{"id":"https://openalex.org/W4401277567","doi":"https://doi.org/10.3389/fimmu.2024.1410784","title":"Chinese medicine PaBing-II protects human iPSC-derived dopaminergic neurons from oxidative stress","display_name":"Chinese medicine PaBing-II protects human iPSC-derived dopaminergic neurons from oxidative stress","publication_year":2024,"publication_date":"2024-08-02","ids":{"openalex":"https://openalex.org/W4401277567","doi":"https://doi.org/10.3389/fimmu.2024.1410784","pmid":"https://pubmed.ncbi.nlm.nih.gov/39156892","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11327085"},"language":"en","primary_location":{"id":"doi:10.3389/fimmu.2024.1410784","doi":"https://doi.org/10.3389/fimmu.2024.1410784","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2024.1410784","pdf_url":null,"source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3389/fimmu.2024.1410784","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5104262471","display_name":"Shouhai Wu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I117532281","display_name":"Guangzhou University of Chinese Medicine","ror":"https://ror.org/03qb7bg95","country_code":"CN","type":"education","lineage":["https://openalex.org/I117532281"]},{"id":"https://openalex.org/I4210105984","display_name":"Guangdong Provincial Hospital of Chinese Medicine","ror":"https://ror.org/01gb3y148","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210105984"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Shouhai Wu","raw_affiliation_strings":["Department of Nephrology, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, China","State Key Laboratory of Dampness Syndrome of Chinese Medicine, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangdong, Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nephrology, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, China","institution_ids":["https://openalex.org/I4210105984"]},{"raw_affiliation_string":"State Key Laboratory of Dampness Syndrome of Chinese Medicine, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangdong, Guangzhou, China","institution_ids":["https://openalex.org/I117532281","https://openalex.org/I4210105984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045231917","display_name":"Cuiping Rong","orcid":"https://orcid.org/0000-0001-6446-841X","observed_orcids":["https://orcid.org/0000-0001-6446-841X"]},"institutions":[{"id":"https://openalex.org/I117532281","display_name":"Guangzhou University of Chinese Medicine","ror":"https://ror.org/03qb7bg95","country_code":"CN","type":"education","lineage":["https://openalex.org/I117532281"]},{"id":"https://openalex.org/I4210105984","display_name":"Guangdong Provincial Hospital of Chinese Medicine","ror":"https://ror.org/01gb3y148","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210105984"]},{"id":"https://openalex.org/I4210106687","display_name":"The First Affiliated Hospital of Guangxi University of Traditional Chinese Medicine","ror":"https://ror.org/01qh7se39","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210106687"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Cuiping Rong","raw_affiliation_strings":["Laboratory of Molecular Biology, The First Affiliated Hospital of Guangxi University of Chinese Medicine, Guangxi, Nanning, China","State Key Laboratory of Dampness Syndrome of Chinese Medicine, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangdong, Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Biology, The First Affiliated Hospital of Guangxi University of Chinese Medicine, Guangxi, Nanning, China","institution_ids":["https://openalex.org/I4210106687"]},{"raw_affiliation_string":"State Key Laboratory of Dampness Syndrome of Chinese Medicine, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangdong, Guangzhou, China","institution_ids":["https://openalex.org/I117532281","https://openalex.org/I4210105984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090688465","display_name":"Ruishan Lin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I117532281","display_name":"Guangzhou University of Chinese Medicine","ror":"https://ror.org/03qb7bg95","country_code":"CN","type":"education","lineage":["https://openalex.org/I117532281"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ruishan Lin","raw_affiliation_strings":["Experimental Teaching Center, School of Basic Medical Sciences, Guangzhou University of Chinese Medicine, Guangdong, Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Experimental Teaching Center, School of Basic Medical Sciences, Guangzhou University of Chinese Medicine, Guangdong, Guangzhou, China","institution_ids":["https://openalex.org/I117532281"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055053314","display_name":"Kaiyuan Ji","orcid":"https://orcid.org/0000-0002-6293-6694","observed_orcids":["https://orcid.org/0000-0002-6293-6694"]},"institutions":[{"id":"https://openalex.org/I4210105982","display_name":"Guangzhou Women and Children Medical Center","ror":"https://ror.org/01g53at17","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210105982"]},{"id":"https://openalex.org/I92039509","display_name":"Guangzhou Medical University","ror":"https://ror.org/00zat6v61","country_code":"CN","type":"education","lineage":["https://openalex.org/I92039509"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Kaiyuan Ji","raw_affiliation_strings":["Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangdong, Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangdong, Guangzhou, China","institution_ids":["https://openalex.org/I4210105982","https://openalex.org/I92039509"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091160712","display_name":"Tongxiang Lin","orcid":"https://orcid.org/0000-0001-7033-6982","observed_orcids":["https://orcid.org/0000-0001-7033-6982"]},"institutions":[{"id":"https://openalex.org/I117532281","display_name":"Guangzhou University of Chinese Medicine","ror":"https://ror.org/03qb7bg95","country_code":"CN","type":"education","lineage":["https://openalex.org/I117532281"]},{"id":"https://openalex.org/I4210105984","display_name":"Guangdong Provincial Hospital of Chinese Medicine","ror":"https://ror.org/01gb3y148","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210105984"]},{"id":"https://openalex.org/I61057504","display_name":"Fujian Agriculture and Forestry University","ror":"https://ror.org/04kx2sy84","country_code":"CN","type":"education","lineage":["https://openalex.org/I61057504"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Tongxiang Lin","raw_affiliation_strings":["College of Animal Sciences, Fujian Agriculture and Forestry University, Fujian, Fuzhou, China","State Key Laboratory of Dampness Syndrome of Chinese Medicine, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangdong, Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Animal Sciences, Fujian Agriculture and Forestry University, Fujian, Fuzhou, China","institution_ids":["https://openalex.org/I61057504"]},{"raw_affiliation_string":"State Key Laboratory of Dampness Syndrome of Chinese Medicine, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangdong, Guangzhou, China","institution_ids":["https://openalex.org/I117532281","https://openalex.org/I4210105984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100442503","display_name":"Weimin Chen","orcid":"https://orcid.org/0000-0002-0946-3605","observed_orcids":["https://orcid.org/0000-0002-0946-3605"]},"institutions":[{"id":"https://openalex.org/I117532281","display_name":"Guangzhou University of Chinese Medicine","ror":"https://ror.org/03qb7bg95","country_code":"CN","type":"education","lineage":["https://openalex.org/I117532281"]},{"id":"https://openalex.org/I4210105984","display_name":"Guangdong Provincial Hospital of Chinese Medicine","ror":"https://ror.org/01gb3y148","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210105984"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Weimin Chen","raw_affiliation_strings":["State Key Laboratory of Dampness Syndrome of Chinese Medicine, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangdong, Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Dampness Syndrome of Chinese Medicine, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangdong, Guangzhou, China","institution_ids":["https://openalex.org/I117532281","https://openalex.org/I4210105984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113930908","display_name":"Wei Mao","orcid":"https://orcid.org/0000-0002-8262-0478","observed_orcids":["https://orcid.org/0000-0002-8262-0478"]},"institutions":[{"id":"https://openalex.org/I117532281","display_name":"Guangzhou University of Chinese Medicine","ror":"https://ror.org/03qb7bg95","country_code":"CN","type":"education","lineage":["https://openalex.org/I117532281"]},{"id":"https://openalex.org/I4210105984","display_name":"Guangdong Provincial Hospital of Chinese Medicine","ror":"https://ror.org/01gb3y148","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210105984"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Wei Mao","raw_affiliation_strings":["Department of Nephrology, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, China","State Key Laboratory of Dampness Syndrome of Chinese Medicine, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangdong, Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nephrology, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, China","institution_ids":["https://openalex.org/I4210105984"]},{"raw_affiliation_string":"State Key Laboratory of Dampness Syndrome of Chinese Medicine, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangdong, Guangzhou, China","institution_ids":["https://openalex.org/I117532281","https://openalex.org/I4210105984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100779940","display_name":"Yang Xu","orcid":"https://orcid.org/0000-0001-5574-921X","observed_orcids":["https://orcid.org/0000-0001-5574-921X"]},"institutions":[{"id":"https://openalex.org/I4210158318","display_name":"Second Affiliated Hospital of Zhejiang University","ror":"https://ror.org/059cjpv64","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210158318"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yang Xu","raw_affiliation_strings":["Department of Cardiology, Heart Regeneration and Repair Key Laboratory of Zhejiang Province, State Key Laboratory of Transvascular Implantation Devices, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China","Research Center for Life Science and Human Health, Binjiang Institute of Zhejiang University, Zhejiang, Hangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Heart Regeneration and Repair Key Laboratory of Zhejiang Province, State Key Laboratory of Transvascular Implantation Devices, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China","institution_ids":["https://openalex.org/I4210158318","https://openalex.org/I76130692"]},{"raw_affiliation_string":"Research Center for Life Science and Human Health, Binjiang Institute of Zhejiang University, Zhejiang, Hangzhou, China","institution_ids":["https://openalex.org/I76130692"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5100779940","https://openalex.org/A5104262471","https://openalex.org/A5113930908"],"corresponding_institution_ids":["https://openalex.org/I117532281","https://openalex.org/I4210105984","https://openalex.org/I4210158318","https://openalex.org/I76130692"],"apc_list":{"value":3295,"currency":"USD","value_usd":3295},"apc_paid":{"value":3295,"currency":"USD","value_usd":3295},"fwci":0.2524,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.53188148,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":94},"biblio":{"volume":"15","issue":null,"first_page":"1410784","last_page":"1410784"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13991","display_name":"Nuclear Receptors and Signaling","score":0.003700000001117587,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11332","display_name":"Genomics, phytochemicals, and oxidative stress","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/parkinson-s-disease","display_name":"Parkinson's disease","score":0.8709999918937683},{"id":"https://openalex.org/keywords/dopaminergic-neurons","display_name":"dopaminergic neurons","score":0.9139999747276306},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.8640000224113464},{"id":"https://openalex.org/keywords/nrf2-signaling-pathway","display_name":"Nrf2 signaling","score":0.9350000023841858},{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":0.703000009059906},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.4779999852180481},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.765999972820282},{"id":"https://openalex.org/keywords/ipsc-derived-neurons","display_name":"iPSC-derived neurons","score":0.8180000185966492},{"id":"https://openalex.org/keywords/6-hydroxydopamine","display_name":"6-hydroxydopamine","score":0.8659999966621399},{"id":"https://openalex.org/keywords/traditional-chinese-medicine","display_name":"traditional Chinese medicine","score":0.7860000133514404},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.6480000019073486}],"concepts":[{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.7781510353088379},{"id":"https://openalex.org/C137183658","wikidata":"https://www.wikidata.org/wiki/Q461076","display_name":"Dopaminergic","level":3,"score":0.6722323298454285},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.5785849094390869},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5770524740219116},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.560904324054718},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.5512710809707642},{"id":"https://openalex.org/C2779734285","wikidata":"https://www.wikidata.org/wiki/Q11085","display_name":"Parkinson's disease","level":3,"score":0.5389485955238342},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.5315340161323547},{"id":"https://openalex.org/C88045685","wikidata":"https://www.wikidata.org/wiki/Q174576","display_name":"Activator (genetics)","level":3,"score":0.47079744935035706},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.46483445167541504},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.4647331237792969},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.4545019567012787},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.45406976342201233},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.41632288694381714},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.3783518671989441},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.32303154468536377},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.31484001874923706},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3130090832710266},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.23524510860443115},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.21950477361679077},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.19263634085655212},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.18595266342163086},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1402384340763092},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.11732867360115051},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004365","descriptor_name":"Drugs, Chinese Herbal","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008516","descriptor_name":"Medicine, Chinese Traditional","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D016627","descriptor_name":"Oxidopamine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D018696","descriptor_name":"Neuroprotective Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D018696","descriptor_name":"Neuroprotective Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D051267","descriptor_name":"NF-E2-Related Factor 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057026","descriptor_name":"Induced Pluripotent Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D059290","descriptor_name":"Dopaminergic Neurons","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D059290","descriptor_name":"Dopaminergic Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.3389/fimmu.2024.1410784","doi":"https://doi.org/10.3389/fimmu.2024.1410784","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2024.1410784","pdf_url":null,"source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},{"id":"doi:10.21203/rs.3.rs-179866/v1","doi":"https://doi.org/10.21203/rs.3.rs-179866/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-179866/v1","pdf_url":"https://www.researchsquare.com/article/rs-179866/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},{"id":"pmh:oai:pubmedcentral.nih.gov:11327085","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11327085","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Immunol","raw_type":"Text"},{"id":"pmid:39156892","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39156892","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in immunology","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:153f9207006b4ae0969a684d734cb4ca","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/153f9207006b4ae0969a684d734cb4ca","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Immunology, Vol 15 (2024)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fimmu.2024.1410784","doi":"https://doi.org/10.3389/fimmu.2024.1410784","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2024.1410784","pdf_url":null,"source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320313841","display_name":"Guangdong Provincial Hospital of Traditional Chinese Medicine","ror":"https://ror.org/01gb3y148"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4401277567.pdf","grobid_xml":"https://content.openalex.org/works/W4401277567.grobid-xml"},"referenced_works_count":51,"referenced_works":["https://openalex.org/W2082893764","https://openalex.org/W2091995999","https://openalex.org/W2093120223","https://openalex.org/W2130410032","https://openalex.org/W2158480093","https://openalex.org/W2168250872","https://openalex.org/W2273064350","https://openalex.org/W2318098379","https://openalex.org/W2352909378","https://openalex.org/W2356687122","https://openalex.org/W2360853149","https://openalex.org/W2369286395","https://openalex.org/W2372001618","https://openalex.org/W2378777225","https://openalex.org/W2585321129","https://openalex.org/W2588008972","https://openalex.org/W2800211923","https://openalex.org/W2921691260","https://openalex.org/W2928665623","https://openalex.org/W2946412700","https://openalex.org/W2951348834","https://openalex.org/W2952443280","https://openalex.org/W2961283112","https://openalex.org/W2974467960","https://openalex.org/W2981209864","https://openalex.org/W2982542630","https://openalex.org/W2982948599","https://openalex.org/W2983175605","https://openalex.org/W2988154783","https://openalex.org/W2989863764","https://openalex.org/W2990393150","https://openalex.org/W2991251511","https://openalex.org/W2994724632","https://openalex.org/W2995547731","https://openalex.org/W2998586063","https://openalex.org/W3015784228","https://openalex.org/W3029656741","https://openalex.org/W3042580583","https://openalex.org/W3047677856","https://openalex.org/W3092609200","https://openalex.org/W3110258185","https://openalex.org/W4211123396","https://openalex.org/W4211246989","https://openalex.org/W4220692813","https://openalex.org/W4229373169","https://openalex.org/W4234561502","https://openalex.org/W4297341527","https://openalex.org/W4323655395","https://openalex.org/W4365452655","https://openalex.org/W4388807836","https://openalex.org/W6603989641"],"related_works":["https://openalex.org/W3127945610","https://openalex.org/W2356687122","https://openalex.org/W2984654711","https://openalex.org/W3017303929","https://openalex.org/W4417152347","https://openalex.org/W3217007203","https://openalex.org/W2585587929","https://openalex.org/W2140603105","https://openalex.org/W916728855","https://openalex.org/W2028469673"],"abstract_inverted_index":{"Abstract":[0],"BackgroundPaBing-II":[1],"Formula":[2],"(PB-II)":[3],"is":[4],"a":[5],"traditional":[6],"Chinese":[7],"medicine":[8],"developed":[9],"to":[10,17,37,56],"treat":[11,38],"Parkinson's":[12],"disease":[13],"(PD).":[14],"However,":[15],"due":[16],"the":[18,23,33,44,58,113,122,143,151,159],"complexity":[19],"of":[20,25,35,61,115,126,130,145],"PB-II":[21,36,62,86,98,119],"and":[22,51,141],"difficulty":[24],"culturing":[26],"human":[27,45],"dopaminergic":[28,128],"neurons":[29,129,153],"(DAn)":[30],"in":[31,73],"vitro,":[32],"mechanism":[34],"PD":[39,74,131,146],"remains":[40],"unclear.":[41],"MethodsWe":[42],"established":[43],"induced":[46,133],"pluripotent":[47],"stem":[48],"cells":[49],"(iPSCs)":[50],"derived":[52,80],"DAn":[53,64,90,139],"from":[54,81,91,154],"hiPSCs":[55],"study":[57],"protective":[59],"effects":[60],"on":[63],"after":[65],"oxidative":[66,155],"stress,":[67],"which":[68,109],"plays":[69],"an":[70],"important":[71],"role":[72],"pathogenesis.":[75],"ResultsWe":[76],"found":[77],"that":[78,83],"serum":[79,100],"rats":[82,132],"had":[84],"ingested":[85],"significantly":[87,149],"protect":[88],"hiPSC-derived":[89],"reactive":[92],"oxygen":[93],"species":[94],"(ROS).":[95],"In":[96,117],"addition,":[97,118],"dependent":[99],"can":[101,120],"activate":[102,121],"nuclear":[103],"erythroid-derived":[104],"factor":[105],"2":[106],"(Nrf2)":[107],"responses,":[108],"are":[110],"required":[111],"for":[112],"neutralization":[114],"ROS.":[116],"Nrf2/ARE":[123],"signal":[124],"pathway":[125],"midbrain":[127],"with":[134],"6-hydroxydopamine":[135],"(6-OHDA)":[136],"injury,":[137],"rescue":[138],"cells,":[140],"improve":[142],"symptoms":[144],"rats.":[147],"ConclusionsPB-II":[148],"protects":[150],"DA":[152],"stress":[156],"by":[157],"activating":[158],"Nrf2":[160],"pathway.":[161]},"counts_by_year":[{"year":2025,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2024-08-03T00:00:00"}