{"id":"https://openalex.org/W4401345666","doi":"https://doi.org/10.3389/fphar.2024.1425157","title":"Commiphora myrrha n-hexane extract suppressed breast cancer progression through induction of G0/G1 phase arrest and apoptotic cell death by inhibiting the Cyclin D1/CDK4-Rb signaling pathway","display_name":"Commiphora myrrha n-hexane extract suppressed breast cancer progression through induction of G0/G1 phase arrest and apoptotic cell death by inhibiting the Cyclin D1/CDK4-Rb signaling pathway","publication_year":2024,"publication_date":"2024-08-05","ids":{"openalex":"https://openalex.org/W4401345666","doi":"https://doi.org/10.3389/fphar.2024.1425157","pmid":"https://pubmed.ncbi.nlm.nih.gov/39161904","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11330881"},"language":"en","primary_location":{"id":"doi:10.3389/fphar.2024.1425157","doi":"https://doi.org/10.3389/fphar.2024.1425157","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fphar.2024.1425157","pdf_url":"https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2024.1425157/pdf","source":{"id":"https://openalex.org/S132108250","display_name":"Frontiers in Pharmacology","issn_l":"1663-9812","issn":["1663-9812"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2024.1425157/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5114429819","display_name":"Huiming Huang","orcid":"https://orcid.org/0000-0002-5006-813X","observed_orcids":["https://orcid.org/0000-0002-5006-813X"]},"institutions":[{"id":"https://openalex.org/I17747738","display_name":"Beijing University of Chinese Medicine","ror":"https://ror.org/05damtm70","country_code":"CN","type":"education","lineage":["https://openalex.org/I17747738"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Huiming Huang","raw_affiliation_strings":["Modern Research Center for Traditional Chinese Medicine, Beijing Research Institute of Chinese Medicine, Beijing University of Chinese Medicine, Beijing, China","School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Modern Research Center for Traditional Chinese Medicine, Beijing Research Institute of Chinese Medicine, Beijing University of Chinese Medicine, Beijing, China","institution_ids":["https://openalex.org/I17747738"]},{"raw_affiliation_string":"School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, China","institution_ids":["https://openalex.org/I17747738"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009463317","display_name":"Jinxin Xie","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I17747738","display_name":"Beijing University of Chinese Medicine","ror":"https://ror.org/05damtm70","country_code":"CN","type":"education","lineage":["https://openalex.org/I17747738"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jinxin Xie","raw_affiliation_strings":["Modern Research Center for Traditional Chinese Medicine, Beijing Research Institute of Chinese Medicine, Beijing University of Chinese Medicine, Beijing, China","School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Modern Research Center for Traditional Chinese Medicine, Beijing Research Institute of Chinese Medicine, Beijing University of Chinese Medicine, Beijing, China","institution_ids":["https://openalex.org/I17747738"]},{"raw_affiliation_string":"School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, China","institution_ids":["https://openalex.org/I17747738"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5116066780","display_name":"Fei Wang","orcid":"https://orcid.org/0009-0003-1472-5483","observed_orcids":["https://orcid.org/0009-0003-1472-5483","https://orcid.org/0009-0003-7782-6193"]},"institutions":[{"id":"https://openalex.org/I17747738","display_name":"Beijing University of Chinese Medicine","ror":"https://ror.org/05damtm70","country_code":"CN","type":"education","lineage":["https://openalex.org/I17747738"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fei Wang","raw_affiliation_strings":["Modern Research Center for Traditional Chinese Medicine, Beijing Research Institute of Chinese Medicine, Beijing University of Chinese Medicine, Beijing, China","School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Modern Research Center for Traditional Chinese Medicine, Beijing Research Institute of Chinese Medicine, Beijing University of Chinese Medicine, Beijing, China","institution_ids":["https://openalex.org/I17747738"]},{"raw_affiliation_string":"School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, China","institution_ids":["https://openalex.org/I17747738"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113922989","display_name":"Shungang Jiao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I17747738","display_name":"Beijing University of Chinese Medicine","ror":"https://ror.org/05damtm70","country_code":"CN","type":"education","lineage":["https://openalex.org/I17747738"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shungang Jiao","raw_affiliation_strings":["Modern Research Center for Traditional Chinese Medicine, Beijing Research Institute of Chinese Medicine, Beijing University of Chinese Medicine, Beijing, China","School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Modern Research Center for Traditional Chinese Medicine, Beijing Research Institute of Chinese Medicine, Beijing University of Chinese Medicine, Beijing, China","institution_ids":["https://openalex.org/I17747738"]},{"raw_affiliation_string":"School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, China","institution_ids":["https://openalex.org/I17747738"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100661814","display_name":"Xingxing Li","orcid":"https://orcid.org/0000-0002-8096-5106","observed_orcids":["https://orcid.org/0000-0002-8096-5106"]},"institutions":[{"id":"https://openalex.org/I17747738","display_name":"Beijing University of Chinese Medicine","ror":"https://ror.org/05damtm70","country_code":"CN","type":"education","lineage":["https://openalex.org/I17747738"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xingxing Li","raw_affiliation_strings":["Dongfang Hospital, Beijing University of Chinese Medicine, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dongfang Hospital, Beijing University of Chinese Medicine, Beijing, China","institution_ids":["https://openalex.org/I17747738"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Longyan Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I17747738","display_name":"Beijing University of Chinese Medicine","ror":"https://ror.org/05damtm70","country_code":"CN","type":"education","lineage":["https://openalex.org/I17747738"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Longyan Wang","raw_affiliation_strings":["Modern Research Center for Traditional Chinese Medicine, Beijing Research Institute of Chinese Medicine, Beijing University of Chinese Medicine, Beijing, China","School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Modern Research Center for Traditional Chinese Medicine, Beijing Research Institute of Chinese Medicine, Beijing University of Chinese Medicine, Beijing, China","institution_ids":["https://openalex.org/I17747738"]},{"raw_affiliation_string":"School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, China","institution_ids":["https://openalex.org/I17747738"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101516631","display_name":"Dongxiao Liu","orcid":"https://orcid.org/0000-0001-9656-8976","observed_orcids":["https://orcid.org/0000-0001-9656-8976"]},"institutions":[{"id":"https://openalex.org/I17747738","display_name":"Beijing University of Chinese Medicine","ror":"https://ror.org/05damtm70","country_code":"CN","type":"education","lineage":["https://openalex.org/I17747738"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Dongxiao Liu","raw_affiliation_strings":["Modern Research Center for Traditional Chinese Medicine, Beijing Research Institute of Chinese Medicine, Beijing University of Chinese Medicine, Beijing, China","School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Modern Research Center for Traditional Chinese Medicine, Beijing Research Institute of Chinese Medicine, Beijing University of Chinese Medicine, Beijing, China","institution_ids":["https://openalex.org/I17747738"]},{"raw_affiliation_string":"School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, China","institution_ids":["https://openalex.org/I17747738"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101759334","display_name":"Chaochao Wang","orcid":"https://orcid.org/0009-0004-3154-6169","observed_orcids":["https://orcid.org/0009-0004-3154-6169"]},"institutions":[{"id":"https://openalex.org/I17747738","display_name":"Beijing University of Chinese Medicine","ror":"https://ror.org/05damtm70","country_code":"CN","type":"education","lineage":["https://openalex.org/I17747738"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chaochao Wang","raw_affiliation_strings":["Modern Research Center for Traditional Chinese Medicine, Beijing Research Institute of Chinese Medicine, Beijing University of Chinese Medicine, Beijing, China","School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Modern Research Center for Traditional Chinese Medicine, Beijing Research Institute of Chinese Medicine, Beijing University of Chinese Medicine, Beijing, China","institution_ids":["https://openalex.org/I17747738"]},{"raw_affiliation_string":"School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, China","institution_ids":["https://openalex.org/I17747738"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065176633","display_name":"Xuejiao Wei","orcid":"https://orcid.org/0000-0003-1663-0691","observed_orcids":["https://orcid.org/0000-0003-1663-0691"]},"institutions":[{"id":"https://openalex.org/I17747738","display_name":"Beijing University of Chinese Medicine","ror":"https://ror.org/05damtm70","country_code":"CN","type":"education","lineage":["https://openalex.org/I17747738"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xuejiao Wei","raw_affiliation_strings":["Modern Research Center for Traditional Chinese Medicine, Beijing Research Institute of Chinese Medicine, Beijing University of Chinese Medicine, Beijing, China","School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Modern Research Center for Traditional Chinese Medicine, Beijing Research Institute of Chinese Medicine, Beijing University of Chinese Medicine, Beijing, China","institution_ids":["https://openalex.org/I17747738"]},{"raw_affiliation_string":"School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, China","institution_ids":["https://openalex.org/I17747738"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Peng Tan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I17747738","display_name":"Beijing University of Chinese Medicine","ror":"https://ror.org/05damtm70","country_code":"CN","type":"education","lineage":["https://openalex.org/I17747738"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Peng Tan","raw_affiliation_strings":["Modern Research Center for Traditional Chinese Medicine, Beijing Research Institute of Chinese Medicine, Beijing University of Chinese Medicine, Beijing, China","School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Modern Research Center for Traditional Chinese Medicine, Beijing Research Institute of Chinese Medicine, Beijing University of Chinese Medicine, Beijing, China","institution_ids":["https://openalex.org/I17747738"]},{"raw_affiliation_string":"School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, China","institution_ids":["https://openalex.org/I17747738"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101489693","display_name":"Pengfei Tu","orcid":"https://orcid.org/0000-0002-3848-8174","observed_orcids":["https://orcid.org/0000-0002-3848-8174"]},"institutions":[{"id":"https://openalex.org/I17747738","display_name":"Beijing University of Chinese Medicine","ror":"https://ror.org/05damtm70","country_code":"CN","type":"education","lineage":["https://openalex.org/I17747738"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Pengfei Tu","raw_affiliation_strings":["Modern Research Center for Traditional Chinese Medicine, Beijing Research Institute of Chinese Medicine, Beijing University of Chinese Medicine, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Modern Research Center for Traditional Chinese Medicine, Beijing Research Institute of Chinese Medicine, Beijing University of Chinese Medicine, Beijing, China","institution_ids":["https://openalex.org/I17747738"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100361689","display_name":"Jun Li","orcid":"https://orcid.org/0000-0001-8243-5267","observed_orcids":["https://orcid.org/0000-0001-8243-5267"]},"institutions":[{"id":"https://openalex.org/I17747738","display_name":"Beijing University of Chinese Medicine","ror":"https://ror.org/05damtm70","country_code":"CN","type":"education","lineage":["https://openalex.org/I17747738"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Jun Li","raw_affiliation_strings":["Modern Research Center for Traditional Chinese Medicine, Beijing Research Institute of Chinese Medicine, Beijing University of Chinese Medicine, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Modern Research Center for Traditional Chinese Medicine, Beijing Research Institute of Chinese Medicine, Beijing University of Chinese Medicine, Beijing, China","institution_ids":["https://openalex.org/I17747738"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5006062390","display_name":"Zhongdong Hu","orcid":"https://orcid.org/0000-0003-4849-3353","observed_orcids":["https://orcid.org/0000-0003-4849-3353"]},"institutions":[{"id":"https://openalex.org/I17747738","display_name":"Beijing University of Chinese Medicine","ror":"https://ror.org/05damtm70","country_code":"CN","type":"education","lineage":["https://openalex.org/I17747738"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Zhongdong Hu","raw_affiliation_strings":["Modern Research Center for Traditional Chinese Medicine, Beijing Research Institute of Chinese Medicine, Beijing University of Chinese Medicine, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Modern Research Center for Traditional Chinese Medicine, Beijing Research Institute of Chinese Medicine, Beijing University of Chinese Medicine, Beijing, China","institution_ids":["https://openalex.org/I17747738"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5006062390","https://openalex.org/A5100361689"],"corresponding_institution_ids":["https://openalex.org/I17747738"],"apc_list":{"value":3295,"currency":"USD","value_usd":3295},"apc_paid":{"value":3295,"currency":"USD","value_usd":3295},"fwci":1.6473,"has_fulltext":true,"cited_by_count":8,"citation_normalized_percentile":{"value":0.80499154,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":98},"biblio":{"volume":"15","issue":null,"first_page":"1425157","last_page":"1425157"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13335","display_name":"Pharmacological Effects of Medicinal Plants","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T13335","display_name":"Pharmacological Effects of Medicinal Plants","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14521","display_name":"Medicinal Plant Research","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12530","display_name":"Bioactive Natural Diterpenoids Research","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/commiphora-myrrha","display_name":"Commiphora myrrha","score":0.9760000109672546},{"id":"https://openalex.org/keywords/n-hexane-extract","display_name":"hexane extract","score":0.9649999737739563},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.996999979019165},{"id":"https://openalex.org/keywords/anticancer-activity","display_name":"anticancer activity","score":0.6850000023841858},{"id":"https://openalex.org/keywords/g0-g1-cell-cycle-arrest","display_name":"G0/G1 cell cycle arrest","score":0.9430000185966492},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9779999852180481},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.6610000133514404},{"id":"https://openalex.org/keywords/tumor-growth-inhibition","display_name":"tumor growth inhibition","score":0.6909999847412109},{"id":"https://openalex.org/keywords/mda-mb-231-cells","display_name":"MDA-MB-231 cells","score":0.8740000128746033},{"id":"https://openalex.org/keywords/mcf-7-cells","display_name":"MCF-7 cells","score":0.9990000128746033},{"id":"https://openalex.org/keywords/anticancer-natural-products","display_name":"anticancer natural products","score":0.6129999756813049},{"id":"https://openalex.org/keywords/gene-expression-profiling","display_name":"gene expression profiling","score":0.33399999141693115}],"concepts":[{"id":"https://openalex.org/C199835354","wikidata":"https://www.wikidata.org/wiki/Q15311861","display_name":"Cyclin D1","level":4,"score":0.7377455234527588},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.6838474273681641},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5584763288497925},{"id":"https://openalex.org/C2994037739","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle progression","level":4,"score":0.5296380519866943},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.4878880977630615},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4675632417201996},{"id":"https://openalex.org/C105696609","wikidata":"https://www.wikidata.org/wiki/Q1068809","display_name":"Cell cycle checkpoint","level":4,"score":0.43869784474372864},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.4289359450340271},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3941526710987091},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3721436858177185},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3639369308948517},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.22779226303100586},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.09055566787719727}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3389/fphar.2024.1425157","doi":"https://doi.org/10.3389/fphar.2024.1425157","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fphar.2024.1425157","pdf_url":"https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2024.1425157/pdf","source":{"id":"https://openalex.org/S132108250","display_name":"Frontiers in Pharmacology","issn_l":"1663-9812","issn":["1663-9812"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Pharmacology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11330881","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11330881","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11330881/pdf/fphar-15-1425157.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Pharmacol","raw_type":"Text"},{"id":"pmid:39161904","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39161904","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in pharmacology","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:5a28e389b8e14d0495c8899fd47b206c","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/5a28e389b8e14d0495c8899fd47b206c","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Pharmacology, Vol 15 (2024)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fphar.2024.1425157","doi":"https://doi.org/10.3389/fphar.2024.1425157","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fphar.2024.1425157","pdf_url":"https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2024.1425157/pdf","source":{"id":"https://openalex.org/S132108250","display_name":"Frontiers in Pharmacology","issn_l":"1663-9812","issn":["1663-9812"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Pharmacology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9922999739646912}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320335787","display_name":"Fundamental Research Funds for the Central Universities","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4401345666.pdf","grobid_xml":"https://content.openalex.org/works/W4401345666.grobid-xml"},"referenced_works_count":46,"referenced_works":["https://openalex.org/W1533199841","https://openalex.org/W1967980682","https://openalex.org/W2012241979","https://openalex.org/W2055181205","https://openalex.org/W2093258731","https://openalex.org/W2106856578","https://openalex.org/W2119239908","https://openalex.org/W2139561751","https://openalex.org/W2150134401","https://openalex.org/W2157833022","https://openalex.org/W2194597307","https://openalex.org/W2365981309","https://openalex.org/W2408954743","https://openalex.org/W2524143805","https://openalex.org/W2565383464","https://openalex.org/W2581286732","https://openalex.org/W2607147912","https://openalex.org/W2773301741","https://openalex.org/W2793972506","https://openalex.org/W2892534406","https://openalex.org/W2894674272","https://openalex.org/W2908313351","https://openalex.org/W2935187964","https://openalex.org/W2988393258","https://openalex.org/W2996469637","https://openalex.org/W3010714596","https://openalex.org/W3018280931","https://openalex.org/W3084509866","https://openalex.org/W3087993150","https://openalex.org/W3111543106","https://openalex.org/W3111820675","https://openalex.org/W3132355241","https://openalex.org/W3134715358","https://openalex.org/W3162350134","https://openalex.org/W3185354749","https://openalex.org/W3198894769","https://openalex.org/W4212865994","https://openalex.org/W4213418594","https://openalex.org/W4229335533","https://openalex.org/W4283735415","https://openalex.org/W4284990126","https://openalex.org/W4294991641","https://openalex.org/W4296334521","https://openalex.org/W4307042106","https://openalex.org/W6675770694","https://openalex.org/W6680785810"],"related_works":["https://openalex.org/W4416202061","https://openalex.org/W2106464702","https://openalex.org/W4405679719","https://openalex.org/W4408725588","https://openalex.org/W4391737353","https://openalex.org/W2074879292","https://openalex.org/W4387435794","https://openalex.org/W2123839175","https://openalex.org/W4220970942","https://openalex.org/W3100131433"],"abstract_inverted_index":{"Background":[0],"Breast":[1],"cancer":[2,242],"(BC)":[3],"is":[4,25,38],"one":[5],"of":[6,31,53,73,82,122,147,151,163,179,195,204,220,241,252,268,296,305,312,323,330,340,353],"the":[7,28,47,71,80,119,144,148,156,160,180,192,202,236,249,266,293,303,310,317,321,328,331,337],"most":[8],"frequently":[9],"observed":[10],"malignancies":[11],"globally,":[12],"yet":[13],"drug":[14],"development":[15],"for":[16,43],"BC":[17,84,164,183,306],"has":[18,343],"been":[19],"encountering":[20],"escalating":[21],"challenges.":[22],"Commiphora":[23],"myrrha":[24,33,55,75],"derived":[26],"from":[27],"dried":[29],"resin":[30],"C.":[32,54,74],"(T.":[34],"Nees)":[35],"Engl.,":[36],"and":[37,50,64,89,105,137,168,177,238,263,281,320],"widely":[39],"adopted":[40],"in":[41,124,159,199,210,223,248,275,292,302,348],"China":[42],"treating":[44],"BC.":[45,276],"However,":[46],"anti-BC":[48,120,149,294,338,345],"effect":[49,72,150,339],"underlying":[51,145],"mechanism":[52,146],"remain":[56],"largely":[57],"unclear.":[58],"Methods":[59],"MTT":[60],"assay,":[61,63,136,265],"EdU":[62],"colony":[65],"formation":[66],"were":[67,91,140,186,225],"used":[68],"to":[69,117,142],"determine":[70],"n-hexane":[76],"extract":[77],"(CMHE)":[78],"on":[79,255],"proliferation":[81],"human":[83],"cells.":[85],"Cell":[86],"cycle":[87,314],"distribution":[88],"apoptosis":[90,178,247],"assessed":[92],"via":[93,327],"flow":[94],"cytometry":[95],"analysis.":[96],"Moreover,":[97,172],"metastatic":[98,193,239],"potential":[99,194,344],"was":[100,115],"evaluated":[101],"using":[102],"wound-scratch":[103],"assay":[104,280],"matrigel":[106],"invasion":[107],"assay.":[108],"The":[109],"4T1":[110,211],"breast":[111],"cancer-bearing":[112],"mouse":[113],"model":[114],"established":[116],"evaluate":[118],"efficacy":[121],"CMHE":[123,189,205,221,233,269,299,342],"vivo.":[125],"RNA-sequencing":[126],"analysis,":[127,133,258],"quantitative":[128,259],"real-time":[129,260],"PCR,":[130,261],"immunoblotting,":[131,262],"immunohistochemical":[132,228],"RNA":[134,256,278],"interference":[135,279],"database":[138,282],"analysis":[139,230,283],"conducted":[141],"uncover":[143],"CMHE.":[152,171,297,341],"Results":[153],"We":[154],"demonstrated":[155,231],"significant":[157],"inhibition":[158,329],"proliferative":[161,237],"capability":[162],"cell":[165,184,307,313,325],"lines":[166,185],"MDA-MB-231":[167],"MCF-7":[169],"by":[170],"CMHE-induced":[173],"G0/G1":[174,318],"phase":[175,319],"arrest":[176,315],"above":[181],"two":[182,197],"also":[187,245],"observed.":[188],"dramatically":[190],"repressed":[191],"these":[196],"cells":[198],"vitro.":[200],"Additionally,":[201],"administration":[203,222,267],"remarkably":[206],"suppressed":[207],"tumor":[208,250],"growth":[209,308],"tumor\u2013bearing":[212],"mice.":[213,253],"No":[214],"obvious":[215],"toxic":[216],"or":[217],"side":[218],"effects":[219],"mice":[224],"noted.":[226],"Furthermore,":[227,277],"(IHC)":[229],"that":[232,285],"treatment":[234,300],"inhibited":[235],"abilities":[240],"cells,":[243],"while":[244],"promoting":[246],"tissues":[251],"Based":[254],"sequencing":[257],"IHC":[264],"downregulated":[270,286],"Cyclin":[271,287,332,354],"D1/CDK4-Rb":[272,333,355],"signaling":[273,289],"pathway":[274],"showed":[284],"D1/CDK4":[288],"cascade":[290],"participated":[291],"activity":[295],"Conclusion":[298],"resulted":[301],"suppression":[304],"through":[309],"stimulation":[311],"at":[316],"induction":[322],"apoptotic":[324],"death":[326],"pathway,":[334],"thereby":[335],"enhancing":[336],"effects,":[346],"particularly":[347],"those":[349],"harboring":[350],"aberrant":[351],"activation":[352],"signaling.":[356]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2024-08-06T00:00:00"}