{"id":"https://openalex.org/W4401342102","doi":"https://doi.org/10.1080/03639045.2024.2387166","title":"Nintedanib and miR-29b co-loaded lipoplexes in idiopathic pulmonary fibrosis: formulation, characterization, and in vitro evaluation","display_name":"Nintedanib and miR-29b co-loaded lipoplexes in idiopathic pulmonary fibrosis: formulation, characterization, and in vitro evaluation","publication_year":2024,"publication_date":"2024-07-02","ids":{"openalex":"https://openalex.org/W4401342102","doi":"https://doi.org/10.1080/03639045.2024.2387166","pmid":"https://pubmed.ncbi.nlm.nih.gov/39099436"},"language":"en","primary_location":{"id":"doi:10.1080/03639045.2024.2387166","doi":"https://doi.org/10.1080/03639045.2024.2387166","is_oa":false,"landing_page_url":"https://doi.org/10.1080/03639045.2024.2387166","pdf_url":null,"source":{"id":"https://openalex.org/S162444473","display_name":"Drug Development and Industrial Pharmacy","issn_l":"0363-9045","issn":["0363-9045","1520-5762"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug Development and Industrial Pharmacy","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5087428312","display_name":"Ceren Duraloglu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I66514158","display_name":"Hacettepe University","ror":"https://ror.org/04kwvgz42","country_code":"TR","type":"education","lineage":["https://openalex.org/I66514158"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Ceren Duraloglu","raw_affiliation_strings":["Department of Pharmaceutical Technology, Faculty of Pharmacy, Hacettepe University, Ankara, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Technology, Faculty of Pharmacy, Hacettepe University, Ankara, Turkey","institution_ids":["https://openalex.org/I66514158"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022978620","display_name":"\u0130pek Baysal","orcid":"https://orcid.org/0000-0002-9607-4199","observed_orcids":["https://orcid.org/0000-0002-9607-4199"]},"institutions":[{"id":"https://openalex.org/I66514158","display_name":"Hacettepe University","ror":"https://ror.org/04kwvgz42","country_code":"TR","type":"education","lineage":["https://openalex.org/I66514158"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Ipek Baysal","raw_affiliation_strings":["Vocational School of Health Services, Hacettepe University, Ankara, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vocational School of Health Services, Hacettepe University, Ankara, Turkey","institution_ids":["https://openalex.org/I66514158"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000057792","display_name":"Samiye Yabanoglu Ciftci","orcid":"https://orcid.org/0000-0001-5467-0497","observed_orcids":["https://orcid.org/0000-0001-5467-0497"]},"institutions":[{"id":"https://openalex.org/I66514158","display_name":"Hacettepe University","ror":"https://ror.org/04kwvgz42","country_code":"TR","type":"education","lineage":["https://openalex.org/I66514158"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Samiye Yabanoglu-Ciftci","raw_affiliation_strings":["Department of Biochemistry, Faculty of Pharmacy, Hacettepe University, Ankara, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Faculty of Pharmacy, Hacettepe University, Ankara, Turkey","institution_ids":["https://openalex.org/I66514158"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103548858","display_name":"Bet\u00fcl Ar\u0131ca","orcid":"https://orcid.org/0000-0001-5386-1646","observed_orcids":["https://orcid.org/0000-0001-5386-1646"]},"institutions":[{"id":"https://openalex.org/I66514158","display_name":"Hacettepe University","ror":"https://ror.org/04kwvgz42","country_code":"TR","type":"education","lineage":["https://openalex.org/I66514158"]}],"countries":["TR"],"is_corresponding":true,"raw_author_name":"Betul Arica","raw_affiliation_strings":["Department of Pharmaceutical Technology, Faculty of Pharmacy, Hacettepe University, Ankara, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Technology, Faculty of Pharmacy, Hacettepe University, Ankara, Turkey","institution_ids":["https://openalex.org/I66514158"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5103548858"],"corresponding_institution_ids":["https://openalex.org/I66514158"],"apc_list":null,"apc_paid":null,"fwci":0.2507,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.3166817,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"50","issue":"7","first_page":"671","last_page":"686"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.6255000233650208,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.6255000233650208,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.28130000829696655,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10870","display_name":"Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis","score":0.04309999942779541,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nintedanib","display_name":"nintedanib","score":0.9789999723434448},{"id":"https://openalex.org/keywords/mir-29b","display_name":"miR-29b","score":0.9980000257492065},{"id":"https://openalex.org/keywords/lipoplexes","display_name":"lipoplexes","score":0.7910000085830688},{"id":"https://openalex.org/keywords/idiopathic-pulmonary-fibrosis","display_name":"idiopathic pulmonary fibrosis","score":0.9139999747276306},{"id":"https://openalex.org/keywords/cationic-liposomes","display_name":"cationic liposomes","score":0.9190000295639038},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.703000009059906},{"id":"https://openalex.org/keywords/antifibrotic-therapy","display_name":"antifibrotic therapy","score":0.7580000162124634},{"id":"https://openalex.org/keywords/microfluidization","display_name":"microfluidization","score":0.628000020980835},{"id":"https://openalex.org/keywords/quality-by-design","display_name":"quality by design","score":0.8500000238418579},{"id":"https://openalex.org/keywords/liposome-formulation-optimization","display_name":"liposome formulation optimization","score":0.5630000233650208},{"id":"https://openalex.org/keywords/tgf-beta1-induced-fibrosis","display_name":"TGF-\u03b21-induced fibrosis","score":0.7390000224113464},{"id":"https://openalex.org/keywords/nih-3t3-cells","display_name":"NIH3T3 cells","score":0.871999979019165},{"id":"https://openalex.org/keywords/nucleic-acid-delivery","display_name":"nucleic acid delivery","score":0.7960000038146973},{"id":"https://openalex.org/keywords/encapsulation-efficiency","display_name":"encapsulation efficiency","score":0.5580000281333923}],"concepts":[{"id":"https://openalex.org/C2780171596","wikidata":"https://www.wikidata.org/wiki/Q15149723","display_name":"Nintedanib","level":4,"score":0.9879586696624756},{"id":"https://openalex.org/C2778341716","wikidata":"https://www.wikidata.org/wiki/Q2290446","display_name":"Idiopathic pulmonary fibrosis","level":3,"score":0.8942701816558838},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5845046639442444},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.5151209235191345},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.49336233735084534},{"id":"https://openalex.org/C2781244666","wikidata":"https://www.wikidata.org/wiki/Q32446","display_name":"Pulmonary fibrosis","level":3,"score":0.492829829454422},{"id":"https://openalex.org/C2776999253","wikidata":"https://www.wikidata.org/wiki/Q1304270","display_name":"Combination therapy","level":2,"score":0.43282458186149597},{"id":"https://openalex.org/C2780559512","wikidata":"https://www.wikidata.org/wiki/Q605709","display_name":"Fibrosis","level":2,"score":0.3711889386177063},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3160809874534607},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.22234392166137695},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.1987747848033905},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.06768518686294556}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007211","descriptor_name":"Indoles","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D007211","descriptor_name":"Indoles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D008081","descriptor_name":"Liposomes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D041681","descriptor_name":"NIH 3T3 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053773","descriptor_name":"Transforming Growth Factor beta1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D053773","descriptor_name":"Transforming Growth Factor beta1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D054990","descriptor_name":"Idiopathic Pulmonary Fibrosis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1080/03639045.2024.2387166","doi":"https://doi.org/10.1080/03639045.2024.2387166","is_oa":false,"landing_page_url":"https://doi.org/10.1080/03639045.2024.2387166","pdf_url":null,"source":{"id":"https://openalex.org/S162444473","display_name":"Drug Development and Industrial Pharmacy","issn_l":"0363-9045","issn":["0363-9045","1520-5762"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug Development and Industrial Pharmacy","raw_type":"journal-article"},{"id":"pmid:39099436","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39099436","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug development and industrial pharmacy","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320324256","display_name":"Y\u00fcksek\u00f6\u011fretim Kurulu","ror":"https://ror.org/00j1q0b46"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":102,"referenced_works":["https://openalex.org/W201818518","https://openalex.org/W1511669342","https://openalex.org/W1539484437","https://openalex.org/W1976075858","https://openalex.org/W1992144920","https://openalex.org/W2002064506","https://openalex.org/W2023976671","https://openalex.org/W2034636421","https://openalex.org/W2040661857","https://openalex.org/W2062398289","https://openalex.org/W2080993426","https://openalex.org/W2082168278","https://openalex.org/W2087158191","https://openalex.org/W2107689216","https://openalex.org/W2120055234","https://openalex.org/W2147322791","https://openalex.org/W2148742913","https://openalex.org/W2153657879","https://openalex.org/W2160025282","https://openalex.org/W2164134225","https://openalex.org/W2187976253","https://openalex.org/W2297071715","https://openalex.org/W2317485478","https://openalex.org/W2399907204","https://openalex.org/W2486665380","https://openalex.org/W2586783706","https://openalex.org/W2589859531","https://openalex.org/W2591957834","https://openalex.org/W2592018871","https://openalex.org/W2620269196","https://openalex.org/W2753400916","https://openalex.org/W2762514850","https://openalex.org/W2765491294","https://openalex.org/W2765990589","https://openalex.org/W2789350179","https://openalex.org/W2804846127","https://openalex.org/W2885120517","https://openalex.org/W2892538508","https://openalex.org/W2896791994","https://openalex.org/W2907368400","https://openalex.org/W2945262322","https://openalex.org/W2951842035","https://openalex.org/W2956457443","https://openalex.org/W2959046046","https://openalex.org/W2965332880","https://openalex.org/W2995891886","https://openalex.org/W3024412561","https://openalex.org/W3026032531","https://openalex.org/W3030925034","https://openalex.org/W3046963126","https://openalex.org/W3087200179","https://openalex.org/W3093823740","https://openalex.org/W3096717513","https://openalex.org/W3120494813","https://openalex.org/W3127037227","https://openalex.org/W3136752605","https://openalex.org/W3137357006","https://openalex.org/W3151708782","https://openalex.org/W3168885456","https://openalex.org/W3176773055","https://openalex.org/W3178241978","https://openalex.org/W3182527991","https://openalex.org/W3184622043","https://openalex.org/W3187333782","https://openalex.org/W3194656105","https://openalex.org/W3202744586","https://openalex.org/W3216124398","https://openalex.org/W4200247641","https://openalex.org/W4205609963","https://openalex.org/W4206527368","https://openalex.org/W4206823274","https://openalex.org/W4210272987","https://openalex.org/W4211067148","https://openalex.org/W4214541112","https://openalex.org/W4221007403","https://openalex.org/W4221040351","https://openalex.org/W4221102254","https://openalex.org/W4229451525","https://openalex.org/W4281771262","https://openalex.org/W4281966185","https://openalex.org/W4283758424","https://openalex.org/W4293769852","https://openalex.org/W4306654686","https://openalex.org/W4306765465","https://openalex.org/W4318305278","https://openalex.org/W4322625623","https://openalex.org/W4353087516","https://openalex.org/W4360853480","https://openalex.org/W4361268063","https://openalex.org/W4365815433","https://openalex.org/W4367052859","https://openalex.org/W4384652050","https://openalex.org/W4385143900","https://openalex.org/W4385637349","https://openalex.org/W4386047939","https://openalex.org/W4386387569","https://openalex.org/W4388291586","https://openalex.org/W4388408481","https://openalex.org/W4389097320","https://openalex.org/W4389763266","https://openalex.org/W4399327504","https://openalex.org/W4411618668"],"related_works":["https://openalex.org/W4396728594","https://openalex.org/W7117306141","https://openalex.org/W4393203328","https://openalex.org/W4389117481","https://openalex.org/W4402069680","https://openalex.org/W4365479741","https://openalex.org/W4416416409","https://openalex.org/W4401562802","https://openalex.org/W4391055561","https://openalex.org/W4405743050"],"abstract_inverted_index":{"Objective":[0],"This":[1,43],"study":[2,196,214],"was":[3,69,76],"aimed":[4],"to":[5,111,135,236],"develop":[6],"a":[7,205],"cationic":[8,61],"lipoplex":[9],"formulation":[10,75],"loaded":[11,92],"with":[12,78,103,125,144,198],"Nintedanib":[13,91,179],"and":[14,82,100,142,155,169,180,186,223,233],"miR-29b":[15,104,181],"(LP-NIN-miR)":[16],"as":[17],"an":[18],"alternative":[19],"approach":[20,68],"in":[21,38,54,138,240],"the":[22,45,51,55,86,116,137,159,194,212,216,237,241],"combination":[23],"therapy":[24],"of":[25,57,89,119,158,178,193,211,221,243],"idiopathic":[26],"pulmonary":[27],"dibrosis":[28],"(IPF)":[29],"by":[30,65,97],"proving":[31],"its":[32],"additive":[33,217],"anti-fibrotic":[34,218],"therapeutic":[35,219],"effects":[36],"through":[37],"vitro":[39,139],"lung":[40],"fibrosis":[41],"model.Significance":[42],"is":[44,204],"first":[46],"research":[47],"article":[48],"reported":[49],"that":[50,202,225],"LP-NIN-MIR":[52],"formulations":[53],"treatment":[56,242],"IPF.Methods":[58],"To":[59,114],"optimize":[60],"liposomes":[62],"(LPs),":[63],"quality":[64],"design":[66],"(QbD)":[67],"carried":[70],"out.":[71],"Optimized":[72],"blank":[73],"LP":[74,93],"prepared":[77],"DOTAP,":[79],"CHOL,":[80],"DOPE,":[81],"DSPE-mPEG":[83],"2000":[84],"at":[85,105],"molar":[87],"ratio":[88],"10:10:1:1.":[90],"(LPs-NIN)":[94],"were":[95,101,123,161,182],"produced":[96],"microfluidization":[98],"method":[99],"incubated":[102,143],"room":[106],"temperature":[107],"for":[108,132,146,231],"30":[109],"min":[110],"obtain":[112],"LP-NIN-miR.":[113],"evaluate":[115],"cellular":[117],"uptake":[118],"LP-NIN-miR,":[120],"NIH/3T3":[121,199,238],"cells":[122,200,239],"treated":[124],"20":[126],"ng.mL-1":[127],"transforming":[128],"growth":[129],"factor-\u03b21":[130],"(TGF-\u03b21)":[131],"96":[133],"h":[134],"establish":[136],"IPF":[140],"model":[141],"LP-NIN-miR":[145,160,203,222],"48":[147],"h.Results":[148],"The":[149,175,191,209],"hydrodynamic":[150],"diameter,":[151],"polydispersity":[152],"index":[153],"(PDI),":[154],"zeta":[156],"potential":[157],"87.3":[162],"\u00b1":[163,167,171,184,188],"0.9":[164],"nm,":[165],"0.184":[166],"0.003,":[168],"+24":[170],"1":[172],"mV,":[173],"respectively.":[174,190],"encapsulation":[176],"efficiencies":[177],"99.8%":[183],"0.08%":[185],"99.7%":[187],"1.2%,":[189],"results":[192],"cytotoxicity":[195],"conducted":[197],"indicated":[201],"safe":[206],"delivery":[207,229],"system.Conclusions":[208],"outcome":[210],"transfection":[213],"proved":[215],"effect":[220],"suggested":[224],"lipoplexes":[226],"are":[227],"effective":[228],"systems":[230],"drug":[232],"nucleic":[234],"acid":[235],"IPF.":[244]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2024-08-06T00:00:00"}
