{"id":"https://openalex.org/W4401412353","doi":"https://doi.org/10.1016/j.tranon.2024.102069","title":"Drug tolerance and persistence in bacteria, fungi and cancer cells: Role of non-genetic heterogeneity","display_name":"Drug tolerance and persistence in bacteria, fungi and cancer cells: Role of non-genetic heterogeneity","publication_year":2024,"publication_date":"2024-08-08","ids":{"openalex":"https://openalex.org/W4401412353","doi":"https://doi.org/10.1016/j.tranon.2024.102069","pmid":"https://pubmed.ncbi.nlm.nih.gov/39121829","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11364053"},"language":"en","primary_location":{"id":"doi:10.1016/j.tranon.2024.102069","doi":"https://doi.org/10.1016/j.tranon.2024.102069","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.tranon.2024.102069","pdf_url":null,"source":{"id":"https://openalex.org/S106638657","display_name":"Translational Oncology","issn_l":"1936-5233","issn":["1936-5233","1944-7124"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","norway-1","oarl","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Translational Oncology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1016/j.tranon.2024.102069","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5071549057","display_name":"Imane El Meouche","orcid":"https://orcid.org/0000-0002-0886-6752","observed_orcids":["https://orcid.org/0000-0002-0886-6752"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I204730241","display_name":"Universit\u00e9 Paris Cit\u00e9","ror":"https://ror.org/05f82e368","country_code":"FR","type":"education","lineage":["https://openalex.org/I204730241"]},{"id":"https://openalex.org/I4210091279","display_name":"Universit\u00e9 Sorbonne Paris Nord","ror":"https://ror.org/0199hds37","country_code":"FR","type":"education","lineage":["https://openalex.org/I4210091279"]},{"id":"https://openalex.org/I4387154366","display_name":"Universit\u00e9 Paris Diderot","ror":"https://ror.org/02n7qrg46","country_code":"FR","type":"education","lineage":["https://openalex.org/I204730241","https://openalex.org/I4387154366"]},{"id":"https://openalex.org/I4387156044","display_name":"Infection, Anti-microbiens, Mod\u00e9lisation, Evolution","ror":"https://ror.org/05hqep952","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I204730241","https://openalex.org/I4387156044"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Imane El Meouche","raw_affiliation_strings":["Universit\u00e9 Paris Cit\u00e9, Universit\u00e9 Sorbonne Paris Nord, INSERM, IAME, F-75018 Paris, France. Electronic address: imane.el-meouche@inserm.fr","IAME (UMR_S_1137 / U1137) - Infection, Anti-microbiens, Mod\u00e9lisation, Evolution (Facult\u00e9 de m\u00e9decine Paris Diderot Paris 7 - site Bichat - 16 rue Henri Huchard 75890 Paris Cedex 18 - France)"],"raw_orcid":"https://orcid.org/0000-0002-0886-6752","affiliations":[{"raw_affiliation_string":"Universit\u00e9 Paris Cit\u00e9, Universit\u00e9 Sorbonne Paris Nord, INSERM, IAME, F-75018 Paris, France. Electronic address: imane.el-meouche@inserm.fr","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I204730241","https://openalex.org/I4210091279","https://openalex.org/I4387156044"]},{"raw_affiliation_string":"IAME (UMR_S_1137 / U1137) - Infection, Anti-microbiens, Mod\u00e9lisation, Evolution (Facult\u00e9 de m\u00e9decine Paris Diderot Paris 7 - site Bichat - 16 rue Henri Huchard 75890 Paris Cedex 18 - France)","institution_ids":["https://openalex.org/I4387154366","https://openalex.org/I4387156044"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008163477","display_name":"Paras Jain","orcid":"https://orcid.org/0000-0001-6057-7993","observed_orcids":["https://orcid.org/0000-0001-6057-7993"]},"institutions":[{"id":"https://openalex.org/I59270414","display_name":"Indian Institute of Science Bangalore","ror":"https://ror.org/04dese585","country_code":"IN","type":"education","lineage":["https://openalex.org/I59270414"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Paras Jain","raw_affiliation_strings":["Department of Bioengineering, Indian Institute of Science, Bangalore, India","IISc Bangalore - Indian Institute of Science [Bangalore] (Bangalore 560 012 - India)"],"raw_orcid":"https://orcid.org/0000-0001-6057-7993","affiliations":[{"raw_affiliation_string":"Department of Bioengineering, Indian Institute of Science, Bangalore, India","institution_ids":["https://openalex.org/I59270414"]},{"raw_affiliation_string":"IISc Bangalore - Indian Institute of Science [Bangalore] (Bangalore 560 012 - India)","institution_ids":["https://openalex.org/I59270414"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083772852","display_name":"Mohit Kumar Jolly","orcid":"https://orcid.org/0000-0002-6631-2109","observed_orcids":["https://orcid.org/0000-0002-6631-2109"]},"institutions":[{"id":"https://openalex.org/I59270414","display_name":"Indian Institute of Science Bangalore","ror":"https://ror.org/04dese585","country_code":"IN","type":"education","lineage":["https://openalex.org/I59270414"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Mohit Kumar Jolly","raw_affiliation_strings":["Department of Bioengineering, Indian Institute of Science, Bangalore, India","IISc Bangalore - Indian Institute of Science [Bangalore] (Bangalore 560 012 - India)"],"raw_orcid":"https://orcid.org/0000-0002-6631-2109","affiliations":[{"raw_affiliation_string":"Department of Bioengineering, Indian Institute of Science, Bangalore, India","institution_ids":["https://openalex.org/I59270414"]},{"raw_affiliation_string":"IISc Bangalore - Indian Institute of Science [Bangalore] (Bangalore 560 012 - India)","institution_ids":["https://openalex.org/I59270414"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5072235870","display_name":"Jean\u2010Pascal Capp","orcid":"https://orcid.org/0000-0002-6470-079X","observed_orcids":["https://orcid.org/0000-0002-6470-079X"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I196454796","display_name":"Institut National des Sciences Appliqu\u00e9es de Toulouse","ror":"https://ror.org/01h8pf755","country_code":"FR","type":"education","lineage":["https://openalex.org/I196454796"]},{"id":"https://openalex.org/I4210088668","display_name":"Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement","ror":"https://ror.org/003vg9w96","country_code":"FR","type":"government","lineage":["https://openalex.org/I4210088668"]},{"id":"https://openalex.org/I4210110888","display_name":"Toulouse Biotechnology Institute, Bio & Chemical Engineering","ror":"https://ror.org/01yypjb30","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I196454796","https://openalex.org/I4210088668","https://openalex.org/I4210110888"]},{"id":"https://openalex.org/I4405258862","display_name":"Universit\u00e9 de Toulouse","ror":"https://ror.org/01ahyrz84","country_code":"FR","type":"education","lineage":["https://openalex.org/I4405258862"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Jean-Pascal Capp","raw_affiliation_strings":["Toulouse Biotechnology Institute, INSA/University of Toulouse, CNRS, INRAE, Toulouse, France. Electronic address: capp@insa-toulouse.fr","TBI - Toulouse Biotechnology Institute (INSA / CNRS 5504  \r\n\r\nUMR INSA /  INRAE 792 \r\n135 avenue de Rangueil \r\n31077 Toulouse CEDEX 04 - France)"],"raw_orcid":"https://orcid.org/0000-0002-6470-079X","affiliations":[{"raw_affiliation_string":"Toulouse Biotechnology Institute, INSA/University of Toulouse, CNRS, INRAE, Toulouse, France. Electronic address: capp@insa-toulouse.fr","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I196454796","https://openalex.org/I4210088668","https://openalex.org/I4210110888","https://openalex.org/I4405258862"]},{"raw_affiliation_string":"TBI - Toulouse Biotechnology Institute (INSA / CNRS 5504  \r\n\r\nUMR INSA /  INRAE 792 \r\n135 avenue de Rangueil \r\n31077 Toulouse CEDEX 04 - France)","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I196454796","https://openalex.org/I4210088668","https://openalex.org/I4210110888"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":11,"corresponding_author_ids":["https://openalex.org/A5071549057","https://openalex.org/A5072235870"],"corresponding_institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I196454796","https://openalex.org/I204730241","https://openalex.org/I4210088668","https://openalex.org/I4210091279","https://openalex.org/I4210110888","https://openalex.org/I4387154366","https://openalex.org/I4387156044","https://openalex.org/I4405258862"],"apc_list":{"value":3130,"currency":"USD","value_usd":3130},"apc_paid":{"value":3130,"currency":"USD","value_usd":3130},"fwci":4.6044,"has_fulltext":true,"cited_by_count":22,"citation_normalized_percentile":{"value":0.96405588,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"49","issue":null,"first_page":"102069","last_page":"102069"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.5663999915122986,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.5663999915122986,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.18440000712871552,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11764","display_name":"Evolution and Genetic Dynamics","score":0.05640000104904175,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/drug-tolerance","display_name":"drug tolerance","score":0.8679999709129333},{"id":"https://openalex.org/keywords/bacterial-persistence","display_name":"bacterial persistence","score":0.8289999961853027},{"id":"https://openalex.org/keywords/fungal-persistence","display_name":"fungal persistence","score":0.9430000185966492},{"id":"https://openalex.org/keywords/cancer-cell-persistence","display_name":"cancer cell persistence","score":0.8140000104904175},{"id":"https://openalex.org/keywords/non-genetic-heterogeneity","display_name":"non-genetic heterogeneity","score":0.9850000143051147},{"id":"https://openalex.org/keywords/gene-expression-variation","display_name":"gene expression variation","score":0.875},{"id":"https://openalex.org/keywords/antibiotic-resistance","display_name":"antibiotic resistance","score":0.5070000290870667},{"id":"https://openalex.org/keywords/antifungal-resistance","display_name":"antifungal resistance","score":0.753000020980835},{"id":"https://openalex.org/keywords/cancer-chemoresistance","display_name":"cancer chemotherapy resistance","score":0.550000011920929}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6907221078872681},{"id":"https://openalex.org/C2781009140","wikidata":"https://www.wikidata.org/wiki/Q7170389","display_name":"Persistence (discontinuity)","level":2,"score":0.6835694313049316},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5221971869468689},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.5046755075454712},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4721498489379883},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.46563994884490967},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.41473588347435},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3733629584312439},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3610534071922302},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.10462597012519836},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C187320778","wikidata":"https://www.wikidata.org/wiki/Q1349130","display_name":"Geotechnical engineering","level":1,"score":0.0}],"mesh":[],"locations_count":6,"locations":[{"id":"doi:10.1016/j.tranon.2024.102069","doi":"https://doi.org/10.1016/j.tranon.2024.102069","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.tranon.2024.102069","pdf_url":null,"source":{"id":"https://openalex.org/S106638657","display_name":"Translational Oncology","issn_l":"1936-5233","issn":["1936-5233","1944-7124"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","norway-1","oarl","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Translational Oncology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11364053","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11364053","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11364053/pdf/main.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transl Oncol","raw_type":"Text"},{"id":"pmid:39121829","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39121829","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Translational oncology","raw_type":"Journal Article"},{"id":"pmh:oai::85999","doi":null,"is_oa":false,"landing_page_url":"https://eprints.iisc.ac.in/85999/3/tra_onc_49_2024.pdf","pdf_url":"https://eprints.iisc.ac.in/85999/3/tra_onc_49_2024.pdf","source":{"id":"https://openalex.org/S4377196309","display_name":"NOT FOUND REPOSITORY (Indian Institute of Science Bangalore)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I59270414","host_organization_name":"Indian Institute of Science Bangalore","host_organization_lineage":["https://openalex.org/I59270414"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Journal Article"},{"id":"pmh:oai:HAL:hal-04720374v1","doi":null,"is_oa":true,"landing_page_url":"https://hal.science/hal-04720374v1/document","pdf_url":"https://hal.science/hal-04720374v1/file/2024%2C%20El%20Meouche%20et%20al%2C%20%20Drug%20tolerance%20and%20persistence%20in%20bacteria%2C%20fungi%20and%20cancer%20cells%2C%20Role%20of%20non-genetic%20heterogeneity.pdf","source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Translational Oncology, 2024, 49, &#x27E8;10.1016/j.tranon.2024.102069&#x27E9;","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:29d4f1f45d604601b38e40f3aed0eb8a","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/29d4f1f45d604601b38e40f3aed0eb8a","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Translational Oncology, Vol 49, Iss , Pp 102069- (2024)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/j.tranon.2024.102069","doi":"https://doi.org/10.1016/j.tranon.2024.102069","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.tranon.2024.102069","pdf_url":null,"source":{"id":"https://openalex.org/S106638657","display_name":"Translational Oncology","issn_l":"1936-5233","issn":["1936-5233","1944-7124"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","norway-1","oarl","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Translational Oncology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4401412353.pdf","grobid_xml":"https://content.openalex.org/works/W4401412353.grobid-xml"},"referenced_works_count":144,"referenced_works":["https://openalex.org/W988015238","https://openalex.org/W1454297154","https://openalex.org/W1569513357","https://openalex.org/W1899580745","https://openalex.org/W1948677335","https://openalex.org/W1966054814","https://openalex.org/W1966066354","https://openalex.org/W1967330678","https://openalex.org/W1968726044","https://openalex.org/W1974053222","https://openalex.org/W1979302584","https://openalex.org/W1981842620","https://openalex.org/W1985002373","https://openalex.org/W1991746217","https://openalex.org/W1999757563","https://openalex.org/W2003324857","https://openalex.org/W2042459898","https://openalex.org/W2042922327","https://openalex.org/W2043487490","https://openalex.org/W2044692345","https://openalex.org/W2044917835","https://openalex.org/W2047453261","https://openalex.org/W2055929620","https://openalex.org/W2058952776","https://openalex.org/W2069250280","https://openalex.org/W2072963835","https://openalex.org/W2101366952","https://openalex.org/W2101491044","https://openalex.org/W2106391833","https://openalex.org/W2111510713","https://openalex.org/W2114870653","https://openalex.org/W2115712103","https://openalex.org/W2117597548","https://openalex.org/W2119797129","https://openalex.org/W2120359082","https://openalex.org/W2127240867","https://openalex.org/W2131534552","https://openalex.org/W2132771466","https://openalex.org/W2135493487","https://openalex.org/W2139472183","https://openalex.org/W2140398671","https://openalex.org/W2148456108","https://openalex.org/W2155706782","https://openalex.org/W2157524679","https://openalex.org/W2162528201","https://openalex.org/W2171280873","https://openalex.org/W2171425427","https://openalex.org/W2171642372","https://openalex.org/W2194393912","https://openalex.org/W2240061877","https://openalex.org/W2272802268","https://openalex.org/W2275679174","https://openalex.org/W2296574497","https://openalex.org/W2323352121","https://openalex.org/W2330875406","https://openalex.org/W2336625825","https://openalex.org/W2399677191","https://openalex.org/W2466599087","https://openalex.org/W2522661577","https://openalex.org/W2561012755","https://openalex.org/W2568840014","https://openalex.org/W2578872550","https://openalex.org/W2600413587","https://openalex.org/W2607462092","https://openalex.org/W2621895366","https://openalex.org/W2739674022","https://openalex.org/W2752322347","https://openalex.org/W2767055857","https://openalex.org/W2773011778","https://openalex.org/W2794707316","https://openalex.org/W2809302957","https://openalex.org/W2809480880","https://openalex.org/W2884607428","https://openalex.org/W2886495199","https://openalex.org/W2897950718","https://openalex.org/W2901933835","https://openalex.org/W2906671565","https://openalex.org/W2910584283","https://openalex.org/W2910593175","https://openalex.org/W2940117744","https://openalex.org/W2945570991","https://openalex.org/W2949614077","https://openalex.org/W2950588209","https://openalex.org/W2951203887","https://openalex.org/W2951527048","https://openalex.org/W2952137042","https://openalex.org/W2961654898","https://openalex.org/W2966075625","https://openalex.org/W2972260587","https://openalex.org/W2972649058","https://openalex.org/W2973173028","https://openalex.org/W2979694653","https://openalex.org/W2980245695","https://openalex.org/W2987148655","https://openalex.org/W2995793704","https://openalex.org/W3006511740","https://openalex.org/W3016753949","https://openalex.org/W3019733875","https://openalex.org/W3028488617","https://openalex.org/W3045715566","https://openalex.org/W3045872583","https://openalex.org/W3045885880","https://openalex.org/W3084424318","https://openalex.org/W3092607059","https://openalex.org/W3099461365","https://openalex.org/W3108966628","https://openalex.org/W3120299806","https://openalex.org/W3127830448","https://openalex.org/W3127993692","https://openalex.org/W3130322169","https://openalex.org/W3130937819","https://openalex.org/W3152566676","https://openalex.org/W3178069091","https://openalex.org/W3187309064","https://openalex.org/W3192577093","https://openalex.org/W3204552119","https://openalex.org/W3206239583","https://openalex.org/W4200028525","https://openalex.org/W4200132645","https://openalex.org/W4213074258","https://openalex.org/W4213353716","https://openalex.org/W4221137216","https://openalex.org/W4225378559","https://openalex.org/W4226229815","https://openalex.org/W4285013480","https://openalex.org/W4286009640","https://openalex.org/W4292117282","https://openalex.org/W4292851275","https://openalex.org/W4295680181","https://openalex.org/W4309271404","https://openalex.org/W4309666648","https://openalex.org/W4319789243","https://openalex.org/W4321485320","https://openalex.org/W4322154380","https://openalex.org/W4324017810","https://openalex.org/W4324357321","https://openalex.org/W4362465492","https://openalex.org/W4378213633","https://openalex.org/W4383557607","https://openalex.org/W4387888723","https://openalex.org/W4388424617","https://openalex.org/W4390460507","https://openalex.org/W4392119611","https://openalex.org/W4399566816"],"related_works":["https://openalex.org/W3042294793","https://openalex.org/W2779023477","https://openalex.org/W2794707316","https://openalex.org/W6929267087","https://openalex.org/W3127993692","https://openalex.org/W2779948636","https://openalex.org/W2899790811","https://openalex.org/W4293464027","https://openalex.org/W4322769981","https://openalex.org/W2891009148"],"abstract_inverted_index":{"A":[0],"common":[1,65,107],"feature":[2],"of":[3,15,30,91,98,114],"bacterial,":[4],"fungal":[5],"and":[6,17,23,50,60,67,70,118,122],"cancer":[7,61],"cell":[8],"populations":[9],"upon":[10],"treatment":[11],"is":[12],"the":[13,28,89,96,112],"presence":[14,29],"tolerant":[16],"persistent":[18],"cells":[19,43,62],"able":[20],"to":[21,63,71,80,124],"survive,":[22],"sometimes":[24],"grow,":[25],"even":[26],"in":[27,44,57,95],"usually":[31],"inhibitory":[32],"or":[33],"lethal":[34],"drug":[35,55],"concentrations,":[36],"driven":[37],"by":[38],"non-genetic":[39,100],"differences":[40],"among":[41],"individual":[42],"a":[45,105],"population.":[46],"Here":[47],"we":[48],"review":[49],"compare":[51],"data":[52],"obtained":[53],"on":[54,88],"survival":[56],"bacteria,":[58],"fungi":[59],"unravel":[64],"characteristics":[66],"cellular":[68],"pathways,":[69],"point":[72],"their":[73],"singularities.":[74],"This":[75],"comparative":[76],"work":[77],"also":[78],"allows":[79],"cross-fertilize":[81],"ideas":[82],"across":[83],"fields.":[84],"We":[85],"particularly":[86],"focus":[87],"role":[90],"gene":[92],"expression":[93],"variability":[94],"emergence":[97],"cell-cell":[99],"heterogeneity":[101],"because":[102],"it":[103],"represents":[104],"possible":[106],"basic":[108],"molecular":[109],"process":[110],"at":[111],"origin":[113],"most":[115],"persistence":[116],"phenomena":[117],"could":[119],"be":[120],"monitored":[121],"tuned":[123],"help":[125],"improve":[126],"therapeutic":[127],"interventions.":[128]},"counts_by_year":[{"year":2026,"cited_by_count":11},{"year":2025,"cited_by_count":10},{"year":2024,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2024-08-09T00:00:00"}
