1991060977","https://openalex.org/W2009573082","https://openalex.org/W2036858087","https://openalex.org/W2052566608","https://openalex.org/W2063396729","https://openalex.org/W2094454542","https://openalex.org/W2115307546","https://openalex.org/W2117552063","https://openalex.org/W2121294918","https://openalex.org/W2125724189","https://openalex.org/W2126961173","https://openalex.org/W2129321174","https://openalex.org/W2130548814","https://openalex.org/W2149311212","https://openalex.org/W2168267246","https://openalex.org/W2332489732","https://openalex.org/W2613618878","https://openalex.org/W2772195672","https://openalex.org/W2773981699","https://openalex.org/W2949380051","https://openalex.org/W2974764749","https://openalex.org/W3004132090","https://openalex.org/W3068772833","https://openalex.org/W3108866617","https://openalex.org/W3206517643","https://openalex.org/W4313446177","https://openalex.org/W4313478249","https://openalex.org/W4324046169","https://openalex.org/W4375856675","https://openalex.org/W4385482955","https://openalex.org/W4387408934","https://openalex.org/W4389613629","https://openalex.org/W4391451249"],"related_works":["https://openalex.org/W4391776382","https://openalex.org/W4313446177","https://openalex.org/W3206517643","https://openalex.org/W2615171435","https://openalex.org/W2898155335","https://openalex.org/W2742716572","https://openalex.org/W3165539809","https://openalex.org/W7125582535","https://openalex.org/W6893033356","https://openalex.org/W4393128264"],"abstract_inverted_index":{"models":[0],"for":[1,132],"studying":[2],"cancer":[3,37,142],"biology":[4],"and":[5,30,67,100,124],"evaluating":[6],"therapeutic":[7,134],"strategies.":[8],"In":[9],"this":[10],"study,":[11],"we":[12,44],"investigated":[13],"the":[14,63,87,103,137],"impact":[15],"of":[16,19,42,54,65,80,113,117],"varying":[17],"lengths":[18,56],"DNA-modified":[20],"cell":[21,48,118],"surfaces":[22,49,119],"on":[23,83],"spheroid":[24,58,104,122],"formation,":[25],"cellular":[26,70],"adhesion":[27,71],"molecule":[28],"expression,":[29],"hypoxia":[31,84,93],"levels":[32,85,94],"within":[33,86,102],"4T1":[34],"mouse":[35],"breast":[36],"spheroids.":[38,88],"Through":[39],"a":[40,77,110],"series":[41],"experiments,":[43],"demonstrated":[45],"that":[46],"modifying":[47],"with":[50],"biotinylated":[51],"DNA":[52,81,90,115],"strands":[53],"different":[55],"facilitated":[57],"formation":[59],"without":[60],"significantly":[61],"altering":[62],"expression":[64],"fibronectin":[66],"e-cadherin,":[68],"key":[69],"molecules.":[72],"However,":[73],"our":[74],"findings":[75],"revealed":[76],"notable":[78],"influence":[79],"length":[82,91],"As":[89],"increased,":[92],"decreased,":[95],"indicating":[96],"enhanced":[97],"intercellular":[98],"spacing":[99],"porosity":[101],"structure.":[105],"These":[106],"results":[107],"contribute":[108],"to":[109,140],"better":[111],"understanding":[112],"how":[114],"modification":[116],"can":[120],"modulate":[121],"architecture":[123],"microenvironmental":[125],"conditions.":[126],"Such":[127],"insights":[128],"may":[129],"have":[130],"implications":[131],"developing":[133],"interventions":[135],"targeting":[136],"tumor":[138],"microenvironment":[139],"improve":[141],"treatment":[143],"efficacy.":[144]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2024-08-09T00:00:00"}
