{"id":"https://openalex.org/W4401226239","doi":"https://doi.org/10.47829/coo.2024.71201","title":"Severe Ocular Adverse Reaction Following Single Pembrolizumab Infusion: A Case Report","display_name":"Severe Ocular Adverse Reaction Following Single Pembrolizumab Infusion: A Case Report","publication_year":2024,"publication_date":"2024-07-22","ids":{"openalex":"https://openalex.org/W4401226239","doi":"https://doi.org/10.47829/coo.2024.71201"},"language":"en","primary_location":{"id":"doi:10.47829/coo.2024.71201","doi":"https://doi.org/10.47829/coo.2024.71201","is_oa":true,"landing_page_url":"http://doi.org/10.47829/coo.2024.71201","pdf_url":"https://doi.org/10.47829/coo.2024.71201","source":{"id":"https://openalex.org/S4210216556","display_name":"Clinics of Oncology","issn_l":"2640-1037","issn":["2640-1037"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinics of oncology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://doi.org/10.47829/coo.2024.71201","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5064324696","display_name":"Nisha Nixon","orcid":"https://orcid.org/0000-0003-3707-0312","observed_orcids":["https://orcid.org/0000-0003-3707-0312"]},"institutions":[{"id":"https://openalex.org/I2802466933","display_name":"Cambridge University Hospitals NHS Foundation Trust","ror":"https://ror.org/04v54gj93","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802466933"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Nisha Nixon","raw_affiliation_strings":["Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK","institution_ids":["https://openalex.org/I2802466933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042223188","display_name":"Vaidehi Konteti","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802466933","display_name":"Cambridge University Hospitals NHS Foundation Trust","ror":"https://ror.org/04v54gj93","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802466933"]},{"id":"https://openalex.org/I4210150286","display_name":"North Middlesex University Hospital NHS Trust","ror":"https://ror.org/048919h66","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4210150286"]},{"id":"https://openalex.org/I4210153090","display_name":"North Middlesex Hospital","ror":"https://ror.org/00eph4903","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4210150286","https://openalex.org/I4210153090"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Vaidehi Konteti","raw_affiliation_strings":["Cambridge University Hospitals NHS Foundation Trust , Cambridge , UK","North Middlesex University Hospital NHS Foundation Trust, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cambridge University Hospitals NHS Foundation Trust , Cambridge , UK","institution_ids":["https://openalex.org/I2802466933"]},{"raw_affiliation_string":"North Middlesex University Hospital NHS Foundation Trust, London, UK","institution_ids":["https://openalex.org/I4210150286","https://openalex.org/I4210153090"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082518296","display_name":"Karan Gupta","orcid":"https://orcid.org/0000-0002-4825-6625","observed_orcids":["https://orcid.org/0000-0002-4825-6625","https://orcid.org/0009-0000-1653-1808"]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Karan Gupta","raw_affiliation_strings":["University of Cambridge Clinical School, Cambridge, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Cambridge Clinical School, Cambridge, UK","institution_ids":["https://openalex.org/I241749"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113729128","display_name":"Anna M. Thompson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210150286","display_name":"North Middlesex University Hospital NHS Trust","ror":"https://ror.org/048919h66","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4210150286"]},{"id":"https://openalex.org/I4210153090","display_name":"North Middlesex Hospital","ror":"https://ror.org/00eph4903","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4210150286","https://openalex.org/I4210153090"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Anna Thompson","raw_affiliation_strings":["North Middlesex University Hospital NHS Foundation Trust, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"North Middlesex University Hospital NHS Foundation Trust, London, UK","institution_ids":["https://openalex.org/I4210150286","https://openalex.org/I4210153090"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111402673","display_name":"Erika Marie Damato","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802466933","display_name":"Cambridge University Hospitals NHS Foundation Trust","ror":"https://ror.org/04v54gj93","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802466933"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Erika Damato","raw_affiliation_strings":["Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK","institution_ids":["https://openalex.org/I2802466933"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5073157378","display_name":"Madhavan S. Rajan","orcid":"https://orcid.org/0000-0003-2223-5364","observed_orcids":["https://orcid.org/0000-0003-2223-5364"]},"institutions":[{"id":"https://openalex.org/I2802466933","display_name":"Cambridge University Hospitals NHS Foundation Trust","ror":"https://ror.org/04v54gj93","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802466933"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Madhavan Rajan","raw_affiliation_strings":["Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK","institution_ids":["https://openalex.org/I2802466933"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.15556744,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"07","issue":"12","first_page":"01","last_page":"04"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.6640999913215637,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.6640999913215637,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13467","display_name":"Drug-Induced Ocular Toxicity","score":0.3127000033855438,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11194","display_name":"Ocular Diseases and Beh\u00e7et\u2019s Syndrome","score":0.013299999758601189,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pembrolizumab","display_name":"pembrolizumab","score":1.0},{"id":"https://openalex.org/keywords/panuveitis","display_name":"panuveitis","score":0.8870000243186951},{"id":"https://openalex.org/keywords/immune-related-adverse-events","display_name":"immune-related adverse events","score":0.8379999995231628},{"id":"https://openalex.org/keywords/immune-checkpoint-inhibitors","display_name":"immune checkpoint inhibitors","score":0.8230000138282776},{"id":"https://openalex.org/keywords/pd-1-inhibitors","display_name":"PD-1 inhibitors","score":0.781000018119812},{"id":"https://openalex.org/keywords/vision-loss","display_name":"vision loss","score":0.7919999957084656},{"id":"https://openalex.org/keywords/ocular-toxicity","display_name":"ocular toxicity","score":0.7160000205039978},{"id":"https://openalex.org/keywords/immunotherapy","display_name":"immunotherapy","score":0.6970000267028809}],"concepts":[{"id":"https://openalex.org/C2780057760","wikidata":"https://www.wikidata.org/wiki/Q13896859","display_name":"Pembrolizumab","level":4,"score":0.9859126210212708},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8679959774017334},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.6886084675788879},{"id":"https://openalex.org/C2776194053","wikidata":"https://www.wikidata.org/wiki/Q280027","display_name":"Uveitis","level":2,"score":0.6503653526306152},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.5268707871437073},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.48725762963294983},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.44924965500831604},{"id":"https://openalex.org/C118487528","wikidata":"https://www.wikidata.org/wiki/Q161437","display_name":"Ophthalmology","level":1,"score":0.33784177899360657},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.27207744121551514},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2609609067440033}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.47829/coo.2024.71201","doi":"https://doi.org/10.47829/coo.2024.71201","is_oa":true,"landing_page_url":"http://doi.org/10.47829/coo.2024.71201","pdf_url":"https://doi.org/10.47829/coo.2024.71201","source":{"id":"https://openalex.org/S4210216556","display_name":"Clinics of Oncology","issn_l":"2640-1037","issn":["2640-1037"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinics of oncology","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.47829/coo.2024.71201","doi":"https://doi.org/10.47829/coo.2024.71201","is_oa":true,"landing_page_url":"http://doi.org/10.47829/coo.2024.71201","pdf_url":"https://doi.org/10.47829/coo.2024.71201","source":{"id":"https://openalex.org/S4210216556","display_name":"Clinics of Oncology","issn_l":"2640-1037","issn":["2640-1037"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinics of oncology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/case-report","display_name":"Case Report"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4401226239.pdf","grobid_xml":"https://content.openalex.org/works/W4401226239.grobid-xml"},"referenced_works_count":8,"referenced_works":["https://openalex.org/W2265285917","https://openalex.org/W2786816161","https://openalex.org/W2793180707","https://openalex.org/W2938559664","https://openalex.org/W3000398809","https://openalex.org/W3130523133","https://openalex.org/W4293217527","https://openalex.org/W4321482790"],"related_works":["https://openalex.org/W3046736595","https://openalex.org/W2991201958","https://openalex.org/W2526699566","https://openalex.org/W2912748007","https://openalex.org/W4406950883","https://openalex.org/W2938559664","https://openalex.org/W3151695062","https://openalex.org/W7164132811","https://openalex.org/W4313561458","https://openalex.org/W4411501381"],"abstract_inverted_index":{"1.1.":[0],"Purpose:":[1],"To":[2,61],"report":[3,19,82],"a":[4,95,107,126],"case":[5,18,85,104],"of":[6,13,64,86,92,99,110,116,120],"severe":[7,87],"sight":[8],"loss":[9,91],"following":[10,78,94],"single":[11,96],"infusion":[12,98],"pembrolzumab":[14],"1.2.":[15],"Methods:":[16],"Retrospective":[17],"1.3.":[20],"Results:":[21],"Ocular":[22],"adverse":[23,123],"events":[24,124],"associated":[25],"with":[26],"immune":[27,59],"checkpoint":[28],"inhibitors,":[29],"due":[30],"to":[31],"their":[32],"rarity,":[33],"remain":[34],"poorly":[35],"characterised.":[36],"Pembrolizumab":[37],"targets":[38],"the":[39,49,56,83,111],"programmed":[40],"cell":[41],"death":[42],"(PD-1)":[43],"protein":[44],"on":[45],"T":[46],"cells,":[47],"circumventing":[48],"mechanisms":[50],"by":[51],"which":[52],"cancer":[53,138],"cells":[54],"evade":[55],"body\u2019s":[57],"adaptive":[58],"response.":[60],"date,":[62],"reports":[63],"ocular":[65,121],"surface":[66],"disease,":[67],"neuro-ophthalmic":[68],"complications,":[69],"orbitopathy,":[70],"retinal":[71],"dysfunction":[72],"and":[73,125,131],"uveitis":[74],"have":[75],"been":[76],"reported":[77],"pembrolizumab":[79],"infusion.":[80],"We":[81],"first":[84],"panuveitis":[88],"resulting":[89],"in":[90,133],"vision,":[93],"initial":[97],"pembrolizumab.":[100],"1.4.":[101],"Conclusion:":[102],"The":[103],"serves":[105],"as":[106],"heartening":[108],"reminder":[109],"need":[112],"for":[113,137],"prompt":[114],"reporting":[115],"visual":[117],"symptoms,":[118],"recognition":[119],"immune-related":[122],"multi-disciplinary":[127],"approach":[128],"between":[129],"oncology":[130],"ophthalmology":[132],"patients":[134],"receiving":[135],"immunotherapy":[136],"treatment.":[139]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2024-08-02T00:00:00"}
