{"id":"https://openalex.org/W4401405486","doi":"https://doi.org/10.1007/s10142-024-01414-y","title":"SIGMAR1 targets AMPK/ULK1 pathway to inhibit SH-SY5Y cell apoptosis by regulating endoplasmic reticulum stress and autophagy","display_name":"SIGMAR1 targets AMPK/ULK1 pathway to inhibit SH-SY5Y cell apoptosis by regulating endoplasmic reticulum stress and autophagy","publication_year":2024,"publication_date":"2024-08-01","ids":{"openalex":"https://openalex.org/W4401405486","doi":"https://doi.org/10.1007/s10142-024-01414-y","pmid":"https://pubmed.ncbi.nlm.nih.gov/39107544"},"language":"en","primary_location":{"id":"doi:10.1007/s10142-024-01414-y","doi":"https://doi.org/10.1007/s10142-024-01414-y","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s10142-024-01414-y","pdf_url":null,"source":{"id":"https://openalex.org/S205083708","display_name":"Functional & Integrative Genomics","issn_l":"1438-793X","issn":["1438-793X","1438-7948"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Functional &amp; Integrative Genomics","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W4401405486"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Min Kong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210156904","display_name":"Third Xiangya Hospital","ror":"https://ror.org/05akvb491","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210156904"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Min Kong","raw_affiliation_strings":["Department of Pediatric, the Third Xiangya Hospital of Central South University, Changsha, 410000, Hunan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatric, the Third Xiangya Hospital of Central South University, Changsha, 410000, Hunan, China","institution_ids":["https://openalex.org/I4210156904"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055508020","display_name":"Zhiheng Chen","orcid":"https://orcid.org/0000-0003-2048-1932","observed_orcids":["https://orcid.org/0000-0003-2048-1932"]},"institutions":[{"id":"https://openalex.org/I4210156904","display_name":"Third Xiangya Hospital","ror":"https://ror.org/05akvb491","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210156904"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhiheng Chen","raw_affiliation_strings":["Department of Pediatric, the Third Xiangya Hospital of Central South University, Changsha, 410000, Hunan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatric, the Third Xiangya Hospital of Central South University, Changsha, 410000, Hunan, China","institution_ids":["https://openalex.org/I4210156904"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103045094","display_name":"Zhiqiang Lin","orcid":"https://orcid.org/0009-0004-3126-2879","observed_orcids":["https://orcid.org/0009-0004-3126-2879"]},"institutions":[{"id":"https://openalex.org/I4210156904","display_name":"Third Xiangya Hospital","ror":"https://ror.org/05akvb491","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210156904"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhiqiang Lin","raw_affiliation_strings":["Department of Neurology, The Third Xiangya Hospital of Central South University, Changsha, 410000, Hunan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, The Third Xiangya Hospital of Central South University, Changsha, 410000, Hunan, China","institution_ids":["https://openalex.org/I4210156904"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101476654","display_name":"Ping Yin","orcid":"https://orcid.org/0000-0003-0404-4759","observed_orcids":["https://orcid.org/0000-0003-0404-4759"]},"institutions":[{"id":"https://openalex.org/I4210156904","display_name":"Third Xiangya Hospital","ror":"https://ror.org/05akvb491","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210156904"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ping Yin","raw_affiliation_strings":["Department of Blood Transfusion, the Third Xiangya Hospital of Central South University, Changsha, 410000, Hunan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Blood Transfusion, the Third Xiangya Hospital of Central South University, Changsha, 410000, Hunan, China","institution_ids":["https://openalex.org/I4210156904"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101036950","display_name":"Qin Zhao","orcid":"https://orcid.org/0000-0003-4956-2541","observed_orcids":["https://orcid.org/0000-0003-4956-2541"]},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]},{"id":"https://openalex.org/I4210156904","display_name":"Third Xiangya Hospital","ror":"https://ror.org/05akvb491","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210156904"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Qin Zhao","raw_affiliation_strings":["Department of Pediatric, the Third Xiangya Hospital of Central South University, Changsha, 410000, Hunan, China. 21862847@qq.com","Department of Pediatric, the Third Xiangya Hospital of Central South University, Changsha, 410000, Hunan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatric, the Third Xiangya Hospital of Central South University, Changsha, 410000, Hunan, China. 21862847@qq.com","institution_ids":["https://openalex.org/I139660479","https://openalex.org/I4210156904"]},{"raw_affiliation_string":"Department of Pediatric, the Third Xiangya Hospital of Central South University, Changsha, 410000, Hunan, China","institution_ids":["https://openalex.org/I4210156904"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5101036950"],"corresponding_institution_ids":["https://openalex.org/I139660479","https://openalex.org/I4210156904"],"apc_list":{"value":3790,"currency":"USD","value_usd":3790},"apc_paid":null,"fwci":1.6203,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":{"value":0.7893771,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":97},"biblio":{"volume":"24","issue":"4","first_page":"134","last_page":"134"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13047","display_name":"Pharmacological Receptor Mechanisms and Effects","score":0.7484999895095825,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T13047","display_name":"Pharmacological Receptor Mechanisms and Effects","score":0.7484999895095825,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11150","display_name":"Endoplasmic Reticulum Stress and Disease","score":0.2207999974489212,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12331","display_name":"Hereditary Neurological Disorders","score":0.013799999840557575,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sigma-1-receptor","display_name":"sigma-1 receptor","score":0.8799999952316284},{"id":"https://openalex.org/keywords/distal-hereditary-motor-neuropathy","display_name":"distal hereditary motor neuropathy","score":0.9290000200271606},{"id":"https://openalex.org/keywords/sh-sy5y-cells","display_name":"SH-SY5Y cells","score":0.7929999828338623},{"id":"https://openalex.org/keywords/motor-neuron-apoptosis","display_name":"motor neuron apoptosis","score":0.843999981880188},{"id":"https://openalex.org/keywords/ampk-ulk1-pathway","display_name":"AMPK/ULK1 pathway","score":0.9570000171661377},{"id":"https://openalex.org/keywords/endoplasmic-reticulum-stress","display_name":"endoplasmic reticulum stress","score":0.9539999961853027},{"id":"https://openalex.org/keywords/unfolded-protein-response","display_name":"unfolded protein response","score":0.9150000214576721},{"id":"https://openalex.org/keywords/autophagy","display_name":"autophagy","score":0.9959999918937683},{"id":"https://openalex.org/keywords/caspase-12","display_name":"caspase-12","score":0.6629999876022339},{"id":"https://openalex.org/keywords/caspase-3","display_name":"caspase-3","score":0.7639999985694885}],"concepts":[{"id":"https://openalex.org/C139447449","wikidata":"https://www.wikidata.org/wiki/Q14633900","display_name":"Unfolded protein response","level":3,"score":0.7801175713539124},{"id":"https://openalex.org/C203522944","wikidata":"https://www.wikidata.org/wiki/Q288322","display_name":"Autophagy","level":3,"score":0.7574654817581177},{"id":"https://openalex.org/C158617107","wikidata":"https://www.wikidata.org/wiki/Q79927","display_name":"Endoplasmic reticulum","level":2,"score":0.7558223605155945},{"id":"https://openalex.org/C2781331208","wikidata":"https://www.wikidata.org/wiki/Q18032378","display_name":"XBP1","level":5,"score":0.739579439163208},{"id":"https://openalex.org/C2778997996","wikidata":"https://www.wikidata.org/wiki/Q18036598","display_name":"ATF6","level":4,"score":0.6845283508300781},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6037282943725586},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6032527685165405},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.5807704925537109},{"id":"https://openalex.org/C2780124434","wikidata":"https://www.wikidata.org/wiki/Q12357464","display_name":"AMPK","level":4,"score":0.5550376772880554},{"id":"https://openalex.org/C2779083432","wikidata":"https://www.wikidata.org/wiki/Q7390126","display_name":"SH-SY5Y","level":4,"score":0.5133053660392761},{"id":"https://openalex.org/C2779725641","wikidata":"https://www.wikidata.org/wiki/Q1076228","display_name":"CHOP","level":3,"score":0.47957462072372437},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.4213988184928894},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.38688650727272034},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.37195587158203125},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.30108946561813354},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.2039099633693695},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.12752118706703186},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.09796887636184692},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.08837208151817322},{"id":"https://openalex.org/C54458228","wikidata":"https://www.wikidata.org/wiki/Q237218","display_name":"RNA splicing","level":4,"score":0.0},{"id":"https://openalex.org/C2776715637","wikidata":"https://www.wikidata.org/wiki/Q938205","display_name":"Neuroblastoma","level":3,"score":0.0},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000071189","descriptor_name":"Autophagy-Related Protein-1 Homolog","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000071189","descriptor_name":"Autophagy-Related Protein-1 Homolog","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000097605","descriptor_name":"Sigma-1 Receptor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001343","descriptor_name":"Autophagy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017480","descriptor_name":"Receptors, sigma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D017480","descriptor_name":"Receptors, sigma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047908","descriptor_name":"Intracellular Signaling Peptides and Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D047908","descriptor_name":"Intracellular Signaling Peptides and Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D055372","descriptor_name":"AMP-Activated Protein Kinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D055372","descriptor_name":"AMP-Activated Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D056811","descriptor_name":"Unfolded Protein Response","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059865","descriptor_name":"Endoplasmic Reticulum Stress","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1007/s10142-024-01414-y","doi":"https://doi.org/10.1007/s10142-024-01414-y","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s10142-024-01414-y","pdf_url":null,"source":{"id":"https://openalex.org/S205083708","display_name":"Functional & Integrative Genomics","issn_l":"1438-793X","issn":["1438-793X","1438-7948"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Functional &amp; Integrative Genomics","raw_type":"journal-article"},{"id":"pmid:39107544","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39107544","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Functional & integrative genomics","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9476000070571899,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5637266012","display_name":null,"funder_award_id":"No. 2017JJ2365","funder_id":"https://openalex.org/F4320322866","funder_display_name":"Natural Science Foundation of Hainan Province"}],"funders":[{"id":"https://openalex.org/F4320322866","display_name":"Natural Science Foundation of Hainan Province","ror":"https://ror.org/01h0zpd94"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":55,"referenced_works":["https://openalex.org/W1994289493","https://openalex.org/W2002439304","https://openalex.org/W2019079031","https://openalex.org/W2032366530","https://openalex.org/W2073045063","https://openalex.org/W2096579721","https://openalex.org/W2101826917","https://openalex.org/W2106322477","https://openalex.org/W2118897192","https://openalex.org/W2135855797","https://openalex.org/W2469536647","https://openalex.org/W2519867542","https://openalex.org/W2523971777","https://openalex.org/W2552888741","https://openalex.org/W2589445559","https://openalex.org/W2591962447","https://openalex.org/W2597871074","https://openalex.org/W2599923511","https://openalex.org/W2736843356","https://openalex.org/W2744123648","https://openalex.org/W2763871199","https://openalex.org/W2767326247","https://openalex.org/W2769632036","https://openalex.org/W2786432324","https://openalex.org/W2806081190","https://openalex.org/W2824490147","https://openalex.org/W2888915647","https://openalex.org/W2953115273","https://openalex.org/W2965229043","https://openalex.org/W2969731445","https://openalex.org/W2981925260","https://openalex.org/W3016585211","https://openalex.org/W3026537903","https://openalex.org/W3036212008","https://openalex.org/W3047634917","https://openalex.org/W3080771184","https://openalex.org/W3112175131","https://openalex.org/W3182763960","https://openalex.org/W3187788701","https://openalex.org/W3198853168","https://openalex.org/W3199510603","https://openalex.org/W4200015118","https://openalex.org/W4200097793","https://openalex.org/W4200569725","https://openalex.org/W4223971556","https://openalex.org/W4307715807","https://openalex.org/W4308294024","https://openalex.org/W4308945162","https://openalex.org/W4313518567","https://openalex.org/W4317425523","https://openalex.org/W4317435597","https://openalex.org/W4318053850","https://openalex.org/W4366826405","https://openalex.org/W4380632812","https://openalex.org/W4384938152"],"related_works":["https://openalex.org/W4409281782","https://openalex.org/W2469536647","https://openalex.org/W2118897192","https://openalex.org/W2106322477","https://openalex.org/W2469696470","https://openalex.org/W6908764895","https://openalex.org/W2595229107","https://openalex.org/W1987210736","https://openalex.org/W2982988585","https://openalex.org/W3047634917"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":4}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2024-08-08T00:00:00"}
