{"id":"https://openalex.org/W4401308149","doi":"https://doi.org/10.1093/toxres/tfae120","title":"Taurine exhibits antioxidant, anti-inflammatory, and antiapoptotic effects against pyraclostrobin exposure in rats","display_name":"Taurine exhibits antioxidant, anti-inflammatory, and antiapoptotic effects against pyraclostrobin exposure in rats","publication_year":2024,"publication_date":"2024-07-01","ids":{"openalex":"https://openalex.org/W4401308149","doi":"https://doi.org/10.1093/toxres/tfae120","pmid":"https://pubmed.ncbi.nlm.nih.gov/39100859","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11295209"},"language":"en","primary_location":{"id":"doi:10.1093/toxres/tfae120","doi":"https://doi.org/10.1093/toxres/tfae120","is_oa":false,"landing_page_url":"https://doi.org/10.1093/toxres/tfae120","pdf_url":null,"source":{"id":"https://openalex.org/S2494971184","display_name":"Toxicology Research","issn_l":"2045-452X","issn":["2045-452X","2045-4538"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","ki-jl-1","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicology Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11295209/pdf/tfae120.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5106277688","display_name":"Ibrahim Serim","orcid":"https://orcid.org/0000-0002-7189-5804","observed_orcids":["https://orcid.org/0000-0002-7189-5804"]},"institutions":[{"id":"https://openalex.org/I52407163","display_name":"Afyon Kocatepe University","ror":"https://ror.org/03a1crh56","country_code":"TR","type":"education","lineage":["https://openalex.org/I52407163"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Ibrahim Serim","raw_affiliation_strings":["Afyon Kocatepe University , Department of Pharmacology and Toxicology, , 03200, Afyonkarahisar, Turkey","Faculty of Veterinary Medicine , Department of Pharmacology and Toxicology, , 03200, Afyonkarahisar, Turkey"],"raw_orcid":"https://orcid.org/0000-0002-7189-5804","affiliations":[{"raw_affiliation_string":"Afyon Kocatepe University , Department of Pharmacology and Toxicology, , 03200, Afyonkarahisar, Turkey","institution_ids":["https://openalex.org/I52407163"]},{"raw_affiliation_string":"Faculty of Veterinary Medicine , Department of Pharmacology and Toxicology, , 03200, Afyonkarahisar, Turkey","institution_ids":["https://openalex.org/I52407163"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034557666","display_name":"Hasan H\u00fcseyin Demirel","orcid":"https://orcid.org/0000-0002-4795-2266","observed_orcids":["https://orcid.org/0000-0002-4795-2266"]},"institutions":[{"id":"https://openalex.org/I52407163","display_name":"Afyon Kocatepe University","ror":"https://ror.org/03a1crh56","country_code":"TR","type":"education","lineage":["https://openalex.org/I52407163"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Hasan Huseyin Demirel","raw_affiliation_strings":["Afyon Kocatepe University, Bayat Vocational School , 03200, Afyonkarahisar, Turkey"],"raw_orcid":"https://orcid.org/0000-0002-4795-2266","affiliations":[{"raw_affiliation_string":"Afyon Kocatepe University, Bayat Vocational School , 03200, Afyonkarahisar, Turkey","institution_ids":["https://openalex.org/I52407163"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058366294","display_name":"Fahriye Zemheri\u2010Navruz","orcid":"https://orcid.org/0000-0003-1744-1091","observed_orcids":["https://orcid.org/0000-0003-1744-1091"]},"institutions":[{"id":"https://openalex.org/I254571519","display_name":"Bartin University","ror":"https://ror.org/03te4vd35","country_code":"TR","type":"education","lineage":["https://openalex.org/I254571519"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Fahriye Zemheri-Navruz","raw_affiliation_strings":["Bart\u0131n University , Department of Molecular Biology and Genetics, , 74100, Bart\u0131n, Turkey","Faculty of Science , Department of Molecular Biology and Genetics, , 74100, Bart\u0131n, Turkey"],"raw_orcid":"https://orcid.org/0000-0003-1744-1091","affiliations":[{"raw_affiliation_string":"Bart\u0131n University , Department of Molecular Biology and Genetics, , 74100, Bart\u0131n, Turkey","institution_ids":["https://openalex.org/I254571519"]},{"raw_affiliation_string":"Faculty of Science , Department of Molecular Biology and Genetics, , 74100, Bart\u0131n, Turkey","institution_ids":["https://openalex.org/I254571519"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5091283369","display_name":"Sinan \u0130nce","orcid":"https://orcid.org/0000-0002-1915-9797","observed_orcids":["https://orcid.org/0000-0002-1915-9797"]},"institutions":[{"id":"https://openalex.org/I52407163","display_name":"Afyon Kocatepe University","ror":"https://ror.org/03a1crh56","country_code":"TR","type":"education","lineage":["https://openalex.org/I52407163"]}],"countries":["TR"],"is_corresponding":true,"raw_author_name":"Sinan Ince","raw_affiliation_strings":["Afyon Kocatepe University , Department of Pharmacology and Toxicology, , 03200, Afyonkarahisar, Turkey","Faculty of Veterinary Medicine , Department of Pharmacology and Toxicology, , 03200, Afyonkarahisar, Turkey"],"raw_orcid":"https://orcid.org/0000-0002-1915-9797","affiliations":[{"raw_affiliation_string":"Afyon Kocatepe University , Department of Pharmacology and Toxicology, , 03200, Afyonkarahisar, Turkey","institution_ids":["https://openalex.org/I52407163"]},{"raw_affiliation_string":"Faculty of Veterinary Medicine , Department of Pharmacology and Toxicology, , 03200, Afyonkarahisar, Turkey","institution_ids":["https://openalex.org/I52407163"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5091283369"],"corresponding_institution_ids":["https://openalex.org/I52407163"],"apc_list":{"value":2688,"currency":"USD","value_usd":2688},"apc_paid":null,"fwci":1.1385,"has_fulltext":true,"cited_by_count":8,"citation_normalized_percentile":{"value":0.71768275,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"13","issue":"4","first_page":"tfae120","last_page":"tfae120"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12533","display_name":"Aldose Reductase and Taurine","score":0.5073000192642212,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12533","display_name":"Aldose Reductase and Taurine","score":0.5073000192642212,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10875","display_name":"Pesticide Exposure and Toxicity","score":0.34380000829696655,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":0.08240000158548355,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/taurine","display_name":"taurine","score":0.9980000257492065},{"id":"https://openalex.org/keywords/pyraclostrobin","display_name":"pyraclostrobin","score":1.0},{"id":"https://openalex.org/keywords/strobilurin-fungicides","display_name":"strobilurin fungicides","score":0.9300000071525574},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.7419999837875366},{"id":"https://openalex.org/keywords/dna-damage","display_name":"DNA damage","score":0.8970000147819519},{"id":"https://openalex.org/keywords/lipid-peroxidation","display_name":"lipid peroxidation","score":0.9580000042915344},{"id":"https://openalex.org/keywords/glutathione","display_name":"glutathione","score":0.8610000014305115},{"id":"https://openalex.org/keywords/catalase","display_name":"catalase","score":0.7829999923706055},{"id":"https://openalex.org/keywords/superoxide-dismutase","display_name":"superoxide dismutase","score":1.0},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.890999972820282},{"id":"https://openalex.org/keywords/cyp2e1","display_name":"CYP2E1","score":0.906000018119812},{"id":"https://openalex.org/keywords/bcl-2","display_name":"Bcl-2","score":0.9980000257492065},{"id":"https://openalex.org/keywords/anti-inflammatory-activity","display_name":"anti-inflammatory activity","score":0.718999981880188},{"id":"https://openalex.org/keywords/hepatotoxicity","display_name":"hepatotoxicity","score":0.828000009059906},{"id":"https://openalex.org/keywords/cytoprotection","display_name":"cytoprotection","score":0.8830000162124634}],"concepts":[{"id":"https://openalex.org/C2779701627","wikidata":"https://www.wikidata.org/wiki/Q207051","display_name":"Taurine","level":3,"score":0.8481416702270508},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.7091102004051208},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.6883714199066162},{"id":"https://openalex.org/C2775838275","wikidata":"https://www.wikidata.org/wiki/Q410776","display_name":"Superoxide dismutase","level":3,"score":0.6659367084503174},{"id":"https://openalex.org/C2778979269","wikidata":"https://www.wikidata.org/wiki/Q106951292","display_name":"Catalase","level":3,"score":0.610392689704895},{"id":"https://openalex.org/C2780829032","wikidata":"https://www.wikidata.org/wiki/Q898539","display_name":"Lipid peroxidation","level":3,"score":0.5687088966369629},{"id":"https://openalex.org/C538909803","wikidata":"https://www.wikidata.org/wiki/Q116907","display_name":"Glutathione","level":3,"score":0.5591163039207458},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5438445806503296},{"id":"https://openalex.org/C164027704","wikidata":"https://www.wikidata.org/wiki/Q3491837","display_name":"Proinflammatory cytokine","level":3,"score":0.5016064643859863},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.46673783659935},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.4444873034954071},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3495067358016968},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.330546110868454},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.31435179710388184},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.20466318726539612},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.11879938840866089},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.07085588574409485},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.04665607213973999}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1093/toxres/tfae120","doi":"https://doi.org/10.1093/toxres/tfae120","is_oa":false,"landing_page_url":"https://doi.org/10.1093/toxres/tfae120","pdf_url":null,"source":{"id":"https://openalex.org/S2494971184","display_name":"Toxicology Research","issn_l":"2045-452X","issn":["2045-452X","2045-4538"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","ki-jl-1","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicology Research","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:11125845","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11295209","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11295209/pdf/tfae120.pdf","source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:39100859","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39100859","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicology research","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11295209","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11295209/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicol Res (Camb)","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:11125845","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11295209","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11295209/pdf/tfae120.pdf","source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8371999859809875}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320312271","display_name":"Afyon Kocatepe \u00dcniversitesi","ror":"https://ror.org/05es91y67"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4401308149.pdf","grobid_xml":"https://content.openalex.org/works/W4401308149.grobid-xml"},"referenced_works_count":39,"referenced_works":["https://openalex.org/W127541880","https://openalex.org/W129846668","https://openalex.org/W1538399032","https://openalex.org/W1775749144","https://openalex.org/W1968690534","https://openalex.org/W1983310681","https://openalex.org/W2016946123","https://openalex.org/W2017376578","https://openalex.org/W2026365242","https://openalex.org/W2052201806","https://openalex.org/W2052202982","https://openalex.org/W2084049042","https://openalex.org/W2096795975","https://openalex.org/W2108244474","https://openalex.org/W2159305277","https://openalex.org/W2169174098","https://openalex.org/W2266929960","https://openalex.org/W2332967459","https://openalex.org/W2394780405","https://openalex.org/W2753286627","https://openalex.org/W2762318481","https://openalex.org/W2768055554","https://openalex.org/W2803877675","https://openalex.org/W2901326859","https://openalex.org/W2942479803","https://openalex.org/W2976210881","https://openalex.org/W3047809404","https://openalex.org/W3087749694","https://openalex.org/W3126339854","https://openalex.org/W3127086915","https://openalex.org/W3134973878","https://openalex.org/W3186185007","https://openalex.org/W3190711042","https://openalex.org/W4206572162","https://openalex.org/W4293082172","https://openalex.org/W4308983984","https://openalex.org/W4386755703","https://openalex.org/W4389635818","https://openalex.org/W4408735366"],"related_works":["https://openalex.org/W7024130455","https://openalex.org/W4293082172","https://openalex.org/W4307230767","https://openalex.org/W3129768374","https://openalex.org/W4387103253","https://openalex.org/W4293004637","https://openalex.org/W2753286627","https://openalex.org/W4320719137","https://openalex.org/W2892783277","https://openalex.org/W2762318481"],"abstract_inverted_index":{"Abstract":[0],"Pyraclostrobin,":[1],"a":[2,138,148,152],"strobilurin-derived":[3],"fungicide,":[4],"causes":[5],"oxidative":[6,163],"stress":[7],"and":[8,26,54,68,78,94,101,106,113,159],"DNA":[9,95],"damage":[10,164],"in":[11,19,39,59,126,134,137],"the":[12,34,142],"organism.":[13],"Taurine":[14,136],"plays":[15],"an":[16],"important":[17],"role":[18],"metabolic":[20],"processes":[21],"such":[22],"as":[23],"osmoregulatory,":[24],"cytoprotective,":[25],"antioxidant":[27],"effects.":[28],"The":[29,47],"study":[30],"aimed":[31],"to":[32,45],"investigate":[33],"protective":[35],"effect":[36,154],"of":[37,104],"taurine":[38,74,150],"Sprague":[40],"Dawley":[41],"male":[42],"rats":[43,48],"exposed":[44],"pyraclostrobin.":[46,146,167],"were":[49,55,63],"separated":[50],"into":[51],"6":[52],"groups":[53],"found":[56],"8":[57],"animals":[58],"each":[60],"group.":[61],"Rats":[62],"given":[64],"30":[65],"mg/kg":[66],"pyraclostrobin":[67,69,88,130],"together":[70],"with":[71],"three":[72],"different":[73],"concentrations":[75],"(50,":[76],"100,":[77],"200":[79],"mg/kg)":[80],"via":[81],"oral":[82],"gavage":[83],"for":[84],"28":[85],"days.":[86],"While":[87],"increased":[89,110],"biochemical":[90],"parameters,":[91],"lipid":[92],"peroxidation,":[93],"damage,":[96],"it":[97],"decreased":[98,125],"glutathione":[99],"levels":[100,124],"enzyme":[102],"activities":[103,161],"catalase":[105],"superoxide":[107],"dismutase.":[108],"Pyraclostrobin":[109],"apoptotic,":[111],"proinflammatory,":[112],"CYP2E1":[114],"mRNA":[115,122],"expression":[116,123],"levels,":[117],"whereas":[118],"antiapoptotic":[119,160],"gene":[120],"Bcl-2":[121],"liver":[127],"tissue.":[128],"Additionally,":[129],"caused":[131,144,165],"histopathological":[132],"alterations":[133],"tissues.":[135],"dose-dependent":[139],"manner":[140],"reversed":[141],"changes":[143],"by":[145,155,166],"As":[147],"result,":[149],"exhibited":[151],"cytoprotective":[153],"showing":[156],"antioxidant,":[157],"anti-inflammatory,":[158],"against":[162]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2024-08-04T00:00:00"}
