{"id":"https://openalex.org/W4401354591","doi":"https://doi.org/10.5455/jelm.20240701091731","title":"Evaluation of Hepatoprotective Potential and oxidative stress of Allium ascalonicum L. methanol leaf extract on liver of Albino rats","display_name":"Evaluation of Hepatoprotective Potential and oxidative stress of Allium ascalonicum L. methanol leaf extract on liver of Albino rats","publication_year":2024,"publication_date":"2024-01-01","ids":{"openalex":"https://openalex.org/W4401354591","doi":"https://doi.org/10.5455/jelm.20240701091731"},"language":"en","primary_location":{"id":"doi:10.5455/jelm.20240701091731","doi":"https://doi.org/10.5455/jelm.20240701091731","is_oa":true,"landing_page_url":"https://doi.org/10.5455/jelm.20240701091731","pdf_url":"https://doi.org/10.5455/jelm.20240701091731","source":{"id":"https://openalex.org/S4404675541","display_name":"Journal of Experimental and Laboratory Medicine.","issn_l":"3041-4814","issn":["3041-4814"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Experimental and Laboratory Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://doi.org/10.5455/jelm.20240701091731","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5010795828","display_name":"Sulaimon Olayiwola Folami","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I98243723","display_name":"Kwara State University","ror":"https://ror.org/05np2xn95","country_code":"NG","type":"education","lineage":["https://openalex.org/I98243723"]}],"countries":["NG"],"is_corresponding":false,"raw_author_name":"Sulaimon Folami","raw_affiliation_strings":["Department of Biochemistry , Faculty of Pure and Applied Sciences , Kwara State University , Kwara , Nigeria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry , Faculty of Pure and Applied Sciences , Kwara State University , Kwara , Nigeria","institution_ids":["https://openalex.org/I98243723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5092655403","display_name":"Oladimeji Lateefah Olabisi","orcid":"https://orcid.org/0000-0002-0915-7587","observed_orcids":["https://orcid.org/0000-0002-0915-7587"]},"institutions":[{"id":"https://openalex.org/I3131979588","display_name":"Al-Hikmah University","ror":"https://ror.org/0008d4756","country_code":"NG","type":"education","lineage":["https://openalex.org/I3131979588"]}],"countries":["NG"],"is_corresponding":false,"raw_author_name":"Lateefah Oladimeji","raw_affiliation_strings":["Department of Public Health , Faculty of Health Sciences , Al-Hikmah University , Ilorin , Nigeria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Public Health , Faculty of Health Sciences , Al-Hikmah University , Ilorin , Nigeria","institution_ids":["https://openalex.org/I3131979588"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Abiodun Lawal","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Abiodun Lawal","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070700931","display_name":"Abdulhafeez Oladimeji Buhari","orcid":"https://orcid.org/0009-0000-2268-3891","observed_orcids":["https://orcid.org/0009-0000-2268-3891"]},"institutions":[{"id":"https://openalex.org/I3131979588","display_name":"Al-Hikmah University","ror":"https://ror.org/0008d4756","country_code":"NG","type":"education","lineage":["https://openalex.org/I3131979588"]}],"countries":["NG"],"is_corresponding":false,"raw_author_name":"Abdulhafeez Buhari","raw_affiliation_strings":["Department of Public Health , Faculty of Health Sciences , Al-Hikmah University , Ilorin , Nigeria","Ministry of Health , Ilorin , Nigeria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Public Health , Faculty of Health Sciences , Al-Hikmah University , Ilorin , Nigeria","institution_ids":["https://openalex.org/I3131979588"]},{"raw_affiliation_string":"Ministry of Health , Ilorin , Nigeria","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5106328784","display_name":"Khadijat Abdulrazaq","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I98243723","display_name":"Kwara State University","ror":"https://ror.org/05np2xn95","country_code":"NG","type":"education","lineage":["https://openalex.org/I98243723"]}],"countries":["NG"],"is_corresponding":false,"raw_author_name":"Khadijat Abdulrazaq","raw_affiliation_strings":["Department of Biochemistry , Faculty of Pure and Applied Sciences , Kwara State University , Kwara , Nigeria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry , Faculty of Pure and Applied Sciences , Kwara State University , Kwara , Nigeria","institution_ids":["https://openalex.org/I98243723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084537206","display_name":"Khadijat A Aliyu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I98243723","display_name":"Kwara State University","ror":"https://ror.org/05np2xn95","country_code":"NG","type":"education","lineage":["https://openalex.org/I98243723"]}],"countries":["NG"],"is_corresponding":false,"raw_author_name":"Khadijat Aliyu","raw_affiliation_strings":["Department of Biochemistry , Faculty of Pure and Applied Sciences , Kwara State University , Kwara , Nigeria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry , Faculty of Pure and Applied Sciences , Kwara State University , Kwara , Nigeria","institution_ids":["https://openalex.org/I98243723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5106328785","display_name":"Ibrahim Pogi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405252860","display_name":"Federal University of Health Sciences, Ila-Orangun","ror":"https://ror.org/00232ct28","country_code":"NG","type":"education","lineage":["https://openalex.org/I4405252860"]}],"countries":["NG"],"is_corresponding":false,"raw_author_name":"Ibrahim Pogi","raw_affiliation_strings":["Department of Biochemistry , Federal University of Health Sciences Ila Orangun , Nigeria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry , Federal University of Health Sciences Ila Orangun , Nigeria","institution_ids":["https://openalex.org/I4405252860"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5104906688","display_name":"Rihanat Bukola Muhammed","orcid":"https://orcid.org/0009-0005-3828-9430","observed_orcids":["https://orcid.org/0009-0005-3828-9430"]},"institutions":[{"id":"https://openalex.org/I3131979588","display_name":"Al-Hikmah University","ror":"https://ror.org/0008d4756","country_code":"NG","type":"education","lineage":["https://openalex.org/I3131979588"]}],"countries":["NG"],"is_corresponding":false,"raw_author_name":"Rihanat Muhammed","raw_affiliation_strings":["Department of Public Health , Faculty of Health Sciences , Al-Hikmah University , Ilorin , Nigeria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Public Health , Faculty of Health Sciences , Al-Hikmah University , Ilorin , Nigeria","institution_ids":["https://openalex.org/I3131979588"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":"0","first_page":"1","last_page":"1"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11979","display_name":"Garlic and Onion Studies","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14521","display_name":"Medicinal Plant Research","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/shallot","display_name":"shallot","score":1.0},{"id":"https://openalex.org/keywords/hepatoprotective-effect","display_name":"hepatoprotection","score":0.8930000066757202},{"id":"https://openalex.org/keywords/acetaminophen-induced-hepatotoxicity","display_name":"acetaminophen hepatotoxicity","score":0.9639999866485596},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.9259999990463257},{"id":"https://openalex.org/keywords/antioxidant-enzymes","display_name":"antioxidant enzymes","score":0.8830000162124634},{"id":"https://openalex.org/keywords/lipid-peroxidation","display_name":"lipid peroxidation","score":0.9890000224113464},{"id":"https://openalex.org/keywords/liver-injury-biomarkers","display_name":"liver injury biomarkers","score":0.6159999966621399},{"id":"https://openalex.org/keywords/methanolic-leaf-extract","display_name":"methanolic leaf extract","score":0.824999988079071},{"id":"https://openalex.org/keywords/phytochemical-screening","display_name":"phytochemical screening","score":0.824999988079071},{"id":"https://openalex.org/keywords/traditional-medicine-validation","display_name":"traditional medicine validation","score":0.8330000042915344},{"id":"https://openalex.org/keywords/anti-inflammatory-cytokines","display_name":"anti-inflammatory cytokines","score":0.6290000081062317}],"concepts":[{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.7542303800582886},{"id":"https://openalex.org/C2776460402","wikidata":"https://www.wikidata.org/wiki/Q49391","display_name":"Allium","level":2,"score":0.641571044921875},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.6092739701271057},{"id":"https://openalex.org/C2779607525","wikidata":"https://www.wikidata.org/wiki/Q14982","display_name":"Methanol","level":2,"score":0.4819231331348419},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4437936842441559},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3997223973274231},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.22771310806274414},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2193073332309723},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.21146360039710999},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.5455/jelm.20240701091731","doi":"https://doi.org/10.5455/jelm.20240701091731","is_oa":true,"landing_page_url":"https://doi.org/10.5455/jelm.20240701091731","pdf_url":"https://doi.org/10.5455/jelm.20240701091731","source":{"id":"https://openalex.org/S4404675541","display_name":"Journal of Experimental and Laboratory Medicine.","issn_l":"3041-4814","issn":["3041-4814"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Experimental and Laboratory Medicine","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.5455/jelm.20240701091731","doi":"https://doi.org/10.5455/jelm.20240701091731","is_oa":true,"landing_page_url":"https://doi.org/10.5455/jelm.20240701091731","pdf_url":"https://doi.org/10.5455/jelm.20240701091731","source":{"id":"https://openalex.org/S4404675541","display_name":"Journal of Experimental and Laboratory Medicine.","issn_l":"3041-4814","issn":["3041-4814"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Experimental and Laboratory Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4401354591.pdf","grobid_xml":"https://content.openalex.org/works/W4401354591.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3097285301","https://openalex.org/W1972378676","https://openalex.org/W7127156535","https://openalex.org/W1987448528","https://openalex.org/W2607765786","https://openalex.org/W2802921343","https://openalex.org/W4312466511","https://openalex.org/W2884729409","https://openalex.org/W7127052037","https://openalex.org/W1521341633"],"abstract_inverted_index":{"Background:":[0],"For":[1],"decades,":[2],"the":[3,14,49,133,141,179,183,198,229,264],"leaves":[4,235],"of":[5,52,76,82,89,108,130,143,155,185,200,205,232],"Allium":[6,53,233],"ascalonicum":[7,54,234],"(commonly":[8],"known":[9],"as":[10,257],"Alubosa":[11],"elewe)":[12],"from":[13],"Liliaceae":[15],"family":[16],"have":[17],"been":[18],"widely":[19],"used":[20],"in":[21,30,59,150,165,182,197],"Nigeria":[22],"for":[23,117,236,266],"managing":[24],"disorders.":[25],"Despite":[26],"its":[27,243,255],"extensive":[28],"use":[29,231],"traditional":[31,41,230],"medicine,":[32],"there":[33],"is":[34],"no":[35],"scientific":[36],"validation":[37],"to":[38,47,71],"support":[39],"this":[40],"use.":[42],"Aim:":[43],"This":[44,225],"study":[45,226],"aimed":[46],"evaluate":[48],"hepatoprotective":[50,80,260],"effect":[51,81],"methanol":[55,244],"extract":[56,245],"(A.":[57],"AMLE)":[58],"albino":[60,201],"rats":[61,98],"with":[62,125],"acetaminophen-induced":[63,163,247],"liver":[64,199,237],"injury.":[65],"Methods:":[66],"Standard":[67],"procedures":[68],"were":[69,99,123,194,218],"employed":[70],"conduct":[72],"a":[73,258],"phytochemical":[74,138],"screening":[75,139],"A.":[77,83,104,151,156,222],"AMLE.":[78,152,223],"The":[79,120,137],"AMLE":[84,105,157],"was":[85],"assessed":[86],"using":[87],"biomarkers":[88],"hepatocellular":[90],"indices,":[91],"oxidative":[92],"stress,":[93],"and":[94,148,174,191,214,216,262,269],"lipid":[95,209],"peroxidation.":[96],"Albino":[97],"administered":[100],"distilled":[101],"water":[102],"or":[103,111],"at":[106],"doses":[107],"100,":[109],"200,":[110],"400":[112],"mg/kg":[113,127],"body":[114,128],"weight,":[115],"respectively,":[116],"seven":[118],"days.":[119],"treatment":[121],"groups":[122],"challenged":[124],"300":[126],"weight":[129],"acetaminophen":[131],"on":[132],"sixth":[134],"day.":[135],"Results:":[136],"revealed":[140],"presence":[142],"flavonoids,":[144],"saponins,":[145],"anthraquinones,":[146],"alkaloids,":[147],"tannins":[149],"Oral":[153],"administration":[154],"significantly":[158,195,219],"(p":[159],"<":[160],"0.05)":[161],"attenuated":[162],"alterations":[164],"serum":[166],"alkaline":[167],"phosphatase,":[168],"alanine":[169],"aminotransferase,":[170,172],"aspartate":[171],"albumin,":[173],"total":[175],"bilirubin":[176],"levels.":[177],"Additionally,":[178],"acetaminophen-mediated":[180],"decrease":[181],"activities":[184],"superoxide":[186],"dismutase,":[187],"catalase,":[188],"glutathione":[189,192],"peroxidase,":[190],"reductase":[193],"ameliorated":[196],"rats.":[202],"Elevated":[203],"levels":[204],"malondialdehyde,":[206],"conjugated":[207],"dienes,":[208],"hydroperoxides,":[210],"tumor":[211],"necrosis":[212],"factor-\u03b1,":[213],"interleukins-6":[215],"-8":[217],"reduced":[220],"by":[221,240],"Conclusion:":[224],"scientifically":[227],"validates":[228],"disorder":[238],"management":[239],"demonstrating":[241],"that":[242],"mitigates":[246],"hepatotoxicity":[248],"through":[249],"enhanced":[250],"antioxidant":[251],"enzyme":[252],"activity,":[253],"highlighting":[254],"potential":[256],"natural":[259],"agent":[261],"paving":[263],"way":[265],"further":[267],"research":[268],"clinical":[270],"application.":[271]},"counts_by_year":[],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2024-08-07T00:00:00"}